Efeito do nível nutricional durante a primeira seca após a desmama, no primeiro intervalo de partos e na idade e peso ao segundo parto de animais de diferentes grupos genéticos.

O objetivo deste trabalho foi avaliar o efeito de nível nutricional após a desmama, de grupo genético (GG) e da interação GG x nível de suplementação sobre o primeiro intervalo de partos, peso e idade ao segundo parto de fêmeas bovinas de corte. Durante dois anos 129 bezerras desmamadas, dos grupos genéticos Y2 Angus + Y2 Nelore (AN), Y2 Canchim + Y2 Nelore (CN), Y2 Simental + Y2 Nelore (SN) e Nelore (N), foram suplementadas com de cana-de-açúcar e 1,S kg ou 3,0 kg de concentrado/animal/dia, durante o primeiro período da seca após a desmama. Nas três secas seguintes todos os animais foram suplementados com cana-de-açúcar mais uréia e 1,5 kg de concentrado. A utilização do nível maior de concentrado (3,0 kg/animal/dia) após a desmama durante a época da seca não reduziu a idade ao segundo parto. A média de idade ao segundo parto dos animais AN foi menor do que a dos demais grupos genéticos independentemente do nível de suplementação. Houve diferença no peso ao segundo parto entre os grupos genéticos, mas não houve diferença entre os níveis de suplementação e nem interação GG x nível de suplementação. Os animais SN apresentaram maior peso ao segundo parto (P<O,OS), mas também maior (P<O,OS) intervalo de partos. Não houve diferença no intervalo de partos entre os animais suplementados com 1,S kg ou suplementados com 3,0 kg de concentrado/animal/dia na primeira seca após a desmama

Efeito do nível nutricional e grupo genético na idade e peso de entrada em reprodução e ao primeiro parto.

O objetivo foi determinar se há efeito de nível nutricional, de grupo genético e interação nível nutricional x grupo genético para o peso e a idade de entrada em reprodução e ao primeiro parto. Durante três anos, 184 bezerras desmamadas, dos grupos genéticos ½ Angus + ½ Nelore (AN), ½ Canchim + ½ Nelore (CN), ½ Simental + ½ Nelore (SN) e Nelore (N), sob pastejo rotacionado, foram suplementadas ou não com 3,0 kg de concentrado/animal/dia, no período das águas, após a desmama. Durante todos os períodos de seca todos animais foram suplementados em pastagem com cana-de-açúcar + uréia e 1,5 kg de concentrado/animal/dia. Houve diferença (P0,05) dos animais SN. A média de idade ao primeiro parto dos animais AN foi menor (P0,05) dos animais SN. Houve diferença (P<0,05) no peso ao primeiro parto entre os animais AN e N e entre SN e N

Measles outbreak in a tertiary level hospital, Porto, Portugal, 2018: challenges in the post-elimination era

A measles outbreak has been occurring in a healthcare setting in Porto, Portugal, since early March 2018, posing public health challenges for a central hospital and the community. Up to 22 April, 96 cases were confirmed, 67 in vaccinated healthcare workers, mostly between 18-39 years old. Following identification of the first cases, control measures were rapidly implemented. Concomitantly, other measles cases were notified in the Northern Region of the country. No common epidemiological link was identified.info:eu-repo/semantics/publishedVersio

Caracterização fisíco-química em progênie de aceroleira proveniente de autopolinização.

A caracterização agronômica e físico-química de frutos, aliada à estimativa da variabilidade genética é fundamental na seleção de parentais para cruzamentos, a fim de explorar sua heterose e desenvolver cultivares superiores. Neste sentido, o objetivo deste trabalho foi caracterizar uma progênie de aceroleira, oriunda da autopolinização do genótipo CMF017, buscando identificar os indivíduos mais dissimilares para cruzamentos.PDF. 135_11

The European Portuguese version of the ASAS Health Index for Patients with Spondyloarthritis: Measurement properties

Objective: The Assessments of SpondyloArthritis international Society Health Index (ASAS HI), estimates the impact of Spondyloarthritis (SpA) on global functioning and health. This article assesses the construct validity, reliability and responsiveness of the Portuguese version of the ASAS HI. Patients And Methods: Patients fulfilling ASAS classification criteria for axial (axSpA) or peripheral SpA (pSpA) were included. Construct validity was assessed through Spearman’s correlation analysis with other health outcomes. Discriminant validity wastested comparing the ASAS HI across disease activity and functionalstates using the Kruskal–Wallistest. Internal consistency was assessed by Cronbach’s a, and test-retest reliability by intraclass correlation coefficients (ICC). Responsiveness was evaluated by the standardized response mean (SRM) in patients with active disease who required therapy escalation. Results: Among the 91 patients included, 67% were male, mean (SD) age 47.2 (12.9) years, 63 patients with axSpA and 28 patients with pSpA. The hypothesis defined a priori to test construct validity were confirmed. The ASAS HI showed ability to discriminate between patients with different disease activity and functional states (p<0.001). Internal consistency (Cronbach’s a: 0.88) and test-retest reliability [ICC=0.76 (95%CI 0.09-0.91)] were good. Responsiveness was moderate\ud (SRM=-0.53). The smallest detectable change was 3.0. Conclusions: The Portuguese version of the ASAS HI is a comprehensible questionnaire that is valid, reliable and responsive. It can be used to assess the impact of SpA and its treatment on functioning and health, in clinical practice and for research purposes

Asas health index for patients with spondyloarthritis: translation into portuguese, validation, and reliability

Trabalho apresentado no Annual European Congress of Rheumatology (EULAR 2017), 14-17 junho de 2017, Madrid, EspanhaN/

SAT0368 PREGNANCY IN WOMEN WITH SPONDYLOARTHRITIS: WHO ARE THE PATIENTS AT RISK OF DISEASE FLARE?

