Programación didáctica para 4º ESO : IES Lagoa de Antela

Traballo fin de grao (UDC.FCDEF). Ciencias da actividade física e do deporte. Curso 2012/201

Extraction of Aromatic Compounds from Their Mixtures with Alkanes: From Ternary to Quaternary (or Higher) Systems

Ionic liquids have been proposed as separation agents for liquid extraction of aromatic compounds from their mixtures with alkanes, with the aim of improving the separation process and replacing conventional organic solvents. A significant number of experimental liquid-liquid equilibrium data for ternary system alkane + aromatic compound + ionic liquid can be found in literature; however there are few data for quaternary or higher systems involving more than one aliphatic compound, several aromatic compounds or a mixture of ionic liquids as separation agent. These data are also necessary because molecular interactions between the compounds in the mixture can modify the affinity of the solvent for the aromatic compound of interest. In this chapter we review the published data involving more than three components, and we present new liquid-liquid equilibrium data for the quaternary systems heptane + cyclohexane + toluene +1-ethyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide and heptane + cyclohexane + toluene + 1-hexyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide

Theragnosis for Duchenne Muscular Dystrophy

Dystrophinopathies cover a spectrum of rare progressive X-linked muscle diseases, arising from DMD mutations. They are among the most common pediatric muscular dystrophies, being Duchenne muscular dystrophy (DMD) the most severe form. Despite the fact that there is still no cure for these serious diseases, unprecedented advances are being made for the development of therapies for DMD. Some of which are already conditionally approved: exon skipping and premature stop codon read-through. The present work aimed to characterize the mutational spectrum of DMD in an Argentinian cohort, to identify candidates for available pharmacogenetic treatments and finally, to conduct a comparative analysis of the Latin American (LA) frequencies of mutations amenable for available DMD therapies. We studied 400 patients with clinical diagnosis of dystrophinopathy, implementing a diagnostic molecular algorithm including: MLPA/PCR/Sanger/Exome and bioinformatics. We also performed a meta-analysis of LA’s metrics for DMD available therapies. The employed algorithm resulted effective for the achievement of differential diagnosis, reaching a detection rate of 97%. Because of this, corticosteroid treatment was correctly indicated and validated in 371 patients with genetic confirmation of dystrophinopathy. Also, 20 were eligible for exon skipping of exon 51, 21 for exon 53, 12 for exon 45 and another 70 for premature stop codon read-through therapy. We determined that 87.5% of DMD patients will restore the reading frame with the skipping of only one exon. Regarding nonsense variants, UGA turned out to be the most frequent premature stop codon observed (47%). According to the meta-analysis, only four LA countries (Argentina, Brazil, Colombia and Mexico) provide the complete molecular algorithm for dystrophinopathies. We observed different relations among the available targets for exon skipping in the analyzed populations, but a more even proportion of nonsense variants (∼40%). In conclusion, this manuscript describes the theragnosis carried out in Argentinian dystrophinopathy patients. The implemented molecular algorithm proved to be efficient for the achievement of differential diagnosis, which plays a crucial role in patient management, determination of the standard of care and genetic counseling. Finally, this work contributes with the international efforts to characterize the frequencies and variants in LA, pillars of drug development and theragnosis.Fil: Luce, Leonela Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Carcione, María Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Mazzanti, Chiara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Buonfiglio, Paula Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Dalamon, Viviana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Mesa, Lilia. Fundacion Favaloro. Instituto de Neurociencias.; ArgentinaFil: Dubrovsky, Alberto. Fundacion Favaloro. Instituto de Neurociencias.; ArgentinaFil: Corderí, José. Fundacion Favaloro. Instituto de Neurociencias.; ArgentinaFil: Giliberto, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentin

La construcción del texto narrativo: análisis y traducción de los cuentos inéditos en español «May’s Lion» y «Sleepwalkers», de Ursula K. Le Guin

