The effect of composition on the mechanism of stress-corrosion cracking of titanium alloys in nitrogen tetroxide, and aqueous and hot- salt environments Annual summary report, 1 May 1967 - 30 Apr. 1968

Stress corrosion data for titanium alloys in aqueous, hot salt, and nitrogen dioxide environment

Solving the problem of the red eye

This software is designed to aid the clinician and the student in the differential diagnosis and treatment of a red eye. The program, consisting of three disks, was designed with HyperCard v. 1.2.5 for the Macintosh computer. Included in the program are objective and subjective findings, diagnostic tests, suggested treatment regimens and any contraindications, follow-up care and prognosis for forty-five etiologies of a red eye. One of the major features of this program allows the clinician to enter subjective and/or objective findings. Given these findings, the computer will provide a list of possible ocular conditions. From this list, the clinician can select one of the possibilities listed in which he/she feels is most appropriate for that particular patient. At this point the program will proceed to a stack of information specific for the selected condition. Once a choice has been made, the clinician always has the freedom of returning back to the list of possible ocular conditions

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of full-length RIα and a truncated RIα(92-381) that contains the tandem cyclic nucleotide binding (CNB) domains A and B. Methodology/Principal Findings: As revealed by circular dichroism (CD) and differential scanning calorimetry, both RIα proteins contain significant residual structure in the heat-denatured state. As evidenced by CD, the predominantly α-helical spectrum at 25°C with double negative peaks at 209 and 222 nm changes to a spectrum with a single negative peak at 212-216 nm, characteristic of β-structure. A similar α→β transition occurs at higher temperature in the presence of cAMP. Thioflavin T fluorescence and atomic force microscopy studies support the notion that the structural transition is associated with cross-β-intermolecular aggregation and formation of non-fibrillar oligomers. Conclusions/Significance: Thermal denaturation of RIα leads to partial loss of native packing with exposure of aggregation-prone motifs, such as the B' helices in the phosphate-binding cassettes of both CNB domains. The topology of the β-sandwiches in these domains favors inter-molecular β-aggregation, which is suppressed in the ligand-bound states of RIα under physiological conditions. Moreover, our results reveal that the CNB domains persist as structural cores through heat-denaturation. © 2011 Dao et al

Beyond crime statistics: the construction and application of a criminogenity monitor in Amsterdam

Criminologists have devoted a great deal of attention to risk factors - also called criminogenic factors - leading to criminal offending. This paper presents a criminogenity monitor which includes 19 risk factors that underlie crime. These factors do not themselves cause criminal behaviour; rather, they must be seen as signals that crimes may be committed. After discussing how the criminogenity monitor was constructed, we apply the risk factors we examined to the situation in Amsterdam, capital city of the Netherlands. The monitor is intended to function particularly as an instrument to rationalise policy-makers' work in targeting and preventing symptoms of crime at three geographical levels: the entire city, its boroughs and its neighbourhoods. © 2012 The Author(s)

Societies of strangers do not speak less complex languages

Many recent proposals claim that languages adapt to their environments. The linguistic niche hypothesis claims that languages with numerous native speakers and substantial proportions of nonnative speakers (societies of strangers) tend to lose grammatical distinctions. In contrast, languages in small, isolated communities should maintain or expand their grammatical markers. Here, we test these claims using a global dataset of grammatical structures, Grambank. We model the impact of the number of native speakers, the proportion of nonnative speakers, the number of linguistic neighbors, and the status of a language on grammatical complexity while controlling for spatial and phylogenetic autocorrelation. We deconstruct “grammatical complexity” into two separate dimensions: how much morphology a language has (“fusion”) and the amount of information obligatorily encoded in the grammar (“informativity”). We find several instances of weak positive associations but no inverse correlations between grammatical complexity and sociodemographic factors. Our findings cast doubt on the widespread claim that grammatical complexity is shaped by the sociolinguistic environment. Spatiophylogenetic modelling allows testing the claim that grammatical complexity is reduced in societies of strangers

Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer

Background: Neoadjuvant chemotherapy (NACT) is an increasingly used approach for treatment of breast cancer. The pathological complete response (pCR) is considered a good predictor of disease-specific survival. This study investigated whether circulating exosomal microRNAs could predict pCR in breast cancer patients treated with NACT. Method: Plasma samples of 20 breast cancer patients treated with NACT were collected prior to and after the first cycle. RNA sequencing was used to determine microRNA profiling. The Cancer Genome Atlas (TCGA) was used to explore the expression patterns and survivability of the candidate miRNAs, and their potential targets based on the expression levels and copy number variation (CNV) data. Results: Three miRNAs before that NACT (miR-30b, miR-328 and miR-423) predicted pCR in all of the analyzed samples. Upregulation of miR-127 correlated with pCR in triple-negative breast cancer (TNBC). After the first NACT dose, pCR was predicted by exo-miR-141, while miR-34a, exo-miR182, and exo-miR-183 predicted non-pCR. A significant correlation between the candidate miRNAs and the overall survival, subtype, and metastasis in breast cancer, suggesting their potential role as predictive biomarkers of pCR. Conclusions: If the miRNAs identified in this study are validated in a large cohort of patients, they might serve as predictive non-invasive liquid biopsy biomarkers for monitoring pCR to NACT in breast cancer

Experimental Everglades Virus Infection of Cotton Rats (Sigmodon hispidus)

We characterized Everglades virus infection of cotton rats from South Florida to validate their role as reservoir hosts in the enzootic transmission cycle