428 research outputs found
Experiment K-6-23. Effect of spaceflight on levels and function of immune cells
Two different immunology experiments were performed on samples received from rats flown on Cosmos 1887. In the first experiment, rat bone marrow cells were examined in Moscow for their response to colony stimulating factor-M. In the second experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States where they were subjected to analysis on a flow cytometer. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor than did bone marrow cells from control rats. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and innate interleukin-2 receptor antigens than from control animals. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin than did equivalent cells from control rats
The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50
The Lick AGN Monitoring Project 2011 observing campaign was carried out over
the course of 11 weeks in Spring 2011. Here we present the first results from
this program, a measurement of the broad-line reverberation lag in the Seyfert
1 galaxy Mrk 50. Combining our data with supplemental observations obtained
prior to the start of the main observing campaign, our dataset covers a total
duration of 4.5 months. During this time, Mrk 50 was highly variable,
exhibiting a maximum variability amplitude of a factor of 4 in the U-band
continuum and a factor of 2 in the H-beta line. Using standard
cross-correlation techniques, we find that H-beta and H-gamma lag the V-band
continuum by tau_cen = 10.64(-0.93,+0.82) and 8.43(-1.28,+1.30) days,
respectively, while the lag of He II 4686 is unresolved. The H-beta line
exhibits a symmetric velocity-resolved reverberation signature with shorter
lags in the high-velocity wings than in the line core, consistent with an
origin in a broad-line region dominated by orbital motion rather than infall or
outflow. Assuming a virial normalization factor of f=5.25, the virial estimate
of the black hole mass is (3.2+-0.5)*10^7 solar masses. These observations
demonstrate that Mrk 50 is among the most promising nearby active galaxies for
detailed investigations of broad-line region structure and dynamics.Comment: Accepted for publication in ApJ Letters. 6 pages, 4 figure
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H0LiCOW X: Spectroscopic/imaging survey and galaxy-group identification around the strong gravitational lens system WFI2033-4723
Galaxies and galaxy groups located along the line of sight towards
gravitationally lensed quasars produce high-order perturbations of the
gravitational potential at the lens position. When these perturbation are too
large, they can induce a systematic error on of a few-percent if the lens
system is used for cosmological inference and the perturbers are not explicitly
accounted for in the lens model. In this work, we present a detailed
characterization of the environment of the lens system WFI2033-4723 (, = 0.6575), one of the core targets of the H0LICOW
project for which we present cosmological inferences in a companion paper (Rusu
et al. 2019). We use the Gemini and ESO-Very Large telescopes to measure the
spectroscopic redshifts of the brightest galaxies towards the lens, and use the
ESO-MUSE integral field spectrograph to measure the velocity-dispersion of the
lens ( km/s) and of several nearby
galaxies. In addition, we measure photometric redshifts and stellar masses of
all galaxies down to mag, mainly based on Dark Energy Survey imaging
(DR1). Our new catalog, complemented with literature data, more than doubles
the number of known galaxy spectroscopic redshifts in the direct vicinity of
the lens, expanding to 116 (64) the number of spectroscopic redshifts for
galaxies separated by less than 3 arcmin (2 arcmin) from the lens. Using the
flexion-shift as a measure of the amplitude of the gravitational perturbation,
we identify 2 galaxy groups and 3 galaxies that require specific attention in
the lens models. The ESO MUSE data enable us to measure the
velocity-dispersions of three of these galaxies. These results are essential
for the cosmological inference analysis presented in Rusu et al. (2019).Comment: Matches the version accepted for publication by MNRAS. Note that this
paper previously appeared as H0LICOW X
The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback
Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease
Semi-empirical catalog of early-type galaxy-halo systems: dark matter density profiles, halo contraction and dark matter annihilation strength
With SDSS galaxy data and halo data from up-to-date N-body simulations we
construct a semi-empirical catalog (SEC) of early-type systems by making a
self-consistent bivariate statistical match of stellar mass (M_star) and
velocity dispersion (sigma) with halo virial mass (M_vir). We then assign
stellar mass profile and velocity dispersion profile parameters to each system
in the SEC using their observed correlations with M_star and sigma.
