92 research outputs found
Learning from a Funders' Collaborative: The Human Services Strategic Restructuring Pilot Project
In 2009, Eighteen funders in Northeast Ohio joined together in the Human Services Strategic Restructuring Pilot Project (the Collaborative) to examine how to support nonprofit organizations in strategic restructuring. This the final report on that project
Integrating health care in Australia : a qualitative evaluation
With aging populations, a growing prevalence of chronic illnesses, higher expectations for quality care and rising costs within limited health budgets, integration of healthcare is seen as a solution to these challenges. Integrated healthcare aims to overcome barriers between primary and secondary care and other disconnected patient services to improve access, continuity and quality of care. Many people in Australia are admitted to hospital for chronic illnesses that could be prevented or managed in the community. Western Sydney has high rates of diabetes, heart and respiratory diseases and the NSW State Ministry of Health has implemented key strategies through the Western Sydney Integrated Care Program (WSICP) to enhance primary care and the outcomes and experiences of patients with these illnesses. We aimed to investigate the WSICPâs effectiveness through a qualitative evaluation focused on the 10 WSICP strategies. The combined WSICP strategies improved patient and carer experience of healthcare and capacity of GPs to provide care in the community. Information sharing required longer-term investment and support, though benefits were evident by the end of our research
Four quasars above redshift 6 discovered by the Canada-France High-z Quasar Survey
The Canada-France High-z Quasar Survey (CFHQS) is an optical survey designed
to locate quasars during the epoch of reionization. In this paper we present
the discovery of the first four CFHQS quasars at redshift greater than 6,
including the most distant known quasar, CFHQS J2329-0301 at z=6.43. We
describe the observational method used to identify the quasars and present
optical, infrared, and millimeter photometry and optical and near-infrared
spectroscopy. We investigate the dust properties of these quasars finding an
unusual dust extinction curve for one quasar and a high far-infrared luminosity
due to dust emission for another. The mean millimeter continuum flux for CFHQS
quasars is substantially lower than that for SDSS quasars at the same redshift,
likely due to a correlation with quasar UV luminosity. For two quasars with
sufficiently high signal-to-noise optical spectra, we use the spectra to
investigate the ionization state of hydrogen at z>5. For CFHQS J1509-1749 at
z=6.12, we find significant evolution (beyond a simple extrapolation of lower
redshift data) in the Gunn-Peterson optical depth at z>5.4. The line-of-sight
to this quasar has one of the highest known optical depths at z~5.8. An
analysis of the sizes of the highly-ionized near-zones in the spectra of two
quasars at z=6.12 and z=6.43 suggest the IGM surrounding these quasars was
substantially ionized before these quasars turned on. Together, these
observations point towards an extended reionization process, but we caution
that cosmic variance is still a major limitation in z>6 quasar observations.Comment: 15 pages, 9 figures, AJ, in press, minor changes to previous versio
A CO Line and Infrared Continuum Study of the Active Star-Forming Complex W51
We present the results of an extensive observational study of the active
star-forming complex W51 that was observed in the J=2-1 transition of the 12CO
and 13CO molecules over a 1.25 deg x 1.00 deg region with the University of
Arizona Heinrich Hertz Submillimeter Telescope. We use a statistical
equilibrium code to estimate physical properties of the molecular gas. We
compare the molecular cloud morphology with the distribution of infrared (IR)
and radio continuum sources, and find associations between molecular clouds and
young stellar objects (YSOs) listed in Spitzer IR catalogs. The ratios of CO
lines associated with HII regions are different from the ratios outside the
active star-forming regions. We present evidence of star formation triggered by
the expansion of the HII regions and by cloud-cloud collisions. We estimate
that about 1% of the cloud mass is currently in YSOs.Comment: 18 pages, 29 figures; accepted for publication in ApJ
Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon
Background The potential for alternative plant protein sources to replace limited marine ingredients in fish feeds is important for the future of the fish farming industry. However, plant ingredients in fish feeds contain antinutritional factors (ANFs) that can promote gut inflammation (enteritis) and compromise fish health. It is unknown whether enteritis induced by plant materials with notable differences in secondary metabolism is characterised by common or distinct gene expression patterns, and how using feeds with single vs mixed plant proteins may affect the gut transcriptome and fish performance. We used Atlantic salmon parr to investigate the transcriptome responses of distal gut to varying dietary levels (0-45%) of soy protein concentrate (SPC) and faba bean (Vicia faba) protein concentrate (BPC) following an 8-week feeding trial. Soybean meal (SBM) and fish meal (FM) were used as positive and negative controls for enteritis, respectively. Gene expression profiling was performed using a microarray platform developed and validated for Atlantic salmon. Results Different plant protein materials (SPC, BPC and SBM) generated substantially different gut gene expression profiles, with relatively few transcriptomic alterations (genes, pathways and GO terms) common for all plant proteins used. When SPC and BPC were simultaneously included in the diet, they induced less extensive alterations of gut transcriptome than diets with either SPC or BPC singly, probably due to reduced levels of individual ANFs. The mixed plant protein diets were also associated with improved body composition of fish relative to the single plant protein diets, which may provide evidence for a link between the magnitude of changes in gut transcriptome and whole-animal performance. Conclusions Our results indicate that gut transcriptomic profiling provides a useful tool for testing the applicability of alternative protein sources for aquaculture feeds and designing diets with reduced impact of ANFs on fish health. Ultimately, understanding diet-gut interactions and intestinal homeostasis in farmed fish is important to maximise performance and to ensure that aquaculture continues to be a sustainable source of food for a growing world population
