Laparoscopic insertion of pelvic tissue expander to prevent radiation enteritis prior to radiotherapy for prostate cancer

Radiation enteritis is a significant complication of external beam radiotherapy (EBRT) to the pelvis, particularly in patients having high dose radiotherapy (>80 Gy) and in those with a low pelvic peritoneal reflection allowing loops of small bowel to enter the radiation field. Laparoscopic insertion and subsequent removal of a pelvic tissue expander before and after external beam radiotherapy is a relatively convenient, safe and effective method for displacing loops of bowel out of the pelvis. We report on a patient with prostate cancer who ordinarily would not have been a candidate for EBRT due to loops of bowel low in the pelvis. With laparoscopic insertion and subsequent removal of a tissue expander, he was able to have radiotherapy to the prostate without developing radiation enteritis

A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a marker for PCa detection and as a target of immunotherapy. The murine IgG1 monoclonal antibody AR47.47, specific for human PSA, has been shown to enhance antigen presentation by human dendritic cells and induce both CD4 andCD8 T-cell activation when complexed with PSA. In this study, we explored the properties of a novel mouse/human chimeric anti-PSA IgE containing the variable regions of AR47.47 as a potential therapy for PCa. Our goal was to take advantage of the unique properties of IgE in order to trigger immune activation against PCa.Fil: Daniels-Wells, Tracy R. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Tecnologia Farmaceutica; Argentina; University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Leuchter, Richard K. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Quintero, Rafael. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Kozman, Maggie. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Rodríguez, José A.. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; University of California. The Molecular Biology Institute; Estados Unidos de América;Fil: Ortiz-Sánchez, E. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; Biomedical Research in Cancer. Basic Research Division. National Institute of Cancerology; Mexico.;Fil: Martínez-Maza, Otonel. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Schultes, Brigit C.. Advanced Immune Therapeutics; Estados Unidos de América;Fil: Nicodemus Christopher. Advanced Immune Therapeutics; Estados Unidos de América;Fil: Penichet, Manuel. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; University of California. The Molecular Biology Institute; Estados Unidos de América

Comparing Journalistic Role Performance Across Thematic Beats: A 37-Country Study

Studies suggest that, at the routine level, news beats function as unique “micro-cultures.” Exploring this “particularist” approach in news content, we compare how the interventionist, watchdog, loyal, service, infotainment, and civic roles materialize across 11 thematic news beats and analyze the moderating effect of platforms, ownership, and levels of political freedom on journalistic role performance in hard and soft news. Based on the second wave of the Journalistic Role Performance (JRP) project, this article reports the findings of a content analysis of 148,474 news items from 37 countries. Our results reveal the transversality of interventionism, the strong associations of some topics and roles, and the limited reach of news beat particularism in the face of moderating variables

Spurring or Blurring Professional Standards? The Role of Digital Technology in Implementing Journalistic Role Ideals in Contemporary Newsrooms

This study examines the perceived relevance and implementation of competing normative ideals in journalism in times of increasing use of digital technology in newsrooms. Based on survey and content analysis data from 37 countries, we found a small positive relationship between the use of digital research tools and “watchdog” performance. However, a stronger and negative relationship emerged between the use of digital audience analytics and the performance of “watchdog” and “civic” roles, leading to an overall increase in conception–performance gaps on both roles. Moreover, journalists’ use of digital community tools was more strongly and positively associated with “infotainment” and “interventionism.”

Construction and testing of the Mirror Fusion Test Facility magnets

This paper describes the construction and testing of the Mirror Fusion Test Facility superconducting magnet set. Construction of the first Yin Yang magnet was started in 1978. And although this particular magnet was later modified, the final construction of these magnets was not completed until 1985. When completed these 42 magnets weighed over 1200 tonnes and had a maximum stored energy of approximately 1200 MJ at full field. Together with power supplies, controls and liquid nitrogen radiation shields the cost of the fabrication of this system was over $100M. General Dynamics/Convair Division was responsible for the system design and the fabrication of 20 of the magnets. This contract was the largest single procurement action at the Lawrence Livermore National Laboratory. During the PACE acceptance tests, the 26 major magnets were operated at full field for more than 24 hours while other MFTF subsystems were tested. From all of the data, the magnets operated to the performance specifications. For physics operation in the future, additional helium and nitrogen leak checking and repair will be necessary. In this report we will discuss the operation and testing of the MFTF Magnet System, the world's largest superconducting magnet set built to date. The topics covered include a schedule of the major events, summary of the fabrication work, summary of the installation work, summary of testing and test results, and lessons learned

Construction and operation of the 12-T superconducting coils for the Mirror Fusion Test Facility

We have successfully constructed and tested a pair of high-field coils that is part of the magnet set of the Mirror Fusion Test Facility (MFTF-B) at the Lawrence Livermore National Laboratory. Each coil consists of a multifilamentary Nb/sub 3/Sn magnet nested inside a multifilamentary NbTi magnet. During our test, these coils produced a central field of 12 T, with a peak conductor field of 12.5 T. The dimensions of the Nb/sub 3/Sn insert coil are: 1.34-m bore, 2.57-m outer diameter, and 1.14-m overall length. These coils were designed to be fully cryogenically stabilized and cooled by pool-boiling liquid helium. The operating current density of the Nb/sub 3/Sn coils is 2000 A/cm/sup 2/ and 2400 A/cm/sup 2/ for the NbTi magnet. In this paper, we present design considerations and details, construction techniques, and operational results of these coils

Mirror Fusion Test Facility magnet system

In 1979, R.H. Bulmer of Lawrence Livermore National Laboratory (LLNL) discussed a proposed tandem-mirror magnet system for the Mirror Fusion Test Facility (MFTF) at the 8th symposium on Engineering Problems in Fusion Research. Since then, Congress has voted funds for expanding LLNL's MFTF to a tandem-mirror facility (designated MFTF-B). The new facility, scheduled for completion by 1985, will seek to achieve two goals: (1) Energy break-even capability (Q or the ratio of fusion energy to plasma heating energy = 1) of mirror fusion, (2) Engineering feasibility of reactor-scale machines. Briefly stated, 22 superconducting magnets contained in a 11-m-diam by 65-m-long vacuum vessel will confine a fusion plasma fueled by 80 axial streaming-plasma guns and over 40 radial neutral beams. We have already completed a preliminary design of this magnet system

Surgical tetralogy : simultaneous perforated gastric ulcer and appendicular perforation with liver and cerebral abscesses

A 73-year-old alcoholic male was referred to our surgical service with rigors and a 3-week history of abdominal pain. He reported regular use of non-steroidal anti-inflammatory medications (NSAIDs) for treatment of his presenting symptoms

Axicell MFTF-B superconducting-magnet system

The Axicell MFTF-B magnet system will provide the field environment necessary for tandem mirror plasma physics investigation with thermal barriers. The performance of the device will stimulate DT to achieve energy break-even plasma conditions. Operation will be with deuterium only. There will be 24 superconducting coils consisting of 2 sets of yin-yang pairs, 14 central-cell solenoids, 2 sets of axicell mirror-coil pairs, and 2 transition coils between the axicell mirror coil-pairs and the yin-yang coils. This paper describes the progress in the design and construction of MFTF-B Superconducting-Magnet System