Stochastic amplification of fluctuations in cortical up-states

Supporting Information: Appendix S1-S7Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5-2 Hz oscillations which are widely known as transitions between Up and Down States. Despite a large number of studies on Up-Down transitions, deciphering its nature, mechanisms and function are still today challenging tasks. In this paper we focus on recent experimental evidence, showing that a class of spontaneous oscillations can emerge within the Up states. In particular, a non-trivial peak around 20 Hz appears in their associated power-spectra, what produces an enhancement of the activity power for higher frequencies (in the 30-90 Hz band). Moreover, this rhythm within Ups seems to be an emergent or collective phenomenon given that individual neurons do not lock to it as they remain mostly unsynchronized. Remarkably, similar oscillations (and the concomitant peak in the spectrum) do not appear in the Down states. Here we shed light on these findings by using different computational models for the dynamics of cortical networks in presence of different levels of physiological complexity. Our conclusion, supported by both theory and simulations, is that the collective phenomenon of >stochastic amplification of fluctuations> - previously described in other contexts such as Ecology and Epidemiology - explains in an elegant and parsimonious manner, beyond model-dependent details, this extra-rhythm emerging only in the Up states but not in the Downs. © 2012 Hidalgo et al.Funding provided by Spanish MICINN-FEDER under project FIS2009-08451 and Junta de Andalucia Proyecto de Excelencia P09FQM-4682. L.S. acknowledges the financial support of Fundacion P. Barrie de la Maza and funding grant 01GQ1001A.Peer Reviewe

Some applications of quasi-velocities in optimal control

In this paper we study optimal control problems for nonholonomic systems defined on Lie algebroids by using quasi-velocities. We consider both kinematic, i.e. systems whose cost functional depends only on position and velocities, and dynamic optimal control problems, i.e. systems whose cost functional depends also on accelerations. The formulation of the problem directly at the level of Lie algebroids turns out to be the correct framework to explain in detail similar results appeared recently (Maruskin and Bloch, 2007). We also provide several examples to illustrate our construction.Comment: Revtex 4.1, 20 pages. To appear in Int. J. Geom. Meth. Modern Physic

Influencia de cinco técnicas enológicas en parámetros relacionados con la acidez y el color en vinos tintos de Mencía

Se ha estudiado la influencia de cinco técnicas (metodología de elaboración, tipo de recipiente de conservación y tiempo de conservación del vino en rama, temperatura de conservación y tiempo de conservación del vino embotellado) sobre parámetros fisico-químicos y descriptores sensoriales ligados a la acidez y al color en vinos tintos jóvenes de la variedad Mencía en la DO. Valdeorras (Ourense, Galicia). Los resultados muestran que los 19 parámetros estudiados son muy sensibles a las técnicas estudiadas. Tres de las cinco técnicas afectan (p<0,05) a los 19 parámetros y las otras dos (p<0,05) a diez de ellos. La maceración prefermentativa en frio y la conservación del vino en barrica aumentaron la acidez, pero la elaboración tradicional, la conservación del vino en depósito, la conservación del vino en botella durante tres meses y el empleo de una temperatura de conservación del vino embotellado baja y constante fueron más adecuadas para el color. Esto hace necesario establecer condiciones muy concretas para cada técnica según el parámetro considerado

Precision and practical usefulness of intraoral scanners in implant dentistry : a systematic literature review

This systematic review aimed to evaluate the efficiency and accuracy of digital impression techniques for implant-supported restorations, and to assess their economic feasibility. Two independent electronic database searches were conducted in the Pubmed/MedLine, Cochrane Library, and Lilacs databases complimented by a manual search, selecting relevant clinical and in vitro studies published between 1st January 2009 and 28st February 2019. All type of studies (in vivo and in vitro) were included in this systematic review. Twenty-seven studies (8 in vivo and 19 in vitro studies) fulfilled the inclusion criteria. No meta-analysis was performed due to a large heterogeneity of the study protocols. The passive fit of superstructures on dental implants presented similar results between digital and conventional impression techniques. The studies considered that several factors influence the accuracy of implant impression taking: distance and angulation between implants, depth of placement, type of scanner, scanning strategy, characteristics of scanbody, and operator experience. Regarding the economic viability of intraoral scanning systems, only one study reported any benefit in comparison with conventional techniques. Digital impressions of dental implants can be considered a viable alternative in cases of one or two contiguous dental implants. However, more studies are needed to evaluate the accuracy of digital techniques in full-arch implant-supported restorations

