El palacio del lloctinent

Treballs Finals de Grau d'Història de l'Art, Facultat de Geografia i Història, Universitat de Barcelona, Curs: 2015-2016, Tutor: Carme NárvaezPara la aproximación a la obra -el Palacio del Lloctinent- se tiene en cuenta el contexto en el que se decidió su construcción: Barcelona a mediados del siglo XVI. Conocer la finalidad de la construcción del edificio nos ayudará a establecer su importancia histórica, que como su nombre indica, se trata de un palacio para el lugarteniente o virrey en Catalunya

Economic impact of pharyngocutaneou fistulae in patients laryngectomy

Objetivo: Analizar el impacto económico derivado de la hospitalización de los pacientes con fístulas faringocutá- neas (FFC) como principal evento adverso tras laringectomía total entre los años 2006 y 2011 en un hospital de segundo nivel. Método: Cálculo estimado de los costes directos generados por la FFC mediante el Grupo de Diagnóstico Relacionado (GRD) y aplicación corporativa de contabilidad analítica del Servicio Andaluz de Salud (COAN h y d) para los años mencionados. Resultados: Entre 2006 y 2011 el coste de todos pacientes con FFC fue de 3.210.586,9€, a diferencia de 1.282.708,5€ para los que no cursaron esta complicación. El coste individual en el período de estudio fue 94.429,0.26€ en las FFC y 35.630,777€ en los que no la tuvieron. Los afectados registraron un incremento de 2,66 veces en el gasto sanitario. Conclusión: La aparición de FFC tras laringectomía supone un coste elevado para el hospital y la organización sanitaria. Se deben plantear estrategias preventivas que minimicen el impacto económico de este evento adverso.Objective: To analyze the economic impact of hospitalization of patients with fistulas pharyngocutaneous (FFC) as the main adverse event after total laryngectomy between 2006 and 2011 in a secondary hospital. Method: Calculate estimated direct costs generated by the FFC using Diagnosis Related Group (DRG) and cost accounting corporate application Andalusian Health Service (COAN hyd) for those years. Results: Between 2006 and 2011 the cost of all patients was € 3,210,586.9 FFC, unlike € 1,282,708.5 for those who missed out this complication. The individual cost in the study period was € 94.429,0.26 in FFC and € 35,630.777 in those without it. The patients had an increase of 2.66 times in health spending. Conclusion: The occurrence of FFC after laryngectomy involves a high cost for the hospital and healthcare organization. Preventive strategies must be implemented to minimize the economic impact of this adverse event

Prevención de enfermedades y de la muerte de terneros doble propósito del trópico bajo Colombiano

Las enfermedades y la muerte de terneros ocasionan grandes pérdidas económicas en la industria ganadera de todo el mundo. En los estados unidos en el año 1991 murieron 2.786.300 cabezas de terneros para carne, ocasionando pérdidas por 976 millones de dólares. Los estudios de seguimiento en las empresas de los ganaderos demuestran que la muerte de los terneros produjo pérdidas de $314 por cada vaca durante un año.Ganado de doble propósito-Ganaderia doble proposit

La protección de los derechos fundamentales de las personas LGTBI

Producción CientíficaEl presente volumen, realizado en el marco del Proyecto estatal "España ante Europa: retos nacionales en materia de derechos fundamentales" (DER2016-75993-P), se articula en torno a dos partes bien diferenciadas. En la primera se examina la protección de los derechos fundamentales de las personas LGTBI en perspectiva internacional y comparada. Comprende un estudio de Ignacio Álvarez Rodríguez sobre el papel desempeñado por la ONU a este respecto; otro de José Díaz Lafuente acerca de los avances habidos en el seno de la UE en este terreno; y un tercero sobre el Consejo de Europa, a cargo de Francisco Ruiz-Risueño Montoya, en el que se disecciona críticamente la muy relevante jurisprudencia del Tribunal Europeo de Derechos Humanos recaída sobre la materia. Esta primera parte se completa con un estudio comparado de Anna Lorenzetti sobre la situación jurídica de las personas LGTBI en diversos Estados europeos. En la segunda parte de la obra se analizan temas específicos que presentan especial interés para el colectivo LGTBI. María Díaz Crego aborda la discriminación por orientación sexual; Miguel Ángel Presno Libera se ocupa del discurso del odio contra las minorías sexuales: Pilar Benavente examina el registro y la filiación de parejas LGTBI; Francisco Javier Matia Portilla se pregunta si sería conveniente regular la gestación subrogada en nuestro país; y finalmente Antonio Arroyo Gil concluye con una reflexión jurídica sobre la intersexualidad.Departamento de Derecho Constitucional, Procesal y Eclesiástico del EstadoMinisterio de Economía, Industria y Competitividad (DER2016-75993-P

