Early cortical surface plasticity relates to basic mathematical learning

Children lay the foundation for later academic achievement by acquiring core mathematical abilities in the first school years. Neural reorganization processes associated with individual differences in early mathematical learning, however, are still poorly understood. To fill this research gap, we followed a sample of 5-6-year-old children longitudinally to the end of second grade in school (age 7–8 years) combining magnetic resonance imaging (MRI) with comprehensive behavioral assessments. We report significant links between the rate of neuroplastic change of cortical surface anatomy, and children's early mathematical skills. In particular, most of the behavioral variance (about 73%) of children's visuospatial abilities was explained by the change in cortical thickness in the right superior parietal cortex. Moreover, half of the behavioral variance (about 55%) of children's arithmetic abilities was explained by the change in cortical folding in the right intraparietal sulcus. Additional associations for arithmetic abilities were found for cortical thickness change of the right temporal lobe, and the left middle occipital gyrus. Visuospatial abilities were related to right precentral and supramarginal thickness, as well as right medial frontal gyrus folding plasticity. These effects were independent of other individual differences in IQ, literacy and maternal education. Our findings highlight the critical role of cortical plasticity during the acquisition of fundamental mathematical abilities

Association between glycosylated haemoglobin A1c and endothelial function in an adult non-diabetic population

A suite of drilling cores and outcrop samples of the Lower Toarcian Posidonia Shale (PS) were collected from multiple locations including the Swabian Alb and Franconian Alb of Southwest-Germany, Runswick Bay of UK and Loon op Zand well (LOZ-1) of the West Netherlands Basin. In order to assess the thermal maturity and quantify the petroleum generation potential of the rocks, elemental analysis, Rock-Eval pyrolysis, organic petrographic investigations and molecular hydrocarbon analyses were performed. Available literature data of the Posidonia Shale from Luxembourg and northwest Germany were used for comparison in the discussion.The Lower Toarcian Shale is more carbonate-rich (about 30% on average) in SW-Germany, NW-Germany and Luxembourg, and is instead more silicate-rich in UK and NL with carbonate contents of about 15% on average. This coincides with the relative distances of the depositional settings to the clastic source areas on the continents during the early Jurassic. However, HI values are similar, approx. 500-700. mg. HC/g TOC on average at all sampling localities, exhibiting typical type II kerogen with excellent hydrocarbon generation potential. Differences in relative abundance of terrigenous organic matter input are deduced from molecular indicators, Rock-Eval data and organic petrography. The highest abundance of terrigenous organic matter is evident for Runswick Bay, UK.Samples from outcrops of the Lower Toarcian Shale from Runswick Bay, UK, have reached the early stage of the oil window, with quite uniform Tmax values (425-438°C, avg. 433°C) and a narrow range of PI (production index) values (0.10-0.19), substantiated by mature fluorescing characteristics of telalginite and lamalginite and vitrinite reflectance values of 0.6-0.7%. Wider ranges of Tmax values (421-443°C, avg. 427°C), vitrinite reflectance (0.4-0.8%) and production indices (0.06-0.29) suggest more variable thermal maturation ranging from immature to almost peak oil generation at the LOZ-1 well, NL, although only some intervals indicate advanced thermal maturity there. In contrast, the Lower Toarcian marlstones from the Swabian and Franconian Alb of SW-Germany are clearly immature, similar to the samples from Luxembourg. In NW-Germany, the Posidonia Shale covers a wide spectrum of maturity ranging from immature to overmature.Source potential index (SPI) indicates the highest value in the LOZ-1, NL followed by Wickensen, NW-Germany and Esch-sur-Alzette, LU, mainly due to differences in thickness of the studied sections. The lowest value was observed in SW-Germany. The Lower Toarcian (Jet Rock) in Runswick Bay, UK, is assumed to have a high shale oil potential because of its advanced thermal maturity, although its SPI is not high due to the limited thickness of the section studied. The PS in SW-Germany has low shale oil potential due to low thermal maturity and limited thickness. © 2015 Elsevier B.V

The emergence of dyslexia in the developing brain

Kuhl U, Neef NE, Kraft I, et al. The emergence of dyslexia in the developing brain. NeuroImage. 2020;211: 116633