Limits on the time variation of the electromagnetic fine-structure constant in the low energy limit from absorption lines in the spectra of distant quasars

Most of the successful physical theories rely on the constancy of few fundamental quantities (such as the speed of light, $c$, the fine-structure constant, \alpha, the proton to electron mass ratio, \mu, etc), and constraining the possible time variations of these fundamental quantities is an important step toward a complete physical theory. Time variation of \alpha can be accurately probed using absorption lines seen in the spectra of distant quasars. Here, we present the results of a detailed many-multiplet analysis performed on a new sample of Mg II systems observed in high quality quasar spectra obtained using the Very Large Telescope. The weighted mean value of the variation in \alpha derived from our analysis over the redshift range 0.4<z<2.3 is \Delta\alpha/\alpha = (-0.06+/-0.06) x 10^{-5}. The median redshift of our sample (z=1.55) corresponds to a look-back time of 9.7 Gyr in the most favored cosmological model today. This gives a 3\sigma limit, -2.5 x 10^{-16} yr^-1 <(\Delta\alpha/\alpha\Delta t) <+1.2x10^{-16} yr^-1, for the time variation of \alpha, that forms the strongest constraint obtained based on high redshift quasar absorption line systems.Comment: uses revtex, 4 pages 3 figures. Accepted for publication in Physical Review Letter

Antisymmetric-Tensor and Electromagnetic effects in an alpha'-non-perturbative Four-Dimensional String Cosmology

Starting from an exact (in the Regge slope alpha') functional method for a bosonic stringy sigma-model, we investigate four-dimensional cosmological string solutions in graviton, dilaton and antisymmetric tensor backgrounds, compatible with world-sheet conformal invariance, and valid beyond perturbative expansions in powers of alpha'. The antisymmetric tensor field, playing the role of an axion in the four-dimensional target space time, leads to spatial anisotropies of the emergent Robertson-Walker expanding Universe, and, upon coupling the system to the electromagnetic field, it results in non-trivial optical activity. Some estimates of the corresponding effects are made and their relevance to current cosmology is briefly discussed

Constraining fundamental constants of physics with quasar absorption line systems

We summarize the attempts by our group and others to derive constraints on variations of fundamental constants over cosmic time using quasar absorption lines. Most upper limits reside in the range 0.5-1.5x10-5 at the 3sigma level over a redshift range of approximately 0.5-2.5 for the fine-structure constant, alpha, the proton-to-electron mass ratio, mu, and a combination of the proton gyromagnetic factor and the two previous constants, gp(alpha^2/mu)^nu, for only one claimed variation of alpha. It is therefore very important to perform new measurements to improve the sensitivity of the numerous methods to at least <0.1x10-5 which should be possible in the next few years. Future instrumentations on ELTs in the optical and/or ALMA, EVLA and SKA pathfinders in the radio will undoutedly boost this field by allowing to reach much better signal-to-noise ratios at higher spectral resolution and to perform measurements on molecules in the ISM of high redshift galaxies.Comment: 11 pages, 3 figure

Improving Power Delivery of Grid-Connected Induction Machine Based Wind Generators under Dynamic Conditions Using Feedforward Linear Neural Networks

In the conventional grid-connected Wind Energy Conversion System (WECS), the generator side inverter is typically controlled via Field Oriented Control (FOC), while Voltage Oriented Control (VOC) controls the grid side inverter. However, robust operation cannot be guaranteed during sudden changes in wind speeds and weak grid connections. This paper presents a novel method to improve the overall dynamic performance of on-grid induction machine-based wind generators. An online mechanical parameter estimation technique is devised using Recursive Least Squares (RLS) to compute the machine inertia and friction coefficient iteratively. An adaptive feedforward neural (AFN) controller is also proposed in the synchronous reference frame, which is constructed using the estimated parameters and the system's inverse. The output of the neural controller is added to the output of the speed PI controller in the outer loop of the FOC to enhance the speed response of the wind generator. A similar approach is taken to improve the classical VOC structure for the grid-side inverter. In this case, the RLS estimates the equivalent Thevenin's grid impedance in real-time. As for the adaptive action, two identical neural networks are integrated with the inner loop direct and quadrature axis current PI controllers. Under nominal operating conditions, it is observed that the PI+AFN provides a faster settling time for the generator's speed and torque response. Upon being subjected to variations in the wind speed, the PI+AFN outperforms the classical PI controller and attains a lower integral-time error. In addition, the proposed PI+AFN controller has a better ability to maintain the grid-side inverter stability during stochastic variations in grid impedance. One significant advantage of the proposed control approach is that no data for training or validation is required since the neural network weights are directly the output of the RLS estimator. Hardware verification for the improved FOC for wind generators using the adaptive controller is also made using the DSPACE 1007 AUTOBOX platform

Could Nanotheranostics be the Answer to the Coronavirus Crisis?

