Cultivating Delight, Crossing Divides, and Solving Impossible Problems: Lessons Learned from a Year of Virtual Conferences

This chapter highlights some of the lessons learned from a year of virtual conferences held by three different honors organizations, the Southern Regional Honors Council (SRHC), the Northeast Regional Honors Council (NRHC), and the Kentucky Honors Roundtable (KHR) during the COVID-19 pandemic

A Comparison of Two Quail Abundance Indices and Their Relationship to Quail Harvest in Texas

Surveys are used to monitor status and trends of animal populations. However, different surveys may give conflicting results for the same species and population being surveyed. Therefore, we compared results of the North American Breeding Bird Survey (BBS) and Texas Parks and Wildlife (TPW) roadside counts for scaled quail (Callipepla squamata) and northern bobwhite (Colinus virginianus) in Texas. Surveys were compared on both an ecoregion and statewide basis. The BBS and TPW surveys gave similar trends for bobwhites and scaled quail for 5 of 8, and 3 of 5 ecoregions, respectively. Survey trends differed at the statewide scale for both species. We compared estimated statewide harvest as an independent index of quail population status in Texas with results from both surveys. The TPW roadside survey was more closely related to estimated statewide harvest for northern bobwhites (R2 = 0.86, P \u3c= 0.001) and scaled quail (R2 = 0.75, P = 0.0001) than the BBS survey (R2 = 0.60, P = 0.001; and R2 = 0.35, P = \u3c0.0001, respectively). Survey methods, sampling frameworks, and issues of scale are important variables to consider when interpreting survey results. The BBS provides useful data on quail populations at a multi-state or national scale. However, most state wildlife agencies require surveys that provide information at finer spatial scales

A randomized controlled pilot trial of different mobile messaging interventions for problem drinking compared to weekly drink tracking

This study was supported by a grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) R34AA021502. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Maintaining the Power Output of An Existing Coal Plant with the Addition of CO 2 Capture: Retrofits Options With Gas Turbine Combined Cycle Plants

AbstractIt is likely that a significant number of existing pulverised coal-fired power plants will be retrofitted with post-combustion capture as part of a global rollout of carbon capture and storage. Previous studies have demonstrated that the energy penalty for post-combustion carbon dioxide (CO2) capture can be greatly minimised by effective integration of the capture system with the power cycle. Nevertheless, the power output of the site is, in most cases, reduced and the volume of electricity sales would drop. For other plants, the existing steam cycle may not be able to be integrated effectively for steam extraction, or space and access around/to the steam cycle may be impossible. As an alternative to steam extraction, it is possible to retrofit existing coal plants with a gas turbine combined cycle plant (CCGT) to maintain, or even increase, the site power output. The gas turbine can be integrated to the existing coal plant in various ways to supply all the heat, or a fraction of the heat, and the power required for the capture systems. An important consideration is whether carbon emissions from both, the combined cycle and the retrofitted coal plant are captured, or from the latter only.This paper examines these different options for carbon capture retrofits to existing coal plant and presents a novel configuration with the sequential combustion of gas turbine flue gas in the existing coal boiler while capturing carbon emissions from the combustion of coal and natural gas

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations in insulin-like growth factor (IGF) signalling genes in 8/112 (7%) of cases. We validate this observation using fluorescence in situ hybridization (FISH) in an additional 87 osteosarcomas, with IGF1 receptor (IGF1R) amplification observed in 14% of tumours. These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma. Analysing patterns of mutation, we identify distinct rearrangement profiles including a process characterized by chromothripsis and amplification. This process operates recurrently at discrete genomic regions and generates driver mutations. It may represent an age-independent mutational mechanism that contributes to the development of osteosarcoma in children and adults alike

Synthesis of bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) derivatives functionalised with two, four or eight hydroxyl groups

Short synthetic routes to a range of BEDT-TTF derivatives functionalised with two, four or eight hydroxyl groups are reported, of interest because of their potential for introducing hydrogen bonding between donor and anion into their radical cation salts. The cycloaddition of 1,3-dithiole-2,4,5-trithione with alkenes to construct 5,6-dihydro-1,3-dithiolo[4,5-b]1,4-dithiin-2-thiones is a key step, with homo- or hetero-coupling procedures and O-deprotection completing the syntheses. The first synthesis of a single diastereomer of tetrakis(hydroxymethyl)BEDT-TTF, the cis, trans product, was achieved by careful choice of O-protecting groups to facilitate separation of homo- and hetero-coupled products. Cyclisation of the trithione with enantiopure 1R,2R,5R,6R-bis(O,O-isopropylidene)hex-3-ene-1,2,5,6-tetrol (from D-mannitol) gave two separable diastereomeric thiones, which can be transformed to enantiomeric BEDT-TTF derivatives with four or eight hydroxyl groups

