La biblioteca virtual especializada de los derivados de la caña de azúcar: consideraciones, experiencias y perspectivas

In this paper, the results of a project for the design and implementation of a specialized virtual library for sugar cane by-products are presented, including initial considerations, an architecture for working in a web environment, and the basic characteristics of software for managing a digital collection. This library supports research into sugar cane by-products and also represents an initial step toward the creation of a specialized virtual centre of information and knowledge for the sugar industry.En este trabajo se describen los resultados del proyecto de diseño e implementación de la biblioteca virtual especializada sobre los derivados de la caña de azúcar. Se abordan consideraciones, arquitectura de trabajo en ambiente de Internet y características básicas del software para la administración de su colección digital. Esta biblioteca es soporte para la investigación sobre los derivados de la caña de azúcar y constituye el paso inicial hacia la creación de un centro virtual especializado de información y conocimiento para el sector azucarero

Relationship of the type of feeding with some infant’s growth, nutritional state and mobility variables

Antecedentes: Las recomendaciones actuales para alimentación del niño durante el primer año de vida es iniciar la lactancia materna tan pronto como sea posible y evitar el uso de cualquier tipo de alimentos o líquidos distintos a la leche de pecho durante los primeros cuatro a seis meses de vida. Objetivo: Determinar si el patrón de alimentación en las etapas iniciales de la vida postnatal influyen en las características del crecimiento y el desarrollo del lactante durante el primer año de la vida. Pacientes y métodos: Se estudiaron 77 lactantes pertenecientes a 14 consultorios del médico de la familia del Policlínico Docente Bejucal en la provincia de La Habana. De ellos 27 lactaron de forma exclusiva por 4 meses y 50 iniciaron la alimentación complementaria antes del cuarto mes. A todos los lactantes se les realizó un estudio clínico y antropométrico, al mes, tres, cinco, nueve y doce meses del nacimiento. El análisis estadístico incluyó las variaciones de los estadígrafos descriptivos (media, desviación estándar, e intervalos de confianza a 95%) así como un análisis de observaciones repetidas para conocer si las variaciones de la evolución dependen del tiempo de lactancia materna exclusiva. Resultados: Se pudo apreciar que no existen variaciones en la evolución de los valores de la media del peso hasta el noveno mes del desarrollo. Las variaciones de la talla no muestran diferencias en su patrón de ganancia entre los grupos en todas las etapas del desarrollo estudiadas. Hay diferencias en las cifras de morbilidad sobre todo en lo referente a las enfermedades respiratorias y diarreicas. Conclusiones: No se evidencian diferencias importantes relacionadas con la evolución del peso y la talla durante el primer año de vida. La morbilidad se ve influida por el tipo de alimentación que se reciba durante el primer año de vida. Background: The present dietary recommendation in infant feeding is to begin breast feeding as soon as possible and avoid the use of other kind of foods including liquids different of breast feeding during the first four to six months of life. Sample and methods: From 14 ambulatory clinics, in Havana Province (Bejucal Community Policlinic), 77 infants were studied; of them 27 received exclusive breast feeding during the first four months and 50 began their complementary feeding before the fourth month. All children were examined and measured at 1, 3, 5, 9 and 12 months. Statistic analysis included the variation of the statistical stadigraphs (media, standard deviation, and confident intervals at 95%). Repeated measures analyses were done to evaluate the association of variables with type of feeding. Results: There were no differences in mean values of weight and height until the ninth month. Weight increased in group receiving early supplementation. There are differences in the morbidity figures mainly for respiratory and diarrhoeal diseases. Conclusions: There are no significant differences related to evolution of weight and height during the first year of life. Morbidity is under influences of the type of feeding used during the first year of life

Calidad de vida profesional de enfermería en urgencias de un hospital de referencia