The COVID-19 pandemic is expanding worldwide. This pandemic associated with COVID-19 placed the spotlight on how bacterial (e.g., methicillin-resistant Staphylococcus aureus) co-infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and rapidly diagnose COVID-19 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely "superhydrophobic self-disinfecting electrospun facemasks/fabrics (SSEF)." SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and "top-five suggestions" for containing COVID-19 are offered, including: i) preventive appraisals-avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics-highly recommending nanodiagnostics, detecting COVID-19 within 10 min. iii) Therapeutics-expanding nanotherapeutics to treat COVID-19 and bacterial co-infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way.Peer reviewe

Constraining the variation of fundamental constants at z ~ 1.3 using 21-cm absorbers

We present high resolution optical spectra obtained with the Ultraviolet and Visual Echelle Spectrograph (UVES) at the Very Large Telescope (VLT) and 21-cm absorption spectra obtained with the Giant Metrewave Radio Telescope (GMRT) and the Green Bank Telescope (GBT) of five quasars along the line of sight of which 21-cm absorption systems at 1.17 < z < 1.56 have been detected previously. We also present milliarcsec scale radio images of these quasars obtained with the Very Large Baseline Array (VLBA). We use the data on four of these systems to constrain the time variation of x = g_p*alpha^2/mu where g_p is the proton gyromagnetic factor, alpha is the fine structure constant, and mu is the proton-to-electron mass ratio. We carefully evaluate the systematic uncertainties in redshift measurements using cross-correlation analysis and repeated Voigt profile fitting. In two cases we also confirm our results by analysing optical spectra obtained with the Keck telescope. We find the weighted and the simple means of Delta_x / x to be respectively -(0.1 +/- 1.3)x10^-6 and (0.0 +/- 1.5)x10^-6 at the mean redshift of = 1.36 corresponding to a look back time of ~ 9 Gyr. This is the most stringent constraint ever obtained on Delta_x / x. If we only use the two systems towards quasars unresolved at milliarcsec scales, we get the simple mean of Delta_x / x = + (0.2 +/- 1.6)x10^-6. Assuming constancy of other constants we get Delta_alpha / alpha = (0.0 +/- 0.8)x10^-6 which is a factor of two better than the best constraints obtained so far using the Many Multiplet Method. On the other hand assuming alpha and g_p have not varied we derive Delta_mmu / mu = (0.0 +/- 1.5)x10^-6 which is again the best limit ever obtained on the variation of mu over this redshift range. [Abridged]Comment: 22 pages, 15 figures, Accepted for publication in MNRA

The Correlation between X-ray spectral slope and FeKalpha line energy in radio-quiet active galactic nuclei

A significant correlation between FeKalpha line energy and X-ray spectral slope has been discovered among radio-quiet active galactic nuclei. The ionization stage of the bulk of the FeKalpha emitting material is not the same in all active galactic nuclei and is related to the shape of the X-ray continua. Active galactic nuclei with a steep X-ray spectrum tend to have a fluorescence FeKalpha line from highly ionized material. In the narrow-line Seyfert 1 galaxies with steeper X-ray spectrum (Gamma_X > 2.1), the FeKalpha line originates from highly ionized material. In the Seyfert 1 galaxies and quasars with flatter X-ray spectrum (Gamma_X < 2.1), bulk of the FeKalpha emission arises from near neutral or weakly ionized material. The correlation is an important observational characteristic related to the accretion process in radio quiet active galactic nuclei and is driven by a fundamental physical parameter which is likely to be the accretion rate relative to the Eddington rate.Comment: 4 pages, To apear in ApJ Letter

Bounds on the Complexity of Halfspace Intersections when the Bounded Faces have Small Dimension

We study the combinatorial complexity of D-dimensional polyhedra defined as the intersection of n halfspaces, with the property that the highest dimension of any bounded face is much smaller than D. We show that, if d is the maximum dimension of a bounded face, then the number of vertices of the polyhedron is O(n^d) and the total number of bounded faces of the polyhedron is O(n^d^2). For inputs in general position the number of bounded faces is O(n^d). For any fixed d, we show how to compute the set of all vertices, how to determine the maximum dimension of a bounded face of the polyhedron, and how to compute the set of bounded faces in polynomial time, by solving a polynomial number of linear programs

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. CEACAM1 possesses adhesive and signaling properties mediated by its intrinsic immunorecep-tor tyrosine-based inhibitory motifs that recruit SHP-1 protein-tyrosine phosphatase. In this study, we demonstrate that CEACAM1 is expressed on the surface and in intracellular pools of platelets. In addition, CEACAM1 serves to negatively regulate signaling of platelets by collagen through the glycoprotein VI (GPVI)/Fc receptor (FcR)-?-chain. ceacam1 -/- platelets displayed enhanced type I collagen and GPVI-selective ligand, collagen-related peptide (CRP), CRP-mediated platelet aggregation, enhanced platelet adhesion on type I collagen, and elevated CRP-mediated alpha and dense granule secretion. Platelets derived from ceacam1-/- mice form larger thrombi when perfused over a collagen matrix under arterial flow compared with wild-type mice. Furthermore, using intravital microscopy to ferric chloride-injured mesenteric arterioles, we show that thrombi formed in vivo in ceacam1-/- mice were larger and were more stable than those in wild-type mice. GPVI depletion using monoclonal antibody JAQ1 treatment of ceacam1-/- mice showed a reversal in the more stable thrombus growth phenotype. ceacam1-/- mice were more susceptible to type I collagen-induced pulmonary thromboembolism than wild-type mice. Thus, CEACAM1 acts as a negative regulator of platelet-collagen interactions and of thrombus growth involving the collagen GPVI receptor in vitro and in vivo