Stability of Relativistic Matter with Magnetic Fields for Nuclear Charges up to the Critical Value

We give a proof of stability of relativistic matter with magnetic fields all the way up to the critical value of the nuclear charge $Z\alpha=2/\pi$.Comment: LaTeX2e, 12 page

SIMULATIONS AND MEASUREMENTS OF THE PRE-ARCING TIMES IN HBC FUSES UNDER TYPICAL ELECTRIC FAULTS

International audienceThis work deals with the comparison between calculations and measurements of pre-arcing times in High Breaking Capacity fuses under typical fault current conditions. This paper also describes the temperature evolution and the Joule energy dissipated in a fuse element during the pre-arcing time. By varying typical electrical parameters, namely the closing angle and the power factor, we show that various prospective currents such as those observed in industrial case can be fairly simulated. The pre-arcing time and then the clearing of the fault current are shown to be deeply dependent on these electrical characteristics. We exhibit simulated results of prospective current and supply voltage waves for given closing angles under two typical power factors which are compared with the experimental ones. A comparison between simulated pre-arcing times with experimental ones shows some discrepancies and a discussion on the numerical assumptions is made

Quantum dots with split enhancement gate tunnel barrier control

We introduce a silicon metal-oxide-semiconductor quantum dot architecture based on a single polysilicon gate stack. The elementary structure consists of two enhancement gates separated spatially by a gap, one gate forming a reservoir and the other a quantum dot. We demonstrate, in three devices based on two different versions of this elementary structure, that a wide range of tunnel rates is attainable while maintaining single-electron occupation. A characteristic change in slope of the charge transitions as a function of the reservoir gate voltage, attributed to screening from charges in the reservoir, is observed in all devices, and is expected to play a role in the sizable tuning orthogonality of the split enhancement gate structure. The all-silicon process is expected to minimize strain gradients from electrode thermal mismatch, while the single gate layer should avoid issues related to overlayers (e.g., additional dielectric charge noise) and help improve yield. Finally, reservoir gate control of the tunnel barrier has implications for initialization, manipulation and readout schemes in multi-quantum dot architectures.Comment: v1: 11 pages, 3 extended data tables, 1 extended data figure, v2: 5 pages, 3 figures, 5 pages supplementary material, 3 extended data tables, 2 extended data figures. Reorganization of the paper structure, modification of the title, abstract and introduction and conclusion, no change to the results and main text figure

Self-phase modulation-based integrated optical regeneration in chalcogenide waveguides

Copyright © 2006 IEEEWe demonstrate integrated all-optical 2R regenerators based on Kerr optical nonlinearities (subpicosecond response) in chalcogenide glass waveguides with integrated Bragg grating filters. By combining a low loss As₂S₃ rib waveguide with an in-waveguide photo-written Bragg grating filter, we realize an integrated all-optical 2R signal regenerator with the potential to process bit rates in excess of 1 Tb/s. The device operates using a combination of self phase modulation induced spectral broadening followed by a linear filter offset from the input centerwavelength.A nonlinear power transfer curve is demonstrated using 1.4 ps pulses, sufficient for suppressing noise in an amplified transmission link. We investigate the role of dispersion on the device transfer characteristics, and discuss future avenues to realizing a device capable of operation at subwatt peak power levels.Vahid G. Ta’eed, Mehrdad Shokooh-Saremi, Libin Fu, Ian C. M. Littler, David J. Moss, Martin Rochette, Benjamin J. Eggleton, Yinlan Ruan, and Barry Luther-Davie

Rochechouart 2017-Drilling Campaign: First Results

No abstract available

Chalcogenide Glasses for All-optical Processing

Copyright © 2006 IEEEChalcogenide glasses, which contain S, Se or Te atoms combined with network forming elements such as Ge, As, Sb have the largest third order optical nonlinearity of any inorganic glass. As a result they are attractive candidates for fibre and waveguide devices for all-optical signal processing in the telecommunications bands. In this talk I will review our recent progress in all-optical devices such as regenerators, wavelength converters and other devices in chalcogenide glasses.B. Luther-Davies, S. J. Madden, D-Y Choi, R-P Wang, A. V. Rode, A. Prasad, R. A. Jarvis, D. Moss, B. Eggleton, C. Grillet, M. R. E. Lamont, E. Magi, V. Ta’eed, M. Shookooh-Saremi, N. Baker, I. Littler, L. Fu, M. Rochette, Y. Rua

