A theoretical analysis of the free vibration of discretely stiffened cylindrical shells with arbitrary end conditions

Theoretical analysis of free vibration of discretely stiffened cylindrical shells with arbitrary end condition

Threshold J/ψ−J/\psi- production in nucleon-nucleon collisions

We analyze $J/\psi-$ production in nucleon-nucleon collisions near threshold in the framework of a general model independent formalism, which can be applied to any reaction $N+N\to N+N+V^0$, where $V^0=\omega$, $\phi$, or $J/\psi$. Such reactions show large isotopic effects: a large difference for $pp$- and $pn$-collisions, which is due to the different spin structure of the corresponding matrix elements. The analysis of the spin structure and of the polarization observables is based on symmetry properties of the strong interaction. Using existing experimental data on the different decays of $J/\psi-$meson, we suggest a model for $N+N\to N+N+J/\psi$, based on $t-$channel $\eta+\pi$-exchanges. We predict polarization phenomena for the $n+p\to n+p+J/\psi$-reaction and the ratio of cross sections for $np$ and $pp$-collisions. For the processes $\eta(\pi)+N\to N+J/\psi$ we apply two different approaches: vector meson exchange and local four-particle interaction. In both cases we find larger $J/\psi$-production in $np$-collisions, with respect to $pp$-collisions.Comment: 17 pages, 6 figure

Neutrophil to Lymphocyte Ratio: A Prognostic Indicator for Astronaut Health

Short-term and long-term spaceflight missions can cause immune system dysfunction in astronauts. Recent studies indicate elevated white blood cells (WBC) and polymorphonuclear neutrophils (PMN) in astronaut blood, along with unchanged or reduced lymphocyte counts, and reduced T cell function, during short-(days) and long-(months) term spaceflight. A high PMN to lymphocyte ratio (NLR) can acts as a strong predictor of poor prognosis in cancer, and as a biomarker for subclinical inflammation in humans and chronic stress in mouse models, however, the NLR has not yet been identified as a predictor of astronaut health during spaceflight. For this, complete blood cell count data collected from astronauts and rodents that have flown for short- and long-term missions on board the International Space Station (ISS) was repurposed to determine the NLR pre-, in-, and post-flight. The results displayed that the NLR progressively increased during spaceflight in both human and mice, while a spike in the NLR was observed at post-flight landing, suggesting stress-induced factors may be involved. In addition, the ground-based chronic microgravity analog, hindlimb unloading in mice, indicated an increased NLR, along with induced myeloperoxidase expression, as measured by quantitative (q)PCR. The mechanism for increased NLR was further assessed in vitro using the NASA-developed rotating wall vessel (RWV) cell culture suspension system with human WBCs. The results indicated that simulated microgravity led to increased mature PMN counts, NLR profiles, and production of reactive oxygen species (ROS). Collectively, these studies show that an increased NLR is observed in spaceflight missions, and in chronic microgravity-analog simulation in mice, and that this effect may be potentiated by the oxidative stress response in blood cells under microgravity conditions. Furthermore, these results suggest that a disrupted NLR profile in spaceflight may further disrupt immune homeostasis, potentially causing chronic immune-mediated inflammatory diseases. Thus, we propose that the health status of astronauts during short- and long-term space missions can be monitored by their NLR profile, in addition to utilizing this measurement as a tool for interventions and countermeasure development to restore homeostatic immunity

The influence of changing end conditions on the resonant response of beams and plates

Approximation method for structural beam and plate resonances at elastic edge excitation

An approximate theory for transverse shear deformation and rotatory inertia effects in vibrating beams

Transverse shear deformation and rotary inertia effects in vibrating beam

Gating of Long-Term Potentiation by Nicotinic Acetylcholine Receptors at the Cerebellum Input Stage

The brain needs mechanisms able to correlate plastic changes with local circuit activity and internal functional states. At the cerebellum input stage, uncontrolled induction of long-term potentiation or depression (LTP or LTD) between mossy fibres and granule cells can saturate synaptic capacity and impair cerebellar functioning, which suggests that neuromodulators are required to gate plasticity processes. Cholinergic systems innervating the cerebellum are thought to enhance procedural learning and memory. Here we show that a specific subtype of acetylcholine receptors, the α7-nAChRs, are distributed both in cerebellar mossy fibre terminals and granule cell dendrites and contribute substantially to synaptic regulation. Selective α7-nAChR activation enhances the postsynaptic calcium increase, allowing weak mossy fibre bursts, which would otherwise cause LTD, to generate robust LTP. The local microperfusion of α7-nAChR agonists could also lead to in vivo switching of LTD to LTP following sensory stimulation of the whisker pad. In the cerebellar flocculus, α7-nAChR pharmacological activation impaired vestibulo-ocular-reflex adaptation, probably because LTP was saturated, preventing the fine adjustment of synaptic weights. These results show that gating mechanisms mediated by specific subtypes of nicotinic receptors are required to control the LTD/LTP balance at the mossy fibre-granule cell relay in order to regulate cerebellar plasticity and behavioural adaptation

