Inhibición de butirilcolinesterasa en dos perros intoxicados y confirmación analítica de carbofuran como agente causal

Ferré, D.M.; Saldeña, E.L.; Albarracín, L.; Neuilly, V.; Gorla, N.B.: Inhibición de butirilcolinesterasa en dos perros intoxicados y confirmación analítica de carbofuran como agente causal. Rev. vet. 26: 1, 43-48, 2015

The Microcalorimeter Arrays for a Rhenium Experiment (MARE): a next-generation calorimetric neutrino mass experiment

Neutrino oscillation experiments have proved that neutrinos are massive particles, but can't determine their absolute mass scale. Therefore the neutrino mass is still an open question in elementary particle physics. An international collaboration is growing around the project of Microcalorimeter Arrays for a Rhenium Experiment (MARE) for directly measuring the neutrino mass with a sensitivity of about 0.2eV/c2. Many groups are joining their experiences and technical expertise in a common effort towards this challenging experiment. We discuss the different scenarios and the impact of MARE as a complement of KATRIN.Comment: 3 pages, 1 figure Nucl. Instr. Meth. A, proceedings of LTD11 workshop, Tokyo 200

A New Limit on the Neutrinoless DBD of 130Te

We report the present results of CUORICINO a cryogenic experiment on neutrinoless double beta decay (DBD) of 130Te consisting of an array of 62 crystals of TeO2 with a total active mass of 40.7 kg. The array is framed inside of a dilution refrigerator, heavily shielded against environmental radioactivity and high-energy neutrons, and operated at a temperature of ~8 mK in the Gran Sasso Underground Laboratory. Temperature pulses induced by particle interacting in the crystals are recorded and measured by means of Neutron Transmutation Doped thermistors. The gain of each bolometer is stabilized with voltage pulses developed by a high stability pulse generator across heater resistors put in thermal contact with the absorber. The calibration is performed by means of two thoriated wires routinely inserted in the set-up. No evidence for a peak indicating neutrinoless DBD of 130Te is detected and a 90% C.L. lower limit of 1.8E24 years is set for the lifetime of this process. Taking largely into account the uncertainties in the theoretical values of nuclear matrix elements, this implies an upper boud on the effective mass of the electron neutrino ranging from 0.2 to 1.1 eV. This sensitivity is similar to those of the 76Ge experiments.Comment: 4 pages, 2 figure

Relações entre altura de plantas em função da radiação solar global acumulada para duas cultivares de Musa sp. em três ciclos de produção em registro/SP/Brasil

A produção de banana é uma das atividades agrícolas de maior destaque mundial. Existem fortes relações entre o crescimento e desenvolvimento das plantas com a radiação solar global acumulada. O presente trabalho teve como objetivo relacionar a radiação solar global acumulada na superfície terrestre com a altura das plantas ao longo de 3 ciclos produtivos. O estudo foi desenvolvido na UNESP Câmpus Experimental de Registro/SP/Brasil durante os anos agrícolas de 2011 a 2013. Foram utilizadas as cultivares de banana a Prata e Grande Naine. A radiação solar global foi fornecida pelo Centro Integrado de Informações Meteorológicas (CIIAGRO). Os resultados mostraram que as plantas necessitam entre 3,96GJ/m2 a 5,2GJ/m2 nos ciclos produtivos, atingindo alturas médias de 267,2cm e 255,6 para as cultivares Prata e Grande Naine, respectivamente.Banana production is one of the major global agricultural activities. There is a strong relationship between the growth and development of plants with the accumulated solar radiation. This study aimed to relate the available solar radiation on the earth's surface with plant height during 3 production cycles. The study was conducted at UNESP Campus Experimental de Registro /SP/Brazil, during the crop years 2011 to 2013. We used the banana cultivars Prata and Grande Naine. The global solar radiation was provided by the Centro Integrado de Informação Meteorológica ( CIIAGRO ) . The results showed that plants needs 3,96GJ/m2 to 5,2GJ/m2 at productive cycles and averaged heights 267,2cm and 255.6 for Prata and Grande Naine, respectively.Tema 11: Radiación solar y clima.Facultad de Arquitectura y Urbanism

