1,208 research outputs found
Michigan\u27s Nursing Home Reform Law
This article examines Michigan\u27s new nursing home reform law, which has been hailed as landmark legislation and as a model for the entire country. Part I examines the past failures of nursing home regulation and the need for reform. Part II analyzes the law\u27s key provisions. Part III examines the weaknesses of certain enforcement measures. The article proposes the following improvements: (1) extension of the law\u27s protection to residents of homes for the aged; (2) greater access to patients by approved organizations; (3) adoption of nurse-patient ratios; (4) improvement of inspection procedures; and (5) allowance for patients or their representatives to initiate receiverships proceedings
Ground-based detections of thermal emission from CoRoT-1b and WASP-12b
We report a new detection of the H-band thermal emission of CoRoT-1b and two
confirmation detections of the Ks-band thermal emission of WASP-12b at
secondary eclipses. The H-band measurement of CoRoT-1b shows an eclipse depth
of 0.145%\pm0.049% with a 3-{\sigma} percentile between 0.033% - 0.235%. This
depth is consistent with the previous conclusions that the planet has an
isother- mal region with inefficient heat transport from dayside to nightside,
and has a dayside thermal inversion layer at high altitude. The two Ks band
detections of WASP-12b show a joint eclipse depth of 0.299%\pm0.065%. This
result agrees with the measurement of Croll & collaborators, providing
independent confirmation of their measurement. The repeatability of the
WASP-12b measurements also validates our data analysis method. Our
measurements, in addition to a number of previous results made with other
telescopes, demonstrate that ground-based observations are becoming widely
available for characterization of atmospheres of hot Jupiters.Comment: 20 pages, including 8 figures and 1 table. Accepted for publication
in Ap
Thermal Phase Variations of WASP-12b: Defying Predictions
[Abridged] We report Warm Spitzer full-orbit phase observations of WASP-12b
at 3.6 and 4.5 micron. We are able to measure the transit depths, eclipse
depths, thermal and ellipsoidal phase variations at both wavelengths. The large
amplitude phase variations, combined with the planet's previously-measured
day-side spectral energy distribution, is indicative of non-zero Bond albedo
and very poor day-night heat redistribution. The transit depths in the
mid-infrared indicate that the atmospheric opacity is greater at 3.6 than at
4.5 micron, in disagreement with model predictions, irrespective of C/O ratio.
The secondary eclipse depths are consistent with previous studies. We do not
detect ellipsoidal variations at 3.6 micron, but our parameter uncertainties
-estimated via prayer-bead Monte Carlo- keep this non-detection consistent with
model predictions. At 4.5 micron, on the other hand, we detect ellipsoidal
variations that are much stronger than predicted. If interpreted as a geometric
effect due to the planet's elongated shape, these variations imply a 3:2 ratio
for the planet's longest:shortest axes and a relatively bright day-night
terminator. If we instead presume that the 4.5 micron ellipsoidal variations
are due to uncorrected systematic noise and we fix the amplitude of the
variations to zero, the best fit 4.5 micron transit depth becomes commensurate
with the 3.6 micron depth, within the uncertainties. The relative transit
depths are then consistent with a Solar composition and short scale height at
the terminator. Assuming zero ellipsoidal variations also yields a much deeper
4.5 micron eclipse depth, consistent with a Solar composition and modest
temperature inversion. We suggest future observations that could distinguish
between these two scenarios.Comment: 19 pages, 10 figures, ApJ in press. Improved discussion of gravity
brightenin
Genome-scale phylogenies reveal relationships among Parastagonospora species infecting domesticated and wild grasses
Several plant pathogenic Parastagonospora species have been identified infecting wheat and other cereals over the past 50 years. As new lineages were discovered, naming conventions grew unwieldy and the relationships with previously recognized species remained unclear. We used genome sequencing to clarify relation-ships among these species and provided new names for most of these species. Six of the nine described Parastagonospora species were recovered from wheat, with five of these species coming from Iran. Genome sequences revealed that three strains thought to be hybrids between P. nodorum and P. pseudonodorum were not actually hybrids, but rather represented rare gene introgressions between those species. Our data are consistent with the hypothesis that P. nodorum originated as a pathogen of wild grasses in the Fertile Crescent, then emerged as a wheat pathogen via host-tracking during the domestication of wheat in the same region. The discovery of a diverse array of Parastagonospora species infecting wheat in Iran suggests that new wheat pathogens could emerge from this region in the future
Evaluation of model refinement in CASP13.
Performance in the model refinement category of the 13th round of Critical Assessment of Structure Prediction (CASP13) is assessed, showing that some groups consistently improve most starting models whereas the majority of participants continue to degrade the starting model on average. Using the ranking formula developed for CASP12, it is shown that only 7 of 32 groups perform better than a "naïve predictor" who just submits the starting model. Common features in their approaches include a dependence on physics-based force fields to judge alternative conformations and the use of molecular dynamics to relax models to local minima, usually with some restraints to prevent excessively large movements. In addition to the traditional CASP metrics that focus largely on the quality of the overall fold, alternative metrics are evaluated, including comparisons of the main-chain and side-chain torsion angles, and the utility of the models for solving crystal structures by the molecular replacement method. It is proposed that the introduction of these metrics, as well as consideration of the accuracy of coordinate error estimates, would improve the discrimination between good and very good models.Wellcome Trust
Marie Sklowdowska-Curie grain for EU Horizon 202
Evaluation of template-based modeling in CASP13.
