Mozart is still blue: a comparison of sensory and verbal scales to describe qualities in music

An experiment was carried out in order to assess the use of non-verbal sensory scales for evaluating perceived music qualities, by comparing them with the analogous verbal scales. Participants were divided into two groups; one group (SV) completed a set of non-verbal scales responses and then a set of verbal scales responses to short musical extracts. A second group (VS) completed the experiment in the reverse order. Our hypothesis was that the ratings of the SV group can provide information unmediated (or less mediated) by verbal association in a much stronger way than the VS group. Factor analysis performed separately on the SV group, the VS group and for all participants shows a recurring patterning of the majority of sensory scales versus the verbal scales into different factors. Such results suggest that the sensory scale items are indicative of a different semantic structure than the verbal scales in describing music, and so they are indexing different qualities (perhaps ineffable), making them potentially special contributors to understanding musical experience

Persistence of pseudogap formation in quasi-2D systems with arbitrary carrier density

The existence of a pseudogap above the critical temperature has been widely used to explain the anomalous behaviour of the normal state of high-temperature superconductors. In two dimensions the existence of a pseudogap phase has already been demonstrated in a simple model. It can now be shown that the pseudogap phase persists even for the more realistic case where coherent interlayer tunneling is taken into account. The effective anisotropy is surprisingly large and even increases with increasing carrier density.Comment: 17 pages, LaTeX, 1 EMTeX figure; extended versio

Synthesis and vectorial functionalisation of pyrazolo[3,4- c ]pyridines

Heterocycles are a cornerstone of fragment-based drug discovery (FBDD) due to their prevalence in biologically active compounds. However, novel heterocyclic fragments are only valuable if they can be suitably elaborated to compliment a chosen target protein. Here we describe the synthesis of 5-halo-1H-pyrazolo[3,4-c]pyridine scaffolds and demonstrate how these compounds can be selectively elaborated along multiple growth-vectors. Specifically, N-1 and N-2 are accessed through protection-group and N-alkylation reactions; C-3 through tandem borylation and Suzuki–Miyaura cross-coupling reactions; C-5 through Pd-catalysed Buchwald–Hartwig amination; and C-7 through selective metalation with TMPMgCl.LiCl followed by reaction with electrophiles or transmetalation to ZnCl2 and Negishi cross-coupling. Linking multiple functionalisation strategies emulates a hit-to-lead pathway and demonstrates the utility of pyrazolo[3,4-c]pyridines to FBDD

EDITORIAL

A Educação em Revista tem o prazer de publicar o número 1, volume 18 que apresenta ao leitor sete artigos na área de educação com diferentes enfoques

EDITORIAL

A Educação em Revista tem o prazer de publicar o número 2, volume 18 que apresenta ao leitor sete artigos na área da Educação com diferentes enfoques:No artigo “Avaliação de Escolas, mudança e inovação dos processos de liderança e gestão do trabalho escolar – uma meta-analise a partir de relatórios oficiais”, Henrique Pereira Ramalho procura compreender o discurso oficial sobre o papel das lideranças e da gestão escolar, tomando por base sete relatórios anuais da avaliação externa das escolas de Portugal, relativos ao período de 2006-2007 e 2012-2013. Para o autor, dentro das escolas portuguesas – contraditoriamente – o discurso oficial reforça as “lideranças aplicadoras”, de feição “conservadora, em detrimento das lideranças orientadas para a pesquisa como suporte à decisão periférica” de tal forma que os gestores orientados pelo “instinto de sobrevivência” subordinam suas ações ao “efeito sedutor do mero elogio”; assim, a avaliação externa de escolas surge como mais um processo de reestruturação do modelo de prestação de contas e de responsabilização, com enfoque nos resultados