Relações entre altura de plantas em função da radiação solar global acumulada para duas cultivares de Musa sp. em três ciclos de produção em registro/SP/Brasil

A produção de banana é uma das atividades agrícolas de maior destaque mundial. Existem fortes relações entre o crescimento e desenvolvimento das plantas com a radiação solar global acumulada. O presente trabalho teve como objetivo relacionar a radiação solar global acumulada na superfície terrestre com a altura das plantas ao longo de 3 ciclos produtivos. O estudo foi desenvolvido na UNESP Câmpus Experimental de Registro/SP/Brasil durante os anos agrícolas de 2011 a 2013. Foram utilizadas as cultivares de banana a Prata e Grande Naine. A radiação solar global foi fornecida pelo Centro Integrado de Informações Meteorológicas (CIIAGRO). Os resultados mostraram que as plantas necessitam entre 3,96GJ/m2 a 5,2GJ/m2 nos ciclos produtivos, atingindo alturas médias de 267,2cm e 255,6 para as cultivares Prata e Grande Naine, respectivamente.Banana production is one of the major global agricultural activities. There is a strong relationship between the growth and development of plants with the accumulated solar radiation. This study aimed to relate the available solar radiation on the earth's surface with plant height during 3 production cycles. The study was conducted at UNESP Campus Experimental de Registro /SP/Brazil, during the crop years 2011 to 2013. We used the banana cultivars Prata and Grande Naine. The global solar radiation was provided by the Centro Integrado de Informação Meteorológica ( CIIAGRO ) . The results showed that plants needs 3,96GJ/m2 to 5,2GJ/m2 at productive cycles and averaged heights 267,2cm and 255.6 for Prata and Grande Naine, respectively.Tema 11: Radiación solar y clima.Facultad de Arquitectura y Urbanism

Relações entre altura de plantas em função da radiação solar global acumulada para duas cultivares de Musa sp. em três ciclos de produção em registro/SP/Brasil

A produção de banana é uma das atividades agrícolas de maior destaque mundial. Existem fortes relações entre o crescimento e desenvolvimento das plantas com a radiação solar global acumulada. O presente trabalho teve como objetivo relacionar a radiação solar global acumulada na superfície terrestre com a altura das plantas ao longo de 3 ciclos produtivos. O estudo foi desenvolvido na UNESP Câmpus Experimental de Registro/SP/Brasil durante os anos agrícolas de 2011 a 2013. Foram utilizadas as cultivares de banana a Prata e Grande Naine. A radiação solar global foi fornecida pelo Centro Integrado de Informações Meteorológicas (CIIAGRO). Os resultados mostraram que as plantas necessitam entre 3,96GJ/m2 a 5,2GJ/m2 nos ciclos produtivos, atingindo alturas médias de 267,2cm e 255,6 para as cultivares Prata e Grande Naine, respectivamente.Banana production is one of the major global agricultural activities. There is a strong relationship between the growth and development of plants with the accumulated solar radiation. This study aimed to relate the available solar radiation on the earth's surface with plant height during 3 production cycles. The study was conducted at UNESP Campus Experimental de Registro /SP/Brazil, during the crop years 2011 to 2013. We used the banana cultivars Prata and Grande Naine. The global solar radiation was provided by the Centro Integrado de Informação Meteorológica ( CIIAGRO ) . The results showed that plants needs 3,96GJ/m2 to 5,2GJ/m2 at productive cycles and averaged heights 267,2cm and 255.6 for Prata and Grande Naine, respectively.Tema 11: Radiación solar y clima.Facultad de Arquitectura y Urbanism

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5?-Monophosphate Dehydrogenase