(M, N)-coherent pairs of order (m, k) and Sobolev orthogonal polynomials

A pair of regular linear functionals (U,V)(U,V) is said to be a (M,N)(M,N)-coherent pair of order (m,k)(m,k) if their corresponding sequences of monic orthogonal polynomials...We thank the referees for the careful revision of the manuscript. Their comments and suggestions have contributed to improve substantially the presentation. The work of F. Marcellán, J. Petronilho, and N.C. Pinzón-Cortés has been supported by Dirección General de Investigación Científica y Técnica, Ministerio de Economía y Competitividad of Spain, under grants MTM2012-36732-C03-01 (FM and NCP-C) and MTM2012-36732-C03-02 (JP). The work of J. Petronilho was also supported by the Centro de Matemática da Universidade de Coimbra (CMUC), funded by the European Regional Development Fund through the program COMPETE and by the Portuguese Government through the FCT—Fundação para a Ciência e a Tecnologia under the project PEst-C/MAT/UI0324/2011, and the research project PTDC/MAT/098060/2008 (FCT)

Analysis and simulation of multiplexed single-bus networks with and without buffering

Performance issues of a single-bus interconnection network for multiprocessor systems, operating in a multiplexed way, are presented in this paper. Several models are developed and used to allow system performance evaluation. Comparisons with equivalent crossbar systems are provided. It is shown how crossbar EBW values can be reached and exceeded when appropriate operation parameters are chosen in a multiplexed single-bus system. Another architectural feature is considered, concerning the utilization of buffers at the memory modules. With the buffering scheme, memory interference can be reduced so that the system performance is practically improved.Peer ReviewedPostprint (published version

Overlapping communication and computation by using a hybrid MPI/SMPSs approach

A previous version of this document was submitted for publication by october 2008.Communication overhead is one of the dominant factors that affect performance in high-performance computing systems. To reduce the negative impact of communication, programmers overlap communication and computation by using asynchronous communication primitives. This increases code complexity, requiring more effort to write parallel code and making less readable code. This paper presents the hybrid use of MPI and SMPSs (SMP superscalar), a task-based shared-memory programming model, enhanced with a restart mechanism allowing the programmer to introduce the asynchronism that is necessary to enable the effective communication/computation overlap in a productive way. We demonstrate the hybrid use of MPI/SMPSs with the high-performance LINPACK benchmark, which uses the lookahead technique to overlap communication and computation. MPI/SMPSs improves the performance of a pure MPI with look-ahead by 7,6% on a 1024 processors machine. In addition to better performance, hybrid MPI/SMPSs substantially reduces code complexity, it is less sensitive to network bandwidth and operating system noise, and improves the use of main memory.Postprint (published version

Evaluación, Calidad y Mejora Continua de los Servicios de Orientación en Educación Secundaria

Los servicios de Orientación educativa y profesional son un observatorio privilegiado del sistema educativo yun eslabón entre la calidad, la diversidad y la equidad. Por ello tienen la responsabilidad de evaluar sus resultados y mejorar sus procesos a través de acciones de evaluación, innovación e investigación. Las metodologías de investigación-acción pueden contribuir a estos objetivos a través de la participación de las personas implicadas y la elaboración conjunta de indicadores de evaluación apropiados para los servicios de orientación en Educación Secundaria. Todo ello permitirá mejorar la calidad de estos servicios dedicando más tiempo a lo que más valor apora a estos servicios, es decir, al trato personal, la realción de confianza y la personalización de la educación