Teaching and Professional Fellowship Report 2007-2008 : Make the Numbers Count, Improving students' learning experiences through an analysis of Library and Learning Resources data

Feedback on Library and Learning Resources (LLR) services and support at the University of the Arts London (UAL) is received from a very extensive range of sources. However, although a considerable quantity of information is available for analysis, it remains very difficult for LLR staff to extract meaningful data from these numerous sources, which can reveal, in depth, the true, individual student experience of LLR services. LLR is aware that there is a lot that is not known, or is not being asked of our students, about their individual experience, which could prove extremely helpful for effective decision-making and service design and delivery. In particular, LLR is interested in identifying and resolving issues of access and support for students currently studying at UAL who are from under represented groups in higher education. Make the numbers counts has enabled the Fellowship Team to move beyond looking at usage figures, gate counts, numbers of issue and renewal transactions, borrower numbers and percentage satisfaction levels, and to extend and add to our knowledge-base of what students at UAL really think and feel about academic libraries. It has enabled us to explore how individual students make use of the services and support provided by LLR. The qualitative data collected through this project has been compared to existing sources of information and to staff experience and understanding of the issues raised, to see if the findings of our research challenge or correlate with other evidence which relates to LLR use and non-use. The focus of the Fellowship has been to explore the particular experience of students who are the first in their family to go to university and who are currently studying at Camberwell, Chelsea and Wimbledon (CCW) and the London College of Communication. Research has shown that this group of students is important amongst the range of students who are now entering higher education through the expansion of participation in university and tertiary-level study. Talking to first generation students was a key element of the project and the greatest source of learning for the Project Team

Reference-Free Validation of Short Read Data

High-throughput DNA sequencing techniques offer the ability to rapidly and cheaply sequence material such as whole genomes. However, the short-read data produced by these techniques can be biased or compromised at several stages in the sequencing process; the sources and properties of some of these biases are not always known. Accurate assessment of bias is required for experimental quality control, genome assembly, and interpretation of coverage results. An additional challenge is that, for new genomes or material from an unidentified source, there may be no reference available against which the reads can be checked.-mers. We apply our methodology to wide range of short read data and show that, surprisingly, strong biases appear to be present. These include gross overrepresentation of some poly-base sequences, per-position biases towards some bases, and apparent preferences for some starting positions over others.The existence of biases in short read data is known, but they appear to be greater and more diverse than identified in previous literature. Statistical analysis of a set of short reads can help identify issues prior to assembly or resequencing, and should help guide chemical or statistical methods for bias rectification

Potassium-mediated zincation of ferrocene and ruthenocene : potassium, the architect behind supramolecular structural variations

Direct zincation of ferrocene and ruthenocene by the synergic base [PMDETA.K(μ-TMP)(μ-Me)Zn(Me)] produces the monozincated complexes [{PMDETA.K(μ-Me)2Zn(Fc)}∞] and [{PMDETA.K(μ-Me)2Zn(Rc)}2] respectively, having similar monomeric (dinuclear) units but aggregating supramolecularly in very different polymeric and dimeric forms

Ultra-High-Resolution 1 m/pixel CaSSIS DTM Using Super-Resolution Restoration and Shape-from-Shading: Demonstration over Oxia Planum on Mars

We introduce a novel ultra-high-resolution Digital Terrain Model (DTM) processing system using a combination of photogrammetric 3D reconstruction, image co-registration, image super-resolution restoration, shape-from-shading DTM refinement, and 3D co-alignment methods. Technical details of the method are described, and results are demonstrated using a 4 m/pixel Trace Gas Orbiter Colour and Stereo Surface Imaging System (CaSSIS) panchromatic image and an overlapping 6 m/pixel Mars Reconnaissance Orbiter Context Camera (CTX) stereo pair to produce a 1 m/pixel CaSSIS Super-Resolution Restoration (SRR) DTM for different areas over Oxia Planum on Mars—the future ESA ExoMars 2022 Rosalind Franklin rover’s landing site. Quantitative assessments are made using profile measurements and the counting of resolvable craters, in comparison with the publicly available 1 m/pixel High-Resolution Imaging Experiment (HiRISE) DTM. These assessments demonstrate that the final resultant 1 m/pixel CaSSIS DTM from the proposed processing system has achieved comparable and sometimes more detailed 3D reconstruction compared to the overlapping HiRISE DT

Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission

BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the majority of mother-to-child transmissions. The blood-milk epithelial barrier markedly restricts the quantity of HIV-1 in breast milk, even in the absence of antiretroviral drugs. The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established. METHODOLOGY/PRINCIPAL FINDINGS. We compared 356 HIV-1 subtype C gp160 envelope (env) gene sequences from the plasma and breast milk of 13 breastfeeding women. A trend towards lower viral population diversity and divergence in breast milk was observed, potentially indicative of clonal expansion within the breast. No differences in potential N-linked glycosylation site numbers or in gp160 variable loop amino acid lengths were identified. Genetic compartmentalization was evident in only one out of six subjects in whom contemporaneously obtained samples were studied. However, in samples that were collected 10 or more days apart, six of seven subjects were classified as having compartmentalized viral populations, highlighting the necessity of contemporaneous sampling for genetic compartmentalization studies. We found evidence of CXCR4 co-receptor using viruses in breast milk and blood in nine out of the thirteen subjects, but no evidence of preferential localization of these variants in either tissue. CONCLUSIONS/SIGNIFICANCE. Despite marked restriction of HIV-1 quantities in milk, our data indicate intermixing of virus between blood and breast milk. Thus, we found no evidence that a restriction in viral genotype diversity in breast milk accounts for the genetic bottleneck observed following transmission. In addition, our results highlight the rapidity of HIV-1 env evolution and the importance of sample timing in analyses of gene flow.National Institute of Child Health and Human Development; National Institutes of Health (R01 HD 39611, R01 HD 40777); International Maternal Pediatric Adolescent AIDS Clinical Trials Group (U01 AI068632-01); National Institutes of Health Cellular, Biochemical; Molecular Sciences Training Program Grant (T 32 067587

Large Area High-Resolution 3D Mapping of the Von Kármán Crater: Landing Site for the Chang’E-4 Lander and Yutu-2 Rover

We demonstrate the creation of a large area of high-resolution (260 × 209 km2 at 1 m/pixel) DTM mosaic from the Lunar Reconnaissance Orbiter Camera (LROC) Narrow Angle Camera (NAC) images over the Chang’E-4 landing site at Von Kármán crater using an in-house deep learning-based 3D modelling system developed at University College London, called MADNet, trained with lunar orthorectified images and digital terrain models (DTMs). The resultant 1 m DTM mosaic is co-aligned with the Chang’E-2 (CE-2) and the Lunar Orbiter Laser Altimeter (LOLA)—SELenological and Engineering Explorer (SELENE) blended DTM product (SLDEM), providing high spatial and vertical congruence. In this paper, technical details are briefly discussed, along with visual and quantitative assessments of the resultant DTM mosaic product. The LROC NAC MADNet DTM mosaic was compared with three independent DTM datasets, and the mean differences and standard deviations are as follows: PDS photogrammetric DTM at 5 m grid-spacing had a mean difference of −0.019 ± 1.09 m, CE-2 DTM at 20 m had a mean difference of −0.048 ± 1.791 m, and SLDEM at 69 m had a mean difference of 0.577 ± 94.940 m. The resultant LROC NAC MADNet DTM mosaic, alongside a blended LROC NAC and CE-2 MADNet DTM mosaic and a separate LROC NAC, orthorectified image mosaic, are made publicly available via the ESA planetary science archive’s guest storage facility

Subpixel-Scale Topography Retrieval of Mars Using Single-Image DTM Estimation and Super-Resolution Restoration

