Efectos en el dolor y en la función de la implementación de un plan de intervención de terapia manual ortopédica a un programa de ejercicios en pacientes con desplazamiento de disco con reducción con dolor.

Los trastornos temporomandibulares (TTM) se definen como problemas clínicos que involucran la musculatura masticatoria, la articulación temporomandibular (ATM), así como las estructuras asociadas. El desplazamiento de disco con reducción (DDCR) es uno de los TTM más comunes y uno de los principales motivos de consulta en la práctica clínica. El DDCR es un trastorno biomecánico intracapsular que involucra el complejo cóndilo-disco, y se caracteriza por el chasquido que produce el movimiento de apertura y cierre de la boca. El tratamiento que presenta mayor evidencia científica es la aplicación de ejercicio terapéutico (ET), el cual se define como un ejercicio planificado y realizado con el objetivo de mejorar parámetros como la fuerza, el rango de movimiento, flexibilidad, coordinación o resistencia. El ET se ha utilizado en otros TTM demostrando una disminución del dolor, un aumento del rango de movimiento y una mejora de la función, el principal objetivo del ET en los sujetos con DDCR es la recaptura del disco para eliminar el chasquido. A pesar de la evidencia científica que existe de la aplicación del ET en los sujetos con DDCR no hay estudios que incluyan sujetos con DDCR que presenten dolor, por lo tanto resulta interesante estudiar los efectos del ET en este tipo de pacientes. Considerando las características clínicas de los sujetos con DDCR con dolor se propone a un programa de ET agregar TMO ya que es una especialidad de la fisioterapia que proporciona un tratamiento integral y conservador del dolor y otros síntomas musculo-esqueléticos.Los objetivos de la TMO en los TTM son disminuir el dolor, aumentar el rango de movimiento y mejorar la función. A pesar de la gran cantidad de publicaciones que existen sobre el ET y la TMO en los TTM, no se ha evaluado su efectividad en pacientes con DDCR con dolor, por lo que no se conocen los efectos en sus diferentes variables clínicas .El objetivo de este estudio fue comparar el efecto a corto y medio plazo de la implementación de un plan de intervención de TMO a un programa de ET frente a un programa de ET aplicado de forma aislada o la no intervención en el dolor y la función de la región temporomandibular en pacientes con DDCR con dolor. Se realizo un ensayo clínico, aleatorizado, controlado y simple ciego. Los sujetos fueron incluidos al estudio si presentaban diagnóstico clínico de DDCR, dolor y perdida de la función. Se excluyeron si presentaban antecedentes quirúrgicos de la ATM, si existía alguna contraindicación de la TMO, si se encontraban en tratamiento odontológico o medicamentoso y si no cumplían con las condiciones del grupo establecido. Los pacientes del estudio se aleatorizaron en tres grupos, 25 sujetos a un grupo que realizaba ejercicio terapéutico, un grupo que realizaba ejercicio terapéutico aunado a un programa de terapia manual ortopédica y un grupo control que no recibió intervención. Las variables dependientes fueron la presencia del chasquido, función mandibular, discapacidad cervical, dolor y rango de movimiento de la ATM.Los resultados de este estudio sugieren que añadir TMO a un programa de ET es más efectivo que el programa de ET aplicado de forma aislada a medio plazo para eliminar el chasquido, mejorar la función, disminuir el dolor en la región temporomandibular, aumentar la apertura de la boca libre de dolor, aumentar la apertura de la boca libre de chasquido en pacientes con DDCR con dolor. En conclusión, el agregar TMO a un programa de ET mejora las características clínicas de los sujetos con DDCR con dolor a medio plazo.<br /

