1,039 research outputs found
Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally rearranged transcripts were found in the cells of seven healthy control subjects. All the patient's IgM heavy-chain and κ light-chain transcripts were functional, suggesting that either non-functional rearrangements were being selectively class-switched to IgG, or that receptor editing was rendering genes non-functional after class-switching. The functional γ-chain sequences showed a normal rate of somatic hypermutation while non-functional sequences contained few somatic mutations, suggesting that most came from cells that had no functional gene and therefore were not receiving signals for hypermutation. However, apoptosis of peripheral blood lymphocytes was not impaired. No defects have been found in any of the genes currently known to be responsible for hyper-IgM syndrome but the phenotype fits best to type 4
Mise en évidence de deux espèces jumelles sympatriques du genre Hylomyscus dans le nord-est du Gabon
Eurasian house mouse (Mus musculus L.) differentiation at microsatellite loci identifies the Iranian plateau as a phylogeographic hotspot
Background: The phylogeography of the house mouse (Mus musculus L.), an emblematic species for genetic and biomedical studies, is only partly understood, essentially because of a sampling bias towards its most peripheral populations in Europe, Asia and the Americas. Moreover, the present-day phylogeographic hypotheses stem mostly from the study of mitochondrial lineages. In this article, we complement the mtDNA studies with a comprehensive survey of nuclear markers (19 microsatellite loci) typed in 963 individuals from 47 population samples, with an emphasis on the putative Middle-Eastern centre of dispersal of the species.
Results: Based on correspondence analysis, distance and allele-sharing trees, we find a good coherence between geographical origin and genetic make-up of the populations. We thus confirm the clear distinction of the three best described peripheral subspecies, M. m. musculus, M. m. domesticus and M. m. castaneus. A large diversity was found in the Iranian populations, which have had an unclear taxonomic status to date. In addition to samples with clear affiliation to M. m. musculus and M. m. domesticus, we find two genetic groups in Central and South East Iran, which are as distinct from each other as they are from the south-east Asian M. m. castaneus. These groups were previously also found to harbor distinct mitochondrial haplotypes.
Conclusion: We propose that the Iranian plateau is home to two more taxonomic units displaying complex
primary and secondary relationships with their long recognized neighbours. This central region emerges as the area with the highest known diversity of mouse lineages within a restricted geographical area, designating it as the focal place to study the mechanisms of speciation and diversification of this species
Vitamin A deficiency impairs contextual fear memory in rats: abnormalities in glucocorticoid pathway
How do heuristics influence creative decisions at advertising agencies? Factors that affect managerial decision making when choosing ideas to show the client
The place of creativity in advertising has long been recognized, however, it remains unclear what creatives actually do and why they do it when it comes to making creative choices between what ideas to show the client. This study focuses upon individual choices made on what ideas to show clients in the absence of copytesting; it examines the decision-making heuristics employed by a global advertising agency. Based on an online survey, the results inter alia suggest that when it comes to deciding which ideas to show to clients, both analytic and pure heuristics are used in various combinations. The results provide insights about the nature of, and factors that influence, decision-making amongst managers with this first field study of managing choices of creative work at an advertising agency
Formation of convective cells in the scrape-off layer of the CASTOR tokamak
Understanding of the scrape-off layer (SOL) physics in tokamaks requires
diagnostics with sufficient temporal and spatial resolution. This contribution
describes results of experiments performed in the SOL of the CASTOR tokamak
(R=40 cm, a = 6 cm) by means of a ring of 124 Langmuir probes surrounding the
whole poloidal cross section. The individual probes measure either the ion
saturation current of the floating potential with the spatial resolution up to
3 mm. Experiments are performed in a particular magnetic configuration,
characterized by a long parallel connection length in the SOL, L_par ~q2piR. We
report on measurements in discharges, where the edge electric field is modified
by inserting a biased electrode into the edge plasma. In particular, a complex
picture is observed, if the biased electrode is located inside the SOL. The
poloidal distribution of the floating potential appears to be strongly
non-uniform at biasing. The peaks of potential are observed at particular
poloidal angles. This is interpreted as formation of a biased flux tube, which
emanates from the electrode along the magnetic field lines and snakes q times
around the torus. The resulting electric field in the SOL is 2-dimensional,
having the radial as well as the poloidal component. It is demonstrated that
the poloidal electric field E_pol convects the edge plasma radially due to the
E_pol x B_T drift either inward or outward depending on its sign. The
convective particle flux is by two orders of magnitude larger than the
fluctuation-induced one and consequently dominates.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
Photometric quality of Dome C for the winter 2008 from ASTEP South
ASTEP South is an Antarctic Search for Transiting Exo- Planets in the South
pole field, from the Concordia station, Dome C, Antarctica. The instrument
consists of a thermalized 10 cm refractor observing a fixed 3.88\degree x
3.88\degree field of view to perform photometry of several thousand stars at
visible wavelengths (700-900 nm). The first winter campaign in 2008 led to the
retrieval of nearly 1600 hours of data. We derive the fraction of photometric
nights by measuring the number of detectable stars in the field. The method is
sensitive to the presence of small cirrus clouds which are invisible to the
naked eye. The fraction of night-time for which at least 50% of the stars are
detected is 74% from June to September 2008. Most of the lost time (18.5% out
of 26%) is due to periods of bad weather conditions lasting for a few days
("white outs"). Extended periods of clear weather exist. For example, between
July 10 and August 10, 2008, the total fraction of time (day+night) for which
photometric observations were possible was 60%. This confirms the very high
quality of Dome C for nearly continuous photometric observations during the
Antarctic winter
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