142 research outputs found
Spectropolarimetry of R Coronae Borealis in 1998--2003: Discovery of Transient Polarization at Maximum Brightness
We present an extended optical spectropolarimetry of R CrB from 1998 January
to 2003 September. The polarization was almost constant in the phase of maximum
brightness, being consistent with past observations. We detected, however,
temporal changes of polarization ( %) in 2001 March and August, which
were the first detection of large polarization variability in R CrB near
maximum brightness. The amplitude and the position angle of the `transient
polarization' were almost constant with wavelength in both two events. There
was a difference by about 20 degrees in the position angle between the two
events. Each event could be explained by light scattering due to short-lived
dust puff occasionally ejected off the line of sight. The flatness of the
polarization against the wavelength suggests that the scatterer is a mixture of
dust grains having various sizes. The rapid growth and fading of the transient
polarization favors the phenomenological model of dust formation near the
stellar photosphere (e.g., within two stellar radii) proposed for the time
evolution of brightness and chromospheric emission lines during deeply
declining periods, although the fading timescale can hardly be explained by a
simple dispersal of expanding dust puff with a velocity of km s
. Higher expansion velocity or some mechanism to destroy the dust grains
should be needed.Comment: 22 pages, 10 figures, accepted for publication in A
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"Engaging with birth stories in pregnancy: a hermeneutic phenomenological study of women's experiences across two generations"
BACKGROUND: The birth story has been widely understood as a crucial source of knowledge about childbirth. What has not been reported is the effect that birth stories may have on primigravid women's understandings of birth. Findings are presented from a qualitative study exploring how two generations of women came to understand birth in the milieu of other's stories. The prior assumption was that birth stories must surely have a positive or negative influence on listeners, steering them towards either medical or midwifery-led models of care.
METHODS: A Heideggerian hermeneutic phenomenological approach was used. Twenty UK participants were purposively selected and interviewed. Findings from the initial sample of 10 women who were pregnant in 2012 indicated that virtual media was a primary source of birth stories. This led to recruitment of a second sample of 10 women who gave birth in the 1970s-1980s, to determine whether they were more able to translate information into knowledge via stories told through personal contact and not through virtual technologies
RESULTS: Findings revealed the experience of 'being-in-the-world' of birth and of stories in that world. From a Heideggerian perspective, the birth story was constructed through 'idle talk' (the taken for granted assumptions of things, which come into being through language). Both oral stories and those told through technology were described as the 'modern birth story'. The first theme 'Stories are difficult like that', examines the birth story as problematic and considers how stories shape meaning. The second 'It's a generational thing', considers how women from two generations came to understand what their experience might be. The third 'Birth in the twilight of certainty,' examines women's experience of Being in a system of birth as constructed, portrayed and sustained in the stories being shared.
CONCLUSIONS: The women pregnant in 2012 framed their expectations in the language of choice, whilst the women who birthed in the 1970s-1980s framed their experience in the language of safety. For both, however, the world of birth was the same; saturated with, and only legitimised by the birth of a healthy baby. Rather than creating meaningful understanding, the 'idle talk' of birth made both cohorts fearful of leaving the relative comfort of the 'system', and of claiming an alternative birth
Edoxaban: an update on the new oral direct factor Xa inhibitor.
Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with non-valvular atrial fibrillation (NVAF) and symptomatic venous thromboembolism (VTE). The ENGAGE AF-TIMI 48 study (NÂ =Â 21,105; mean CHADS2 score 2.8) compared edoxaban 60Â mg once daily (high-dose regimen) and edoxaban 30Â mg once daily (low-dose regimen) with dose-adjusted warfarin [international normalized ratio (INR) 2.0-3.0] and found that both regimens were non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with NVAF. Both edoxaban regimens also provided significant reductions in the risk of hemorrhagic stroke, cardiovascular mortality, major bleeding and intracranial bleeding. The Hokusai-VTE study (NÂ =Â 8,292) in patients with symptomatic VTE had a flexible treatment duration of 3-12Â months and found that following initial heparin, edoxaban 60Â mg once daily was non-inferior to dose-adjusted warfarin (INR 2.0-3.0) for the prevention of recurrent VTE, and also had a significantly lower risk of bleeding events. Both studies randomized patients at moderate-to-high risk of thromboembolic events and were further designed to simulate routine clinical practice as much as possible, with edoxaban dose reduction (halving dose) at randomisation or during the study if required, a frequently monitored and well-controlled warfarin group, a well-monitored transition period at study end and a flexible treatment duration in Hokusai-VTE. Given the phase III results obtained, once-daily edoxaban may soon be a key addition to the range of antithrombotic treatment options
A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration
