Tectonic implications of paleontologic dating of Cretaceous-Danian sections of Eastern Cuba

The sedimentary rocks intercalated in volcanic and metavolcanic sections of Mayarí-Baracoa and Sierra del Purial Mountains (Eastern Cuba), yielded Cretaceous through Danian microfossils. In the Mayarí Mountains the Téneme Fm consists of basalts and hyaloclastites with minor intercalations of well-bedded foliated limestone and shaly limestone that in the type area contain a Turonian or early Coniacian planktonic foraminifera assemblage. In the Morel area (Moa-Baracoa massif), back-arc pillow basalts with ribbon cherts include a late Turonian or Coniacian limestone bed intercalated with interbedded organic-rich calcareous shales near the top. The upper part of the Coniacian (?)-Campanian Santo Domingo Fm crops out west of Moa and it consists of finegrained well-bedded volcaniclastic rocks with two intercalated lenses of coarse-grained impure biocalcirudites to biocalcarenites. These rocks yielded a mixed penecontemporaneous planktonic and benthonic microfossil assemblage attributed to the lower part of the late Campanian (Globotruncanita calcarata Zone). At Sierra del Purial, crystalline limestones embedded within the metavulcano-sedimentary Río Baracoa section (Purial metamorphic complex) yielded Campanian microfossils. The Maastrichtian Yaguaneque (=Cañas) limestones crop out extensively in both Mayarí-Baracoa and Purial Mountains. All the formations previously mentioned unconformably overlie and tectonically intermingle with the late Maastrichtian-early Danian clastic rocks of the Mícara and La Picota Fms. Our new dates demonstrate that in the Greater Antilles the PIA (Primitive Island Arc-tholeiite) recorded by the Téneme Fm would be Late Cretaceous in age in opposition to the Lower Cretaceous age proposed for the PIA basalts. The protolith of the Purial metamorphic complex is probably Maastrichtian-early Danian, but certainly Campanian and older in age. This fact suggests that the metamorphism that affected the Purial rocks took place probably in the late Maastrichtian and was coeval with the detachment, exhumation and emplacement of mafic-ultramafic thrust-sheet bodies. This event recorded in Eastern Cuba/Western Hispaniola and Guatemala might have been related to the insertion of thick oceanic ridges into the subduction zone

In vitro evaluation of pathogen inactivated platelet quality: An 8 year experience of routine use in Galicia, Spain

BACKGROUND: Platelet concentrates (PCs) treated by the pathogen inactivation technology (PI) using amotosalen and UVA illumination (PI-PCs) can be manufactured in additive solutions (PAS-III and PAS-IIIM) or in 100% Plasma. Quality control (QC) is an integral part of the production. We capitalized on our ongoing QC program to capture 8 years-worth of data on parameters related to the quality of 116,214 PI-PCs produced under different manufacturing methods. MATERIALS AND METHODS: Selected in vitro parameters of metabolism, activation, and storage were analyzed for the different manufacturing periods to compare PI-PCs versus conventional PCs (C-PCs) resuspended in different PAS. RESULTS AND DISCUSSION: All BC-PCs met quality standards for pH and dose and residual leucocytes. As expected, storage time correlated with increased lactate, LDH, Annexin V, CD62, sCD40 L levels and decreased glucose and pH. With PAS-IIIM, higher levels of glucose were observed toward the end of shelf life (p < 0.0001) with lower platelet activation markers Annexin V (p = 0.038) and CD62 (p = 0.0006). Following PI implementation, a low expire rate of <0.5% was observed. While a 2.3% mean increase in the production of PCs occurred from 2011 to 2015, the distribution of red blood cell concentrates dropped by 4.4%. A mean incidence of 0.14% for transfusion-related adverse reaction was observed while PI-PCs were distributed, similar to the one observed with C-PCs. Overall, PI-PCs prepared in additive solutions consistently met quality standards. Those prepared in PAS-IIIM appeared to have better retention of in vitro characteristics compared to PAS-III though all demonstrated functionality and clinical effectiveness

Comparison of different treatments used for polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a disease that currently affects many women of reproductive age. In recent years, the incidence of PCOS has increased, affecting 4% of all women worldwide, with a prevalence of 6% in Mexico. PCOS is a condition characterized by different metabolic, reproductive and hormonal disorders such as hyperandrogenism, chronic anovulation, menorrhagia or infertility. Patients commonly develop clinical alterations such as hirsutism, acne and in some cases, they become overweight or obese. Different medications and therapeutic methods from different literatures were evaluated, both pharmacological such as inositol, metformin, resveratrol, simvastatin, dapagliflozin, which showed great improvement, decreasing the levels of hyperandrogenism in patients, as well as non-pharmacological, of which significant improvements were found with a change in lifestyle, such as exercise, ketogenic diet and herbal medications such as chamomile and cinnamon, which showed a positive change in patients. It is important to make a diffusion and early diagnosis of PCOS, since in this way it will be possible to have a timely treatment, which can be individualized according to the characteristics and needs of each patient

