High resolution analysis of satellite gradiometry

Satellite gravity gradiometry is a technique now under development which, by the middle of the next decade, may be used for the high resolution charting from space of the gravity field of the earth and, afterwards, of other planets. Some data analysis schemes are reviewed for getting detailed gravity maps from gradiometry on both a global and a local basis. It also presents estimates of the likely accuracies of such maps, in terms of normalized spherical harmonics expansions, both using gradiometry alone and in combination with data from a Global Positioning System (GPS) receiver carried on the same spacecraft. It compares these accuracies with those of current and future maps obtained from other data (conventional tracking, satellite-satellite tracking, etc.), and also with the spectra of various signals of geophysical interest

Gravitational spectra from direct measurements

A simple rapid method is described for determining the spectrum of a surface field from harmonic analysis of direct measurements along great circle arcs. The method is shown to give excellent overall trends to very high degree from even a few short arcs of satellite data. Three examples are taken with perfect measurements of satellite tracking over a planet made up of hundreds of point-masses using (1) altimetric heights from a low orbiting spacecraft, (2) velocity residuals between a low and a high satellite in circular orbits, and (3) range-rate data between a station at infinity and a satellite in highly eccentric orbit. In particular, the smoothed spectrum of the Earth's gravitational field is determined to about degree 400(50 km half wavelength) from 1 D x 1 D gravimetry and the equivalent of 11 revolutions of Geos 3 and Skylab altimetry. This measurement shows there is about 46 cm of geoid height remaining in the field beyond degree 180

Altimetry, Orbits and Tides

The nature of the orbit error and its effect on the sea surface heights calculated with satellite altimetry are explained. The elementary concepts of celestial mechanics required to follow a general discussion of the problem are included. Consideration of errors in the orbits of satellites with precisely repeating ground tracks (SEASAT, TOPEX, ERS-1, POSEIDON, amongst past and future altimeter satellites) are detailed. The theoretical conclusions are illustrated with the numerical results of computer simulations. The nature of the errors in this type of orbits is such that this error can be filtered out by using height differences along repeating (overlapping) passes. This makes them particularly valuable for the study and monitoring of changes in the sea surface, such as tides. Elements of tidal theory, showing how these principles can be combined with those pertinent to the orbit error to make direct maps of the tides using altimetry are presented

Gravity field information from Gravity Probe-B

The Gravity Probe-B Mission will carry the Stanford Gyroscope relativity experiment into orbit in the mid 1990's, as well as a Global Positioning System (GPS) receiver whose tracking data will be used to study the earth gravity field. Estimates of the likely quality of a gravity field model to be derived from the GPS data are presented, and the significance of this experiment to geodesy and geophysics are discussed

Internal anatomy of an erg sequence from the aeolian-fluvial system of the De La Cuesta Formation (Paganzo Basin, northwestern Argentina)

Permian red beds of the De La Cuesta Formation in the Sierra de Narváez (Paganzo Basin, northwestern Argentina) are essentially composed of sandstones associated with mudstones and subordinate conglomerates. Facies distributions and stacking patterns indicate that these sediments resulted from the interaction between aeolian and ephemeral fluvial systems, and are represented by aeolian dune, dry aeolian interdune and Aeolian sand sheet, mudflat, wet aeolian interdune, and fluvial deposits. The De La Cuesta Formation is characterized by aeolian (erg) sequences alternating with non-aeolian (terminal alluvial fan - mudflat) sequences. Each erg sequence is bounded at its base by a regionally extensive sand-drift surface and at the top by an extinction surface. A number of architectural elements, including aeolian dunes limited by interdunes, grouped crescentic Aeolian dunes, longitudinal dunes, and draa with superimposed crescentic dunes are recognised in the erg sequences. The sand sea developed during phases of increasing aridity, whereas non-aeolian deposition might have occurred during more humid phases. Thus, the styles of aeolian-fluvial interaction are considered to result from cyclical climatic changes. Within the drier hemicycles, the rhythmic alternation between draa deposits and aeolian dune and interdune deposits indicates higher frequency cycles that could be attributed to subtle climatic oscillations and/ or changes in sand supply and availability. The development of the Permian sand sea in the inland Paganzo Basin seems to be related to the growth of a volcanic chain to the west. This topographic barrier separated the Paganzo Basin from the Chilean Basin, located along the western margin of Gondwana and characterised by shallow marine carbonate sedimentation. The correlation between the Permian erg and the shallow marine carbonates suggests a regional warming period during the Middle Permian in western Gondwana

