Alien Registration- Cummings, Gordon (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/14126/thumbnail.jp

REACHING THE "ATTENTIVE PUBLIC" WITH DISCUSSION GROUP FACT SHEETS

Teaching/Communication/Extension/Profession,

Seeing the big PICTURE: A framework for improving the communication of requirements within the Business-IT relationship

The relationship between the business and IT departments in the context of the organisation has been characterised as highly divisive. Contributing problems appear to revolve around the failure to adequately communicate and understand the required information for the alignment of business and IT strategies and infrastructures. This study takes a communication-based view on the concept of alignment, in terms of the relationship between the retail business and IT within a major high street UK bank. A research framework (PICTURE) is used to provide insight into this relationship and guide the analysis of interviews with 29 individuals on mid-high management level for their thematic content. The paper highlights the lessons that can be derived from the study of the BIT relationship and how possible improvements could be made

In vitro bacterial vaginosis biofilm community manipulation using endolysin therapy

Bacterial vaginosis (BV) affects approximately 26% of women of childbearing age globally, presenting with 3–5 times increased risk of miscarriage and two-fold risk of pre-term birth. Antibiotics (metronidazole and clindamycin) are typically employed to treat BV; however the success rate is low due to the formation of recalcitrant polymicrobial biofilms. As a novel therapeutic, promising results have been obtained in vitro using Gardnerella endolysins, although to date their efficacy has only been demonstrated against simple biofilm models. In this study, a four-species biofilm was developed consisting of Gardnerella vaginalis, Fannyhessea vaginae, Prevotella bivia and Mobiluncus curtisii. Biofilms were grown in NYC III broth and treated using antibiotics and an anti-Gardnerella endolysin (CCB7.1) for 24 h. Biofilm composition, viability and structure were assessed using colony counts, live/dead qPCR and scanning electron microscopy. All species colonised biofilms to varying degrees, with G. vaginalis being the most abundant. Biofilm composition remained largely unchanged when challenged with escalated concentrations of conventional antibiotics. A Gardnerella-targeted endolysin candidate (CCB7.1) showed efficacy against several Gardnerella species planktonically, and significantly reduced viable G. vaginalis within polymicrobial biofilms at 1 to 4X pMIC (p < 0.05 vs. vehicle control). Collectively, this study highlights the resilience of biofilm-embedded pathogens against the currently used antibiotics and provides a polymicrobial model that allows for more effective pre-clinical screening of BV therapies. The Gardnerella-specific endolysin CCB7.1 demonstrated significant activity against G. vaginalis within polymicrobial biofilms, altering the overall community dynamic and composition

A framework to explore micronutrient deficiency in maternal and child health in Malawi, Southern Africa

<p>Abstract</p> <p>Background</p> <p>Global food insecurity is associated with micronutrient deficiencies and it has been suggested that 4.5 billion people world-wide are affected by deficiencies in iron, vitamin A and iodine. Zinc has also been identified to be of increasing concern. The most vulnerable are young children and women of childbearing age. A pilot study has been carried out in Southern Malawi, to attempt to link the geochemical and agricultural basis of micronutrient supply through spatial variability to maternal health and associated cultural and social aspects of nutrition. The aim is to establish the opportunity for concerted action to deliver step change improvements in the nutrition of developing countries.</p> <p>Results</p> <p>Field work undertaken in August 2007 and July/August 2008 involved the collection of blood, soil and crop samples, and questionnaires from ~100 pregnant women. Complex permissions and authorisation protocols were identified and found to be as much part of the cultural and social context of the work as the complexity of the interdisciplinary project. These issues are catalogued and discussed. A preliminary spatial evaluation is presented linking soil quality and food production to nutritional health. It also considers behavioural and cultural attitudes of women and children in two regions of southern Malawi, (the Shire Valley and Shire Highlands plateau). Differences in agricultural practice and widely varying soil quality (e.g. pH organic matter, C/N and metal content) were observed for both regions and full chemical analysis of soil and food is underway. Early assessment of blood data suggests major differences in health and nutritional status between the two regions. Differences in food availability and type and observations of life style are being evaluated through questionnaire analysis.</p> <p>Conclusion</p> <p>The particular emphasis of the study is on the interdisciplinary opportunities and the barriers to progress in development support in subsistence communities. Engaging at the community level and the balance of expectations from both study subjects and research team highlight the merit of careful and detailed planning and project delivery.</p

Is GRB 050904 at z=6.3 absorbed by dust?

