Arab Consumer Attitudes towards International Marketing as a Result of the Ongoing Arab Spring: A Systematic Literature Review

The Middle East has been recently and continues to be affected by a phenomenon referred to popularly as the ‘Arab Spring’. The phenomenon appears to have sparked a wave of candidness amongst Arab consumers in a way that hitherto was not apparent. A question as to whether the uprisings are about the pursuit of democracy, political reform or freedom of speech remains to be settled. The purpose of this discussion paper is to ask what effects the Arab Spring may have on marketing theory and practice. To that end, the paper presents the results of a systematic literature review pertaining to marketing in the Middle East. A quantitative bibliometric method of citation analysis is deployed to identify the range of themes that have been previously researched. From this review, the paper identifies the particular relevance of the Arab Spring phenomenon to international marketing theory and practice. Thus, this study makes the first attempt to conceptualize what the Arab Spring means for future international marketing theory and practice and marks the start of a first investigation, and potential beginning of a longitudinal study into the phenomenon as it continues to unfold, grounded firmly in the marketing discipline

Genome-wide Association Study Identifies New Loci for Resistance to Leptosphaeria maculans in Canola

Blackleg, caused by Leptosphaeria maculans, is a significant disease which affects the sustainable production of canola. This study reports a genome-wide association study based on 18,804 polymorphic SNPs to identify loci associated with qualitative and quantitative resistance to L. maculans. Genomic regions delimited with 503 significant SNP markers, that are associated with resistance evaluated using 12 single spore isolates and pathotypes from four canola stubble were identified. Several significant associations were detected at known disease resistance loci including in the vicinity of recently cloned Rlm2/LepR3 genes, and at new loci on chromosomes A01/C01, A02/C02, A03/C03, A05/C05, A06, A08, and A09. In addition, we validated statistically significant associations on A01, A07 and A10 in four genetic mapping populations, demonstrating that GWAS marker loci are indeed associated with resistance to L. maculans. One of the novel loci identified for the first time, Rlm12, conveys adult plant resistance and mapped within 13.2 kb from Arabidopsis R gene of TIR-NBS class. We showed that resistance loci are located in the vicinity of R genes of A. thaliana and B. napus on the sequenced genome of B. napus cv. Darmor-bzh. Significantly associated SNP markers provide a valuable tool to enrich germplasm for favorable alleles in order to improve the level of resistance to L. maculans in canola

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p

Subnational migration in the United Kingdom: producing a consistent time series using a combination of available data and estimates

There is no single framework in place in the United Kingdom for collating and harmonizing the data on migration taking place between the subnational administrative units that constitute the home nations, together with the flows of international migration between these areas and the 'rest of the world'. This paper proposes the construction of complete matrices of subnational migration statistics on an annual basis which can then be used to monitor migration trends throughout the UK in a comprehensive manner. The paper reviews how various 'known' flows are estimated by the national statistics agencies and develops estimates to fill in the gaps in the matrices. It then looks at changing patterns of migration in the UK between 2001/2002 and 2010/2011, showing that migration exhibits most activity in the middle of the decade. Flows within the home nations are the most consistent over time, while the patterns of international migration and migration across the borders of the home nations exhibit more substantial change. The latter flows, although relatively small in magnitude, have not previously been studied at the subnational level in any detail. Patterns of subnational internal and international net migration are found to be negatively correlated