412 research outputs found
Utilisation de la grille pour la simulation de température de brillance dans une atmosphère nuageuse composée de cirrus
Utilisation de la grille pour la simulation de température de brillance dans une atmosphère nuageuse composée de cirru
Stress orientation evaluated from strain localisation analysis in Aigion fault
Within the frame of the 'CRL' (Corinth Rift Laboratory project) (Cornet et
al, 2004a) centered on the south western sector of the Gulf of Corinth
(http://www.corinth-rift-lab.org), fault zone cores from the active Aigion
fault have been collected continuously from depths between 708 m to 782 m.
Inside this clayey core, a clear shearing surface with marked slip lines is
visible on a plane that makes a 68 degree angle with respect to the core axis.
This failure surface was not induced by the decompression process but is indeed
a slip plane as clear striation is observed at the interface. On the basis of
an elastoplastic constitutive model calibrated on triaxial tests on the clayey
gouge, it is shown that shear band formation inside the clayey core is
possible. The solution for the orientation of the shear band is compared to the
orientation of an existing slip surface inside the clayey gouge and this result
is used to deduce the orientation of the principal stresses. It is shown that
as commonly observed in weak fault zones, the orientation of the principal
stresses is locally almost parallel and perpendicular to the fault axis
Titan Science with the James Webb Space Telescope (JWST)
The James Webb Space Telescope (JWST), scheduled for launch in 2018, is the
successor to the Hubble Space Telescope (HST) but with a significantly larger
aperture (6.5 m) and advanced instrumentation focusing on infrared science
(0.6-28.0 m ). In this paper we examine the potential for scientific
investigation of Titan using JWST, primarily with three of the four
instruments: NIRSpec, NIRCam and MIRI, noting that science with NIRISS will be
complementary. Five core scientific themes are identified: (i) surface (ii)
tropospheric clouds (iii) tropospheric gases (iv) stratospheric composition and
(v) stratospheric hazes. We discuss each theme in depth, including the
scientific purpose, capabilities and limitations of the instrument suite, and
suggested observing schemes. We pay particular attention to saturation, which
is a problem for all three instruments, but may be alleviated for NIRCam
through use of selecting small sub-arrays of the detectors - sufficient to
encompass Titan, but with significantly faster read-out times. We find that
JWST has very significant potential for advancing Titan science, with a
spectral resolution exceeding the Cassini instrument suite at near-infrared
wavelengths, and a spatial resolution exceeding HST at the same wavelengths. In
particular, JWST will be valuable for time-domain monitoring of Titan, given a
five to ten year expected lifetime for the observatory, for example monitoring
the seasonal appearance of clouds. JWST observations in the post-Cassini period
will complement those of other large facilities such as HST, ALMA, SOFIA and
next-generation ground-based telescopes (TMT, GMT, EELT).Comment: 50 pages, including 22 figures and 2 table
Work addiction test questionnaire to assess workaholism: Validation of French version
Background: Work addiction is a significant public health problem with a growing prevalence. The Work Addiction Risk Test (WART) is the gold standard questionnaire to detect workaholism. Objective: The main objective of this study was to validate the French version of the WART. Methods: Questionnaires were proposed to voluntary French workers using the WittyFit software. There were no exclusion criteria. The questionnaire was administered anonymously for initial validity testing and readministered one week later for test-retest reliability. We also assessed the workers’ sociodemographic characteristics, as well as other measurements for external validity, such as stress, well-being, and coaddictions to tobacco, alcohol, and cannabis. Several psychometric properties of the French-WART were explored: acceptability, reliability (internal consistency [Cronbach alpha coefficient] and reproducibility [Lin concordance coefficient]), construct validity (correlation coefficients and principal component analysis), and external validity (correlation coefficients). Results: Among the 1580 workers using WittyFit, 187 (11.83%) agreed to complete the WART questionnaire. Of those, 128 completed the test-retest survey (68.4%). Acceptability found that all respondents had fully completed the questionnaire, with few floor or ceiling effects. Reliability was very good with a Cronbach alpha coefficient at .90 (internal consistency) and Lin concordance coefficient at .90 (95% CI .87-.94] with a difference on the retest of .04 (SD 4.9) (95% CI −9.6 to 9.7) (reproducibility). We identified three main dimensions (construct validity). Relationships between WART and stress and well-being confirmed its external validity. Conclusions: The French version of the WART is a valid and reliable instrument to assess work addiction with satisfactory psychometric properties. Used in occupational medicine, this tool would allow the diagnosis of work addiction and can be easily implemented in current practice