On the retrofitting and repowering of coal power plants with post-combustion carbon capture: An advanced integration option with a gas turbine windbox

Retrofitting a significant fraction of existing coal-fired power plants is likely to be an important part of a global rollout of carbon capture and storage. For plants suited for a retrofit, the energy penalty for post-combustion carbon capture can be minimised by effective integration of the capture system with the power cycle. Previous work on effective integration options has typically been focused on either steam extraction from the power cycle with a reduction of the site power output, or the supply of heat and electricity to the capture system via the combustion of natural gas, with little consideration for the associated carbon emissions. This article proposes an advanced integration concept between the gas turbine, the existing coal plant and post-combustion capture processes with capture of carbon emissions from both fuels. The exhaust gas of the gas turbine enters the existing coal boiler via the windbox for sequential combustion to allow capture in a single dedicated capture plant, with a lower flow rate and a higher CO2 concentration of the resulting flue gas. With effective integration of the heat recovery steam generator with the boiler, the existing steam cycle and the carbon capture process, the reference subcritical unit used in this study can be repowered with an electricity output penalty of 295 kWh/tCO2 – 5% lower than a conventional steam extraction retrofit of the same unit – and marginal thermal efficiency of natural gas combustion of 50% LHV – 5% point higher than in a configuration where the gas turbine has a dedicated capture unit

A randomized controlled pilot trial of different mobile messaging interventions for problem drinking

IntroductionRecent evidence suggests that text messaging may help to reduce problem drinking as an extension to in-person services, but very little is known about the effectiveness of remote messaging on problem drinking as a stand-alone intervention, or how different types of messages may improve drinking outcomes in those seeking to moderate their alcohol consumption. Methods We conducted an exploratory, single-blind randomized controlled pilot study comparing four different types of alcohol reduction-themed text messages sent daily to weekly drink self-tracking texts in order to determine their impact on drinking outcomes over a 12-week period in 152 participants (≈ 30 per group) seeking to reduce their drinking on the internet. Messaging interventions included: weekly drink self-tracking mobile assessment texts (MA), loss-framed texts (LF), gain-framed texts (GF), static tailored texts (ST), and adaptive tailored texts (TA). Poisson and least squares regressions were used to compare differences between each active messaging group and the MA control. Results When adjusting for baseline drinking, participants in all messaging groups except GF significantly reduced the number of drinks consumed per week and the number of heavy drinking days compared to MA. Only the TA and GF groups were significantly different from MA in reducing the number of drinking days. While the TA group yielded the largest effect sizes on all outcome measures, there were no significant differences between active messaging groups on any outcome measure. 79.6% of individuals enrolled in the study wanted to continue receiving messages for an additional 12 weeks at the end of the study. Discussion Results of this pilot study indicate that remote automated text messages delivered daily can help adult problem drinkers reduce drinking frequency and quantity significantly more than once-a-week self-tracking messages only, and that tailored adaptive texts yield the largest effect sizes across outcomes compared to MA. Larger samples are needed to understand differences between messaging interventions and to target their mechanisms of efficacy

Single-cell paired-end genome sequencing reveals structural variation per cell cycle

The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain elusive. Although single-cell genome analyses could resolve these problems, such analyses are error-prone because of whole-genome amplification (WGA) artefacts and are limited in the types of DNA mutation that can be discerned. We developed methods for paired-end sequence analysis of single-cell WGA products that enable (i) detecting multiple classes of DNA mutation, (ii) distinguishing DNA copy number changes from allelic WGA-amplification artefacts by the discovery of matching aberrantly mapping read pairs among the surfeit of paired-end WGA and mapping artefacts and (iii) delineating the break points and architecture of structural variants. By applying the methods, we capture DNA copy number changes acquired over one cell cycle in breast cancer cells and in blastomeres derived from a human zygote after in vitro fertilization. Furthermore, we were able to discover and fine-map a heritable inter-chromosomal rearrangement t(1;16)(p36;p12) by sequencing a single blastomere. The methods will expedite applications in basic genome research and provide a stepping stone to novel approaches for clinical genetic diagnosis