Content Analysis of Digital Media Coverage of the Human Papillomavirus Vaccine School-Entry Requirement Policy in Puerto Rico

BACKGROUND: In August 2018, Puerto Rico (PR) became the 4th state or territory in the United States to adopt a human papillomavirus (HPV) vaccine school-entry requirement, for students 11-12 years old. Evidence suggests that the content of media coverage may impact people\u27s perception of HPV vaccine and their willingness to vaccinate. This study aimed to analyze the content of digital news coverage related to the implementation of the policy in PR. METHODS: A content review was conducted of digital media published from January 2017 through December 2018. The content reviewed was carried out in two steps: 1) creating a matrix to summarize each article\u27s content about the policy and 2) qualitative analysis using a grounded theory approach. RESULTS: The search resulted in 34 articles obtained from 17 online local and international news outlets that reported the policy\u27s implementation. Analyses showed that 61% of the news articles did not mention the number of required doses, and 79% discussed the new policy concerning cancer prevention. In 2017, news coverage focused mostly on describing the policy, while 2018 coverage focused on controversies surrounding the implementation. Neutral emergent codes included: 1) Description of the policy; 2) Information about HPV related cancers; and 3) General information about HPV vaccine. Negative emergent codes included: 1) infringement to patient and parental autonomy; 2) Hesitancy from the political sector, and 3) Hesitancy from groups and coalitions. Positive content included: 1) knowledge and acceptance of HPV vaccine for cancer prevention; 2) importance of education and protective sexual behaviors; and 3) new vaccination law proposal. CONCLUSIONS: Most of the media coverage in PR was neutral and included limited information related to the vaccine, HPV, and HPV-related cancers. Neutral and negative themes could influence public concerns regarding the new policy, as well as HPV vaccination rates in PR

Identification of guinea pig remains in the Pucará de Tilcara (Jujuy, Argentina): Evidence in favour of the presence of the Andean breed in the Quebrada de Humahuaca

In this article, we identified rodent remains found in the Pucará de Tilcara, an archaeological site from the Argentine Northwest that was occupied by humans from 1,100 ad until the Spanish conquest. The zooarchaeological analyses were carried out using anatomical descriptions and geometric morphometric analyses of the dorsal and ventral views of mandibular remains. The results and the archaeological context discussed showed that all the rodent remains could correspond to the Andean breed of domestic guinea pigs. The combination of the methods used here gave us a strong support to the taxonomical assignment. The presence of domestic guinea pigs in archaeological sites of the northwestern Argentina was never proposed. This approach allowed us to increase knowledge about the distribution of caviines in the region, and their relationship to anthropic processes.Fil: Lopez Geronazzo, Lautaro Nahuel. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Otero, Clarisa. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentina. Universidad de Buenos Aires. Facultad de Filosofía y Letras; ArgentinaFil: Alvarez, Alicia. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentina. Universidad Nacional de Jujuy. Instituto de Geología Minera; ArgentinaFil: Ercoli, Marcos Darío. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; Argentina. Universidad Nacional de Jujuy. Instituto de Geología Minera; ArgentinaFil: Cortés Delgado, Natalia. University of Illinois; Estados Unido

Age determination procedures on small and medium pelagic species in Spanish Institute of Oceanography (IEO)

This handbook presents a summary of the age estimation procedures used in Spanish Institute of Oceanography (IEO) for some of the main commercial small and medium pelagic species of the Spanish fleet: anchovy (Engraulis encrasicolus), sardine (Sardina pichardus), mackerel (Scomber scombrus), chuck mackerel (Scomber colias), horse mackerel (Trachurus trachurus), Mediterranean horse mackerel (Trachurus mediterraneus) and blue whiting (Micromesistius poutassou). It provides information about the sampling program, otolith extraction and preparation, and the age estimation criteria. A summary of the information related to the age accuracy, validation and corroboration of each species is also presented, as well as that related to the age precision, quality control and verification

Refugios, período reproductivo y composición social de las poblaciones de desmodus rotundus (geoffroy, 1810) (chiroptera: phyllostomidae), en zonas rurales del departamento de sucre, colombia