Màster en Traducció Literària i Audiovisual (UPF Barcelona School of Management). Curs 2020-2021Mentora: Ana Mata BuilEn este trabajo de fin de posgrado se desarrolla una propuesta de análisis y traducción al español de «May’s Lion» y «Sleepwalkers», dos cuentos de Ursula K. Le Guin inéditos en el ámbito hispanohablante. Para dar forma a dicha propuesta, se utiliza un enfoque orientado a la construcción de los textos narrativos, que permite estudiar algunos de los aspectos más relevantes de los relatos seleccionados: las técnicas narrativas empleadas (mise en abyme, monólogo interior y focalización interna variable) y características textuales como la ficcionalidad o la transtextualidad. Además de reivindicar la obra de la autora, con este trabajo se pretende subrayar la importancia de atender a la configuración de un texto literario antes de abordar su traducción.This postgraduate thesis develops a proposal for the analysis and translation into Spanish of “May's Lion” and “Sleepwalkers”, two short stories by Ursula K. Le Guin that remain unpublished in the Spanish-speaking world. The proposal has been shaped using an approach oriented to the construction of narrative texts, which allows studying some of the most relevant aspects of the stories selected: the narrative techniques applied (mise en abyme, interior monologue and variable internal focalization) and textual characteristics such as fictionality and transtextuality. In addition to vindicating the author’s work, this thesis aims to highlight the importance of paying attention to the configuration of a literary work before approaching its translation

Institutions, Technological Change and Economic Growth.

Theories of economic growth try to explain variations in per capita income across countries by differences in capital accumulation and productivity. However, many scholars consider that integrating institutions into economic theory and economic history is an essential step in improving explanations of why some societies are richer than others. This paper develops the empirical and theoretical case that differences in institutions are the fundamental cause of differences in technological change (productivity), hence in economic growth. First, I give a definition of institutions and how they influence economic performance, from a New Institutional Economics point of view. Then, I introduce the theoretical framework based on the economics of ideas and endogenous growth models. Finally, I argue that R&D expenditures -a proxy for technological change- will vary across countries depending on some measures of institutional quality. In the end, this paper finds that stronger institutions (measured by an aggregate of institutional quality) encourage greater R&D expenditures. At a disaggregate level, the rule of law is positively correlated and the regulatory burden is negatively correlated with R&D expenditures. Human capital level (measured by the tertiary and primary school enrolment rates) has also a significant positive impact in R&D expenditures.

Institutions, Technological Change and Economic Growth

Theories of economic growth try to explain variations in per capita income across countries by differences in capital accumulation and productivity. However, many scholars consider that integrating institutions into economic theory and economic history is an essential step in improving explanations of why some societies are richer than others. This paper develops the empirical and theoretical case that differences in institutions are the fundamental cause of differences in technological change (productivity), hence in economic growth. First, I give a definition of institutions and how they influence economic performance, from a New Institutional Economics point of view. Then, I introduce the theoretical framework based on the economics of ideas and endogenous growth models. Finally, I argue that R&D expenditures -a proxy for technological change- will vary across countries depending on some measures of institutional quality. In the end, this paper finds that stronger institutions (measured by an aggregate of institutional quality) encourage greater R&D expenditures. At a disaggregate level, the rule of law is positively correlated and the regulatory burden is negatively correlated with R&D expenditures. Human capital level (measured by the tertiary and primary school enrolment rates) has also a significant positive impact in R&D expenditures

Institutions, Technological change and Economic Growth

Las teorías del crecimiento económico intentan explicar las variaciones en las rentas per capita en los países por diferencias en la acumulación de capital y en la productividad. No obstante, muchos investigadores consideran que integrar instituciones en la teoría y la historia económica es un paso esencial para dar una mejor respuesta a por qué algunas sociedades son más ricas que otras. Este artículo desarrolla el caso empírico y teórico de que las diferencias en las instituciones son la causa fundamental de las divergencias en el cambio tecnológico (productividad) y, por tanto, en el crecimiento económico. En primer lugar, daré una definición de instituciones y cómo influyen en el rendimiento económico, desde un punto de vista de la Nueva Economía Institucional. Seguidamente, introduzco el marco teórico basado en la economía de ideas y en los modelos de crecimiento endógeno. Finalmente, argumento que el gasto en I+D (poder para el cambio teconológico) variará en cada país dependiendo de algunas medidas de calidad institucional. Al final, en este artículo se observa que las instituciones más fuertes (medidas por un conjunto de calidad institucional) fomentan un mayor gasto en I+D. A nivel disgregador, el Estado de Derecho está correlacionado positivamente y la carga reguladora está correlacionada negativamente con el gasto en I+D. El nivel de capital humano (medido por las tasas de matriculación en la educación primaria y superior) también tiene un impacto positivo en el gasto en I+D

Simple, Exact Placement of Data in Containers

Abstract—Storage and other systems frequently need to distribute objects equally over several sites or devices. While this is simple for a static system, organizing the distribution when additional containers (for example, hard drives, or web content delivery sites) become available is difficult. We present here a very simple scheme based on the factorial number system that allows equal, dynamic distribution of mirrored or replicated objects. I