Z' Coupling Information from the LHeC
If the LHC discovers a -like state the extraction of its couplings to the
particles of the Standard Model becomes mandatory in order to determine the
nature of the underlying new physics theory. It has been well-known for some
time that the direct measurements performed at the LHC in the Drell-Yan channel
cannot determine these parameters uniquely in a model-independent manner even
if large integrated luminosities, , become available and the
is relatively light \lsim 1.5 TeV. Here we examine the possibility that
a proposed collider upgrade at the LHC, the LHeC, with TeV could be helpful with such coupling determinations in the years
before a Linear Collider is constructed. We show that the polarization and
charge asymmetries constructed from the cross sections for these processes can
be useful in this regard depending upon the specific values of the particular
model parameters.Comment: 16 pages, 9 figs, minor modification
Exploring structural and electronic effects in three isomers of tris{bis(trifluoromethyl)phenyl}borane: Towards the combined electrochemical-frustrated Lewis pair activation of H2
Three structural isomers of tris{bis(trifluoromethyl)phenyl}borane have been studied as the acidic com- ponent of frustrated Lewis pairs. While the 3,5-substituted isomer is already known to heterolytically cleave H2 to generate a bridging-hydride; ortho-substituents in the 2,4- and 2,5-isomers quench such reactivity through electron donation into the vacant boron pz orbital and steric blocking of the boron centre; as shown by electrochemical, structural and computational studies. Electrochemical studies of the corresponding borohydrides identify that the two-electron oxidation of terminal-hydrides occurs at more positive potentials than observed for [HB(C6F5)3]−, while the bridging-hydride oxidizes at a higher poten- tial still, comparable to that of free H2
Cartography with Accelerators: Locating Fermions in Extra Dimensions at Future Lepton Colliders
In the model of Arkani-Hamed and Schmaltz the various chiral fermions of the
Standard Model(SM) are localized at different points on a thick wall which
forms an extra dimension. Such a scenario provides a way of understanding the
absence of proton decay and the fermion mass hierarchy in models with extra
dimensions. In this paper we explore the capability of future lepton colliders
to determine the location of these fermions in the extra dimension through
precision measurements of conventional scattering processes both below and on
top of the lowest lying Kaluza-Klein gauge boson resonance. We show that for
some classes of models the locations of these fermions can be very precisely
determined while in others only their relative positions can be well measured.Comment: 32 pages, 10 figs, LaTe
PLANNING OF HUMAN RESOURCE COMPETENCY DEVELOPMENT IN PT.XYZ WITH TAGUCHI METHOD
The problem of human resources is still a concern within the company to remain competitive in
this globalization world. This shows that the problem of human resources greatly affect the
implementation and success of the company in achieving goals and objectives. The company
demand to obtain the development process and get quality human resources more urgent. And
the development of human resource competence is necessary. This study uses experimental
testing with several parameters of validity and reliability testing. For testing analysis using
Taguchi Method. Based on the Response Table for Signal to Noise Ratios Nominal is best
obtained taguchi test results obtained values obtained from the effect plot for means with the
approach of table of means, then the intellectual competence is needed for the improvement of
HR performance
Protocol of the IntenSify-Trial:An open-label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab-paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy
Expression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A isozymes restores the cells sensitivity to paclitaxel. The combination of gemcitabine and nab-paclitaxel is an established regimen for the treatment of metastasized or locally advanced inoperable pancreatic cancer. Cobicistat is a CYP3A inhibitor developed for the pharmacoenhancement of protease inhibitors. The addition of cobicistat to gemcitabine and nab-paclitaxel may increase the antitumor effect. We will conduct a phase I dose escalation trial with a classical 3 + 3 design to investigate the safety, tolerability, and pharmacokinetics (PKs) of gemcitabine, nab-paclitaxel, and cobicistat. Although the doses of gemcitabine (1000 mg/m2) and cobicistat (150 mg) are fixed, three dose levels of nab-paclitaxel (75, 100, and 125 mg/m2) will be explored to account for a potential PK drug interaction. After the dose escalation phase, we will set the recommended dose for expansion (RDE) and treat up to nine patients in an expansion part of the trial. The trial is registered under the following identifiers EudraCT-Nr. 2019-001439-29, drks.de: DRKS00029409, and ct.gov: NCT05494866. Overcoming resistance to paclitaxel by CYP3A5 inhibition may lead to an increased efficacy of the gemcitabine and nab-paclitaxel regimen. Safety, efficacy, PK, and RDE data need to be acquired before investigating this combination in a large-scale clinical study.</p
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