Performance in the template-based modeling (TBM) category of CASP13 is assessed here, using a variety of metrics. Performance of the predictor groups that participated is ranked using the primary ranking score that was developed by the assessors for CASP12. This reveals that the best results are obtained by groups that include contact predictions or inter-residue distance predictions derived from deep multiple sequence alignments. In cases where there is a good homolog in the wwPDB (TBM-easy category), the best results are obtained by modifying a template. However, for cases with poorer homologs (TBM-hard), very good results can be obtained without using an explicit template, by deep learning algorithms trained on the wwPDB. Alternative metrics are introduced, to allow testing of aspects of structural models that are not addressed by traditional CASP metrics. These include comparisons to the main-chain and side-chain torsion angles of the target, and the utility of models for solving crystal structures by the molecular replacement method. The alternative metrics are poorly correlated with the traditional metrics, and it is proposed that modeling has reached a sufficient level of maturity that the best models should be expected to satisfy this wider range of criteria
On the detection of Lorentzian profiles in a power spectrum: A Bayesian approach using ignorance priors
Aims. Deriving accurate frequencies, amplitudes, and mode lifetimes from
stochastically driven pulsation is challenging, more so, if one demands that
realistic error estimates be given for all model fitting parameters. As has
been shown by other authors, the traditional method of fitting Lorentzian
profiles to the power spectrum of time-resolved photometric or spectroscopic
data via the Maximum Likelihood Estimation (MLE) procedure delivers good
approximations for these quantities. We, however, show that a conservative
Bayesian approach allows one to treat the detection of modes with minimal
assumptions (i.e., about the existence and identity of the modes).
Methods. We derive a conservative Bayesian treatment for the probability of
Lorentzian profiles being present in a power spectrum and describe an efficient
implementation that evaluates the probability density distribution of
parameters by using a Markov-Chain Monte Carlo (MCMC) technique.
Results. Potentially superior to "best-fit" procedure like MLE, which only
provides formal uncertainties, our method samples and approximates the actual
probability distributions for all parameters involved. Moreover, it avoids
shortcomings that make the MLE treatment susceptible to the built-in
assumptions of a model that is fitted to the data. This is especially relevant
when analyzing solar-type pulsation in stars other than the Sun where the
observations are of lower quality and can be over-interpreted. As an example,
we apply our technique to CoRoT observations of the solar-type pulsator HD
49933.Comment: 12 pages, 11 figures, accepted for publication in Astronomy and
Astrophysic
A search for p-modes and other variability in the binary system 85 Pegasi using MOST photometry
Context: Asteroseismology has great potential for the study of metal-poor
stars due to its sensitivity to determine stellar ages. Aims: Our goal was to
detect p-mode oscillations in the metal-poor sub-dwarf 85 Peg A and to search
for other variability on longer timescales. Methods: We have obtained
continuous high-precision photometry of the binary system 85 Pegasi with the
MOST space telescope in two seasons (2005 & 2007). Furthermore, we redetermined
vsini for 85 Peg A using high resolution spectra obtained through the ESO
archive, and used photometric spot modeling to interpret long periodic
variations. Results: Our frequency analysis yields no convincing evidence for
p-modes significantly above a noise level of 4 ppm. Using simulated p-mode
patterns we provide upper RMS amplitude limits for 85 Peg A. The light curve
shows evidence for variability with a period of about 11 d and this periodicity
is also seen in the follow up run in 2007; however, as different methods to
remove instrumental trends in the 2005 run yield vastly different results, the
exact shape and periodicity of the 2005 variability remain uncertain. Our
re-determined vsini value for 85 Peg A is comparable to previous studies and we
provide realistic uncertainties for this parameter. Using these values in
combination with simple photometric spot models we are able to reconstruct the
observed variations. Conclusions: The null-detection of p-modes in 85 Peg A is
consistent with theoretical values for pulsation amplitudes in this star. The
detected long-periodic variation must await confirmation by further
observations with similar or better precision and long-term stability. If the
11 d periodicity is real, rotational modulation of surface features on one of
the components is the most likely explanation.Comment: 11 pages, 9 figures, accepted for publication in A&
Interface Shape Control Using Localized Heating during Bridgman Growth
Numerical calculations were performed to assess the effect of localized radial heating on the melt-crystal interface shape during vertical Bridgman growth. System parameters examined include the ampoule, melt and crystal thermal conductivities, the magnitude and width of localized heating, and the latent heat of crystallization. Concave interface shapes, typical of semiconductor systems, could be flattened or made convex with localized heating. Although localized heating caused shallower thermal gradients ahead of the interface, the magnitude of the localized heating required for convexity was less than that which resulted in a thermal inversion ahead of the interface. A convex interface shape was most readily achieved with ampoules of lower thermal conductivity. Increasing melt convection tended to flatten the interface, but the amount of radial heating required to achieve a convex interface was essentially independent of the convection intensity
Demonstrating Cerebral Vascular Networks: A Comparison of Methods for the Teaching Laboratory
One challenge of neuroscience educators is to make accessible to students as many aspects of brain structure and function as possible. The anatomy and function of the cerebrovasculature is among many topics of neuroscience that are underrepresented in undergraduate neuroscience education. Recognizing this deficit, we evaluated methods to produce archival tissue specimens of the cerebrovasculature and the “neurovascular unit” for instruction and demonstration in the teaching lab. An additional goal of this project was to identify the costs of each method as well as to determine which method(s) could be adapted into lab exercises, where students participate in the tissue preparation, staining, etc. In the present report, we detail several methods for demonstrating the cerebrovasculature and suggest that including this material can be a valuable addition to more traditional anatomy/physiology demonstrations and exercises
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