Low-Mass Eclipsing Binaries in the Initial Kepler Data Release

We identify 231 objects in the newly released Cycle 0 dataset from the Kepler Mission as double-eclipse, detached eclipsing binary systems with Teff < 5500 K and orbital periods shorter than ~32 days. We model each light curve using the JKTEBOP code with a genetic algorithm to obtain precise values for each system. We identify 95 new systems with both components below 1.0 M_sun and eclipses of at least 0.1 magnitudes, suitable for ground-based follow-up. Of these, 14 have periods less than 1.0 day, 52 have periods between 1.0 and 10.0 days, and 29 have periods greater than 10.0 days. This new sample of main-sequence, low-mass, double-eclipse, detached eclipsing binary candidates more than doubles the number of previously known systems, and extends the sample into the completely heretofore unexplored P > 10.0 day period regime. We find preliminary evidence from these systems that the radii of low-mass stars in binary systems decrease with period. This supports the theory that binary spin-up is the primary cause of inflated radii in low-mass binary systems, although a full analysis of each system with radial-velocity and multi-color light curves is needed to fully explore this hypothesis. As well, we present 7 new transiting planet candidates that do not appear among the recently released list of 706 candidates by the Kepler team, nor in the Kepler False Positive Catalog, along with several other new and interesting systems. We also present novel techniques for the identification, period analysis, and modeling of eclipsing binaries.Comment: 22 pages in emulateapj format. 9 figures, 4 tables, 2 appendices. Accepted to AJ. Includes a significant addition of new material since last arXiv submission and an updated method for estimating masses and radi

Solutions for 10,000 Eclipsing Binaries in the Bulge Fields of OGLE II Using DEBiL

We have developed a fully-automated pipeline for systematically identifying and analyzing eclipsing binaries within large datasets of light curves. The pipeline is made up of multiple tiers which subject the light curves to increasing levels of scrutiny. After each tier, light curves that did not conform to a given criteria were filtered out of the pipeline, reducing the load on the following, more computationally intensive tiers. As a central component of the pipeline, we created the fully automated Detached Eclipsing Binary Light curve fitter (DEBiL), which rapidly fits large numbers of light curves to a simple model. Using the results of DEBiL, light curves of interest can be flagged for follow-up analysis. As a test case, we analyzed the 218699 light curves within the bulge fields of the OGLE II survey and produced 10862 model fits. We point out a small number of extreme examples as well as unexpected structure found in several of the population distributions. We expect this approach to become increasingly important as light curve datasets continue growing in both size and number.Comment: Accepted for publication in ApJ, 36 pages, 15 figures, 5 tables. See http://cfa-www.harvard.edu/~jdevor/DEBiL.html for high-resolution figures and further informatio

Searching for transits in the Wide Field Camera Transit Survey with difference-imaging light curves

The Wide Field Camera Transit Survey is a pioneer program aiming at for searching extra-solar planets in the near-infrared. The images from the survey are processed by a data reduction pipeline, which uses aperture photometry to construct the light curves. We produce an alternative set of light curves using the difference-imaging method for the most complete field in the survey and carry out a quantitative comparison between the photometric precision achieved with both methods. The results show that differencephotometry light curves present an important improvement for stars with J > 16. We report an implementation on the box-fitting transit detection algorithm, which performs a trapezoid-fit to the folded light curve, providing more accurate results than the boxfitting model. We describe and optimize a set of selection criteria to search for transit candidates, including the V-shape parameter calculated by our detection algorithm. The optimized selection criteria are applied to the aperture photometry and difference-imaging light curves, resulting in the automatic detection of the best 200 transit candidates from a sample of ~475 000 sources. We carry out a detailed analysis in the 18 best detections and classify them as transiting planet and eclipsing binary candidates. We present one planet candidate orbiting a late G-type star. No planet candidate around M-stars has been found, confirming the null detection hypothesis and upper limits on the occurrence rate of short-period giant planets around M-dwarfs presented in a prior study. We extend the search for transiting planets to stars with J ≤ 18, which enables us to set a stricter upper limit of 1.1%. Furthermore, we present the detection of five faint extremely-short period eclipsing binaries and three M-dwarf/M-dwarf binary candidates. The detections demonstrate the benefits of using the difference-imaging light curves, especially when going to fainter magnitudes.Peer reviewe

Planets in Stellar Clusters Extensive Search. III. A search for transiting planets in the metal-rich open cluster NGC 6791

We have undertaken a long-term project, Planets in Stellar Clusters Extensive Search (PISCES), to search for transiting planets in open clusters. In this paper we present the results for NGC 6791 -- a very old, populous, metal rich cluster. We have monitored the cluster for over 300 hours, spread over 84 nights. We have not detected any good transiting planet candidates. Given the photometric precision and temporal coverage of our observations, and current best estimates for the frequency and radii of short-period planets, the expected number of detectable transiting planets in our sample is 1.5. We have discovered 14 new variable stars in the cluster, most of which are eclipsing binaries, and present high precision light curves, spanning two years, for these new variables and also the previously known variables.Comment: 18 pages LaTeX, including 11 figures and 6 tables. Limb darkening included in the computation of the planet detection efficiency. Version with full resolution figures available through ftp at ftp://cfa-ftp.harvard.edu/pub/bmochejs/PISCES/papers/3_N6791

