The surface energy balance during foehn events at Joyce Glacier, McMurdo Dry Valleys, Antarctica

The McMurdo Dry Valleys (MDV) are a polar desert, where glacial melt is the main source of water to streams and the ecosystem. Summer air temperatures are typically close to zero, and therefore foehn events can have a large impact on the meltwater production. A 14-month record of automatic weather station (AWS) data on Joyce Glacier is used to force a 1D surface energy balance model to study the impact of foehn events on the energy balance. AWS data and output of the Antarctic Mesoscale Prediction System (AMPS) on a 1.7 km grid are used to detect foehn events at the AWS site. Foehn events at Joyce Glacier occur under the presence of cyclones over the Ross Sea. The location of Joyce Glacier on the leeward side of the Royal Society Range during these synoptic events causes foehn warming through isentropic drawdown. This mechanism differs from the foehn warming through gap flow that was earlier found for other regions in the MDV and highlights the complex interaction of synoptic flow with local topography of the MDV. Shortwave radiation is the primary control on melt at Joyce Glacier, and melt often occurs with subzero air temperatures. During foehn events, melt rates are enhanced, contributing to 23 % of the total annual melt. Foehn winds cause a switch from a diurnal stability regime in the atmospheric surface layer to a continuous energy input from sensible heat flux throughout the day. The sensible heating during foehn, through an increase in turbulent mixing resulting from gustier and warmer wind conditions, is largely compensated for by extra heat losses through sublimation. Melt rates are enhanced through an additional energy surplus from a reduced albedo during foehn.</p

How do Stability Corrections Perform in the Stable Boundary Layer Over Snow?

We assess sensible heat-flux parametrizations in stable conditions over snow surfaces by testing and developing stability correction functions for two alpine and two polar test sites. Five turbulence datasets are analyzed with respect to, (a) the validity of the Monin–Obukhov similarity theory, (b) the model performance of well-established stability corrections, and (c) the development of new univariate and multivariate stability corrections. Using a wide range of stability corrections reveals an overestimation of the turbulent sensible heat flux for high wind speeds and a generally poor performance of all investigated functions for large temperature differences between snowand the atmosphere above (>10 K).Applying the Monin–Obukhov bulk formulation introduces a mean absolute error in the sensible heat flux of 6W m-2 (compared with heat fluxes calculated directly from eddy covariance). The stability corrections produce an additional error between 1 and 5W m-2, with the smallest error for published stability corrections found for the Holtslag scheme. We confirm from previous studies that stability corrections need improvements for large temperature differences and wind speeds, where sensible heat fluxes are distinctly overestimated. Under these atmospheric conditions our newly developed stability corrections slightly improve the model performance. However, the differences between stability corrections are typically small when compared to the residual error, which stems from the Monin–Obukhov bulk formulation

A call for refining the role of humic-like substances in the oceanic iron cycle

Primary production by phytoplankton represents a major pathway whereby atmospheric CO2 is sequestered in the ocean, but this requires iron, which is in scarce supply. As over 99% of iron is complexed to organic ligands, which increase iron solubility and microbial availability, understanding the processes governing ligand dynamics is of fundamental importance. Ligands within humic-like substances have long been considered important for iron complexation, but their role has never been explained in an oceanographically consistent manner. Here we show iron co-varying with electroactive humic substances at multiple open ocean sites, with the ratio of iron to humics increasing with depth. Our results agree with humic ligands composing a large fraction of the iron-binding ligand pool throughout the water column. We demonstrate how maximum dissolved iron concentrations could be limited by the concentration and binding capacity of humic ligands, and provide a summary of the key processes that could influence these parameters. If this relationship is globally representative, humics could impose a concentration threshold that buffers the deep ocean iron inventory. This study highlights the dearth of humic data, and the immediate need to measure electroactive humics, dissolved iron and iron-binding ligands simultaneously from surface to depth, across different ocean basins

Metal-enriched halo gas across galaxy overdensities over the last 10 billion years

We present a study of metal-enriched halo gas traced by Mg II and C IV absorption at z 1. It is clear from our results that environmental processes have a significant impact on the distribution of metals around galaxies and need to be fully accounted for when analysing correlations between gaseous haloes and galaxy properties

Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis

BACKGROUND: Limited data from small series have suggested that brain metastases from biliary tract cancers (BrM-BTC) affect ≤2% of patients with BTC. We sought to review our experience with patients with BrM-BTC and to identify associations of tumor-related molecular alterations with outcomes. MATERIALS AND METHODS: A retrospective review of patients with BTC seen at a tertiary referral center from 2005 to 2021 was performed; patients with BrM-BTC were identified, and clinical and molecular data were collected. RESULTS: Twenty-one of 823 patients with BTC (2.6%) developed BrM. For patients with BrM-BTC, median follow-up time was 27.9 months after primary BTC diagnosis and 3.1 months after BrM diagnosis. Median time from primary diagnosis to diagnosis of BrM was 14.4 [range, 1.1-66.0] months. Median overall survival (OS) from primary diagnosis was 31.5 [2.9-99.8] months and median OS from BrM diagnosis was 4.2 [0.2-33.8] months. Patients who underwent BrM-directed therapy trended toward longer OS following BrM diagnosis than patients receiving supportive care only (median 6.5 vs 0.8 months, P = .060). The BrM-BTC cohort was enriched for BRAF (30%), PIK3CA (25%), and GNAS (20%) mutations. patients with BrM-BTC with BRAF mutations trended toward longer OS following BrM diagnosis (median 13.1 vs 4.2 months, P = .131). CONCLUSION: This is the largest series of patients with BrM-BTC to date and provides molecular characterization of this rare subgroup of patients with BTC. Patients with BrM-BTC may be more likely to have BRAF mutations. With advances in targeted therapy for patients with BTC with actionable mutations, continued examination of shifting patterns of failure, with emphasis on BrM, is warranted

