Seismic vulnerability of churches in Faial and Pico islands, Azores

Earthquakes represent one of the main cause of serious damage and loss of historic and architectural heritage. Interventions to preserve these building should start with a careful knowledge and assessment of their seismic vulnerability, in order to support any needed retrofitting and strengthening measures. This paper proposes a procedure to register and diagnose of the level of damage on churches after the occurrence of an earthquake, and also to assess the seismic vulnerability of this type of construction. This procedure was applied to sixteen churches in the Azores islands which were hit by the July 9th 1998 earthquake. Belfries of church towers are elements with a particular seismic vulnerability. For this reason, and based on the Italian methodology proposed by the Linee Guida (2006), it is applied to belfries of two churches from Pico (Azores), a simplified mechanical model for assessment of seismic vulnerability of this type of structures

Metodologia para a avaliação da vulnerabilidade sísmica do património religioso: caso de estudo - Faial e Pico, Açores

Os sismos representam uma das grandes causas de danos graves e perda do património histórico e arquitectónico. Qualquer intervenção de reabilitação destes edifícios deve partir de uma cuidada avaliação e análise da sua vulnerabilidade sísmica, de modo a desenvolver, se necessário, estratégias de reforço sísmico adequadas. O principal objectivo do presente artigo é estudar a vulnerabilidade sísmica do património religioso das ilhas do Faial e do Pico, nos Açores. Para tal, numa primeira parte deste trabalho, é proposta uma metodologia para o diagnóstico e registo do grau de dano em igrejas após a ocorrência de um sismo, assim como para a avaliação da vulnerabilidade associada a estas. A partir da análise dos danos observados em dezasseis igrejas afectadas pelo sismo de 9 de Julho de 1998 nos Açores, é elaborada uma base de dados que, para além de reunir as características de cada igreja estudada, apoia o cálculo simplificado do índice de dano, vulnerabilidade e coeficiente de segurança global. O campanário das torres sineiras é um elemento particularmente vulnerável aos sismos, devido à sua geometria típica. Por um lado, a existência de grandes aberturas a certos níveis produz tipicamente elementos verticais muito esbeltos. Por outro lado, a elevada concentração de massa no topo das torres também contribui para esta vulnerabilidade. Assim, na segunda parte deste trabalho, é aplicada a metodologia italiana, proposta na Linee Guida per la Valutazione e Reduzione del Rischio Sísmico del Patrimônio Culturale, aos campanários de duas igrejas localizadas na ilha do Pico, com base num modelo mecânico simplificado para a avaliação da vulnerabilidade deste tipo de estruturas. Com o trabalho desenvolvido, pretende-se contribuir para uma sistematização de processos de inspecção e registo de informação relativa a igrejas, com vista a apoiar estratégias de intervenção quer em situações de pós-sismo, quer na mitigação do risco sísmico destas estruturas

Consequences of converting graded to action potentials upon neural information coding and energy efficiency

Information is encoded in neural circuits using both graded and action potentials, converting between them within single neurons and successive processing layers. This conversion is accompanied by information loss and a drop in energy efficiency. We investigate the biophysical causes of this loss of information and efficiency by comparing spiking neuron models, containing stochastic voltage-gated Na+ and K+ channels, with generator potential and graded potential models lacking voltage-gated Na+ channels. We identify three causes of information loss in the generator potential that are the by-product of action potential generation: (1) the voltage-gated Na+ channels necessary for action potential generation increase intrinsic noise and (2) introduce non-linearities, and (3) the finite duration of the action potential creates a ‘footprint’ in the generator potential that obscures incoming signals. These three processes reduce information rates by ~50% in generator potentials, to ~3 times that of spike trains. Both generator potentials and graded potentials consume almost an order of magnitude less energy per second than spike trains. Because of the lower information rates of generator potentials they are substantially less energy efficient than graded potentials. However, both are an order of magnitude more efficient than spike trains due to the higher energy costs and low information content of spikes, emphasizing that there is a two-fold cost of converting analogue to digital; information loss and cost inflation

World Press Photo 2012: the discursive construction of the Arab Spring

O presente artigo pretende analisar a forma como o fenómeno da Primavera Árabe foi retratado nas fotografias vencedoras do concurso World Press Photo em 2012. As fotografias jornalísticas, embora se apresentem como índices do real, condicionam frequentemente a percepção dos indivíduos e influenciam as suas práticas sociais. Também as fotografias vencedoras do World Press Photo, um dos concursos mais prestigiados de fotojornalismo, em 2012 não fogem ao construtivismo discursivo que molda a representação e a percepção dos acontecimentos. A partir da análise crítica do discurso, nomeadamente dos instrumentos teóricos da semiótica barthesiana e da semiótica social de Gunther Kress e Theo van Leeuwen, procurámos interpretar as 38 fotografias vencedoras do World Press Photo 2012, a fim de reflectirmos sobre o modo como contribuíram para a compreensão da Revolta Árabe e como despertaram o nosso interesse e a nossa imaginação para o desenrolar do conflito.ABSTRACT:This article aims to analyze how the Arab Spring phenomenon was represented in the award-winning photographs of the World Press Photo contest in 2012. Although news photographs are usually seen as indexes of the real, they often limit the perception of individuals and influence their social practices. Also the winning photographs in 2012 of the World Press Photo, one of the most prestigious photojournalism contests, do not escape the discursive constructivism that shapes the representation and perception of events. Drawing from critical discourse analysis, namely from the theoretical tools of barthesian semiotics and Gunther Kress’s and Theo van Leeuwen’s social semiotics, we sought to interpret the 38 award-winning photographs of the World Press Photo contest in 2012, in order to reflect on the way they have contributed to our understanding of the Arab Revolt and aroused our interest and imagination to the unfolding of the conflict.info:eu-repo/semantics/publishedVersio

KNOWLEDGE AND VIEWPOINTS ON THE EFFECTS OF CORRUPTION ON HEALTHCARE: A SURVEY CONDUCTED AMONG STUDENTS OF PALERMO UNIVERSITY MEDICAL SCHOOL, ITALY

Corruption affects healthcare effectiveness and efficiency and limits equity in access to health services. Aim of the survey was to document knowledge and viewpoints on the impact of corruption on healthcare system in a sample of students attending pre-lauream healthcare professional courses at Palermo University Medical school and to evaluate any improvement in their awareness on this topic after a dedicated multidisciplinary educational intervention. An anonymous questionnaire was administered to students before and after the intervention. Absolute and relative frequency of correct and incorrect answers was computed. Chi-squared test was used to compare answers given before and after the educational intervention. Approximately less than a quarter of the respondents were able to correctly estimate impact of corruption, inappropriateness and waste in healthcare on NHS. The study documented how improving students\u2019 knowledge of the impact of corruption in the healthcare system could represent a possible strategy to prevent corruption in healthcare

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction of CRTH2 and NKp30 with elevated tumour-derived PGD2 and B7H6, respectively. ILC2s, in turn, activate monocytic myeloid-derived suppressor cells (M-MDSCs) via IL-13 secretion. Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored. Similarly, disruption of this tumour immunosuppressive axis by specifically blocking PGD2, IL-13 and NKp30 partially restores ILC2 and M-MDSC levels and results in increased survival. Thus, using APL as a model, we uncover a tolerogenic pathway that may represent a relevant immunosuppressive, therapeutic targetable, mechanism operating in various human tumour types, as supported by our observations in prostate cancer.Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth