Pengetahuan Masyarakat Di Desa Tombatu I Kecamatan Tombatu Kabupaten Minahasa Tenggara Tentang Penyakit Malaria

: Malaria is a very dominant infectious disease in the tropical and subtropical areas which can lead to death of more than a million people every year. Malaria is caused by infection of the protozoan parasite of the genus Plasmodium. Symptoms of malaria are not specific, such as headache, weakness, fatigue, abdominal discomfort, as well as muscle and joint pain, usually followed by fever, chills, sweating, anorexia, vomiting, and worsening malaise. Malaria control requires an integrated approach as follows: prevention (primary vector control) and immediate treatment with effective antimalarial drugs. This study aimed to determine the knowledge of malaria of villagers Tombatu I subdistrict Tombatu Southeast Minahasa District. This was a descriptive study with a cross-sectional design by using questionnaire. The study involved 95 respondents: 46 males (48.4%) and 49 females (51.6%). Ages of the majority were more than 41 years (57.9%), most were high school educated (45.2 %), and most were housewives (46.3%). Resources of malaria were obtained from TV/ Electronic Media (66.7%). Approximately 21% respondents knew that the cause of malaria spreading was Anopheles species and as much as 50.9% knew that mosquitoes bit at night. A total of 34.5% of respondents chose that puddles were breeding places of mosquitoes. A total of 42.2% of respondents knew that chills and fever were the symptoms of malaria. A total of 36.4% of respondents chose that the way of prevention was using mosquito nets. Conclusion: Knowledge about malaria transmission was good but about the species that caused malaria, the biting behavior of mosquitoes spreading malaria, and malaria breeding places was still poor

The 1-1000 micron SEDs of far-infrared galaxies

Galaxies selected at 170um by the ISO FIRBACK survey represent the brightest \~10% of the Cosmic Infrared Background. Examining their nature in detail is therefore crucial for constraining models of galaxy evolution. Here we combine Spitzer archival data with previous near-IR, far-IR, and sub-mm observations of a representative sample of 22 FIRBACK galaxies spanning three orders of magnitude in infrared luminosity. We fit a flexible, multi-component, empirical SED model of star-forming galaxies designed to model the entire ~1-1000um wavelength range. The fits are performed with a Markov Chain Monte Carlo (MCMC) approach, allowing for meaningful uncertainties to be derived. This approach also highlights degeneracies such as between Td and beta, which we discuss in detail. From these fits and standard relations we derive: L_IR, L_PAH, SFR, tau_V, M_star, M_dust, Td, and beta. We look at a variety of correlations between these and combinations thereof in order to examine the physical nature of these galaxies. Our conclusions are supplemented by morphological examination of the sources, and comparison with local samples. We find the bulk of our sample to be consistent with fairly standard size and mass disk galaxies with somewhat enhanced star-formation relative to local spirals, but likely not bona fide starbursts. A few higher-z LIGs and ULIGs are also present, but contrary to expectation, they are weak mid-IR emitters and overall are consistent with star-formation over an extended cold region rather than concentrated in the nuclear regions. We discuss the implications of this study for understanding populations detected at other wavelengths, such as the bright 850um SCUBA sources or the faint Spitzer 24um sources.Comment: 19 pages, 20 figures, accepted for publication in MNRA

A Monte Carlo Approach to Evolution of the Far-Infrared Luminosity Function with BLAST

We constrain the evolution of the rest-frame far-infrared (FIR) luminosity function out to high redshift, by combining several pieces of complementary information provided by the deep Balloon-borne Large-Aperture Submillimeter Telescope surveys at 250, 350 and 500 micron, as well as other FIR and millimetre data. Unlike most other phenomenological models, we characterise the uncertainties in our fitted parameters using Monte Carlo Markov Chains. We use a bivariate local luminosity function that depends only on FIR luminosity and 60-to-100 micron colour, along with a single library of galaxy spectral energy distributions indexed by colour, and apply simple luminosity and density evolution. We use the surface density of sources, Cosmic Infrared Background (CIB) measurements and redshift distributions of bright sources, for which identifications have been made, to constrain this model. The precise evolution of the FIR luminosity function across this crucial range has eluded studies at longer wavelengths (e.g., using SCUBA and MAMBO) and at shorter wavelengths (e.g., Spitzer), and should provide a key piece of information required for the study of galaxy evolution. Our adoption of Monte Carlo methods enables us not only to find the best-fit evolution model, but also to explore correlations between the fitted parameters. Our model-fitting approach allows us to focus on sources of tension coming from the combination of data-sets. We specifically find that our choice of parameterisation has difficulty fitting the combination of CIB measurements and redshift distribution of sources near 1 mm. Existing and future data sets will be able to dramatically improve the fits, as well as break strong degeneracies among the models. [abridged]Comment: 20 pages, 14 figures, accepted to MNRA

