Turbulent Concentration of mm-Size Particles in the Protoplanetary Nebula: Scale-Dependent Cascades

The initial accretion of primitive bodies (here, asteroids in particular) from freely-floating nebula particles remains problematic. Traditional growth-by-sticking models encounter a formidable "meter-size barrier" (or even a mm-to-cm-size barrier) in turbulent nebulae, making the preconditions for so-called "streaming instabilities" difficult to achieve even for so-called "lucky" particles. Even if growth by sticking could somehow breach the meter size barrier, turbulent nebulae present further obstacles through the 1-10km size range. On the other hand, nonturbulent nebulae form large asteroids too quickly to explain long spreads in formation times, or the dearth of melted asteroids. Theoretical understanding of nebula turbulence is itself in flux; recent models of MRI (magnetically-driven) turbulence favor low-or- no-turbulence environments, but purely hydrodynamic turbulence is making a comeback, with two recently discovered mechanisms generating robust turbulence which do not rely on magnetic fields at all. An important clue regarding planetesimal formation is an apparent 100km diameter peak in the pre-depletion, pre-erosion mass distribution of asteroids; scenarios leading directly from independent nebula particulates to large objects of this size, which avoid the problematic m-km size range, could be called "leapfrog" scenarios. The leapfrog scenario we have studied in detail involves formation of dense clumps of aerodynamically selected, typically mm-size particles in turbulence, which can under certain conditions shrink inexorably on 100-1000 orbit timescales and form 10-100km diameter sandpile planetesimals. There is evidence that at least the ordinary chondrite parent bodies were initially composed entirely of a homogeneous mix of such particles. Thus, while they are arcane, turbulent concentration models acting directly on chondrule size particles are worthy of deeper study. The typical sizes of planetesimals and the rate of their formation can be estimated using a statistical model with properties inferred from large numerical simulations of turbulence. Nebula turbulence is described by its Reynolds number Re = (L/eta)(exp 4/3), where L = H alpha(exp 1/2) is the largest eddy scale, H is the nebula gas vertical scale height, alpha the turbulent viscosity parameter, and eta is the Kolmogorov or smallest scale in turbulence (typically about 1km), with eddy turnover time t(sub eta). In the nebula, Re is far larger than any numerical simulation can handle, so some physical arguments are needed to extend the results of numerical simulations to nebula conditions. In this paper, we report new physics to be incorporated into our statistical models

Planetesimal Initial Mass Functions and Creation Rates Under Turbulent Concentration Using Scale-Dependent Cascades

The initial accretion of primitive bodies from freely-floating nebula particles remains problematic. Traditional growth-by-sticking models in turbulent nebulae encounter a "meter-size barrier" due to both drift and destruction, or even a millimeter-to-centimeter-size "bouncing" barrier. Recent suggestions have been made that some "lucky" particles might be able to outgrow the collision and/or drift barriers, and lead to so-called "streaming instabilities" or SI. However, new full models of growth by sticking in the presence of radial drift show that lucky particles (the largest particles, at the tail of the size distribution, that grow beyond the nominal fragmentation and drift barriers) are far too rare to lead to any collective effects such as streaming or gravitational instabilities. Thus we need to focus on typical radii gamma(sub M) which contain most of the mass. Our models of disks with weak-to-moderate turbulence, which include all the most recent experimental constraints on collisional growth, erosion, bouncing, and fragmentation, as well as radial drift, find that growth stalls quite generally at sizes gamma(sub M) which are too small to settle into layers which are dense enough for any collective effects (streaming or gravitational instabilities) to arise. Even if growth by sticking could somehow breach the nominal barriers (perhaps if the actual sticking or strength is larger than current estimates for pure ice or pure silicate, with specific grain sizes), turbulent nebulae present subsequent formidable obstacles to incremental growth through the 1-10km size range. On the other hand, non-turbulent nebulae alpha is less than 10(Sup -4)

Charging and coagulation of dust in protoplanetary plasma environments

Combining a particle-particle, particle-cluster and cluster-cluster agglomeration model with an aggregate charging model, the coagulation and charging of dust particles in various plasma environments relevant for proto-planetary disks have been investigated. The results show that charged aggregates tend to grow by adding small particles and clusters to larger particles and clusters, leading to greater sizes and masses as compared to neutral aggregates, for the same number of monomers in the aggregate. In addition, aggregates coagulating in a Lorentzian plasma (containing a larger fraction of high-energy plasma particles) are more massive and larger than aggregates coagulating in a Maxwellian plasma, for the same plasma densities and characteristic temperature. Comparisons of the grain structure, utilizing the compactness factor, {\phi}{\sigma}, demonstrate that a Lorentzian plasma environment results in fluffier aggregates, with small {\phi}{\sigma}, which exhibit a narrow compactness factor distribution. Neutral aggregates are more compact, with larger {\phi}{\sigma}, and exhibit a larger variation in fluffiness. Measurement of the compactness factor of large populations of aggregates is shown to provide information on the disk parameters that were present during aggregation

