Heat sink analytical modelling

Electronics has leaded most technological advances of the past 60 years. There are technologies with domains particularly developed for electronics such as material science, electromagnetism, system dynamics and also heat transfer. The relation to heat transfer is because the heat generation of electronics devices. Commonly, these devices need additional cooling in order to avoid extreme temperatures inside it. Heat sinks allow this supplementary cooling, so they are omnipresent in electronic assemblies. Heat sink can work by forced convection, natural convection or liquid cooling. Normally in electronic assemblies they are made of materials with good thermal conduction such as aluminum or copper. The heat transfer in sinks is especially by convection, but also by radiation. Radiation heat transfer can represent up to 30% of heat rate in natural convection heat sinks. The manufacturing process is usually by extrusion, but also by cast, bonded, folded, skived and stamped processes. There are a lot of geometries available and they are generally adapted to each specific requirement. However, a very common heat sink profile is the rectangular parallel fin one. This profile forms Uchannels, where the convection phenomenon is able to be modeled by empirical correlations. The radiation process is almost a geometric problem, so its analysis will be a minor order study. The modeling of rectangular parallel fin heat sinks allows an analytical study. This study can lead to determining the parameters of a heat sink for a specific application, mainly for electronics industry. The heat transfer processes that occur in a heat sink are studied in this work. There is also proposed an algorithm for rectangular parallel fin heat sinks and the computation study of its results. These computation results are compared to a finite element program solution in order to know the error of the proposed model. Finally, is suggested an optimization application for this algorithm.Outgoin

WOLF: A modular estimation framework for robotics based on factor graphs

© 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This paper introduces WOLF, a C++ estimation framework based on factor graphs and targeted at mobile robotics. WOLF can be used beyond SLAM to handle self-calibration, model identification, or the observation of dynamic quantities other than localization. The architecture of WOLF allows for a modular yet tightly-coupled estimator. Modularity is enhanced via reusable plugins that are loaded at runtime depending on application setup. This setup is achieved conveniently through YAML files, allowing users to configure a wide range of applications without the need of writing or compiling code. Most procedures are coded as abstract algorithms in base classes with varying levels of specialization. Overall, all these assets allow for coherent processing and favor code re-usability and scalability. WOLF can be used with ROS, and is made publicly available and open to collaboration.Peer ReviewedPostprint (author's final draft

Metformin-induced preferential killing of breast cancer initiating CD44+CD24−/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts

Trastuzumab-refractory breast cancer stem cells (CSCs) could explain the high rate of primary resistance to single-agent trastuzumab in HER2 gene-amplified breast cancer patients. The identification of agents with strong selective toxicity for trastuzumab-resistant breast CSCs may have tremendous relevance for how HER2+ breast cancer patients should be treated. Using the human breast cancer cell line JIMT-1, which was established from the pleural metastasis of a patient who was clinically resistant to trastuzumab ab initio, we examined whether preferential killing of the putative CD44+CD24 −/low breast CSC population might be sufficient to overcome primary resistance to trastuzumab in vivo. Because recent studies have shown that the anti-diabetic biguanide metformin can exert antitumor effects by targeted killing of CSC-like cells, we explored whether metformin's ability to preferentially kill breast cancer initiating CD44+CD24 −/low cells may have the potential to sensitize JIMT-1 xenograft mouse models to trastuzumab. Upon isolation for breast cancer initiating CD44+CD24 −/low cells by employing magnetic activated cell sorting, we observed the kinetics of metformin-induced killing drastically varied among CSC and non-CSC subpopulations. Metformin's cell killing effect increased dramatically by more than 10-fold in CD44+CD24 −/low breast CSC cells compared to non-CD44+CD24 −/low immunophenotypes. While seven-weeks treatment length with trastuzumab likewise failed to reduce tumor growth of JIMT-1 xenografts, systemic treatment with metformin as single agent resulted in a significant two-fold reduction in tumor volume. When trastuzumab was combined with concurrent metformin, tumor volume decreased sharply by more than four-fold. Given that metformin-induced preferential killing of breast cancer initiating CD44+CD24 −/low subpopulations is sufficient to overcome in vivo primary resistance to trastuzumab, the incorporation of metformin into trastuzumab-based regimens may provide a valuable strategy for treatment of HER2+ breast cancer patients