The K+ Channel Opener 1-EBIO Potentiates Residual Function of Mutant CFTR in Rectal Biopsies from Cystic Fibrosis Patients

BACKGROUND: The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K⁺ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl⁻ secretion in cultured cells and mouse colon. However, the effects of 1-EBIO on wild-type and mutant CFTR function in native human colonic tissues remain unknown. METHODS: We studied the effects of 1-EBIO on CFTR-mediated Cl⁻ secretion in rectal biopsies from 47 CF patients carrying a wide spectrum of CFTR mutations and 57 age-matched controls. Rectal tissues were mounted in perfused micro-Ussing chambers and the effects of 1-EBIO were compared in control tissues, CF tissues expressing residual CFTR function and CF tissues with no detectable Cl⁻ secretion. RESULTS: Studies in control tissues demonstrate that 1-EBIO activated CFTR-mediated Cl⁻ secretion in the absence of cAMP-mediated stimulation and potentiated cAMP-induced Cl⁻ secretion by 39.2±6.7% (P<0.001) via activation of basolateral Ca²⁺-activated and clotrimazole-sensitive KCNN4 K⁺ channels. In CF specimens, 1-EBIO potentiated cAMP-induced Cl⁻ secretion in tissues with residual CFTR function by 44.4±11.5% (P<0.001), but had no effect on tissues lacking CFTR-mediated Cl⁻ conductance. CONCLUSIONS: We conclude that 1-EBIO potentiates Cl⁻secretion in native CF tissues expressing CFTR mutants with residual Cl⁻ channel function by activation of basolateral KCNN4 K⁺ channels that increase the driving force for luminal Cl⁻ exit. This mechanism may augment effects of CFTR correctors and potentiators that increase the number and/or activity of mutant CFTR channels at the cell surface and suggests KCNN4 as a therapeutic target for CF

Four ultra-short period eclipsing M-dwarf binaries in the WFCAM Transit Survey

We report on the discovery of four ultra-short period (P<0.18 days) eclipsing M-dwarf binaries in the WFCAM Transit Survey. Their orbital periods are significantly shorter than of any other known main-sequence binary system, and are all significantly below the sharp period cut-off at P~0.22 days as seen in binaries of earlier type stars. The shortest-period binary consists of two M4 type stars in a P=0.112 day orbit. The binaries are discovered as part of an extensive search for short-period eclipsing systems in over 260,000 stellar lightcurves, including over 10,000 M-dwarfs down to J=18 mag, yielding 25 binaries with P<0.23 days. In a popular paradigm, the evolution of short period binaries of cool main-sequence stars is driven by loss of angular momentum through magnetised winds. In this scheme, the observed P~0.22 day period cut-off is explained as being due to timescales that are too long for lower-mass binaries to decay into tighter orbits. Our discovery of low-mass binaries with significantly shorter orbits implies that either these timescales have been overestimated for M-dwarfs, e.g. due to a higher effective magnetic activity, or that the mechanism for forming these tight M-dwarf binaries is different from that of earlier type main-sequence stars.Comment: 22 pages, 17 figures, 3 tables Accepted for publication in MNRA

Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed

BACKGROUND: Intermediate-conductance, calcium-activated potassium channels (IKs) modulate proliferation and differentiation in mesodermal cells by enhancing calcium influx, and they contribute to the physiology of fluid movement in certain epithelia. Previous reports suggest that IK channels stimulate proliferative growth in a keratinocyte cell line; however, because these channels indirectly promote calcium influx, a critically unique component of the keratinocyte differentiation program, an alternative hypothesis is that they would be anti-proliferative and pro-differentiating. This study addresses these hypotheses. METHODS: Real-time PCR, patch clamp electrophysiology, and proliferation assays were used to determine if human IK1 (hIK1) expression and function are correlated with either proliferation or differentiation in cultured human skin epidermal keratinocytes, and skin biopsies grown in explant culture. RESULTS: hIK1 mRNA expression in human keratinocytes and skin was increased in response to anti-proliferative/pro-differentiating stimuli (elevated calcium and Vitamin D). Correspondingly, the hIK1 agonist 1-EBIO inhibited keratinocyte proliferation suggesting that the channel could be anti-proliferative and pro-differentiating. However, this proliferative inhibition by 1-EBIO was not reversed by a panel of hIK1 blockers, calling into question the mechanism of 1-EBIO action. Subsequent patch clamp electrophysiological analysis failed to detect hIK1 channel currents in keratinocytes, even those expressing substantial hIK1 mRNA in response to calcium and Vitamin D induced differentiation. Identical electrophysiological recording conditions were then used to observe robust IK1 currents in fibroblasts which express IK1 mRNA levels comparable to those of keratinocytes. Thus, the absence of observable hIK1 currents in keratinocytes was not a function of the electrophysiological techniques. CONCLUSION: Human keratinocyte differentiation is stimulated by calcium mobilization and influx, and differentiation stimuli coordinately upregulate mRNA levels of the calcium-activated hIK1 channel. This upregulation is paradoxical in that functional hIK1 channels are not observed in cultured keratinocytes. It appears, therefore, that hIK1 does not contribute to the functional electrophysiology of primary human keratinocytes, nor intact human skin. Further, the results indicate caution is required when interpreting experiments utilizing pharmacological hIK1 modulators in human keratinocytes