Effect of terminal accuracy requirements on temporal gaze-hand coordination during fast discrete and reciprocal pointings

Background\ud \ud Rapid discrete goal-directed movements are characterized by a well known coordination pattern between the gaze and the hand displacements. The gaze always starts prior to the hand movement and reaches the target before hand velocity peak. Surprisingly, the effect of the target size on the temporal gaze-hand coordination has not been directly investigated. Moreover, goal-directed movements are often produced in a reciprocal rather than in a discrete manner. The objectives of this work were to assess the effect of the target size on temporal gaze-hand coordination during fast 1) discrete and 2) reciprocal pointings.\ud \ud Methods\ud \ud Subjects performed fast discrete (experiment 1) and reciprocal (experiment 2) pointings with an amplitude of 50 cm and four target diameters (7.6, 3.8, 1.9 and 0.95 cm) leading to indexes of difficulty (ID = log2[2A/D]) of 3.7, 4.7, 5.7 and 6.7 bits. Gaze and hand displacements were synchronously recorded. Temporal gaze-hand coordination parameters were compared between experiments (discrete and reciprocal pointings) and IDs using analyses of variance (ANOVAs).\ud \ud Results\ud \ud Data showed that the magnitude of the gaze-hand lead pattern was much higher for discrete than for reciprocal pointings. Moreover, while it was constant for discrete pointings, it decreased systematically with an increasing ID for reciprocal pointings because of the longer duration of gaze anchoring on target.\ud \ud Conclusion \ud \ud Overall, the temporal gaze-hand coordination analysis revealed that even for high IDs, fast reciprocal pointings could not be considered as a concatenation of discrete units. Moreover, our data clearly illustrate the smooth adaptation of temporal gaze-hand coordination to terminal accuracy requirements during fast reciprocal pointings. It will be interesting for further researches to investigate if the methodology used in the experiment 2 allows assessing the effect of sensori-motor deficits on gaze-hand coordination

Cloud forcing of surface energy balance from in situ measurements in diverse mountain glacier environments

Clouds are an important component of the climate system, yet our understanding of how they directly and indirectly affect glacier melt in different climates is incomplete. Here we analyse high-quality datasets from 16 mountain glaciers in diverse climates around the globe to better understand how relationships between clouds and near-surface meteorology, radiation and surface energy balance vary. The seasonal cycle of cloud frequency varies markedly between mountain glacier sites. During the main melt season at each site, an increase in cloud cover is associated with increased vapour pressure and relative humidity, but relationships to wind speed are site specific. At colder sites (average near-surface air temperature in the melt season <0gg C), air temperature generally increases with increasing cloudiness, while for warmer sites (average near-surface air temperature in the melt season ≫0gg C), air temperature decreases with increasing cloudiness. At all sites, surface melt is more frequent in cloudy compared to clear-sky conditions. The proportion of melt from temperature-dependent energy fluxes (incoming longwave radiation, turbulent sensible heat and latent heat) also universally increases in cloudy conditions. However, cloud cover does not affect daily total melt in a universal way, with some sites showing increased melt energy during cloudy conditions and others decreased melt energy. The complex association of clouds with melt energy is not amenable to simple relationships due to many interacting physical processes (direct radiative forcing; surface albedo; and co-variance with temperature, humidity and wind) but is most closely related to the effect of clouds on net radiation. These results motivate the use of physics-based surface energy balance models for representing glacier-climate relationships in regional- and global-scale assessments of glacier response to climate change

Phase I Trial of Single-Photon Emission Computed Tomography-Guided Liver-Directed Radiotherapy for Patients With Low Functional Liver Volume

BACKGROUND: Traditional constraints specify that 700 cc of liver should be spared a hepatotoxic dose when delivering liver-directed radiotherapy to reduce the risk of inducing liver failure. We investigated the role of single-photon emission computed tomography (SPECT) to identify and preferentially avoid functional liver during liver-directed radiation treatment planning in patients with preserved liver function but limited functional liver volume after receiving prior hepatotoxic chemotherapy or surgical resection. METHODS: This phase I trial with a 3 + 3 design evaluated the safety of liver-directed radiotherapy using escalating functional liver radiation dose constraints in patients with liver metastases. Dose-limiting toxicities were assessed 6-8 weeks and 6 months after completing radiotherapy. RESULTS: All 12 patients had colorectal liver metastases and received prior hepatotoxic chemotherapy; 8 patients underwent prior liver resection. Median computed tomography anatomical nontumor liver volume was 1584 cc (range = 764-2699 cc). Median SPECT functional liver volume was 1117 cc (range = 570-1928 cc). Median nontarget computed tomography and SPECT liver volumes below the volumetric dose constraint were 997 cc (range = 544-1576 cc) and 684 cc (range = 429-1244 cc), respectively. The prescription dose was 67.5-75 Gy in 15 fractions or 75-100 Gy in 25 fractions. No dose-limiting toxicities were observed during follow-up. One-year in-field control was 57%. One-year overall survival was 73%. CONCLUSION: Liver-directed radiotherapy can be safely delivered to high doses when incorporating functional SPECT into the radiation treatment planning process, which may enable sparing of lower volumes of liver than traditionally accepted in patients with preserved liver function. TRIAL REGISTRATION: NCT02626312