Broad-band high-resolution rotational spectroscopy for laboratory astrophysics

We present a new experimental set-up devoted to the study of gas phase molecules and processes using broad-band high spectral resolution rotational spectroscopy. A reactor chamber is equipped with radio receivers similar to those used by radio astronomers to search for molecular emission in space. The whole range of the Q (31.5-50 GHz) and W bands (72-116.5 GHz) is available for rotational spectroscopy observations. The receivers are equipped with 16 × 2.5 GHz fast Fourier transform spectrometers with a spectral resolution of 38.14 kHz allowing the simultaneous observation of the complete Q band and one-third of the W band. The whole W band can be observed in three settings in which the Q band is always observed. Species such as CH3CN, OCS, and SO2 are detected, together with many of their isotopologues and vibrationally excited states, in very short observing times. The system permits automatic overnight observations, and integration times as long as 2.4 × 105 s have been reached. The chamber is equipped with a radiofrequency source to produce cold plasmas, and with four ultraviolet lamps to study photochemical processes. Plasmas of CH4, N2, CH3CN, NH3, O2, and H2, among other species, have been generated and the molecular products easily identified by the rotational spectrum, and via mass spectrometry and optical spectroscopy. Finally, the rotational spectrum of the lowest energy conformer of CH3CH2NHCHO (N-ethylformamide), a molecule previously characterized in microwave rotational spectroscopy, has been measured up to 116.5 GHz, allowing the accurate determination of its rotational and distortion constants and its search in space.We thank the European Research Council for funding support under Synergy Grant ERC-2013-SyG, G.A. 610256 (NANOCOSMOS). IT, VJH, and JLD acknowledge additional partial support from the Spanish State Research Agency (AEI) through grant FIS2016-77726-C3-1-P. JAMG, LM, and GS acknowledge additional partial support from the Spanish State Research Agency (AEI) through grant MAT2017-85089-C2-1R. We thank David López Romero for his help during the process of installation, commissioning, and cleaning of the chamber. We would like to thank Kremena Makasheva for the useful comments and suggestions during the experiments with Hexamethyldisiloxane. We would also like to thank Rosa Lebrón, Jesús Quintanilla, and Cristina Soria for providing us with the sample of N-ethylformamide. Sandra I. Ramírez acknowledges support from the FONCICYT under grant number 291842. Celina Bermúdez thanks the Spanish Ministerio de Ciencia Innovación y Universidades for the Juan de la Cierva grant FJCI-2016-27983

Study of the crystal structure, superconducting and magnetic properties of Ru1-xFexSr2GdCu2O8

Samples of the Ru1-xFexSr2GdCu2O8 system with x = 0, 0.025, 0.05, 0.075, 0.1 and 0.2, were prepared and their structural, superconducting and magnetic properties were studied. Rietveld refinement of the X-ray diffraction patterns show that the Fe substitution occurs in both Ru and Cu sites. An increase of Fe concentration produces no significant changes in the bond angle Ru-O(3)-Ru, which is a measure of the rotation of the RuO6 octahedra around the c-axis, and also in the bond angle Ru-O(1)-Cu, which is a measure of the canting of the RuO6 octahedra. On the other hand, the bond angle Cu-O(2)-Cu, which is a measure of the buckling of the CuO2 layer, has a slight tendency to decrease with the increase of the Fe content. We found thet both ferromagnetic and superconducting transition temperatures are reduced with the increase of Fe concentration. Analisys related to the decay of the superconducting and ferromagnetic states is presented.Comment: 9 pages, 7 figure

A high-precision near-infrared survey for radial velocity variable low-mass stars using CSHELL and a methane gas cell

We present the results of a precise near-infrared (NIR) radial velocity (RV) survey of 32 low-mass stars with spectral types K2-M4 using CSHELL at the NASA InfraRed Telescope Facility in the K band with an isotopologue methane gas cell to achieve wavelength calibration and a novel, iterative RV extraction method. We surveyed 14 members of young (≈25-150 Myr) moving groups, the young field star ϵ Eridani, and 18 nearby (&lt;25 pc) low-mass stars and achieved typical single-measurement precisions of 8-15 m s-1with a long-term stability of 15-50 m s-1 over longer baselines. We obtain the best NIR RV constraints to date on 27 targets in our sample, 19 of which were never followed by high-precision RV surveys. Our results indicate that very active stars can display long-term RV variations as low as ∼25-50 m s-1 at ≈2.3125 μm, thus constraining the effect of jitter at these wavelengths. We provide the first multiwavelength confirmation of GJ 876 bc and independently retrieve orbital parameters consistent with previous studies. We recovered RV variabilities for HD 160934 AB and GJ 725 AB that are consistent with their known binary orbits, and nine other targets are candidate RV variables with a statistical significance of 3σ-5σ. Our method, combined with the new iSHELL spectrograph, will yield long-term RV precisions of ≲5 m s-1 in the NIR, which will allow the detection of super-Earths near the habitable zone of mid-M dwarfs