EDITORIAL

A Educação em Revista tem o prazer de publicar o número 19, volume 01 que apresenta ao leitor 10 (dez) artigos na área da Educação com diferentes enfoques: A Apropriação do Ruralismo Pedagógico e a Materialidade da Escola Rural no Estado de Sergipe (1947 – 1951); A Racionalidade Subjacente em Processos de Implantações Curriculares: um Olhar Habermasiano sobre Relatos de Professores de Matemática; A Filosofia no Ensino Médio: o Cinema como Recurso Didático; Sentidos Atribuídos ao Mundo do Trabalho pelas Crianças: a Escola como parte desse Processo; Gerencialismo e Performatividade na Gestão da Educação Brasileira; Programa Escola da Família: a Escola a Desserviço da Escola; Relações entre Pares e Violência na Escola: Percepções de Estudantes Paraenses; O Mediador Escolar no Segundo Segmento do Ensino Fundamental: Interlocuções entre Espaços, Desafios e Possibilidades da Inclusão Escolar; Práticas de Leitura na EJA: Contribuições para a Formação Política de Leitores no Ensino Médio; Influência do Apoio dos Pais e Encarregados de Educação no Desempenho Escolar dos Educandos em Moçambique

EDITORIAL

A Educação em Revista tem o prazer de publicar o número 2, volume 19. Na Seção Artigos serão apresentados ao leitor dez artigos na área da Educação com diferentes enfoques. Boa leitura a todos/as

Superconductivity in graphene stacks: from the bilayer to graphite

We study the superconducting phase transition, both in a graphene bilayer and in graphite. For that purpose we derive the mean-field effective potential for a stack of graphene layers presenting hopping between adjacent sheets. For describing superconductivity, we assume there is an on-site attractive interaction between electrons and determine the superconducting critical temperature as a function of the chemical potential. This displays a dome-shaped curve, in agreement with previous results for two-dimensional Dirac fermions. We show that the hopping between adjacent layers increases the critical temperature for small values of the chemical potential. Finally, we consider a minimal model for graphite and show that the transition temperature is higher than that for the graphene bilayer for small values of chemical potential. This might explain why intrinsic superconductivity is observed in graphite

Simple Model for the Variation of Superfluid Density with Zn Concentration in YBCO

We describe a simple model for calculating the zero-temperature superfluid density of Zn-doped YBa_2Cu_3O_{7-\delta} as a function of the fraction x of in-plane Cu atoms which are replaced by Zn. The basis of the calculation is a ``Swiss cheese'' picture of a single CuO_2 layer, in which a substitutional Zn impurity creates a normal region of area $\pi\xi_{ab}^2$ around it as originally suggested by Nachumi et al. Here $\xi_{ab}$ is the zero-temperature in-plane coherence length at x = 0. We use this picture to calculate the variation of the in-plane superfluid density with x at temperature T = 0, using both a numerical approach and an analytical approximation. For $\delta = 0.37$, if we use the value $\xi_{ab}$ = 18.3 angstrom, we find that the in-plane superfluid decreases with increasing x and vanishes near $x_c = 0.01$ in the analytical approximation, and near $x_c = 0.014$ in the numerical approach. $x_c$ is quite sensitive to $\xi_{ab}$, whose value is not widely agreed upon. The model also predicts a peak in the real part of the conductivity, Re$\sigma_e(\omega, x)$, at concentrations $x \sim x_c$, and low frequencies, and a variation of critical current density with x of the form $J_c(x) \propto n_{S,e}(x)^{7/4}$ near percolation, where $n_{S,e}(x)$ is the in-plane superfluid density.Comment: 19 pages including 6 figures, submitted to Physica

Periodontal disease and periodontal bacteria as triggers for rheumatoid arthritis

There is an epidemiological association between periodontitis and rheumatoid arthritis (RA), which is hypothesised to lead to enhanced generation of RA-related autoantibodies that can be detected years before the onset of RA symptoms. Periodontitis is a common dysbiotic disease; tissue damage occurs because the immune system fails to limit both the resident microbial community and the associated local immune response. Certain periodontal bacteria, including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, may contribute to RA autoantibody production through direct post-translational modification of proteins or, indirectly, by influencing neutrophil-mediated neo-epitope generation. Oral bacteria that invade the blood may also contribute to chronic inflammatory responses and generation of autoantibodies. The putative association between periodontitis and the development of RA raises the potential of finding novel predictive markers of disease and disease progression and for periodontitis treatment to be included in the future as an adjunct to conventional RA immunotherapy or as part of a preventive strategy