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylation in intracellular amastigotes of Leishmania donovani. Using clinically-relevant stages of wild type parasites and an Alamar blue-based detection method, parasite survival following drug treatment of infected macrophages is monitored after macrophage lysis and transformation of freed amastigotes into replicative extracellular promastigotes. The latter transformation step is essential to amplify the signal for determination of parasite burden, a factor dependent on equivalent proliferation rate between samples. Validation of the assay has been achieved using the anti-leishmanial gold standard drugs, amphotericin B and miltefosine, with EC50 values correlating well with published values. This assay has been used, in parallel with enzyme activity data and direct assay on isolated extracellular amastigotes, to test lead-like and hit-like inhibitors of Leishmania Nmyristoyl transferase (NMT). These were derived both from validated in vivo inhibitors of Trypanosoma brucei NMT and a recent high-throughput screen against L. donovani NMT. Despite being a potent inhibitor of L. donovani NMT, the activity of the lead T. brucei NMT inhibitor (DDD85646) against L. donovani amastigotes is relatively poor. Encouragingly, analogues of DDD85646 show improved translation of enzyme to cellular activity. In testing the high-throughput L. donovani hits, we observed macrophage cytotoxicity with compounds from two of the four NMT-selective series identified, while all four series displayed low enzyme to cellular translation, also seen here with the T. brucei NMT inhibitors. Improvements in potency and physicochemical properties will be required to deliver attractive lead-like Leishmania NMT inhibitors

Spatio-temporal variability of the North Sea cod recruitment in relation to temperature and zooplankton

The North Sea cod (Gadus morhua, L.) stock has continuously declined over the past four decades linked with overfishing and climate change. Changes in stock structure due to overfishing have made the stock largely dependent on its recruitment success, which greatly relies on environmental conditions. Here we focus on the spatio-temporal variability of cod recruitment in an effort to detect changes during the critical early life stages. Using International Bottom Trawl Survey (IBTS) data from 1974 to 2011, a major spatio-temporal change in the distribution of cod recruits was identified in the late 1990s, characterized by a pronounced decrease in the central and southeastern North Sea stock. Other minor spatial changes were also recorded in the mid-1980s and early 1990s. We tested whether the observed changes in recruits distribution could be related with direct (i.e. temperature) and/or indirect (i.e. changes in the quantity and quality of zooplankton prey) effects of climate variability. The analyses were based on spatially-resolved time series, i.e. sea surface temperature (SST) from the Hadley Center and zooplankton records from the Continuous Plankton Recorder Survey. We showed that spring SST increase was the main driver for the most recent decrease in cod recruitment. The late 1990s were also characterized by relatively low total zooplankton biomass, particularly of energy-rich zooplankton such as the copepod Calanus finmarchicus , which have further contributed to the decline of North Sea cod recruitment. Long-term spatially- resolved observations were used to produce regional distribution models that could further be used to predict the abundance of North Sea cod recruits based on temperature and zooplankton food availability.Publicado

The role of agonist and antagonist muscles in explaining isometric knee extension torque variation with hip joint angle.

PURPOSE: The biarticular rectus femoris (RF), operating on the ascending limb of the force-length curve, produces more force at longer lengths. However, experimental studies consistently report higher knee extension torque when supine (longer RF length) compared to seated (shorter RF length). Incomplete activation in the supine position has been proposed as the reason for this discrepancy, but differences in antagonistic co-activation could also be responsible due to altered hamstrings length. We examined the role of agonist and antagonist muscles in explaining the isometric knee extension torque variation with changes in hip joint angle. METHOD: Maximum voluntary isometric knee extension torque (joint MVC) was recorded in seated and supine positions from nine healthy males (30.2 ± 7.7 years). Antagonistic torque was estimated using EMG and added to the respective joint MVC (corrected MVC). Submaximal tetanic stimulation quadriceps torque was also recorded. RESULT: Joint MVC was not different between supine (245 ± 71.8 Nm) and seated (241 ± 69.8 Nm) positions and neither was corrected MVC (257 ± 77.7 and 267 ± 87.0 Nm, respectively). Antagonistic torque was higher when seated (26 ± 20.4 Nm) than when supine (12 ± 7.4 Nm). Tetanic torque was higher when supine (111 ± 31.9 Nm) than when seated (99 ± 27.5 Nm). CONCLUSION: Antagonistic co-activation differences between hip positions do not account for the reduced MVC in the supine position. Rather, reduced voluntary knee extensor muscle activation in that position is the major reason for the lower MVC torque when RF is lengthened (hip extended). These findings can assist standardising muscle function assessment and improving musculoskeletal modelling applications

Flexible prey handling, preference and a novel capture technique in invasive, sub-adult Chinese mitten crabs

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The attached file is the published version of the article