Objective: The objective of this study was to measure the quality of professional life of nurses in their workplace in the emergency unit of a Hospital, through three dimensions intrinsic motivation, support and management workloads. Most studies on quality of life worldwide are made primarily in teaching groups and health professionals. According to various studies, this group is very likely to suffer burnout. If we improve the quality of care provided, we must start knowing how nursing professionals perceive quality of life, as well as whether there are constraining factors involved.Methods: Cross-sectional study survey of nurses working in an Emergency Unit of a Spanish public hospital. It was conducted between March and May of 2014. The sample consisted on 60 subjects. Data were collected using the CVP-35 questionnaire.Results: The response rate was high. The nurses perceived low quality of professional life. The professional quality of life correlates with management support and intrinsic motivation, although no association with the workload was found. Age is the demographic variable that influences how they perceive their quality of working life emergency nurses.Conclusion: Compared to other studies, if we improve the management support, perception of the quality of working life of nurses working in emergency increase.Objetivo: El objetivo de este estudio fue medir la Calidad de Vida Profesional de los enfermeros en la unidad de urgencias de un hospital en su puesto de trabajo, a través de tres dimensiones: motivación intrínseca, apoyo directivo y cargas de trabajo. La mayoría de estudios sobre calidad de vida a nivel mundial se hacen principalmente en colectivos de enseñanza y también los profesionales de la salud, sufren desgaste profesional, según estudios diversos. Si queremos mejorar la calidad de los cuidados prestados, debemos empezar conociendo cómo percibe el profesional de Enfermería dicha calidad de vida, así como si existen o no factores que la condicionen.Métodos: Estudio descriptivo transversal con análisis correlacional. El presente estudió investigó la calidad de vida profesional de los enfermeros de una Unidad de Urgencias de  un Hospital público español. Fue llevado a cabo entre Marzo y Mayo de 2014. Para ello se utilizó el “cuestionario CVP-35”.Resultados: La tasa de respuesta fue alta. Los enfermeros percibieron una baja calidad de vida profesional. La calidad de vida profesional se correlaciona con el Apoyo directivo y la Motivación intrínseca, aunque no se asocia con la Carga de Trabajo. La edad es la variable sociodemográfica que influye en cómo perciben su calidad de vida profesional los enfermeros de urgencias.Conclusión: En relación con otros estudios, si mejoramos el Apoyo directivo, la percepción de la calidad de vida profesional de los profesionales de enfermería que trabajan en urgencias aumentaría.

LA GESTIÓN DE INFORMACIÓN EN LA FORMACIÓN DEL PROFESIONAL

The present work discusses the importance of the information management as well as the essential elements that contributes to the development of the professional ability of information management. The analysis reveals the need of systematic development in the formative process in the meantime the student foments a culture of work based in the knowledge of a set of tools for navigation, searching, the reviewing, processing and socialization information in digital format that supports the graduated in the processes management and the decisions making of the organization from the perspective of the continuous improvement of his capabilities in the academic, labor and research components of the process.  El trabajo aborda la importancia de la gestión de información y su relación con el desarrollo de la habilidad profesional gestionar información. El análisis revela la necesidad del desarrollo sistemático en el proceso formativo, en tanto se fomenta una cultura de trabajo basada en el conocimiento de un conjunto de herramientas para la navegación, la búsqueda, la revisión, el procesamiento y socialización de la información en formato digital que apoya al profesional en la gestión de procesos y la toma de decisiones desde la perspectiva del mejoramiento continuo de sus capacidades en los componentes académico, laboral e investigativo del proceso

Establecimiento de la glycine (Neonotonia wightii) con fertilizante mineral, estiércol vacuno y cal en suelos Ferralíticos y Fersialíticos

Because of its high raw protein content, and adaptation to different agroecosystems, Glycine is one of the most extended legumes over the country; nevertheless, it needs fertile and not too acid soils. In Camagüey province, most of cattle raising areas are located on soils whose fertility and pH are medium to low; for that reason, two experiments were carried out in glass-house conditions to determine the effect of three soil fertility improvers on Glycine (Neonotonia wightii) cv. Tinaroo, behavior in fersialitic and ferralitic soils. Pots of 1,5 kg of capacity were used to study three doses of mineral fertilizer, cattle manure and lime in a randomized design with a factorial arrangement and four repetitions, evaluated by a double classification variance test (P≤ 0,05) and when there were significant differences Dunca'ns multiple range test was applied for comparison in case of significant differences (P≤ 0,05). Significant increases in Glycine yields were detected when applying the three mentioned improvers, while the highest dry matter production (8,23 and 21,54 g/pot) was registered with 50 t/ha of cattle manure combined to intermediate P-K doses (50-100 and 100-200 kg/ha for ferralitic and fersialitic soils) in addition to 2 t/ha CaCo3. Moreover, Glycine showed suitable contents of raw protein (15,69 and 18,80 %) and calcium (0,86 and 1,44 %) for animal normal growing up.Por sus altos contenidos en proteína bruta y su adaptabilidad a diferentes agroecosistemas, la Glycine es una de las leguminosas que más se ha extendido por todo el país; pero requiere de suelos fértiles y no muy ácidos. En Camagüey la mayoría de las áreas ganaderas están ubicadas en suelos de fertilidad y pH de medios a bajos, por lo que en condiciones de casa de cristal se condujeron dos experimentos para determinar el efecto de tres mejoradores de la fertilidad del suelo sobre el establecimiento de la Glycine (Neonotonia wightii) cv. Tinaroo, en suelos Ferralíticos y Fersialíticos. En macetas de 1,5 kg de capacidad se estudiaron tres dosis de fertilizante mineral, estiércol vacuno y cal (CaCO3) en cada suelo, mediante un diseño completamente aleatorizado con arreglo factorial y cuatro repeticiones, que se evaluaron por análisis de varianza de doble clasificación (P≤ 0,05) y en los casos de significación las medias se compararon por la prueba de rango múltiple de Duncan (P≤ 0,05). Se encontró que los rendimiento aumentaron significativamente con la aplicación de los tres mejoradores y que las mayores producciones de materia seca (8,23 y 21,54 g/maceta) se obtuvieron con el empleo de dosis equivalentes a 50 t/ha de estiércol vacuno combinado con la dosis intermedia de P-K (50-100 y 100-200 kg/ha para el suelo Ferralítico y Fersialítico, respectivamente) así como cuando se añadieron 2 t/ha de CaCO3. Además se encontró que esta especie muestra contenidos adecuados de proteína bruta (15,69 y 18,80 %) y calcio (0,86 y 1,44 %) para el normal desarrollo de los animales

Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility

Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546047/Background: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single nucleotide polymorphisms in the development of male infertility as a consequence of severe spermatogenic failure. Objectives: The main objective of the present study is to evaluate the effect of the common genetic variation of KATNAL1 in a large and phenotypically well-characterised cohort of infertile men because of severe spermatogenic failure. Materials and methods: A total of 715 infertile men because of severe spermato genic failure, including 210 severe oligospermia and 505 non-obstructive azoospermia patients, as well as 1058 unaffected controls were genotyped for three KATNAL1 single-nucleotide polymorphism taggers (rs2077011, rs7338931 and rs2149971). Case–control association analyses by logistic regression assuming different models and in silico functional characterisation of risk variants were conducted. Results: Genetic associations were observed between the three analysed taggers and different severe spermatogenic failure groups. However, in all cases, the haplotype model (rs2077011*C | rs7338931*T | rs2149971*A) better explained the observed associations than the three risk alleles independently. This haplotype was associated with non-obstructive azoospermia (adjusted p = 4.96E-02, odds ratio = 2.97), Sertoli cell only syndrome (adjusted p = 2.83E-02, odds ratio = 5.16) and testicular sperm extraction unsuccessful outcomes (adjusted p = 8.99E-04, odds ratio = 6.13). The in silico analyses indicated that the effect on severe spermatogenic failure predisposition could be because of an alteration of the KATNAL1 splicing pattern. Conclusions: Specific allelic combinations of KATNAL1 genetic polymorphisms may confer a risk of developing severe male infertility phenotypes by favouring the overrepresentation of a short non-functional transcript isoform in the testis.This work was supported by the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (refs. SAF2016-78722-R and PID2020-120157RB-I00), the ‘Instituto de Salud Carlos III’ (Fondo de Investigaciones Sanitarias)/Fondo Europeo de Desarrollo Regional ‘Una manera de hacer Europa’ (FIS/FEDER) (ref. DTS18/00101 to Sara Larriba), the Generalitat de Catalunya (ref. 2017SGR191), the ‘Ramón y Cajal’ program (ref. RYC-2014-16458) and the ‘Juan de la Cierva Incorporación’ program (ref. IJC2018-038026-I), as well as the Andalusian Government through the R&D&i Projects Grants for Universities and Public Research Entities (ref. PY20_00212), which include FEDER funds. Andrea Guzmán-Jiménez was a recipient of a grant from the Spanish Ministry of Education and Professional Training (‘Becas de Colaboración en Departamentos Universitarios para el curso académico 2020/2021’). Patricia I. Marques is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Tech nology and High Education and from the European Social Fund, available through the ‘Programa Operacional do Capital Humano’. João Gonçalves was partially funded by FCT/MCTES through national funds attributed to the Centre for Toxicogenomics and Human Health— ToxOmics (UID/BIM/00009/2016 and UIDB/00009/2020). Sara Larriba is sponsored by the Researchers Consolidation Program (ISCIII SNS/Dpt. Salut Generalitat de Catalunya) (CES09/020).info:eu-repo/semantics/publishedVersio

Common genetic variation in KATNAL1 non‐coding regions is involved in the susceptibility to severe phenotypes of male infertility