Artículos publicados en el diario El País sobre Antonio Fernández Alba

Artículos publicados sobre Antonio Fernández Alba en el diario El Paí

Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3

Members of the genus Brucella cluster in two phylogenetic groups: classical and non-classical species. The former group is composed of Brucella species that cause disease in mammals, including humans. A Brucella species, labeled as Brucella sp. BCCN84.3, was isolated from the testes of a Saint Bernard dog suffering orchiepididymitis, in Costa Rica. Following standard microbiological methods, the bacterium was first defined as "Brucella melitensis biovar 2." Further molecular typing, identified the strain as an atypical "Brucella suis." Distinctive Brucella sp. BCCN84.3 markers, absent in other Brucella species and strains, were revealed by fatty acid methyl ester analysis, high resolution melting PCR and omp25 and omp2a/omp2b gene diversity. Analysis of multiple loci variable number of tandem repeats and whole genome sequencing demonstrated that this isolate was different from the currently described Brucella species. The smooth Brucella sp. BCCN84.3 clusters together with the classical Brucella Glade and displays all the genes required for virulence. Brucella sp. BCCN84.3 is a species nova taxonomical entity displaying pathogenicity; therefore, relevant for differential diagnoses in the context of brucellosis. Considering the debate on the Brucella species concept, there is a need to describe the extant taxonomical entities of these pathogens in order to understand the dispersion and evolution

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics

© The Author(s) 2019.A better understanding of the molecular mechanisms that participate in the development and clinical manifestations of schizophrenia can lead to improve our ability to diagnose and treat this disease. Previous data strongly associated the levels of deregulated ADAMTS2 expression in peripheral blood mononuclear cells (PBMCs) from patients at first episode of psychosis (up) as well as in clinical responders to treatment with antipsychotic drugs (down). In this current work, we performed an independent validation of such data and studied the mechanisms implicated in the control of ADAMTS2 gene expression. Using a new cohort of drug-naïve schizophrenia patients with clinical follow-up, we confirmed that the expression of ADAMTS2 was highly upregulated in PBMCs at the onset (drug-naïve patients) and downregulated, in clinical responders, after treatment with antipsychotics. Mechanistically, ADAMTS2 expression was activated by dopaminergic signalling (D1-class receptors) and downstream by cAMP/CREB and mitogen-activated protein kinase (MAPK)/ERK signalling. Incubation with antipsychotic drugs and selective PKA and MEK inhibitors abrogated D1-mediated activation of ADAMTS2 in neuronal-like cells. Thus, D1 receptors signalling towards CREB activation might participate in the onset and clinical responses to therapy in schizophrenia patients, by controlling ADAMTS2 expression and activity. The unbiased investigation of molecular mechanisms triggered by antipsychotic drugs may provide a new landscape of novel targets potentially associated with clinical efficacy.This work was supported by: SAF2016-76046-R and SAF2013-46292-R (MINECO and FEDER) to B.C.F., PI16/00156 (isciii and FEDER) to J.P.V., LUCHAMOS POR LA VIDA project to F.R.J. and J.P.V., SAF2017-83702-R (MINECO and FEDER), Red TERCEL RD12/0019/0024 (ISCIII) and GVA-PROMETEO 2018/041 (Generalitat Valenciana) to S.M. J.P.V. is supported by the RyC research programme (RYC-2013-14097) and F.R.J. by the predoctoral research programme (BES-2014-070615), from MINECO and FEDER

Database of spatial distribution of non indigenous species in Spanish marine waters

Research in marine Spanish waters are focused on several actions to achieve an effectively management on protected areas, with the active participation of the stakeholders and research as basic tools for decision-making. Among these actions, there is one about the knowledge and control on NIS. One of its objectives is the creation of NIS factsheets, which are going to be added to the National Marine Biodiversity Geographical System (GIS) providing complementary information about taxonomic classification, common names, taxonomic synonyms, species illustrations, identification morphological characters, habitat in the native and introduced regions, biological and ecological traits, GenBank DNA sequences, world distribution, first record and evolution in the introduced areas, likely pathways of introduction, effects in the habitats and interaction with native species, and potential management measures to apply. The database will also provide data for (1) the European online platforms, (2) the environmental assessment for the Descriptor 2 (D2-NIS) of the EU Marine Strategy Framework Directive (MSFD), as well as (3) supporting decisions made by stakeholders. It is the result of extensive collaboration among scientist, manager’s and citizen science in the Spanish North-Atlantic, South-Atlantic, Gibraltar Strait-Alboran, Levantine-Balearic and Canary Islands marine divisions, providing an updated overview of the spatial distribution of relevant extended and invasive NIS of recent and established NIS introduced by maritime transport and aquaculture pathways, as well as on cryptogenic or native species in expansion due to the climatic water warming trend

Efficacy of a strategy for implementing a guideline for the control of cardiovascular risk in a primary healthcare setting: the SIRVA2 study a controlled, blinded community intervention trial randomised by clusters

This work describes the methodology used to assess a strategy for implementing clinical practice guidelines (CPG) for cardiovascular risk control in a health area of Madrid