Cryptosporidium parvum is an enteric protozoan parasite that has emerged as a major cause of diarrhea, malnutrition, and gastroenteritis and poses a potential bioterrorism threat. C. parvum synthesizes guanine nucleotides from host adenosine in a streamlined pathway that relies on inosine 5?-monophosphate dehydrogenase (IMPDH). We have previously identified several parasite-selective C. parvum IMPDH (CpIMPDH) inhibitors by high-throughput screening. In this paper, we report the structure–activity relationship (SAR) for a series of benzoxazole derivatives with many compounds demonstrating CpIMPDH IC50 values in the nanomolar range and >500-fold selectivity over human IMPDH (hIMPDH). Unlike previously reported CpIMPDH inhibitors, these compounds are competitive inhibitors versus NAD+. The SAR study reveals that pyridine and other small heteroaromatic substituents are required at the 2-position of the benzoxazole for potent inhibitory activity. In addition, several other SAR conclusions are highlighted with regard to the benzoxazole and the amide portion of the inhibitor, including preferred stereochemistry. An X-ray crystal structure of a representative E·IMP·inhibitor complex is also presented. Overall, the secondary amine derivative 15a demonstrated excellent CpIMPDH inhibitory activity (IC50 = 0.5 ± 0.1 nM) and moderate stability (t1/2 = 44 min) in mouse liver microsomes. Compound 73, the racemic version of 15a, also displayed superb antiparasitic activity in a Toxoplasma gondii strain that relies on CpIMPDH (EC50 = 20 ± 20 nM), and selectivity versus a wild-type T. gondii strain (200-fold). No toxicity was observed (LD50 > 50 ?M) against a panel of four mammalian cells lines

Double-beta decay of 130^{130}Te to the first 0+^{+} excited state of 130^{130}Xe with CUORICINO

The CUORICINO experiment was an array of 62 TeO$_{2}$ single-crystal bolometers with a total $^{130}$Te mass of $11.3\,$kg. The experiment finished in 2008 after more than 3 years of active operating time. Searches for both $0\nu$ and $2\nu$ double-beta decay to the first excited $0^{+}$ state in $^{130}$Xe were performed by studying different coincidence scenarios. The analysis was based on data representing a total exposure of N($^{130}$Te)$\cdot$t=$9.5\times10^{25}\,$y. No evidence for a signal was found. The resulting lower limits on the half lives are $T^{2\nu}_{1/2}(^{130} Te\rightarrow^{130} Xe^{*})>1.3\times10^{23}\,$y (90% C.L.), and $T^{0\nu}_{1/2}(^{130} Te\rightarrow^{130} Xe^{*})>9.4\times10^{23}\,$y (90% C.L.).Comment: 6 pages, 4 figure

Evaluación de riesgo ecológico del ambiente acuático mediante biomarcadores de contaminación en peces.

Los peces son utilizados cómo centinelas de contaminación de ecosistemas acuáticos, debido a su elevada posición en la cadena alimentaria y el requerimiento de alto volumen de agua para su respiración, generando una exposición intensiva a contaminantes y desarrollando alteraciones (biomarcadores). Con el fin de conocer el estado ecosanitario de un ambiente acuático se busca determinar alteraciones y efectos producidos por contaminantes plaguicidas

The CUORE cryostat: an infrastructure for rare event searches at millikelvin temperatures

The CUORE experiment is the world's largest bolometric experiment. The detector consists of an array of 988 TeO2 crystals, for a total mass of 742 kg. CUORE is presently taking data at the Laboratori Nazionali del Gran Sasso, Italy, searching for the neutrinoless double beta decay of 130Te. A large custom cryogen-free cryostat allows reaching and maintaining a base temperature of about 10 mK, required for the optimal operation of the detector. This apparatus has been designed in order to achieve a low noise environment, with minimal contribution to the radioactive background for the experiment. In this paper, we present an overview of the CUORE cryostat, together with a description of all its sub-systems, focusing on the solutions identified to satisfy the stringent requirements. We briefly illustrate the various phases of the cryostat commissioning and highlight the relevant steps and milestones achieved each time. Finally, we describe the successful cooldown of CUORE