Claim of dust extinction for this GRB has been debated in the past. We suggest that the discrepant results occur primarily because most of previous studies have not simultaneously investigated the X-ray to near-IR spectral energy distribution of this GRB. The difficulty with this burst is that the X-ray afterglow is dominated by strong flares at early times and is poorly monitored at late times. In addition, the Z band photometry, which is the most sensitive to dust extinction, has been found to be affected by strong systematics. In this paper we carefully re-analyze the Swift/XRT afterglow observations of this GRB, using extensive past studies of X-ray flare properties when computing the X-ray afterglow flux level and exploiting the recent reanalysis of the optical (UV rest frame) data of the same GRB. We extract the X-ray to optical/near-IR afterglow SED for the three epochs where the best spectral coverage is available: 0.47, 1.25, and 3.4 days after the trigger. A spectral power-law model has been fitted to the extracted SEDs. We discuss that no spectral breaks or chromatic temporal breaks are expected in the epochs of interest. To fit any UV rest-frame dust absorption, we tested the Small Magellanic Cloud (SMC) extinction curve, the mean extinction curve (MEC) found for a sample of QSO at $z>4$ and its corresponding attenuation curve, as well as a starburst attenuation curve, and the extinction curve consistent with a supernova dust origin (SN-type). The SMC extinction curve and the SN-type one provide good fit to the data at all epochs, with an average amount of dust absorption at $\lambda_{rest} = 3000 \AA$ of $A_{3000} = 0.25\pm 0.07$ mag. These results indicate that the primeval galaxy at $z = 6.3$ hosting this GRB has already enriched its ISM with dust.Comment: 8 pages, 3 figures, accepted for publication in Astronomy and Astrophysics; figure 1 has been degraded, full resolution version at http://dl.dropbox.com/u/1670579/fig01.p

Factors Associated with Suicide Ideation in Severely Obese Bariatric Surgery‐Seeking Individuals

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93709/1/j.1943-278X.2012.00110.x.pd

Review of anthraquinone applications for pest management and agricultural crop protection

We have reviewed published anthraquinone applications for international pest management and agricultural crop protection from 1943 to 2016. Anthraquinone (AQ) is commonly found in dyes, pigments and many plants and organisms. Avian repellent research with AQ began in the 1940s. In the context of pest management, AQ is currently used as a chemical repellent, perch deterrent, insecticide and feeding deterrent in many wild birds, and in some mammals, insects and fishes. Criteria for evaluation of effective chemical repellents include efficacy, potential for wildlife hazards, phytotoxicity and environmental persistence. As a biopesticide, AQ often meets these criteria of efficacy for the non-lethal management of agricultural depredation caused by wildlife. We summarize published applications of AQ for the protection of newly planted and maturing crops from pest birds. Conventional applications of AQ-based repellents include preplant seed treatments [e.g. corn (Zea mays L.), rice (Oryza sativa L.), sunflower (Helianthus annuus L.), wheat (Triticum spp.), millet (Panicum spp.), sorghum (Sorghumbicolor L.), pelletized feed and forest tree species] and foliar applications for rice, sunflower, lettuce (Lactuca sativa L.), turf, sugar beets (Beta vulgaris L.), soybean (Glycine max L.), sweet corn and nursery, fruit and nut crops. In addition to agricultural repellent applications, AQ has also been used to treat toxicants for the protection of non-target birds. Few studies have demonstrated AQ repellency in mammals, including wild boar (Sus scrofa, L.), thirteen-lined ground squirrels (Ictidomys tridecemlineatus,Mitchill), black-tailed prairie dogs (Cyomys ludovicainus, Ord.), common voles (Microtus arvalis, Pallas), housemice (Musmusculus, L.), Tristram’s jirds (Meriones tristrami, Thomas) and black rats (Rattus rattus L.). Natural sources of AQ and its derivatives have also been identified as insecticides and insect repellents. As a natural or synthetic biopesticide, AQ is a promising candidate for many contexts of non-lethal and insecticidal pest management

Perspectives of general practitioners on the issues surrounding the late diagnosis of Alzheimer’s Disease

We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer’s disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagnosis of AD. This was a semi-structured, qualitative and audio-recorded interview of seven GPs, from five GP surgeries in Milton Keynes and Luton, using the framework analysis. GPs reported challenges with the current patient’s consultation time, a lack of continuity of care, inadequate training, limited support for patients after diagnosis, and poor treatment of the UK’s aging population. The study highlights important changes that would facilitate the earlier diagnosis of AD