Faciliating More Efficient Negotiations for Innovative Therapies: A Value-Based Negotiation Framework

OBJECTIVES: An increasing number of innovative therapies (e.g., gene- and cell-based treatments) have been developed in the past 20 years. Despite the significant clinical potential of these therapies, access delays may arise because of differing perspectives of manufacturers and payers regarding issues such as the value of the product, clinical and financial uncertainties, and sustainability.Managed entry agreements (MEAs) can enable access to treatments that would not be reimbursed by conventional methods because of such concerns. However, although MEA typologies exist, there is currently no structured process to come to agreements on MEAs, which can be difficult to decide upon and implement.To facilitate more structured MEA negotiations, we propose a conceptual "value-based negotiation framework" with corresponding application tools. METHODS: The framework was developed based on an iterative process of scientific literature review and expert input. RESULTS: The framework aims to (i) systematically identify and prioritize manufacturer and payer concerns about a new treatment, and (ii) select a mutually acceptable combination of MEA terms that can best address priority concerns, with the lowest possible implementation burden. CONCLUSIONS: The proposed framework will be tested in practice, and is a step toward supporting payers and manufacturers to engage in more structured, transparent negotiations to balance the needs of both sides, and enabling quicker, more transparent MEA negotiations and patient access to innovative products

Isotope study of monthly rainfall and its response in the Santos Formation phreatic aquifer, Mesa de Los Santos, Santander (Colombia)

Mesa de Los Santos is an elevated plateau located in the Eastern Cordillera of Colombia (Andean region) in the Department of Santander (altimetric variation 300 to 1800 m a.s.l.). The region is marked by a shortage of potable surface water. The isotopic study of the rain and its relation to Los Santos Formation phreatic and fractured aquifer was carried out. Four rain stations were installed on top of the plateau (1275 to 1684 m a.s.l.) to collect monthly rainwater samples for stable isotopes. The rainwater stations recorded 1469 to 764 mm from North to South, and the seasonal patterns of stable isotopes were similar in all stations. The preliminary Local Meteoric Water Line is δ2H = 8.22×δ18O + 13.9, slightly above the GMWL with an intercept of +13.9 ‰, possibly indicating continental vapor recycling. The rain-weighted annual isotope means showed more depleted values in the southmost rain station (δ18O = −8.99 ‰, 1275 m a.s.l.). From the phreatic and fractured aquifer, 35 groundwater points were monitored bimonthly for stable isotopes (n=134) and three trends were differentiated in the isotopic content value of δ18O. Large temporal variability characterized 10 groundwater points (amplitudes greater than 1 ‰ in δ18O for each point) consistently with the seasonal behaviour of the rain, indicating flows with rapid transit on a monthly scale. 21 groundwater points showed a low temporal variability with year-round differences under 1 ‰ and presenting a spatial distribution of δ18O with enriched values towards the north (between −6.71 ‰ and −6.00 ‰) and depleted values towards the south (−8.97 ‰ to −8.14 ‰), which tends to be also consistent with the rainwater isotope distribution observed. The stability of year-round groundwater isotopic values is a sign of efficient mixing of groundwater and a slower transit. Finally, 4 groundwater points presented signs of evaporation, showing d-excess values between −6.4 ‰ and +4.3 ‰, in connection with surface water bodies that undergo evaporation before infiltration.</p

A 50-year record of NOx and SO2 sources in precipitation in the Northern Rocky Mountains, USA

