Status of CMB Polarization Measurements from DASI and Other Experiments

We review the current status and future plans for polarization measurements of the cosmic microwave background radiation, as well as the cosmology these measurements will address. After a long period of increasingly sensitive upper limits, the DASI experiment has detected the E-mode polarization and both the DASI and WMAP experiments have detected the TE correlation. These detections provide confirmation of the standard model of adiabatic primordial density fluctuations consistent with inflationary models. The WMAP TE correlation on large angular scales provides direct evidence of significant reionization at higher redshifts than had previously been supposed. These detections mark the beginning of a new era in CMB measurements and the rich cosmology that can be gleaned from them.Comment: 22 pages, 9 figures; To be published in the proceedings of "The Cosmic Microwave Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and K.A. Olive

Internal representations of smell in the Drosophila brain

Recent advances in sensory neuroscience using Drosophila olfaction as a model system have revealed brain maps representing the external world. Once we understand how the brain's built-in capability generates the internal olfactory maps, we can then elaborate how the brain computes and makes decision to elicit complex behaviors. Here, we review current progress in mapping Drosophila olfactory circuits and discuss their relationships with innate olfactory behaviors

Romosozumab Treatment in Postmenopausal Women with Osteoporosis.

Background Romosozumab, a monoclonal antibody that binds sclerostin, increases bone formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal women who had a T score of -2.5 to -3.5 at the total hip or femoral neck. Patients were randomly assigned to receive subcutaneous injections of romosozumab (at a dose of 210 mg) or placebo monthly for 12 months; thereafter, patients in each group received denosumab for 12 months, at a dose of 60 mg, administered subcutaneously every 6 months. The coprimary end points were the cumulative incidences of new vertebral fractures at 12 months and 24 months. Secondary end points included clinical (a composite of nonvertebral and symptomatic vertebral) and nonvertebral fractures. Results At 12 months, new vertebral fractures had occurred in 16 of 3321 patients (0.5%) in the romosozumab group, as compared with 59 of 3322 (1.8%) in the placebo group (representing a 73% lower risk with romosozumab; P<0.001). Clinical fractures had occurred in 58 of 3589 patients (1.6%) in the romosozumab group, as compared with 90 of 3591 (2.5%) in the placebo group (a 36% lower risk with romosozumab; P=0.008). Nonvertebral fractures had occurred in 56 of 3589 patients (1.6%) in the romosozumab group and in 75 of 3591 (2.1%) in the placebo group (P=0.10). At 24 months, the rates of vertebral fractures were significantly lower in the romosozumab group than in the placebo group after each group made the transition to denosumab (0.6% [21 of 3325 patients] in the romosozumab group vs. 2.5% [84 of 3327] in the placebo group, a 75% lower risk with romosozumab; P<0.001). Adverse events, including instances of hyperostosis, cardiovascular events, osteoarthritis, and cancer, appeared to be balanced between the groups. One atypical femoral fracture and two cases of osteonecrosis of the jaw were observed in the romosozumab group. Conclusions In postmenopausal women with osteoporosis, romosozumab was associated with a lower risk of vertebral fracture than placebo at 12 months and, after the transition to denosumab, at 24 months. The lower risk of clinical fracture that was seen with romosozumab was evident at 1 year. (Funded by Amgen and UCB Pharma; FRAME ClinicalTrials.gov number, NCT01575834 .)

La Psicoterapia Dinamica basata sul Modello Dinamico-Maturativo.

Un vantaggio del Modello Dinamico-Maturativo (DMM) \ue8 che considera tre livelli distinti del funzionamento umano, ognuno dei quali pu\uf2 essere oggetto specifico di trattamenti anche diversi (Crittenden, 2008a): le distorsioni di pensieri e affetti, che possono comportare inadeguatezze del comportamento, gli aspetti relazionali (in particolare quelli familiari) e le strategie utilizzate per proteggersi dal pericolo. Le stesse tecniche di valutazione del DMM, poi, in quanto esperienze relazionali, oltre a fornire informazioni fondamentali sulla configurazione di attaccamento del paziente possono costituire una prima occasione di trattamento e di sviluppo di un\u2019alleanza terapeutica. Le innovazioni introdotte dalla teoria dell\u2019attaccamento e dal DMM risultano quindi straordinariamente utili e compatibili con una psicoterapia di tipo psicoanalitico, per cui oggi si pu\uf2 parlare di una \u201cPsicoterapia Dinamica basata sul DMM\u201d (DMM based Dynamic Psychotherapy o DMM-DP) (Baldoni, 2011)

Inelastic J/Psi production in deep inelastic scattering from hydrogen and deuterium and the gluon distribution of free nucleons

Allasia D, Amaudruz P, Arneodo M, et al. Inelastic J/Psi production in deep inelastic scattering from hydrogen and deuterium and the gluon distribution of free nucleons. Phys.Lett. B. 1991;258(3-4):493-498