Material enhancement in protoplanetary nebulae by particle drift through evaporation fronts

Solid material in a protoplanetary nebula is subject to vigorous redistribution processes relative to the nebula gas. Meter-sized particles drift rapidly inwards near the nebula midplane, and material evaporates when the particles cross a condensation/evaporation boundary. The material cannot be removed as fast in its vapor form as it is being supplied in solid form, so its concentration increases locally by a large factor (more than an order of magnitude under nominal conditions). As time goes on, the vapor phase enhancement propagates for long distances inside the evaporation boundary (potentially all the way in to the star). Meanwhile, material is enhanced in its solid form over a characteristic lengthscale outside the evaporation boundary. This effect is applicable to any condensible (water, silicates, {\it etc.}). Three distinct radial enhancement/depletion regimes can be discerned by use of a simple model. Meteoritics applications include oxygen fugacity and isotopic variations, as well as isotopic homogenization in silicates. Planetary system applications include more robust enhancement of solids in Jupiter's core formation region than previously suggested. Astrophysical applications include differential, time-dependent enhancement of vapor phase CO and H$_2$O in the terrestrial planet regions of actively accreting protoplanetary disks.Comment: To appear in Astrophys. J., vol 614, Oct 10 2004 issu

Oral lesions in leprosy

BACKGROUND: Leprotic oral lesions are more common in the lepromatous form of leprosy, indicate a late manifestation, and have a great epidemiological importance as a source of infection. METHODS: Patients with leprosy were examined searching for oral lesions. Biopsies of the left buccal mucosa in all patients, and of oral lesions, were performed and were stained with H&E and Wade. RESULTS: Oral lesions were found in 26 patients, 11 lepromatous leprosy, 14 borderline leprosy, and one tuberculoid leprosy. Clinically 5 patients had enanthem of the anterior pillars, 3 of the uvula and 3 of the palate. Two had palatal infiltration. Viable bacilli were found in two lepromatous patients. Biopsies of the buccal mucosa showed no change or a nonspecific inflammatory infiltrate. Oral clinical alterations were present in 69% of the patients; of these 50% showed histopathological features in an area without any lesion. DISCUSSION: Our clinical and histopathological findings corroborate earlier reports that there is a reduced incidence of oral changes, which is probably due to early treatment. The maintenance of oral infection in this area can also lead to and maintain lepra reactions, while they may also act as possible infection sources. Attention should be given to oral disease in leprosy because detection and treatment of oral lesions can prevent the spread of the disease

Forming Planetesimals by Gravitational Instability: II. How Dust Settles to its Marginally Stable State

Dust at the midplane of a circumstellar disk can become gravitationally unstable and fragment into planetesimals if the local dust-to-gas density ratio mu is sufficiently high. We simulate how dust settles in passive disks and ask how high mu can become. We settle the dust using a 1D code and test for dynamical stability using a 3D shearing box code. This scheme allows us to explore the behavior of small particles having short but non-zero stopping times in gas: 0 < t_stop << the orbital period. The streaming instability is thereby filtered out. Dust settles until shearing instabilities in the edges of the dust layer threaten to overturn the entire layer. In this state of marginal stability, mu=2.9 for a disk whose bulk (height-integrated) metallicity is solar. For a disk whose bulk metallicity is 4x solar, mu reaches 26.4. These maximum values of mu, which depend on the background radial pressure gradient, are so large that gravitational instability of small particles is viable in disks whose bulk metallicities are just a few (<4) times solar. Earlier studies assumed that dust settles until the Richardson number Ri is spatially constant. Our simulations are free of this assumption but provide support for it within the dust layer's edges, with the proviso that Ri increases with bulk metallicity in the same way that we found in Paper I. Only modest enhancements in bulk metallicity are needed to spawn planetesimals directly from small particles.Comment: Accepted to Ap

A Recent Impact Origin of Saturn’s Rings and Mid-sized Moons

We simulate the collision of precursor icy moons analogous to Dione and Rhea as a possible origin for Saturn's remarkably young rings. Such an event could have been triggered a few hundred million years ago by resonant instabilities in a previous satellite system. Using high-resolution smoothed particle hydrodynamics simulations, we find that this kind of impact can produce a wide distribution of massive objects and scatter material throughout the system. This includes the direct placement of pure-ice ejecta onto orbits that enter Saturn's Roche limit, which could form or rejuvenate rings. In addition, fragments and debris of rock and ice totaling more than the mass of Enceladus can be placed onto highly eccentric orbits that would intersect with any precursor moons orbiting in the vicinity of Mimas, Enceladus, or Tethys. This could prompt further disruption and facilitate a collisional cascade to distribute more debris for potential ring formation, the re-formation of the present-day moons, and evolution into an eventual cratering population of planetocentric impactors

