1,719 research outputs found
Weak Convergence of the Scaled Median of Independent Brownian Motions
We consider the median of n independent Brownian motions, and show that this
process, when properly scaled, converges weakly to a centered Gaussian process.
The chief difficulty is establishing tightness, which is proved through direct
estimates on the increments of the median process. An explicit formula is given
for the covariance function of the limit process. The limit process is also
shown to be Holder continuous with exponent gamma for all gamma < 1/4.Comment: to appear in Probability Theory and Related Field
Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone
BACKGROUND
New strains of meticillin-resistant Staphylococcus aureus (MRSA) may be associated with changes in rates of disease or clinical presentation. Conventional typing techniques may not detect new clonal variants that underlie changes in epidemiology or clinical phenotype.
AIM
To investigate the role of clonal variants of MRSA in an outbreak of MRSA bacteraemia at a hospital in England.
METHODS
Bacteraemia isolates of the major UK lineages (EMRSA-15 and -16) from before and after the outbreak were analysed by whole-genome sequencing in the context of epidemiological and clinical data. For comparison, EMRSA-15 and -16 isolates from another hospital in England were sequenced. A clonal variant of EMRSA-16 was identified at the outbreak hospital and a molecular signature test designed to distinguish variant isolates among further EMRSA-16 strains.
FINDINGS
By whole-genome sequencing, EMRSA-16 isolates during the outbreak showed strikingly low genetic diversity (P < 1 × 10(-6), Monte Carlo test), compared with EMRSA-15 and EMRSA-16 isolates from before the outbreak or the comparator hospital, demonstrating the emergence of a clonal variant. The variant was indistinguishable from the ancestral strain by conventional typing. This clonal variant accounted for 64/72 (89%) of EMRSA-16 bacteraemia isolates at the outbreak hospital from 2006.
CONCLUSIONS
Evolutionary changes in epidemic MRSA strains not detected by conventional typing may be associated with changes in disease epidemiology. Rapid and affordable technologies for whole-genome sequencing are becoming available with the potential to identify and track the emergence of variants of highly clonal organisms
Dielectric and conductivity relaxation in mixtures of glycerol with LiCl
We report a thorough dielectric characterization of the alpha relaxation of
glass forming glycerol with varying additions of LiCl. Nine salt concentrations
from 0.1 - 20 mol% are investigated in a frequency range of 20 Hz - 3 GHz and
analyzed in the dielectric loss and modulus representation. Information on the
dc conductivity, the dielectric relaxation time (from the loss) and the
conductivity relaxation time (from the modulus) is provided. Overall, with
increasing ion concentration, a transition from reorientationally to
translationally dominated behavior is observed and the translational ion
dynamics and the dipolar reorientational dynamics become successively coupled.
This gives rise to the prospect that by adding ions to dipolar glass formers,
dielectric spectroscopy may directly couple to the translational degrees of
freedom determining the glass transition, even in frequency regimes where
usually strong decoupling is observed.Comment: 8 pages, 7 figure
Survival, pathologic response, and genomics in CALGB 40601 (Alliance), a neoadjuvant Phase III trial of paclitaxel-trastuzumab with or without lapatinib in HER2-positive breast cancer
PURPOSE CALGB 40601 assessed whether dual versus single human epidermal growth factor receptor 2 (HER2) -targeting drugs added to neoadjuvant chemotherapy increased pathologic complete response (pCR). Here, we report relapse-free survival (RFS), overall survival (OS), and gene expression signatures that predict pCR and survival. PATIENTS AND METHODS Three hundred five women with untreated stage II and III HER2-positive breast cancer were randomly assigned to receive weekly paclitaxel combined with trastuzumab plus lapatinib (THL), trastuzumab (TH), or lapatinib (TL). The primary end point was pCR, and secondary end points included RFS, OS, and gene expression analyses. mRNA sequencing was performed on 264 pretreatment samples. RESULTS One hundred eighteen patients were randomly allocated to THL, 120 to TH, and 67 to TL. At more than 7 years of follow-up, THL had significantly better RFS and OS than did TH (RFS hazard ratio, 0.32; 95% CI, 0.14 to 0.71; P 5.005; OS hazard ratio, 0.34; 95% CI, 0.12 to 0.94; P 5.037), with no difference between TH and TL. Of 688 previously described gene expression signatures, significant associations were found in 215 with pCR, 45 with RFS, and only 22 with both pCR and RFS (3.2%). Specifically, eight immune signatures were significantly correlated with a higher pCR rate and better RFS. Among patients with residual disease, the immunoglobulin G signature was an independent, good prognostic factor, whereas the HER2-enriched signature, which was associated with a higher pCR rate, showed a significantly shorter RFS. CONCLUSION In CALGB 40601, dual HER2-targeting resulted in significant RFS and OS benefits. Integration of intrinsic subtype and immune signatures allowed for the prediction of pCR and RFS, both overall and within the residual disease group. These approaches may provide means for rational escalation and de-escalation treatment strategies in HER2-positive breast cancer
Effects of Large CP violating phases on g_{\m}-2 in MSSM
Effects of CP violation on the supersymmetric electro-weak correction to the
anomalous magnetic moment of the muon are investigated with the most general
allowed set of CP violating phases in MSSM. The analysis includes contributions
from the chargino and the neutralino exchanges to the muon anomaly. The
supersymmetric contributions depend only on specific combinations of CP phases.
The independent set of such phases is classified. We analyse the effects of the
phases under the EDM constraints and show that large CP violating phases can
drastically affect the magnitude of the supersymmetric electro-weak
contribution to and may even affect its overall sign.Comment: 26 pages Latex file including 4 figure
Using the past to constrain the future: how the palaeorecord can improve estimates of global warming
Climate sensitivity is defined as the change in global mean equilibrium
temperature after a doubling of atmospheric CO2 concentration and provides a
simple measure of global warming. An early estimate of climate sensitivity,
1.5-4.5{\deg}C, has changed little subsequently, including the latest
assessment by the Intergovernmental Panel on Climate Change.
The persistence of such large uncertainties in this simple measure casts
doubt on our understanding of the mechanisms of climate change and our ability
to predict the response of the climate system to future perturbations. This has
motivated continued attempts to constrain the range with climate data, alone or
in conjunction with models. The majority of studies use data from the
instrumental period (post-1850) but recent work has made use of information
about the large climate changes experienced in the geological past.
In this review, we first outline approaches that estimate climate sensitivity
using instrumental climate observations and then summarise attempts to use the
record of climate change on geological timescales. We examine the limitations
of these studies and suggest ways in which the power of the palaeoclimate
record could be better used to reduce uncertainties in our predictions of
climate sensitivity.Comment: The final, definitive version of this paper has been published in
Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All
rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso
Effect of 15n-labeled hairy vetch and nitrogen fertilization on maize nutrition and yield under no-tillage¹
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