© 2022 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Background: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single-nucleotide polymorphisms in the development of male infertility as a consequence of severe spermatogenic failure. Objectives: The main objective of the present study is to evaluate the effect of the common genetic variation of KATNAL1 in a large and phenotypically well-characterised cohort of infertile men because of severe spermatogenic failure. Materials and methods: A total of 715 infertile men because of severe spermatogenic failure, including 210 severe oligospermia and 505 non-obstructive azoospermia patients, as well as 1058 unaffected controls were genotyped for three KATNAL1 single-nucleotide polymorphism taggers (rs2077011, rs7338931 and rs2149971). Case-control association analyses by logistic regression assuming different models and in silico functional characterisation of risk variants were conducted. Results: Genetic associations were observed between the three analysed taggers and different severe spermatogenic failure groups. However, in all cases, the haplotype model (rs2077011*C | rs7338931*T | rs2149971*A) better explained the observed associations than the three risk alleles independently. This haplotype was associated with non-obstructive azoospermia (adjusted p = 4.96E-02, odds ratio = 2.97), Sertoli-cell only syndrome (adjusted p = 2.83E-02, odds ratio = 5.16) and testicular sperm extraction unsuccessful outcomes (adjusted p = 8.99E-04, odds ratio = 6.13). The in silico analyses indicated that the effect on severe spermatogenic failure predisposition could be because of an alteration of the KATNAL1 splicing pattern. Conclusions: Specific allelic combinations of KATNAL1 genetic polymorphisms may confer a risk of developing severe male infertility phenotypes by favouring the overrepresentation of a short non-functional transcript isoform in the testis.This work was supported by the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (refs. SAF2016-78722-R and PID2020-120157RB-I00), the ‘Instituto de Salud Carlos III’ (Fondo de Investigaciones Sanitarias)/Fondo Europeo de Desarrollo Regional ‘Una manera de hacer Europa’ (FIS/FEDER) (ref. DTS18/00101 to Sara Larriba), the Generalitat de Catalunya (ref. 2017SGR191), the ‘Ramón y Cajal’ program (ref. RYC-2014-16458) and the ‘Juan de la Cierva Incorporación’ program (ref. IJC2018-038026-I), as well as the Andalusian Government through the R&D&i Projects Grants for Universities and Public Research Entities (ref. PY20_00212), which include FEDER funds. Andrea Guzmán-Jiménez was a recipient of a grant from the Spanish Ministry of Education and Professional Training (‘Becas de Colaboración en Departamentos Universitarios para el curso académico 2020/2021’). Patricia I. Marques is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Technology and High Education and from the European Social Fund, available through the ‘Programa Operacional do Capital Humano’. João Gonçalves was partially funded by FCT/MCTES through national funds attributed to the Centre for Toxicogenomics and Human Health—ToxOmics (UID/BIM/00009/2016 and UIDB/00009/2020). Sara Larriba is sponsored by the Researchers Consolidation Program (ISCIII SNS/Dpt. Salut Generalitat de Catalunya) (CES09/020).info:eu-repo/semantics/publishedVersio

Evaluación de las causas de anestro en rebaños bovinos lecheros en Camagüey

To determine the reproductive, metabolic, health and food status and evaluate the physical-productive status of the farms of two dairy cattle herds with a high incidence of anestric females belonging to a livestock company in the province of Camagüey, Cuba was performed on all animals the clinical-gynecological examination, the evaluation of the body condition, the determination of the live weight, a parasitological analysis and the evaluation of the metabolic state were used four groups of females: pregnant women in the last third (> 7½ months), recentins, between 15 and 20 days and 60 days of births and females with more than 60 days postpartum without being inseminated (empty), finally the evaluation of the availability of pastures and the consumption of dry matter in each of the herds was carried out . The data obtained were processed using the generalized linear model. The clinical-gynecological diagnosis showed problems with estrous cyclicity related to deficiencies in the detection of heat, high parasitic infestation (Fasciola hepatica), food problems and metabolic disorders (energy metabolism, protein, immune deficit, hypocalcemia and hypophosphoremia). The reproductive behavior of the herds and their state of health were related to the physical-productive state of the farms. It is recommended to improve the productive physical state of the farms to ensure an adequate forage balance and reproductive management in the herds based on the body condition and other health indicators of the female.Para determinar el estado reproductivo, metabólico, de salud y alimentario y evaluar el estado físico-productivo de las fincas de dos rebaños bovinos lecheros con elevada incidencia de hembras anéstricas pertenecientes a una empresa pecuaria de la provincia Camagüey, Cuba se realizó a todos los animales el examen clínico-ginecológico, la evaluación de la condición corporal, la determinación del peso vivo, un análisis parasitológico y la evaluación del estado metabólico fueron utilizados cuatro grupos de hembras: gestantes en el último tercio (> 7 ½ meses), recentinas, entre 15 y 20 días y de 60 días de paridas y hembras con mas de 60 días post parto sin ser inseminadas (vacías), por último se realizó la evaluación de la disponibilidad de los pastos y del consumo de materia seca en cada uno de los rebaños. Los datos obtenidos se procesaron mediante el modelo lineal generalizado. El diagnóstico clínico-ginecológico evidenció problemas con la ciclicidad estral relacionados con deficiencias en la detección del celo, alta infestación parasitaria (Fasciola hepatica), problemas alimentarios y desórdenes metabólicos (metabolismo energético, protéico, déficit inmunitario, hipocalcemia e hipofosforemia). El comportamiento reproductivo de los rebaños y su estado de salud estuvieron relacionados con el estado físico-productivo de las fincas. Se recomienda mejorar el estado físico productivo de las fincas para garantizar un balance forrajero adecuado y el manejo reproductivo en los rebaños sobre la base de la condición corporal y otros indicadores de salud de la hembra

Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome

Funding Information: Funding: This work was supported by the Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020) (ref. PY20_00212, P20_00583), and the Spanish Ministry of Economy and Competitiveness through the Spanish National Plan for Scientific and Technical Research and Innovation (ref. SAF2016–78722-R, PID2020–120157RB-I00) and the Proyectos I + D + i del Programa Operativo FEDER 2020 (ref. B-CTS-584-UGR20, B-CTS-260-UGR20). FDC was supported by the “Ramón y Cajal” program (ref. RYC-2014–16458), and LBC was supported by the Spanish Ministry of Economy and Competitiveness through the “Juan de la Cierva Incorporación” program (Grant ref. IJC2018– 038026-I, funded by MCIN/AEI/10.13039/501100011033), all of them including FEDER funds. AGJ was funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”(grant ref. FPU20/02926). SGM was funded by a previously mentioned project (ref. PY20_00212). IPATIMUP integrates the i3S Research Unit, which is partially supported by the Portuguese Foundation for Science and Technology (FCT), financed by the European Social Funds (COMPETE-FEDER) and National Funds (projects PEstC/SAU/LA0003/2013 and POCI-01–0145-FEDER-007274). AML is funded by the Portuguese Government through FCT (IF/01262/2014). PIM is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Technology and High Education and from the European Social Fund, available through the Programa Operacional do Capital Humano. ToxOmics—Centre for Toxicogenomics and Human Health, Genetics, Oncology and Human Toxicology, Nova Medical School, Lisbon, is also partially supported by FCT (Projects: UID/BIM/00009/2013 and UIDB/UIDP/00009/2020). SLarriba received support from Instituto de Salud Carlos III (grant DTS18/00101], co-funded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe), and from “Generalitat de Catalunya” (grant 2017SGR191). SLarriba is sponsored by the “Researchers Consolidation Program” from the SNS-Dpt. Salut Generalitat de Catalunya (Exp. CES09/020). This article is related to the Ph.D. Doctoral Thesis of Miriam Cerván-Martín (grant ref. BES-2017–081222 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.We aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood–testis barrier, in the genetic risk of developing male infertility due to a severe spermatogenic failure (SPGF). Genotyping was performed using TaqMan genotyping assays for three PIN1 taggers (rs2287839, rs2233678 and rs62105751). The study cohort included 715 males diagnosed with SPGF and classified as suffering from non-obstructive azoospermia (NOA, n = 505) or severe oligospermia (SO, n = 210), and 1058 controls from the Iberian Peninsula. The allelic frequency differences between cases and controls were analyzed by the means of logistic regression models. A subtype specific genetic association with the subset of NOA patients classified as suffering from the Sertoli cell-only (SCO) syndrome was observed with the minor alleles showing strong risk effects for this subset (ORaddrs2287839 = 1.85 (1.17–2.93), ORaddrs2233678 = 1.62 (1.11–2.36), ORaddrs62105751 = 1.43 (1.06–1.93)). The causal variants were predicted to affect the binding of key transcription factors and to produce an altered PIN1 gene expression and isoform balance. In conclusion, common non-coding single-nucleotide polymorphisms located in PIN1 increase the genetic risk to develop SCO.publishersversionpublishe