Origin and Evolution of Saturn's Ring System

The origin and long-term evolution of Saturn's rings is still an unsolved problem in modern planetary science. In this chapter we review the current state of our knowledge on this long-standing question for the main rings (A, Cassini Division, B, C), the F Ring, and the diffuse rings (E and G). During the Voyager era, models of evolutionary processes affecting the rings on long time scales (erosion, viscous spreading, accretion, ballistic transport, etc.) had suggested that Saturn's rings are not older than 100 My. In addition, Saturn's large system of diffuse rings has been thought to be the result of material loss from one or more of Saturn's satellites. In the Cassini era, high spatial and spectral resolution data have allowed progress to be made on some of these questions. Discoveries such as the ''propellers'' in the A ring, the shape of ring-embedded moonlets, the clumps in the F Ring, and Enceladus' plume provide new constraints on evolutionary processes in Saturn's rings. At the same time, advances in numerical simulations over the last 20 years have opened the way to realistic models of the rings's fine scale structure, and progress in our understanding of the formation of the Solar System provides a better-defined historical context in which to understand ring formation. All these elements have important implications for the origin and long-term evolution of Saturn's rings. They strengthen the idea that Saturn's rings are very dynamical and rapidly evolving, while new arguments suggest that the rings could be older than previously believed, provided that they are regularly renewed. Key evolutionary processes, timescales and possible scenarios for the rings's origin are reviewed in the light of tComment: Chapter 17 of the book ''Saturn After Cassini-Huygens'' Saturn from Cassini-Huygens, Dougherty, M.K.; Esposito, L.W.; Krimigis, S.M. (Ed.) (2009) 537-57

A simple model for the evolution of the dust population in protoplanetary disks

Context: The global size and spatial distribution of dust is an important ingredient in the structure and evolution of protoplanetary disks and in the formation of larger bodies, such as planetesimals. Aims: We aim to derive simple equations that explain the global evolution of the dust surface density profile and the upper limit of the grain size distribution and which can readily be used for further modeling or for interpreting of observational data. Methods: We have developed a simple model that follows the upper end of the dust size distribution and the evolution of the dust surface density profile. This model is calibrated with state-of-the-art simulations of dust evolution, which treat dust growth, fragmentation, and transport in viscously evolving gas disks. Results: We find very good agreement between the full dust-evolution code and the toy model presented in this paper. We derive analytical profiles that describe the dust-to-gas ratios and the dust surface density profiles well in protoplanetary disks, as well as the radial flux by solid material "rain out", which is crucial for triggering any gravity assisted formation of planetesimals. We show that fragmentation is the dominating effect in the inner regions of the disk leading to a dust surface density exponent of -1.5, while the outer regions at later times can become drift-dominated, yielding a dust surface density exponent of -0.75. Our results show that radial drift is not efficient in fragmenting dust grains. This supports the theory that small dust grains are resupplied by fragmentation due to the turbulent state of the disk.Comment: 12 pages, 10 figures, accepted to A&

Mycobacterium tuberculosis Immune Response in Patients With Immune-Mediated Inflammatory Disease

Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have an intrinsic higher probability to develop active-tuberculosis (TB) compared to the general population. The risk ranges from 2.0 to 8.9 in RA patients not receiving therapies. According to the WHO, the RA prevalence varies between 0.3% and 1% and is more common in women and in developed countries. Therefore, the identification and treatment of TB infection (TBI) in this fragile population is important to propose the TB preventive therapy. We aimed to study the M. tuberculosis (Mtb) specific T-cell response to find immune biomarkers of Mtb burden or Mtb clearance in patients with different TB status and different risk to develop active-TB disease. We enrolled TBI subjects as example of Mtb-containment, the active-TB as example of a replicating Mtb status, and the TBI-IMID as fragile population. To study the Mtb-specific response in a condition of possible Mtb sterilization, we longitudinally enrolled TBI subjects and active-TB patients before and after TB therapy. Peripheral blood mononuclear cells were stimulated overnight with Mtb peptides contained in TB1- and TB2-tubes of the Quantiferon-Plus kit. Then, we characterized by cytometry the Mtb-specific CD4 and CD8 T cells. In TBI-IMID, the TB therapy did not affect the ability of CD4 T cells to produce interferon-γ, tumor necrosis factor-α, and interleukin-2, their functional status, and their phenotype. The TB therapy determined a contraction of the triple functional CD4 T cells of the TBI subjects and active-TB patients. The CD45RA- CD27+ T cells stood out as a main subset of the Mtb-specific response in all groups. Before the TB-preventive therapy, the TBI subjects had higher proportion of Mtb-specific CD45RA-CD27+CD4+ T cells and the active-TB subjects had higher proportion of Mtb-specific CD45RA-CD27-CD4+ T cells compared to other groups. The TBI-IMID patients showed a phenotype similar to TBI, suggesting that the type of IMID and the IMID therapy did not affect the activation status of Mtb-specific CD4 T cells. Future studies on a larger and better-stratified TBI-IMID population will help to understand the change of the Mtb-specific immune response over time and to identify possible immune biomarkers of Mtb-containment or active replication