Antropoestratigrafía: nuevas unidades litológicas del Cuaternario controladas por la actividad humana

Many areas around the world such as the Mediterranean region have been inhabited without interruption for thousands of years. This is the case of the city of Barcelona (Spain), where remains of human settlements dating from pre-Roman times until the present have been found. A detailed geological mapping of the area occupied by the city of Barcelona raises a number of questions about the Holocene stratigraphy affected by human activity. In the old urban and surrounding areas most of the sedimentary deposits accumulated during settlement result from human interactions. Thus, new anthropostratigraphic units are proposed. The sedimentary deposits and the infill of rock excavations due to human presence may be divided into three categories: Natural lithoanthropogenic units (NAU) when their formation is not directly affected by anthropogenic activity but these contain artefacts of human origin. Induced lithoanthropogenic units (IAU) when natural processes together with human actions produce sedimentation or erosion due to natural phenomena; Constructed lithoanthropogenic units (CAU) when sedimentary accumulations and sharp contacts result from direct human activity.A lo largo de todo el globo terrestre, existen muchas zonas como la región mediterránea que han sido habitadas ininterrumpidamente durante miles de años. Este es el caso de la ciudad de Barcelona donde se han encontrado restos de asentamientos humanos desde los tiempos pre-romanos hasta la actualidad. Un mapa geológico detallado de la zona ocupada por la ciudad de Barcelona plantea una serie de interrogantes sobre la estratigrafía del Holoceno influenciado por la actividad humana. En la zona urbana antigua y en áreas circundantes, la mayoría de los depósitos acumulados durante el asentamiento se han producido por las interacciones humanas. Por tanto, se proponen nuevas unidades antropoestratigráficas. Los depósitos sedimentarios así como los rellenos de lasexcavaciones debidos a la presencia humana pueden ser divididos en tres categorías: Unidades litoantropogénicas naturales (NAU) cuando su generación no ha sido afectada directamente por la actividad humana, pero contienen diversos artefactos artificiales. Unidades litoantropogénicas inducidas (IAU) cuando los procesos naturales junto a las acciones humanas producen sedimentación o erosión debido a los fenómenos naturales. Unidades litoantropogénicas construidas (CAU) cuando las acumulaciones sedimentarias y los contactos nítidos son el resultado de la actividad humana directa

Comparison of Linear and Nonlinear MPC on Operator-In-the-Loop Overhead Cranes

Model Predictive Control has been proved to enhance the control performance of overhead cranes. However, in Operator-In-the-Loop (OIL) overhead cranes the trajectory of the payload strongly depends on the runtime decisions of the user and can not be predicted beforehand. Simple assumptions on the future references evolution have therefore to be made. In this paper we investigate the applicability of linear and nonlinear MPC strategies to the case of OIL overhead cranes, based on different assumptions on the future evolution of the length of the hoisting cable

Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development

During the last decade there has been a growing interest in glycoimmunology, a relatively new research field dealing with the specific interactions of carbohydrates with the immune system. Pathogens\u2019 cell surfaces are covered by a thick layer of oligo- and polysaccharides that are crucial virulence factors, as they mediate receptors binding on host cells for initial adhesion and organism invasion. Since in most cases these saccharide structures are uniquely exposed on the pathogen surface, they represent attractive targets for vaccine design. Polysaccharides isolated from cell walls of microorganisms and chemically conjugated to immunogenic proteins have been used as antigens for vaccine development for a range of infectious diseases. However, several challenges are associated with carbohydrate antigens purified from natural sources, such as their difficult characterization and heterogeneous composition. Consequently, glycoconjugates with chemically well-defined structures, that are able to confer highly reproducible biological properties and a better safety profile, are at the forefront of vaccine development. Following on from our previous review on the subject, in the present account we specifically focus on the most recent advances in the synthesis and preliminary immunological evaluation of next generation glycoconjugate vaccines designed to target bacterial and fungal infections that have been reported in the literature since 2011

Caracterização de linhagens comerciais de café através de marcadores moleculares.