Esta investigación se realizó en la zona rural de los municipios Toluviejo, San Onofrey San Antonio de Palmito, pertenecientes al departamento de Sucre, Colombia, duranteel período comprendido entre noviembre de 2004 y noviembre de 2005 y tuvo comoobjetivo la determinación de los tipos de refugio utilizados por Desmodus rotundus enlas localidades mencionadas, así como conocer su composición social en esos sitiosy la época reproductiva. Se hicieron capturas mediante redes de niebla, en huecos detroncos de árboles, cuevas y construcciones humanas, que mostraban evidencia deheces sanguinolentas. Los animales eran obligados a salir mediante el humo y una vezcapturados eran conservados en alcohol al 70%. El número de animales en esos sitiosfluctúa entre 4 y 93. La proporción de machos activos sexualmente resultó siempremenor que la de hembras con diferentes estadios reproductivos (1:6, 1:7, 1:3, 1:2, 1:2)para los diferentes refugios. Además aparecen varios machos inactivos sexualmentey neonatos. Esta composición y número parece influir en la eficiencia reproductiva,la estabilidad del grupo y en el establecimiento de su conducta de cooperación parala alimentación. Esta especie es monótoca y la reproducción puede efectuarse encualquier época del año, lo cual garantiza la supervivencia de la misma, dadas lasconocidas dificultades que afrontan cuando no pueden alimentars

Accessible opera : overcoming linguistic and sensorial barriers

The desire to make media available for all has been rapidly accepted and implemented by most European countries. Opera, as one of the many audiovisual representations, also falls under the category of production which needs to be made accessible and this article aims to analyse how opera has gone through a complete transformation to become a cultural event for all, overcoming not only linguistic but also sensorial barriers. The first part of the article analyses the various forms of translation associated with opera and the main challenges they entail. The second presents different systems used to make opera accessible to the sensorially challenged, highlighting their main difficulties. Examples from research carried out at the Barcelona's Liceu opera house are presented to illustrate various modalities, especially audio description. All in all, it is our aim to show how translated-related processes have made it possible to open opera to a wider audience despite some initial reluctance

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome

Identification of new markers associated with long-term efficacy in patients treated with CAR T cells is a current medical need, particularly in diseases such as multiple myeloma. In this study, we address the impact of CAR density on the functionality of BCMA CAR T cells. Functional and transcriptional studies demonstrate that CAR T cells with high expression of the CAR construct show an increased tonic signaling with up-regulation of exhaustion markers and increased in vitro cytotoxicity but a decrease in in vivo BM infiltration. Characterization of gene regulatory networks using scRNA-seq identified regulons associated to activation and exhaustion up-regulated in CARHigh T cells, providing mechanistic insights behind differential functionality of these cells. Last, we demonstrate that patients treated with CAR T cell products enriched in CARHigh T cells show a significantly worse clinical response in several hematological malignancies. In summary, our work demonstrates that CAR density plays an important role in CAR T activity with notable impact on clinical response

Efficacy and safety of a hexanic extract of Serenoa repens (Permixon (R)) for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH): systematic review and meta-analysis of randomised controlled trials and observational studies

Objectives To comprehensively evaluate the efficacy and safety of the hexanic extract of Serenoa repens (HESr, Permixon (R); Pierre Fabre Medicament, Castres, France), at a dose of 320 mg daily, as monotherapy for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). Materials and methods We conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) and prospective observational studies in patients with LUTS/BPH identified through searches in Medline, Web of Knowledge (Institute for Scientific Information), Scopus, the Cochrane Library, and bibliographic references up to March 2017. Articles studying S. repens extracts other than Permixon were excluded. Data were collected on International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), nocturia, quality of life, prostate volume, sexual function, and adverse drug reactions (ADRs). Data obtained from RCTs and observational studies were analysed jointly and separately using a random effects model. A sub-group analysis was performed of studies that included patients on longer-term treatment (= 1 year). Results Data from 27 studies (15 RCTs and 12 observational studies) were included for meta-analysis (total N = 5 800). Compared with placebo, the HESr was associated with 0.64 (95% confidence interval [CI] -0.98 to -0.31) fewer voids/ night (P < 0.001) and an additional mean increase in Q(max) of 2.75 mL/s (95% CI 0.57 to 4.93; P = 0.01). When compared with a-blockers, the HESr showed similar improvements on IPSS (weighted mean difference [WMD] 0.57, 95% CI -0.27 to 1.42; P = 0.18) and a comparable increase in Q(max) to tamsulosin (WMD -0.02, 95% CI -0.71 to 0.66; P = 0.95). Efficacy assessed using the IPSS was similar after 6 months of treatment between the HESr and 5a-reductase inhibitors (5ARIs). Analysis of all available published data for the HESr showed a mean improvement in IPSS from baseline of -5.73 points (95% CI -6.91 to -4.54; P < 0.001). HESr did not negatively affect sexual function and no clinically relevant effect was observed on prostate-specific antigen. Prostate volume decreased slightly. Similar efficacy results were seen in patients treated for = 1 year (n = 447). The HESr had a favourable safety profile, with gastrointestinal disorders being the most frequent ADR (mean incidence of 3.8%). Conclusion The present meta-analysis, which includes all available RCTs and observational studies, shows that the HESr (Permixon) reduced nocturia and improved Q(max) compared with placebo and had a similar efficacy to tamsulosin and short-term 5ARI in relieving LUTS. HESr (Permixon) appears to be an efficacious and well-tolerated therapeutic option for the longterm medical treatment of LUTS/BPH