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice

Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death receptors’ such as Fas/APO-1; and the ‘intrinsic’ pathway, which is triggered by diverse cellular stresses, and is regulated by prosurvival and pro-apoptotic members of the Bcl-2 family of proteins. Pro-survival Mcl-1, which can block activation of the proapoptotic proteins, Bax and Bak, appears critical for the survival and maintenance of multiple haemopoietic cell types. To investigate the impact on haemopoiesis of simultaneously inhibiting both apoptosis pathways, we introduced the vavP-Mcl-1 transgene, which causes overexpression of Mcl-1 protein in all haemopoietic lineages, into Faslpr/lpr mice, which lack functional Fas and are prone to autoimmunity. The combined mutations had a modest impact on myelopoiesis, primarily an increase in the macrophage/monocyte population in Mcl-1tg/lpr mice compared with lpr or Mcl-1tg mice. The impact on lymphopoiesis was striking, with a marked elevation in all major lymphoid subsets, including the non-conventional double-negative (DN) T cells (TCRβ+ CD4– CD8– B220+ ) characteristic of Faslpr/lpr mice. Of note, the onset of autoimmunity was markedly accelerated in Mcl-1tg/lpr mice compared with lpr mice, and this was preceded by an increase in immunoglobulin (Ig)-producing cells and circulating autoantibodies. This degree of impact was surprising, given the relatively mild phenotype conferred by the vavP-Mcl-1 transgene by itself: a two- to threefold elevation of peripheral B and T cells, no significant increase in the non-conventional DN T-cell population and no autoimmune disease. Comparison of the phenotype with that of other susceptible mice suggests that the development of autoimmune disease in Mcl-1tg/lpr mice may be influenced not only by Ig-producing cells but also other haemopoietic cell types

Neutral weak currents in pion electroproduction on the nucleon

Parity violating asymmetry in inclusive scattering of longitudinally polarized electrons by unpolarized protons with $\pi^0$ or $\pi^+$ meson production, is calculated as a function of the momentum transfer squared $Q^2$ and the total energy $W$ of the $\pi N$-system. This asymmetry, which is induced by the interference of the one-photon exchange amplitude with the parity-odd part of the $Z^0$-exchange amplitude, is calculated for the $\gamma^*(Z^*)+p\to N+\pi$ processes ($\gamma^*$ is a virtual photon and $Z^*$ a virtual Z-boson) considering the $\Delta$-contribution in the $s-$channel, the standard Born contributions and vector meson ($\rho$ and $\omega$) exchanges in the $t-$channel. Taking into account the known isotopic properties of the hadron electromagnetic and neutral currents, we show that the P-odd term is the sum of two contributions. The main term is model independent and it can be calculated exactly in terms of fundamental constants. It is found to be linear in $Q^2$. The second term is a relatively small correction which is determined by the isoscalar component of the electromagnetic current. Near threshold and in the $\Delta$-region, this isoscalar part is much smaller (in absolute value) than the isovector one: its contribution to the asymmetry depend on the polarization state (longitudinal or transverse) of the virtual photon.Comment: 30 pages 9 figure

The X-ray Telescope of CAST

The Cern Axion Solar Telescope (CAST) is in operation and taking data since 2003. The main objective of the CAST experiment is to search for a hypothetical pseudoscalar boson, the axion, which might be produced in the core of the sun. The basic physics process CAST is based on is the time inverted Primakoff effect, by which an axion can be converted into a detectable photon in an external electromagnetic field. The resulting X-ray photons are expected to be thermally distributed between 1 and 7 keV. The most sensitive detector system of CAST is a pn-CCD detector combined with a Wolter I type X-ray mirror system. With the X-ray telescope of CAST a background reduction of more than 2 orders off magnitude is achieved, such that for the first time the axion photon coupling constant g_agg can be probed beyond the best astrophysical constraints g_agg < 1 x 10^-10 GeV^-1.Comment: 19 pages, 25 figures and images, replaced by the revised version accepted for publication in New Journal of Physic

Polarization phenomena in open charm photoproduction processes

We analyze polarization effects in associative photoproduction of pseudoscalar ($\bar{D}$) charmed mesons in exclusive processes $\gamma+ N\to Y_c +\bar{D}$, $Y_c=\Lambda_c^+$, $\Sigma_c$. Circularly polarized photons induce nonzero polarization of the $Y_c$-hyperon with $x$- and $z$-components (in the reaction plane) and non vanishing asymmetries ${\cal A}_x$ and ${\cal A}_z$ for polarized nucleon target. These polarization observables can be predicted in model-independent way for exclusive $\bar{D}$-production processes in collinear kinematics. The T-even $Y_c$-polarization and asymmetries for non-collinear kinematics can be calculated in framework of an effective Lagrangian approach. The depolarization coefficients $D_{ab}$, characterizing the dependence of the $Y_c$-polarization on the nucleon polarization are also calculated.Comment: 36 pages 13 figure