Background:Patients with Spondyloarthritis (SpA) can experience flares during pregnancy and postpartum even though the available data are limited and not conclusive.Objectives:To assess disease activity and treatment modification during pregnancy and postpartum in patients with SpA and to identify risk factors for disease flare.Methods:Data on SpA pregnancies prospectively-followed in a pregnancy clinic from 2010 to 2019 were retrospectively analysed. Disease activity was assessed during each trimester and postpartum using ASDAS-CRP or DAS28-CRP. Flare was defined as an increase of disease activity leading to treatment modification (introduction or increase ≥5mg/day of prednisone, introduction of cDMARD or bDMARD)1.Results:Data on 50 pregnancies in 46 patients were collected (mean age at conception 33±4.7 years; median disease duration: 60 months (IQR 24-132); 33 psoriatic arthritis, 6 axialSpA, 2 reactive arthritis, 2 IBD-related SpA; 6 undifferentiated SpA, 1 juvenile idiopathic arthritis). Six pregnancies ended in miscarriage, so they weren't considered for the analysis of flares during pregnancy (table 1). Fifteen out of 44 (34%) pregnancies had at least one flare during pregnancy (6, 7 and 4 during 1st, 2ndand 3rdtrimester respectively; 2 pregnancies had multiple flares). A higher rate of flare was observed in pregnancies of patients with axial involvement (p=0.01), on treatment with bDMARDs at preconceptional visit (p=0.03) and who stopped TNFi at positive pregnancy test (p=0.03). Peripheral involvement was associated with a lower rate of flares (p=0.02). Medications resumed during pregnancy were steroids (in 6 pregnancies), cDMARDs (2 sulfasalazine, 1 cyclosporine) and bDMARDs (4 certolizumab, 4 etanercept). During postpartum period flares were recorded in 46% of patients.Table 1.clinical features, medication and disease activity in pregnancies with flare vs without flareCLINICAL FEATURESFLARE (15)NO FLARE (29)pAxial involvement, n (%)11/15 (73)9/29 (31)0.01Peripheral arthritis, n (%)8/15 (53)26/29 (90)0.02Enthesitis, n (%)5/15 (33)14/29 (48)nsDactilitis, n (%)3/15 (20)8/29 (28)nsPsoriasis, n (%)6/15 (40)17/29 (59)nsIBD, n (%)2/15 (13)0nsUveitis, n(%)1/15 (7)3/29 (10)nsHLAB27 +7/11 (64)5/12 (42)nsMEDICATION HISTORYbDMARDs, n (%)11/15 (73)7/29 (24)0.003bDMARDs at preconception visit, n (%)8/15 (53)6/29 (21)0.04bDMARDs stopped at positive pregnancy test, n (%)7/15 (47)4/29 (14)0.03cDMARDs, n (%)12/15 (80)25/29 (86)nsDISEASE ACTIVITYACTIVE DISEASE* preconception visit, n(%)3/14 (21)4/23 (17)nsACTIVE DISEASE 1sttrimester, n(%)6/15 (40)1/29 (3)0.004ACTIVE DISEASE 2ndtrimester, n(%)8/15 (47)2/29 (7)0.001ACTIVE DISEASE 3rdtrimester, n(%)2/15 (13)1/29 (3)ns*DAS28-CRP>3.2 or ASDAS-CRP≥2.1Conclusion:In our cohort of prospectively-followed SpA pregnancies, 34% experienced a flare during pregnancy and 46% during postpartum. Flares occurred especially in those patients who discontinued TNFi early in pregnancy and with axial involvement. When resumed during pregnancy, TNFi was able to control the disease. At preconception counselling, the continuation of TNFi during pregnancy should be considered to ensure a better control of disease.References:[1]Fischer-Betz R et al.Arthritis Rheumatol. 2015; 67.Disclosure of Interests: :None declare

The influence of semantic and phonological factors on syntactic decisions: An event-related brain potential study

During language production and comprehension, information about a word's syntactic properties is sometimes needed. While the decision about the grammatical gender of a word requires access to syntactic knowledge, it has also been hypothesized that semantic (i.e., biological gender) or phonological information (i.e., sound regularities) may influence this decision. Event-related potentials (ERPs) were measured while native speakers of German processed written words that were or were not semantically and/or phonologically marked for gender. Behavioral and ERP results showed that participants were faster in making a gender decision when words were semantically and/or phonologically gender marked than when this was not the case, although the phonological effects were less clear. In conclusion, our data provide evidence that even though participants performed a grammatical gender decision, this task can be influenced by semantic and phonological factors