The determinants of the academic outcome: an Bayesian approach using a sample of economics students from the University of Brasilia, Brazil

Using a survey conduct with 240 Economics students of the University of Brasília in August, 2011, this paper explores the determinants of the academic outcome, measured as the Gross Point Average of the University. The econometric method used to estimate is Ordinary Least Squares with Bayesian Inference. The explanatory variables include the habits of the students, such as study, frequency to classes and frequency to parties (the last one is a new approach in Brazil). Also, dummies of gender, work, type of high school and quota student were added. Study and frequency to classes turned out to be the most important determinants. The frequency to parties have not affected the Gross Point Average. The dummies had different results according to the group. There were no divergence with the major prior beliefs, with just one small exception

The Persistent Inequality in the Great Brazilian Cities: The Case of Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

A Persistente Desigualdade nas Grandes Cidades Brasileiras: o Caso de Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

A Persistente Desigualdade nas Grandes Cidades Brasileiras: o Caso de Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

KIR and a specific HLA-C gene are associated with susceptibility and resistance to hepatitis B virus infection in a Brazilian population

Colsan Associacao Beneficente Coleta Sangue, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Gynecol, São Paulo, BrazilFed Univ Rio de Janeiro UERJ, Inst Biol, Mol Virol Lab, Rio de Janeiro, RJ, BrazilFed Univ Rio de Janeiro UERJ, Histocompatibil & Cryopreservat Lab, Rio de Janeiro, RJ, BrazilFed Univ São Paulo UNIFESP, Retrovirol Lab, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Gynecol, São Paulo, BrazilFed Univ São Paulo UNIFESP, Retrovirol Lab, São Paulo, BrazilWeb of Scienc

Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation

Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the activity of both glial cells and neurons. The effects of adenosine are mediated via four adenosine receptor subtypes: A1R, A2AR, A2BR, A3R. The A2AR has a wide-spread distribution but it is especially enriched in the ventral and dorsal striatum where it is mainly located in the striato-pallidal GABA neurons at a synaptic and extrasynaptic location. A number of A2AR heteroreceptor complexes exist in the striatum. The existence of A2AR-D2R heteroreceptor complexes with antagonistic A2AR-D2R interactions in the striato-pallidal GABA neurons is well-known with A2AR activation inhibiting Gi/o mediated signaling of D2Rs. A2AR-mGluR5 heteroreceptor complexes were also found in with synergistic receptor-receptor interactions enhancing the inhibition of the D2R protomer signaling. They are located mainly in extrasynaptic regions of the striato-pallidal GABA neurons. Results recently demonstrated the existence of brain A2AR-A2BR heteroreceptor complexes, in which A2BR protomer constitutively inhibited the function of the A2AR protomer. These adenosine A2AR heteroreceptor complexes may modulate alpha-synuclein aggregation and toxicity through postulated bidirectional direct interactions leading to marked increases in A2AR signaling both in nerve cells and microglia. It is of high interest that formation of A2AR-A2ABR heteroreceptor complexes provides a brake on A2AR recognition and signaling opening up a novel strategy for treatment of A2AR mediated neurodegeneration. KEYWORDS: G protein-coupled receptor; Parkinson's diseases; adenosine A2A receptor; adenosine receptor; heteroreceptor complexes; neurodegeneration; neuroinflammation; oligomerizatio

Quaternary structure of a G-protein coupled receptor heterotetramer in complex with Gi and Gs

Background: G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. Results: We used single-particle tracking experiments in cells expressing functional adenosine A1-A2A receptors fused to fluorescent proteins to show the loss of Brownian movement of the A1 receptor in the presence of the A2A receptor, and a preponderance of cell surface 2:2 receptor heteromers (dimer of dimers). Using computer modeling, aided by bioluminescence resonance energy transfer assays to monitor receptor homomerization and heteromerization and G-protein coupling, we predict the interacting interfaces and propose a quaternary structure of the GPCR tetramer in complex with two G proteins. Conclusions: The combination of results points to a molecular architecture formed by a rhombus-shaped heterotetramer, which is bound to two different interacting heterotrimeric G proteins (Gi and Gs). These novel results constitute an important advance in understanding the molecular intricacies involved in GPCR function

Sage Tea Drinking Improves Lipid Profile and Antioxidant Defences in Humans

Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40–50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization

Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological conditions to facilitate protection and regeneration of tissues. Adenosine acts via specific GPCRs to either stimulate cyclic AMP formation, as exemplified by Gs-protein-coupled adenosine receptors (A2A and A2B), or inhibit AC activity, in the case of Gi/o-coupled adenosine receptors (A1 and A3). Recent advances in our understanding of GPCR structure have provided insights into the conformational changes that occur during receptor activation following binding of agonists to orthosteric (i.e. at the same binding site as an endogenous modulator) and allosteric regulators to allosteric sites (i.e. at a site that is topographically distinct from the endogenous modulator). Binding of drugs to allosteric sites may lead to changes in affinity or efficacy, and affords considerable potential for increased selectivity in new drug development. Herein, we provide an overview of the properties of selective allosteric regulators of the adenosine A1 and A3 receptors, focusing on the impact of receptor dimerization, mechanistic approaches to single-cell ligand-binding kinetics and the effects of A1- and A3-receptor allosteric modulators on in vivo pharmacology