Estudos sobre a diversidade genética de espécies com finalidade de melhoramento genético representam importante preocupação dos melhoristas. Diversas técnicas moleculares têm permitido revelar uma diversidade genética presente no genoma que até então era desconhecida pelos cientistas. Muitas espécies de interesse agronômico têm sido alvo de estudos que abordam a diversidade genética em nível molecular. De uma maneira geral, os resultados obtidos a partir do uso dos marcadores têm sido bastante satisfatórios, principalmente para aquelas espécies que apresentam ampla base genética e insuficiente número de descritores botânicos para diferenciação de genótipos, como é o caso da mandioca. A base genética formada pelos cultivares de C. arabica, principal espécie cultivada, é considerada estreita. Em relação ao Brasil, principal produtor mundial desta cultura, a própria história explica em parte a ausência de variação genética nos materiais atualmente em cultivo. Historicamente, as primeiras plantações de café formaram-se há mais de dois séculos a partir de poucas plantas, constituindo material muito uniforme e de pouca variabilidade genética. De fato, estudos sobre a diversidade genética de cafeeiros em cultivo realizados no IAC utilizando descritores botânicos e agronômicos têm revelado baixo nível de variação genética entre as diferentes linhagens que compõem um cultivar. Entre diferentes cultivares esta variação é mais notória, mão não tão acentuada como se pensava, mesmo quando diferentes espécies participam da genealogia destes cultivares. Desta maneira, este trabalho teve como objetivo principal a avaliação das técnicas de RAPD e AFLP para a identificação e caracterização de diversas linhagens comerciais de C. arabica selecionadas pelo IAC. Os resultados obtidos com estes marcadores confirmam os dados obtidos anteriormente de que a variabilidade genética entre as linhagens é pequena. Além disso, os dados sugerem que a técnica de RAPD não é eficiente para a identificação e determinação da distância genética entre as linhagens avaliadas, apesar de representar uma ferramenta adequada para avaliação da variabilidade no cafeeiro. No entanto, embora o nível de variação observado através dos marcadores moleculares seja baixo, sabe-se que estas linhagens apresentam comportamento agronômico bastante diferenciado. Isso nos leva a pensar que poucos genes diferenciam os principais materiais genéticos de cafeeiro de importância agronômica e que o uso de marcadores moleculares para estudos de diversidade genética e localização de genes de interesse agronômico deve ser repensada

Lumican is upregulated in osteoarthritis and contributes to TLR4-induced pro-inflammatory activation of cartilage degradation and macrophage polarization

Objective: Lumican (LUM) is a major extracellular matrix glycoprotein in adult articular cartilage and its expression is known to be upregulated upon cartilage degeneration. LUM is associated with the pathogen-associated molecular pattern (PAMP) activation of the TLR4 signalling cascade, with TLR4 being highly associated with inflammation in rheumatic diseases. However, the main role of the LUM structural molecule in osteoarthritis (OA) remains elusive. The aim of this study was, therefore, to understand the role of LUM during TLR4-mediated activation in OA. Methods: After measuring LUM levels in synovial fluid (SF) of OA patients and lipopolysaccharide (LPS)-induced TLR4 activation, the role of LUM in the expression of pro-inflammatory molecules and cartilage degradation was assessed in vitro and ex vivo in a cartilage explant model. Primary macrophage activation and polarization were studied upon LUM co-stimulation with LPS. Results: We demonstrate that LUM is not only significantly upregulated in SF from OA patients compared to healthy controls, but also that LUM increases lipopolysaccharide (LPS)-induced TLR4 activation. Furthermore, we show that a pathophysiological level of LUM augments the LPS-induced TLR4 activation and expression of downstream pro-inflammatory molecules, resulting in extensive cartilage degradation. LUM co-stimulation with LPS also provided a pro-inflammatory stimulus, upregulating primary macrophage activation and polarization towards the M1-like phenotype. Conclusions: These findings strongly support the role of LUM as a mediator of PAMP-induced TLR4 activation of inflammation, cartilage degradation, and macrophage polarization in the OA joint and potentially other rheumatic diseases. (C) 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.Peer reviewe