We propose using coupled deep learning based super-resolution restoration (SRR) and single-image digital terrain model (DTM) estimation (SDE) methods to produce subpixel-scale topography from single-view ESA Trace Gas Orbiter Colour and Stereo Surface Imaging System (CaSSIS) and NASA Mars Reconnaissance Orbiter High Resolution Imaging Science Experiment (HiRISE) images. We present qualitative and quantitative assessments of the resultant 2 m/pixel CaSSIS SRR DTM mosaic over the ESA and Roscosmos Rosalind Franklin ExoMars rover’s (RFEXM22) planned landing site at Oxia Planum. Quantitative evaluation shows SRR improves the effective resolution of the resultant CaSSIS DTM by a factor of 4 or more, while achieving a fairly good height accuracy measured by root mean squared error (1.876 m) and structural similarity (0.607), compared to the ultra-high-resolution HiRISE SRR DTMs at 12.5 cm/pixel. We make available, along with this paper, the resultant CaSSIS SRR image and SRR DTM mosaics, as well as HiRISE full-strip SRR images and SRR DTMs, to support landing site characterisation and future rover engineering for the RFEXM22

Editorial: Macrocognition: The Science and Engineering of Sociotechnical Work Systems

The increasing complexity of work systems and changes in the nature of workplace technology over the past century have resulted in an exponential shift in the nature of work activities, from physical labor to cognitive work. Modern work systems have many characteristics that make them cognitively complex: They can be highly interactive; comprised of multiple agents and artifacts; information may be limited and distributed across space and time; task goals are frequently ill-defined, conflicting, dynamic and emergent; planning may only be possible at general levels of abstraction or require adaptive solutions; some degree of proficiency or expertise is required; the stakes are often high; and uncertainty, time-constraints and stress are seldom absent. To complicate matters further, cognition in complex work settings is typically constrained by broader professional, organizational, and institutional practice and policy. These features of cognitive work present significant challenges to scientific methodology and theory, and subsequent design of reliable interventions. Historically, philosophers and scientists have attempted to understand the mental activities experienced during cognitive work at multiple levels of analysis using divergent methods. Some have examined cognition at an associative, contextual, functional or holistic level, relying on naturalistic methods to understand the higher mental processes as they work in harmony during goal-directed behavior. Others have embraced experimental methods and favored internal over external validity, often reducing cognition to a psychology of fundamental acts, such as short-term memory access with millisecond shifts in attention. More recently, Macrocognition has evolved as a complementary paradigm. Macrocognitive researchers have studied the cognitive functions and processes associated with skilled, adaptive, collaborative, and resilient cognitive work in the context of the aforementioned complexities of psychotechnical and sociotechnical work systems. Typically, this research has been carried out using cognitive task analytic techniques that draw on both naturalistic and (quasi-)experimental methods. The primary goals of research in Macrocognition are to better understand cognitive adaptations to complexity, to increase our theoretical understanding of the organism-environment relations by studying the mapping between cognitive work and real-world demands, and to promote use-inspired research capable of improving system performance

Validation of Chichewa short musculoskeletal function assessment (SMFA) questionnaire: A cross-sectional study

Background: The Short Musculoskeletal Function Assessment (SMFA) tool measures function and quality of life in patients with musculoskeletal conditions. Objective: This study aimed to translate and adapt culturally the SMFA into Chichewa, and assess its clinimetric properties. Methods: The translated Chichewa version was administered to 53 patients with musculoskeletal disorders. To assess repeatability, an additional 20 patients answered the questionnaire twice over a time interval of two weeks. Internal consistency, floor and ceiling effects, and repeatability were tested; construct validity was assessed with the World Health Organization Quality of Life Assessment tool (WHOQOL-BREF). Results: There was good internal consistency for both Dysfunction and Bothersome indices (Cronbach’s alpha 0.90) and good construct validity between both indices with the WHOQOL-BREF. Pearson’s correlation coefficient and intraclass correlation coefficient (ICC) for repeatability for the Dysfunction Index were 0.941 and 0.922 (95% CI: 0.772, 0.971) respectively, and 0.877 and 0.851 (95% CI: 0.629, 0.941) for the Bothersome Index respectively. Conclusion: The translated Chichewa SMFA is a valid tool for populations that speak the Chichewa language.publishedVersio