Modifiable risk factors associated with prediabetes in men and women: A cross-sectional analysis of the cohort study in primary health care on the evolution of patients with prediabetes

Background: Prediabetes is a high-risk state for diabetes development, but little is known about the factors associated with this state. The aim of the study was to identify modifiable risk factors associated with the presence of prediabetes in men and women. Methods: Cohort Study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS-Study) is a prospective study on a cohort of 1184 subjects with prediabetes and another cohort of 838 subjects without glucose metabolism disorders. It is being conducted by 125 general practitioners in Spain. Data for this analysis were collected during the baseline stage in 2012. The modifiable risk factors included were: smoking habit, alcohol consumption, low physical activity, inadequate diet, hypertension, dyslipidemia, and obesity. To assess independent association between each factor and prediabetes, odds ratios (ORs) were estimated using logistic regression models. Results: Abdominal obesity, low plasma levels of high-density lipoprotein cholesterol (HDL-cholesterol), and hypertension were independently associated with the presence of prediabetes in both men and women. After adjusting for all factors, the respective ORs (95% Confidence Intervals) were 1.98 (1.41-2.79), 1.88 (1.23-2.88) and 1.86 (1.39-2.51) for men, and 1.89 (1.36-2.62), 1.58 (1.12-2.23) and 1.44 (1.07-1.92) for women. Also, general obesity was a risk factor in both sexes but did not reach statistical significance among men, after adjusting for all factors. Risky alcohol consumption was a risk factor for prediabetes in men, OR 1.49 (1.00-2.24). Conclusions: Obesity, low HDL-cholesterol levels, and hypertension were modifiable risk factors independently related to the presence of prediabetes in both sexes. The magnitudes of the associations were stronger for men than women. Abdominal obesity in both men and women displayed the strongest association with prediabetes. The findings suggest that there are some differences between men and women, which should be taken into account when implementing specific recommendations to prevent or delay the onset of diabetes in adult population

Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study

[EN] Regulated expression of the Ena1 Na+-ATPase is a crucial event for adaptation to high salt and/or alkaline pH stress in the budding yeast Saccharomyces cerevisiae. ENA1 expression is under the control of diverse signaling pathways, including that mediated by the calcium-regulatable protein phosphatase calcineurin and its downstream transcription factor Crz1. We present here a quantitative study of the expression of Ena1 in response to alkalinization of the environment and we analyze the contribution of Crz1 to this response. Experimental data and mathematical models substantiate the existence of two stress-responsive Crz1-binding sites in the ENA1 promoter and estimate that the contribution of Crz1 to the early response of the ENA1 promoter is about 60%. The models suggest the existence of a second input with similar kinetics, which would be likely mediated by high pH-induced activation of the Snf1 kinase.This work was supported by grants BFU2011-30197-C3-01, BFU2014-54591-C2-1-P and EUI2009-04147 (SysMo2) to JA. (Ministry of Industry and Competitivity, Spain, and Fondo Europeo de Desarrollo Regional [FEDER]). JA is the recipient of an Ajut 2014SGR-4 award (Generalitat de Catalunya). DC was recipient of a predoctoral fellowship from the Spanish Ministry of Education. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Petrezsélyová, S.; López-Malo, M.; Canadell, D.; Roque, A.; Serra-Cardona, A.; Marques Romero, MC.; Vilaprinyó, E.... (2016). Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study. PLoS ONE. 11(6):e0158424-e0158424. https://doi.org/10.1371/journal.pone.0158424Se0158424e015842411

Is there a role for melatonin in fibromyalgia?

Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a multifactorial aetiology has made the development of effective therapeutic strategies challenging. Physiological properties of the neurohormone melatonin appear related to the symptom profile exhibited by patients with fibromyalgia and thus disturbance of it’s production would be compatible with the pathophysiology. Altered levels of melatonin have been observed in patients with fibromyalgia which are associated with lower secretion during dark hours and higher secretion during daytime. However, inconsistencies of available clinical evidence limit conclusion of a relationship between levels of melatonin and symptom profiles in patients with fibromyalgia. Administration of melatonin to patients with fibromyalgia has demonstrated suppression of many symptoms and an improved quality of life consistent with benefit as a therapy for the management of this condition. Further studies with larger samples, however, are required to explore the potential role of melatonin in the pathophysiology of fibromyalgia and determine the optimal dosing regimen of melatonin for the management of fibromyalgia

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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