A novel locus for autosomal recessive primary microcephaly (MCPH6) maps to 13q12.2

Key points: • Autosomal recessive primary microcephaly (MCPH) is a genetic disorder in which an affected subject is born with a head circumference >3 SD below the expected mean and is mentally retarded. • We report a novel locus (MCPH6) mapped to chromosome 13q12.2 in a Brazilian family. • The minimal critical region spans 6 Mb between markers AL139378GT17 and D13S1244 with a maximum two point lod score of 6.25

The impact of anger on creative process engagement: The role of social contexts

Drawing on the cognitive persistence perspective of creativity and conservation of resources theory, we investigated how 2 social contexts (perceived relationship conflict and coworker support for creativity) influence the relationship between anger and creative process engagement (CPE) in organizations. We tested our hypotheses using 422 daily surveys from 98 participants, collected over 5 consecutive workdays. The results show that anger perceived relationship conflict and coworker support for creativity interact to influence CPE. Specifically, when relationship conflict is high, the anger–CPE relationship is positive for employees who receive high coworker support for creativity, but negative for those who receive low coworker support for creativity. In contrast, when relationship conflict is low, the anger–CPE relationship is positive but does not differ at high versus low coworker support for creativity

Species identification and authentication of hare (Lepus) meat by the use of the mitochondrial cytb gene

Nowadays, consumers are increasingly concerned with issues of food safety and authenticity. In particular, game meat has been much appreciated by consumers for their exotic flavour and texture, low in fat and cholesterol as well as by the absence of steroids or other drugs. Food authenticity assessment is important in that it avoids unfair competition among producers and allows consumers to have accurate information about the products they purchase. Therefore, it is important to ensure that species of high commercial value declared are not replaced by other species of lesser value [I]

Observed flux density enhancement at submillimeter wavelengths during an X-class flare

We analyse the 30 October, 2004, X1.2/SF solar event that occurred in AR 10691 (N13 W18) at around 11:44 UT. Observations at 212 and 405 GHz of the Solar Submillimeter Telescope (SST), with high time resolution (5 ms), show an intense impulsive burst followed by a long-lasting thermal phase. EUV images from the Extreme Ultraviolet Imaging Telescope (SOHO/EIT) are used to identify the possible emitting sources. Data from the Radio Solar Telescope Network (RSTN) complement our spectral observations below 15 GHz. During the impulsive phase the turnover frequency is above 15.4 GHz. The long-lasting phase is analysed in terms of thermal emission and compared with GOES observations. From the ratio between the two GOES soft X-ray bands, we derive the temperature and emission measure, which is used to estimate the free-free submillimeter flux density. Good temporal agreement is found between the estimated and observed profiles, however the former is larger than the latter.Comment: 13 pages, 7 figure

Broken-symmetry magnetic phases in two-dimensional triangulene crystals

We provide a comprehensive theory of magnetic phases in two-dimensional triangulene crystals, using both Hubbard model and density functional theory (DFT) calculations. We consider centrosymmetric and noncentrosymmetric triangulene crystals. In all cases DFT and the mean-field Hubbard model predict the emergence of broken-symmetry antiferromagnetic (ferrimagnetic) phases for the centrosymmetric (noncentrosymmetric) crystals. This includes the special case of the [4,4]triangulene crystal, whose noninteracting energy bands feature a gap with flat valence and conduction bands. We show how the lack of contrast between the local density of states of these bands, recently measured via scanning tunneling spectroscopy, is a natural consequence of a broken-symmetry Néel state that blocks intermolecular hybridization. Using random phase approximation, we also compute the spin wave spectrum of these crystals, including the recently synthesized [4,4]triangulene crystal. The results are in excellent agreement with the predictions of a Heisenberg spin model derived from multiconfiguration calculations for the unit cell. We conclude that experimental results are compatible with an antiferromagnetically ordered phase where each triangulene retains the spin predicted for the isolated species.G.C. acknowledges financial support from Fundação para a Ciência e a Tecnologia (FCT) for the Ph.D. scholarship grant with reference No. SFRH/BD/138806/2018. J.F.-R., J.C.G.H., and A.T.C. acknowledge financial support from FCT (Grant No. PTDC/FIS-MAC/2045/2021), Swiss National Science Foundation (Grant No. CRSII5_205987), and the European Union (Grant FUNLAYERS-101079184). J.F.-R. acknowledges funding from FEDER/Junta de Andalucía (Grant No. P18-FR-4834), Generalitat Valenciana (Grants No. Prometeo2021/017 and No. MFA/2022/045), and MICIN-Spain (Grants No. PID2019-109539GB-C41 and No. PRTRC1y.I1). A.M.-S. acknowledges financial support by the Ramón y Cajal program (Grant No. RYC2018-024024-I; MINECO, Spain), Agencia Estatal de Investigación (AEI) through the project PID2020-112507GB-I00 (Novel quantum states in heterostructures of 2D materials), and the Generalitat Valenciana (Grants No. PROMETEO/2021/082 and No. SEJIGENT/2021/034). This study forms part of the Advanced Materials program and was supported by MCIN with funding from European Union NextGenerationEU (Grant No. PRTRC17.I1) and by the Generalitat Valenciana, project SPINO2D, reference MFA/2022/009