Simultaneously, we solve for dark matter density profile of each halo using the
spherical Jeans equation. The resulting dark matter density profiles deviate in
general from the dissipationless profile of NFW or Einasto and their mean inner
density slope and concentration vary systematically with M_vir. Statistical
tests of the distribution of profiles at fixed M_vir rule out the null
hypothesis that it follows the distribution predicted by N-body simulations for
M_vir ~< 10^{13.5-14.5} M_solar. These dark matter profiles imply that dark
matter density is, on average, enhanced significantly in the inner region of
halos with M_vir ~< 10^{13.5-14.5} M_solar supporting halo contraction. The
main characteristics of halo contraction are: (1) the mean dark matter density
within the effective radius has increased by a factor varying systematically up
to ~ 3-4 at M_vir = 10^{12} M_solar, and (2) the inner density slope has a mean
of ~ 1.3 with rho(r) ~ r^{-alpha} and a halo-to-halo rms scatter of
rms(alpha) ~ 0.4-0.5 for 10^{12} M_solar ~< M_vir ~< 10^{13-14} M_solar steeper
than the NFW profile (alpha=1). Based on our results we predict that halos of
nearby elliptical and lenticular galaxies can, in principle, be promising
targets for gamma-ray emission from dark matter annihilation.Comment: 43 pages, 20 figures, JCAP, revised and accepted versio
The Lick AGN Monitoring Project 2011: Dynamical Modeling of the Broad Line Region in Mrk 50
We present dynamical modeling of the broad line region (BLR) in the Seyfert 1
galaxy Mrk 50 using reverberation mapping data taken as part of the Lick AGN
Monitoring Project (LAMP) 2011. We model the reverberation mapping data
directly, constraining the geometry and kinematics of the BLR, as well as
deriving a black hole mass estimate that does not depend on a normalizing
factor or virial coefficient. We find that the geometry of the BLR in Mrk 50 is
a nearly face-on thick disk, with a mean radius of 9.6(+1.2,-0.9) light days, a
width of the BLR of 6.9(+1.2,-1.1) light days, and a disk opening angle of
25\pm10 degrees above the plane. We also constrain the inclination angle to be
9(+7,-5) degrees, close to face-on. Finally, the black hole mass of Mrk 50 is
inferred to be log10(M(BH)/Msun) = 7.57(+0.44,-0.27). By comparison to the
virial black hole mass estimate from traditional reverberation mapping
analysis, we find the normalizing constant (virial coefficient) to be log10(f)
= 0.78(+0.44,-0.27), consistent with the commonly adopted mean value of 0.74
based on aligning the M(BH)-{\sigma}* relation for AGN and quiescent galaxies.
While our dynamical model includes the possibility of a net inflow or outflow
in the BLR, we cannot distinguish between these two scenarios.Comment: Accepted for publication in ApJ. 8 pages, 6 figure
Size magnification as a complement to Cosmic Shear
We investigate the extent to which cosmic size magnification may be used to
com- plement cosmic shear in weak gravitational lensing surveys, with a view to
obtaining high-precision estimates of cosmological parameters. Using simulated
galaxy images, we find that size estimation can be an excellent complement,
finding that unbiased estimation of the convergence field is possible with
galaxies with angular sizes larger than the point-spread function (PSF) and
signal-to-noise ratio in excess of 10. The statistical power is similar to, but
not quite as good as, cosmic shear, and it is subject to different systematic
effects. Application to ground-based data will be challeng- ing, with
relatively large empirical corrections required to account for with biases for
galaxies which are smaller than the PSF, but for space-based data with 0.1
arcsecond resolution, the size distribution of galaxies brighter than i=24 is
ideal for accurate estimation of cosmic size magnification.Comment: 11 pages, 11 figures, accepted by MNRA
Multiple images of a highly magnified supernova formed by an early-type cluster galaxy lens
In 1964, Refsdal hypothesized that a supernova whose light traversed multiple paths around a strong gravitational lens could be used to measure the rate of cosmic expansion. We report the discovery of such a system. In Hubble Space Telescope imaging, we have found four images of a single supernova forming an Einstein cross configuration around a redshift z = 0.54 elliptical galaxy in the MACS J1149.6+2223 cluster. The cluster's gravitational potential also creates multiple images of the z = 1.49 spiral supernova host galaxy, and a future appearance of the supernova elsewhere in the cluster field is expected. The magnifications and staggered arrivals of the supernova images probe the cosmic expansion rate, as well as the distribution of matter in the galaxy and cluster lenses
The reach of citizenship: Locating the politics of industrial air pollution in Durban and beyond
This paper develops a relational understanding of the geographies of citizenship action, using the example of environmental activism in Durban as an empirical reference point. We argue that citizenship involves an interactive dynamic shaped by different actors' capacities to project authority and influence over distance by enacting different modalities of spatial reach. Post-apartheid environmental politics illustrates how the relationship between the subjects of environmental rights and agents of obligation is both de-territorialised and re-territorialised by the activities of environmental activists. We examine the politics of attributing responsibility for urban industrial pollution in Durban, and identify two modalities of spatial reach through which environmental rights have been given weight. We conclude by emphasising that forms of transnational activism, while indicative in some respects of emergent styles of cosmopolitan citizenship, remain oriented by the goals of realizing national citizenship rights
Survey of Gravitationally Lensed Objects in HSC Imaging (SuGOHI): VII. Discovery and confirmation of three strongly lensed quasars
Large scale structure and cosmolog
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