The Infrared Imaging Spectrograph (IRIS) for TMT: Instrument Overview
We present an overview of the design of IRIS, an infrared (0.85 - 2.5 micron)
integral field spectrograph and imaging camera for the Thirty Meter Telescope
(TMT). With extremely low wavefront error (<30 nm) and on-board wavefront
sensors, IRIS will take advantage of the high angular resolution of the narrow
field infrared adaptive optics system (NFIRAOS) to dissect the sky at the
diffraction limit of the 30-meter aperture. With a primary spectral resolution
of 4000 and spatial sampling starting at 4 milliarcseconds, the instrument will
create an unparalleled ability to explore high redshift galaxies, the Galactic
center, star forming regions and virtually any astrophysical object. This paper
summarizes the entire design and basic capabilities. Among the design
innovations is the combination of lenslet and slicer integral field units, new
4Kx4k detectors, extremely precise atmospheric dispersion correction, infrared
wavefront sensors, and a very large vacuum cryogenic system.Comment: 13 pages, SPIE Proceedings 201
1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study
Abstract
Background
There is a lack of consensus regarding optimal surgical excision margins for primary cutaneous melanomaâ>â1Â mm in Breslow thickness (BT). A narrower surgical margin is expected to be associated with lower morbidity, improved quality of life (QoL), and reduced cost. We report the results of a pilot international study (MelMarT) comparing a 1 versus 2-cm surgical margin for patients with primary melanomaâ>â1Â mm in BT.
Methods
This phase III, multicentre trial [NCT02385214] administered by the Australia & New Zealand Medical Trials Group (ANZMTG 03.12) randomised patients with a primary cutaneous melanomaâ>â1Â mm in BT to a 1 versus 2-cm wide excision margin to be performed with sentinel lymph node biopsy. Surgical closure technique was at the discretion of the treating surgeon. Patientsâ QoL was measured (FACT-M questionnaire) at baseline, 3, 6, and 12Â months after randomisation.
Results
Between January 2015 and June 2016, 400 patients were randomised from 17 centres in 5 countries. A total of 377 patients were available for analysis. Primary melanomas were located on the trunk (56.9%), extremities (35.6%), and head and neck (7.4%). More patients in the 2-cm margin group required reconstruction (34.9 vs. 13.6%; pâ<â0.0001). There was an increased wound necrosis rate in the 2-cm arm (0.5 vs. 3.6%; pâ=â0.036). After 12Â monthsâ follow-up, no differences were noted in QoL between groups.
Discussion
This pilot study demonstrates the feasibility of a large international RCT to provide a definitive answer to the optimal excision margin for patients with intermediate- to high-risk primary cutaneous melanoma.
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Atomic Resonance and Scattering
Contains reports on eight research projects.National Science Foundation (Grant PHY77-09155)Joint Services Electronics Program (Contract DAAG29-78-C-0020)U. S. Department of Energy (Grant EG-77-S-02-4370)National Science Foundation (Grant DMR 77-10084)National Aeronautics and Space Administration (Grant NSG-1551)U. S. Air Force - Office of Scientific Research (Grant AFOSR-76-2972)National Science Foundation (Grant CHE76-81750
Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions
A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield
Maps, Memories and Manchester: The Cartographic Imagination of the Hidden Networks of the Hydraulic City
The largely unseen channelling, culverting and controlling of water into, through and out of cities is the focus of our cartographic interpretation. This paper draws on empirical material depicting hydraulic infrastructure underlying the growth of Manchester in mapped form. Focusing, in particular, on the 19th century burst of large-scale hydraulic engineering, which supplied vastly increased amounts of clean drinking water, controlled unruly rivers to eliminate flooding, and safely removed sewage, this paper explores the contribution of mapping to the making of a more sanitary city, and towards bold civic minded urban intervention. These extensive infrastructures planned and engineered during Victorian and Edwardian Manchester are now taken-for-granted but remain essential for urban life. The maps, plans and diagrams of hydraulic Manchester fixed particular forms of elite knowledge (around planning foresight, topographical precision, civil engineering and sanitary science) but also facilitated and freed flows of water throughout the city. The survival of these maps and plans in libraries, technical books and obscure reports allows the changing cultural work of water to be explored and evokes a range of socially specific memories of a hidden city. Our aetiology of hydraulic cartographics is conducted using ideas from science and technology studies, semiology, and critical cartography with the goal of revealing how they work as virtual witnesses to an 1 unseen city, dramatizing engineering prowess and envisioning complex and messy materiality into a logical, holistic and fluid network underpinning the urban machine. 1
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