The anisotropic Ashkin-Teller model: a renormalization group study

The two-dimensional ferromagnetic anisotropic Ashkin-Teller model is investigated through a real-space renormalization-group approach. The critical frontier, separating five distinct phases, recover all the known exacts results for the square lattice. The correlation length $(\nu_T)$ and crossover $(\phi)$ critical exponents are also calculated. With the only exception of the four-state Potts critical point, the entire phase diagram belongs to the Ising universality class.Comment: 3 ps figures, accepted for publication in Physica

Ti6Al4V-PEEK multi-material structures – design, fabrication and tribological characterization focused on orthopedic implants

Acknowledgements: This work was supported by FCT through the grants SFRH/BD/128657/2017 and SFRH/BPD/112111/2015, the project PTDC/EMSTEC/5422/2014 and also by project NORTE 01-0145_FEDER-000018. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.A multi-material concept that gathers Ti6Al4V and PEEK properties in a cellular structured component was designed, fabricated and investigated targeting hip implants. SLM and pressure assisted injection techniques were used to obtain Ti6Al4V-PEEK multi-material structures. Aiming to reproduce to some extension the tribological phenomena occurring during and after hip implant insertion, five tribological tests were outlined and performed. The obtained results showed that the presence of PEEK on the Ti6Al4V-PEEK cellular structures led to a substantial improvement on the wear resistance (62% reduction in the mass loss) when compared to the material currently available on market for hip implants. The multi-material solution here investigated shows a good compromise between the primary stability after implant insertion and the wear performance.info:eu-repo/semantics/publishedVersio

Validade e reprodutibilidade de receptores para o GPS em relação à distância percorrida Validez y reproducibilidad de receptores GPS en relación de la distancia recorrida

ResumenObjetivoEl presente estudio evaluó la validez y reproducibilidad de dos modelos de receptores para el Global Positioning System (GPS). La validez fue evaluada comparando la distancia registrada por los receptores con la distancia conocida de estos trayectos.MétodoSeis jóvenes tenistas (177,6±6,2cm; 76,6±3,2kg) recorrieron tres trayectos: 1) 100m en la pista de atletismo (número de “disparos” = 120); 2) 400m en la pista de atletismo (número de “disparos” = 60) y 3) 100m con cambios de dirección (número de “disparos” = 120), utilizando los equipos Garmin© Forerunner 405 y Polar© RS800.ResultadosEn los trayectos sin cambios de dirección (100 y 400m), a través de la ANOVA two way (distancia y velocidad) no se detectaron diferencias entre la distancia conocida y las distancias registradas por los receptores analizados (p>0,05). En el trayecto de 100m con cambios de dirección, se observaron diferencias entre la distancia conocida y las registradas tanto por el Polar© RS800 como por el Garmin© Forerunner 405 (p<0,05). También se verificó la diferencia en las distancias registradas por el Polar® RS800 y por el Garmin© Forerunner 405 para el trayecto realizado con cambios de dirección (p<0,05).ConclusiónA través de los datos, se puede afirmar que los receptores para GPS evaluados presentaron un nivel aceptable de precisión para distancias recorridas sin cambios de dirección, sin embargo, la precisión de estos equipos en trayectos con cambios de dirección fue limitada.AbstractObjectiveThe present study evaluated the reproducibility and validity of two models of receivers for the Global Positioning System (GPS). Validity was assessed by comparing the distance recorded by the GPS receivers with the known distance.MethodSix young players (177.6±6.2cm; 76.6±3.2kg) performed three routes with different characteristics: 1) 100m in the athletics track (number of “sprints” = 120); 2) 400m in the athletics track (number of “sprints” = 60) and 3) 100m with changes of direction (number of “sprints” = 120), using equipment Garmin© Forerunner 405 and Polar© RS800.ResultsRegarding linear routes (100 and 400m), no differences were detected using ANOVA two-way (distance and speed) between the known distance and distance recorded by GPS receivers analyzed (p>0.05). Regarding non-linear route of, significant differences were observed between the known distance and recorded distance by the GPS receivers (p<0.05). There was also a significant difference between the distance recorded by Polar© RS800 and Garmin© Forerunner 405 for the non-linear route (p<0.05). Analysis of the limits of agreement reinforces the limitation of equipment in relation to accuracy for the non-linear route.ConclusionThese data suggest that the GPS receivers evaluated showed acceptable level of accuracy for linear routes, however, the accuracy of such devices on non-linear routes was limited

A aprendizagem ao longo da vida no espaço europeu: proposta de um observatório/ Lifelong learning in the european space: proposal for an observatory

In this paper, we intend to present the European Observatory on Lifelong Learning (EOLL), a proposal of the National PT Learning Workgroup to identify and monitor lifelong learning initiatives in Europe