Un nuovo autografo stendhaliano

Ce trou est vraiment plus laid que S[ain]t-Cloud Stendhal Testimonianza di una storia d’amicizia che rende lecita l’estensione a dinamiche socio-politiche è, senza dubbio alcuno, la corrispondenza epistolare tra Stendhal e l’avvocato empolese Vincenzo Salvagnoli; un legame maturato nelle sale del Gabinetto Vieusseux, estesosi poi in seno alla società fiorentina, che tanto Henri Beyle predilesse, entrando con essa in risonanza, e dalle cui relazioni scaturirono passaggi determinanti nel suo vi..

Interopérabilité des systèmes d'information : approches dirigées par les modèles

National audienceInformation systems are more and more often based on aggregation of other systems that must be maintained and evolved in an agile way and with no entropy creation. This is not without interoperability problems! Among others, the aim of Model-Driven Engineering (MDE) is to provide solutions for interoperability issues between systems. This paper summarizes thoughts that have come up from the specific action "Interoper- ability of information systems and model-driven engineering: What challenges? What solutions?" supported by inforsid. We propose a summary of approaches that are based on MDE and knowledge engineering and that tackle interoperability issues in the industry. Open questions and limitations that raised during the meetings are also reported

Spatio-temporal analysis of compound hydro-hazard extremes across the UK

There exists an increasing need to understand the impact of climate change on the hydrological extremes of flood and drought, collectively referred to as ‘hydro-hazards’. At present, current methodology are limited in their scope, particularly with respect to inadequate representation of the uncertainty in the hydroclimatological modelling chain. This paper proposes spatially consistent comprehensive impact and uncertainty methodological framework for the identification of compound hydro-hazard hotspots – hotspots of change where concurrent increase in mean annual flood and drought events is projected. We apply a quasi-ergodic analysis of variance (QE-ANOVA) framework, to detail both the magnitude and the sources of uncertainty in the modelling chain for the mean projected mean change signal whilst accounting for non-stationarity. The framework is designed for application across a wide geographical range and is thus readily transferable. We illustrate the ability of the framework through application to 239 UK catchments based on hydroclimatological projections from the EDgE project (5 CMI5-GCMs and 3 HMs, forced under RCP8.5). The results indicate that half of the projected hotspots are temporally concurrent or temporally successive within the year, exacerbating potential impacts on society. The north-east of Scotland and south-west of the UK were identified as spatio-temporally compound hotspot regions and are of particular concern. This intensification of the hydrologic dynamic (timing and seasonality of hydro-hazards) over a limited time frame represents a major challenge for future water management. Hydrological models were identified as the largest source of variability, in some instances exceeding 80% of the total variance. Critically, clear spatial variability in the sources of modelling uncertainty was also observed; highlighting the need to apply a spatially consistent methodology, such as that presented. This application raises important questions regarding the spatial variability of hydroclimatological modelling uncertainty. In terms of water management planning, such findings allow for more focussed studies with a view to improving the projections which inform the adaptation process

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue

The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease. Here, we have shown that a single residue strongly modifies both the redox properties of thioredoxin fold proteins and their ability to interact with substrates. This residue is adjacent in three-dimensional space to the characteristic CXXC active site motif of thioredoxin fold proteins but distant in sequence. This residue is just N-terminal to the conservative cis-proline. It is isoleucine 75 in the case of thioredoxin. Our findings support the conclusion that a very small percentage of the amino acid residues of thioredoxin-related proteins are capable of dictating the functions of these proteins

Former à l'égalité : défi pour une mixité véritable

Comprend des référence bibliographique

Are We Doing ‘Systems’ Research? An Assessment of Methods for Climate Change Adaptation to Hydrohazards in a Complex World

Climate change is a product of the Anthropocene, and the human⁻nature system in which we live. Effective climate change adaptation requires that we acknowledge this complexity. Theoretical literature on sustainability transitions has highlighted this and called for deeper acknowledgment of systems complexity in our research practices. Are we heeding these calls for ‘systems’ research? We used hydrohazards (floods and droughts) as an example research area to explore this question. We first distilled existing challenges for complex human⁻nature systems into six central concepts: Uncertainty, multiple spatial scales, multiple time scales, multimethod approaches, human⁻nature dimensions, and interactions. We then performed a systematic assessment of 737 articles to examine patterns in what methods are used and how these cover the complexity concepts. In general, results showed that many papers do not reference any of the complexity concepts, and no existing approach addresses all six. We used the detailed results to guide advancement from theoretical calls for action to specific next steps. Future research priorities include the development of methods for consideration of multiple hazards; for the study of interactions, particularly in linking the short- to medium-term time scales; to reduce data-intensivity; and to better integrate bottom⁻up and top⁻down approaches in a way that connects local context with higher-level decision-making. Overall this paper serves to build a shared conceptualisation of human⁻nature system complexity, map current practice, and navigate a complexity-smart trajectory for future research

Evidence for conformational changes within DsbD: possible role for membrane-embedded proline residues.

The mechanism by which DsbD transports electrons across the cytoplasmic membrane is unknown. Here we provide evidence that DsbD's conformation depends on its oxidation state. Our data also suggest that four highly conserved prolines surrounding DsbD's membrane-embedded catalytic cysteines may have an important functional role, possibly conferring conformational flexibility to DsbD