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor (EGFR) exon 19 mutation delE746-A750, we developed erlotinib-refractory derivatives in which hyperactive Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling associated with enrichment in epithelial-to-mesenchymal transition (EMT)-related morphological and transcriptional features. We then explored whether an IGF-1R/EMT crosstalk was sufficient to promote erlotinib refractoriness in the absence of second-site EGFR mutations, MET and AXL hyperactivation. Transforming Growth Factor-beta1 (TGF beta 1)-induced mesenchymal trans-differentiation was sufficient to impede erlotinib functioning in the presence of drug-sensitive delE746-A750 EGFR mutation. Pharmacological blockade of IGF-1R fully prevented the TGF beta 1's ability to activate an EMT protein signature [E-cadherin low/vimentin high]. The sole presence of erlotinib was capable of rapidly activate an IGF-1R-dependent, vimentin-enriched mesenchymal-like phenotype in delE746-A750-mutated epithelial cells. Even if transient, NSCLC cells' intrinsic plasticity to undergo crosstalk between IGF-1R and EMT signaling pathways can sufficiently eliminate the erlotinib-sensitizing effect of highly prevalent EGFR mutations and suggests the urgent need for dual IGF-1R/EMT-targeting strategies to circumvent erlotinib resistance

Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance to erlotinib. As a single agent, silibinin significantly decreased the tumor volumes of erlotinib-refractory NSCLC xenografts by approximately 50%. Furthermore, the complete abrogation of tumor growth was observed with the co-treatment of erlotinib and silibinin. Silibinin fully reversed the EMT-related high miR-21/low miR-200c microRNA signature and repressed the mesenchymal markers SNAIL, ZEB, and N-cadherin observed in erlotinib-refractory tumors. Silibinin was sufficient to fully activate a reciprocal mesenchymal-to-epithelial transition (MET) in erlotinib-refractory cells and prevent the highly migratogenic phenotype of erlotinib-resistant NSCLC cells. Given that the various mechanisms of resistance to erlotinib result from EMT, regardless of the EGFR mutation status, a water-soluble, silibinin-rich milk thistle extract might be a suitable candidate therapy for upcoming clinical trials aimed at preventing or reversing NSCLC progression following erlotinib treatment

Impacts of Use and Abuse of Nature in Catalonia with Proposals for Sustainable Management

This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the current economic model, which is environmentally unsustainable in that it does not take into account environmental impacts. Lastly, we propose a series of reasonable and feasible priority measures and actions related to each use made of the country's natural resources, to the impacts they have had, and to their management, in the hope that these can contribute to improving the conservation and management of the environment and biodiversity and move towards sustainability

Impacts of Use and Abuse of Nature in Catalonia with Proposals for Sustainable Management

This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is Land 2021, 10, 144 3 of 53 more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today’s problems with nature derive from the current economic model, which is environmentally unsustainable in that it does not take into account environmental impacts. Lastly, we propose a series of reasonable and feasible priority measures and actions related to each use made of the country’s natural resources, to the impacts they have had, and to their management, in the hope that these can contribute to improving the conservation and management of the environment and biodiversity and move towards sustainability.info:eu-repo/semantics/publishedVersio

Organització no jeràrquica de l'empresa

Se ha analizado los problemas de organización del trabajo y de dirección así como las modificaciones en las teorías clásicas de organización. también se han estudiado las experiencias practicas. a partir de ello se ha propuesto un modelo de organización no jerárquico para solucionar los problemas detectado

Heat sink analytical modelling

Electronics has leaded most technological advances of the past 60 years. There are technologies with domains particularly developed for electronics such as material science, electromagnetism, system dynamics and also heat transfer. The relation to heat transfer is because the heat generation of electronics devices. Commonly, these devices need additional cooling in order to avoid extreme temperatures inside it. Heat sinks allow this supplementary cooling, so they are omnipresent in electronic assemblies. Heat sink can work by forced convection, natural convection or liquid cooling. Normally in electronic assemblies they are made of materials with good thermal conduction such as aluminum or copper. The heat transfer in sinks is especially by convection, but also by radiation. Radiation heat transfer can represent up to 30% of heat rate in natural convection heat sinks. The manufacturing process is usually by extrusion, but also by cast, bonded, folded, skived and stamped processes. There are a lot of geometries available and they are generally adapted to each specific requirement. However, a very common heat sink profile is the rectangular parallel fin one. This profile forms Uchannels, where the convection phenomenon is able to be modeled by empirical correlations. The radiation process is almost a geometric problem, so its analysis will be a minor order study. The modeling of rectangular parallel fin heat sinks allows an analytical study. This study can lead to determining the parameters of a heat sink for a specific application, mainly for electronics industry. The heat transfer processes that occur in a heat sink are studied in this work. There is also proposed an algorithm for rectangular parallel fin heat sinks and the computation study of its results. These computation results are compared to a finite element program solution in order to know the error of the proposed model. Finally, is suggested an optimization application for this algorithm.Outgoin

L'autonomia energètica de Catalunya: una opció possible

Un estudi alternatiu de la gestió dels recursos naturals de Cataluny