Ice-core samples from Upper Fremont Glacier (UFG), Wyoming, were used as proxy records for the chemical composition of atmospheric deposition. Results of analysis of the ice-core samples for stable isotopes of nitrogen (δ15N, ) and sulfur (δ34S, ), as well as and deposition rates from the late-1940s thru the early-1990s, were used to enhance and extend existing National Atmospheric Deposition Program/National Trends Network (NADP/NTN) data in western Wyoming. The most enriched δ34S value in the UFG ice-core samples coincided with snow deposited during the 1980 eruption of Mt. St. Helens, Washington. The remaining δ34S values were similar to the isotopic composition of coal from southern Wyoming. The δ15N values in ice-core samples representing a similar period of snow deposition were negative, ranging from -5.9 to -3.2 ‰ and all fall within the δ15N values expected from vehicle emissions. Ice-core nitrate and sulfate deposition data reflect the sharply increasing U.S. emissions data from 1950 to the mid-1970s

A far infrared view of the Lockman Hole from ISO 95 micron observations - II. Optical identifications and insights into the nature of the far-infrared sources

We present the optical identifications of a 95 micron ISOPHOT sample in the Lockman Hole over an area of about half square degree. The catalogue (Rodighiero et al. 2003) includes 36 sources, making up a complete flux-limited sample for fluxes > 100 mJy. Reliable sources were detected, with decreasing but well-controlled completeness, down to 20 mJy. We have combined mid-IR and radio catalogues in this area to identify the potential optical counterparts of the far-IR sources. We found 14 radio and 13 15 micron associations, 10 of which have both associations. For the 11 sources with spectroscopic redshift, we have performed a spectrophotometric analysis of the observed Spectral Energy Distributions. Four of these 95 micron sources have been classified as faint IR galaxies (L_FIR<1.e11 solar luminosity), six as LIRGs and only one ULIRG. We have discussed the redshift distribution of these objects, comparing our results with evolutionary model predictions 95 and 175 micron. Given their moderate distances (the bulk of the closest spectroscopically identified objects lying at z<0.2), their luminosities and star formation rates (median value 10 solar masses/yr), the sources unveiled by ISOPHOT at 95 micron seem to correspond to the low redshift (z<0.3) FIRBACK 175 micron population, composed of dusty, star-forming galaxies with moderate star formation rates. We computed and compared different SFR estimators, and found that the SF derived from the bolometric IR luminosity is well correlated with that computed from the radio and mid-IR fluxes.Comment: Accepted for publication in MNRAS, a full resolution version can be downloaded from http://dipastro.pd.astro.it/giulia/PHOT/ME681rv.ps.g

Inter-annual decrease in pulse rate and peak frequency of Southeast Pacific blue whale song types

The decrease in the frequency of two southeast Pacific blue whale song types was examined over decades, usingacoustic data from several different sources ranging between the Equator and Chilean Patagonia. The pulse rate ofthe song units as well as their peak frequency were measured using two different methods (summed auto-correlationand Fourier transform). The sources of error associated with each measurement were assessed. There was a lineardecline in both parameters for the more common song type (southeast Pacific song type n ◦ 2). An abbreviated analysisalso showed a frequency decline in the scarcer southeast Pacific song type n ◦ 1 between 1970 to 2014, revealing thatboth song types are declining at similar rates. We discussed the use of measuring both pulse rate and peak frequencyto examine the frequency decline. Finally, a comparison of the rates of frequency decline with other song typesreported in the literature is presented.La décroissance en fréquence des deux chants de baleine bleue de l'océan pacifique sud est est examiné sur plusieurs décennies en utilisant comme source des données acoustiques de l'Equateur à la Patagonie chilienne. La fréquence de pulsation et la fréquence pic des signaux sont mesurés en utilisant deux méthodes distinctes (auto-corrélation sommée et transformée de Fourier rapide). Les sources d'erreur associées à chaque mesure sont estimées. Il y a un déclin linéaire de ces deux fréquences pour le chant le plus commun de cette zone (chant du Pacifique Sud Est n°2, SEP2). Un analyse plus rapide montre aussi une baisse linéaire, entre 1970 et 2014, de la fréquence du chant SEP1, plus rarement enregistré dans cette zone. Ces deux baisses ont des amplitudes similaires. L'intérêt de mesurer la fréquence de pulsation et la fréquence pic de façon concomitante est estimé. Enfin, une comparaison globale des déclins en fréquence de tous les types de chants de baleines bleues est fournie