Amyloid β1-42 (Aβ1-42) plays a central role in Alzheimer’s disease. The link between structure, assembly and neuronal toxicity of this peptide is of major current interest but still poorly defined. Here, we explored this relationship by rationally designing a variant form of Aβ1-42 (vAβ1-42) differing in only two amino acids. Unlike Aβ1-42, we found that the variant does not self-assemble, nor is it toxic to neuronal cells. Moreover, while Aβ1-42 oligomers impact on synaptic function, vAβ1-42 does not. In a living animal model system we demonstrate that only Aβ1-42 leads to memory deficits. Our findings underline a key role for peptide sequence in the ability to assemble and form toxic structures. Furthermore, our non-toxic variant satisfies an unmet demand for a closely related control peptide for Aβ1-42 cellular studies of disease pathology, offering a new opportunity to decipher the mechanisms that accompany Aβ1-42-induced toxicity leading to neurodegeneration
Very Massive Stars in the local Universe
Recent studies have claimed the existence of very massive stars (VMS) up to 300 M ⊙ in the local Universe. As this finding may represent a paradigm shift for the canonical stellar upper-mass limit of 150 M ⊙, it is timely to discuss the status of the data, as well as the far-reaching implications of such objects. We held a Joint Discussion at the General Assembly in Beijing to discuss (i) the determination of the current masses of the most massive stars, (ii) the formation of VMS, (iii) their mass loss, and (iv) their evolution and final fate. The prime aim was to reach broad consensus between observers and theorists on how to identify and quantify the dominant physical processe
Obscured Activity: AGN, Quasars, Starbursts and ULIGs observed by the Infrared Space Observatory
Some of the most active galaxies in the Universe are obscured by large
quantities of dust and emit a substantial fraction of their bolometric
luminosity in the infrared. Observations of these infrared luminous galaxies
with the Infrared Space Observatory (ISO) have provided a relatively unabsorbed
view to the sources fuelling this active emission. The improved sensitivity,
spatial resolution and spectroscopic capability of ISO over its predecessor
Infrared Astronomical Satellite (IRAS), has enabled significant advances in the
understanding of the infrared properties of active galaxies. ISO surveyed a
wide range of active galaxies which, in the context of this review, includes
those powered by intense bursts of star-formation as well as those containing a
dominant active galactic nucleus (AGN). Mid infrared imaging resolved for the
first time the dust enshrouded nuclei in many nearby galaxies, while a new era
in infrared spectroscopy was opened by probing a wealth of atomic, ionic and
molecular lines as well as broad band features in the mid and far infrared.
This was particularly useful since it resulted in the understanding of the
power production, excitation and fuelling mechanisms in the nuclei of active
galaxies including the intriguing but so far elusive ultraluminous infrared
galaxies. Detailed studies of various classes of AGN and quasars greatly
improved our understanding of the unification scenario. Far-infrared imaging
and photometry also revealed the presence of a new very cold dust component in
galaxies and furthered our knowledge of the far-infrared properties of faint
starbursts, ULIGs and quasars. We summarise almost nine years of key results
based upon ISO data spanning the full range of luminosity and type of active
galaxies.Comment: Accepted for publication in 'ISO science legacy - a compact review of
ISO major achievements', Space Science Reviews - dedicated ISO issue. To be
published by Springer in 2005. 62 pages (low resolution figures version).
Higher resolution PDFs available from
http://users.physics.uoc.gr/~vassilis/papers/VermaA.pdf or
http://www.iso.vilspa.esa.es/science/SSR/Verma.pd
Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep
BackgroundAntenatal steroids are standard of care for women who are at risk of preterm delivery; however, antenatal steroid dosing and formulation have not been evaluated adequately. The standard clinical 2-dose treatment with betamethasone-acetate+betamethasone-phosphate is more effective than 2 doses of betamethasone-phosphate for the induction of lung maturation in preterm fetal sheep. We hypothesized that the slowly released betamethasone-acetate component induces similar lung maturation to betamethasone-phosphate+betamethasone-acetate with decreased dose and fetal exposure.ObjectiveThe purpose of this study was to investigate pharmacokinetics and fetal lung maturation of antenatal betamethasone-acetate in preterm fetal sheep.Study designGroups of 10 singleton-pregnant ewes received 1 or 2 intramuscular doses 24 hours apart of 0.25 mg/kg/dose of betamethasone-phosphate+betamethasone-acetate (the standard of care dose) or 1 intramuscular dose of 0.5 mg/kg, 0.25 mg/kg, or 0.125 mg/kg of betamethasone-acetate. Fetuses were delivered 48 hours after the first injection at 122 days of gestation (80% of term) and ventilated for 30 minutes, with ventilator settings, compliance, vital signs, and blood gas measurements recorded every 10 minutes. After ventilation, we measured static lung pressure-volume curves and sampled the lungs for messenger RNA measurements. Other groups of pregnant ewes and fetuses were catheterized and treated with intramuscular injections of betamethasone-phosphate 0.125 mg/kg, betamethasone-acetate 0.125 mg/kg, or betamethasone-acetate 0.5 mg/kg. Maternal and fetal betamethasone concentrations in plasma were measured for 24 hours.ResultsAll betamethasone-treated groups had increased messenger RNA expression of surfactant proteins A, B, and C, ATP-binding cassette subfamily A member 3, and aquaporin-5 compared with control animals. Treatment with 1 dose of intramuscular betamethasone-acetate 0.125mg/kg improved dynamic and static lung compliance, gas exchange, and ventilation efficiency similarly to the standard treatment of 2Â doses of 0.25 m/kg of betamethasone-acetate+betamethasone-phosphate. Betamethasone-acetate 0.125 mg/kg resulted in lower maternal and fetal peak plasma concentrations and decreased fetal exposure to betamethasone compared with betamethasone-phosphate 0.125 mg/kg.ConclusionA single dose of betamethasone-acetate results in similar fetal lung maturation as the 2-dose clinical formulation of betamethasone-phosphate+betamethasone-acetate with decreased fetal exposure to betamethasone. A lower dose of betamethasone-acetate may be an effective alternative to induce fetal lung maturation with less risk to the fetus
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