Reducing smoking in adolescents: cost-effectiveness results from the cluster randomized ASSIST (A Stop Smoking In Schools Trial)

Introduction: School-based smoking prevention programmes can be effective, but evidence on cost-effectiveness is lacking. We conducted a cost-effectiveness analysis of a school-based “peer-led” intervention.<p></p> Methods: We evaluated the ASSIST (A Stop Smoking In Schools Trial) programme in a cluster randomized controlled trial. The ASSIST programme trained students to act as peer supporters during informal interactions to encourage their peers not to smoke. Fifty-nine secondary schools in England and Wales were randomized to receive the ASSIST programme or usual smoking education. Ten thousand seven hundred and thirty students aged 12–13 years attended participating schools. Previous work has demonstrated that the ASSIST programme achieved a 2.1% (95% CI = 0%–4.2%) reduction in smoking prevalence. We evaluated the public sector cost, prevalence of weekly smoking, and cost per additional student not smoking at 24 months.<p></p> Results: The ASSIST programme cost of £32 (95% CI = £29.70–£33.80) per student. The incremental cost per student not smoking at 2 years was £1,500 (95% CI = £669–£9,947). Students in intervention schools were less likely to believe that they would be a smoker at age 16 years (odds ratio [OR] = 0.80; 95% CI = 0.66–0.96).<p></p> Conclusions: A peer-led intervention reduced smoking among adolescents at a modest cost. The intervention is cost-effective under realistic assumptions regarding the extent to which reductions in adolescent smoking lead to lower smoking prevalence and/or earlier smoking cessation in adulthood. The annual cost of extending the intervention to Year 8 students in all U.K. schools would be in the region of £38 million and could result in 20,400 fewer adolescent smokers.<p></p&gt

Reflections in the Mirror: Women’s Self Comparisons to Mannequins and Peers

The fashion industry has been under fire for years for using unrealistic body sizes in the form of stick-thin fashion models to promote the sale of clothing. Typical Western fashion models in today’s society are sized 0-2 and weigh approximately 23% less than the average U.S. woman, who weighs approximately 163 pounds and wears a size 14 (Vesilind, 2009). According to Vartanian (2009), many women suffer from body image self-discrepancies when they compare themselves with others, including fashion models. As such, social comparison has been documented to create negative emotions, such as body dissatisfaction and disappointment (Posavac & Posavac, 2002). Although a number of studies have investigated how an idealized body image in media impacts social comparison among females, no research has explored to what extent comparisons of mannequins to a customer’s self may impact self-image and consumer behavior. Since mannequins serve to show consumers how clothing may look on the human body and consumers may be drawn to the clothing due to the way the clothing fits the mannequin and/or the poise, stature, or grace of the mannequin itself (Schneider, 1997), it should be expected that mannequins would also influence self-image and behavior. Utilizing Social Comparison Theory as the theoretical foundation, this study examines the influencing factors affecting U.S. females\u27 social comparison tendencies and psychological well-being when a female compares her body to that of a mannequin and to other women. Data was collected using an online survey through the use of snowball convenience sampling, yielding 314 usable responses. Results indicate that the use of idealized mannequins in retail stores have a significant impact on social comparison and body dissatisfaction for female consumers. These results suggest that female consumers do indeed compare their bodies to those of mannequins and that the greater the discrepancy between the size of the mannequin and their own size, the more dissatisfied the woman is with her body. This research extends Social Comparison Theory as the findings show women also compare themselves to mannequins. In addition, results of this study show that women who are categorized with a BMI classification of overweight or obese are more likely to compare themselves to other females. Results also show that the top five body parts/characteristics most commonly compared to mannequins and other females are body size, weight, body shape, waist, and legs

A note on the index bundle over the moduli space of monopoles

Donaldson has shown that the moduli space of monopoles $M_k$ is diffeomorphic to the space \Rat_k of based rational maps from the two-sphere to itself. We use this diffeomorphism to give an explicit description of the bundle on \Rat_k obtained by pushing out the index bundle from $M_k$. This gives an alternative and more explicit proof of some earlier results of Cohen and Jones.Comment: 9 page

Performance Evaluation of a High Bandwidth Liquid Fuel Modulation Valve for Active Combustion Control

At the NASA Glenn Research Center, a characterization rig was designed and constructed for the purpose of evaluating high bandwidth liquid fuel modulation devices to determine their suitability for active combustion control research. Incorporated into the rig s design are features that approximate conditions similar to those that would be encountered by a candidate device if it were installed on an actual combustion research rig. The characterized dynamic performance measures obtained through testing in the rig are planned to be accurate indicators of expected performance in an actual combustion testing environment. To evaluate how well the characterization rig predicts fuel modulator dynamic performance, characterization rig data was compared with performance data for a fuel modulator candidate when the candidate was in operation during combustion testing. Specifically, the nominal and off-nominal performance data for a magnetostrictive-actuated proportional fuel modulation valve is described. Valve performance data were collected with the characterization rig configured to emulate two different combustion rig fuel feed systems. Fuel mass flows and pressures, fuel feed line lengths, and fuel injector orifice size was approximated in the characterization rig. Valve performance data were also collected with the valve modulating the fuel into the two combustor rigs. Comparison of the predicted and actual valve performance data show that when the valve is operated near its design condition the characterization rig can appropriately predict the installed performance of the valve. Improvements to the characterization rig and accompanying modeling activities are underway to more accurately predict performance, especially for the devices under development to modulate fuel into the much smaller fuel injectors anticipated in future lean-burning low-emissions aircraft engine combustors

Computing Hilbert Class Polynomials

We present and analyze two algorithms for computing the Hilbert class polynomial $H_D$ . The first is a p-adic lifting algorithm for inert primes p in the order of discriminant D < 0. The second is an improved Chinese remainder algorithm which uses the class group action on CM-curves over finite fields. Our run time analysis gives tighter bounds for the complexity of all known algorithms for computing $H_D$, and we show that all methods have comparable run times

Classical analogous of quantum cosmological perfect fluid models

Quantization in the mini-superspace of a gravity system coupled to a perfect fluid, leads to a solvable model which implies singularity free solutions through the construction of a superposition of the wavefunctions. We show that such models are equivalent to a classical system where, besides the perfect fluid, a repulsive fluid with an equation of state $p_Q = \rho_Q$ is present. This leads to speculate on the true nature of this quantization procedure. A perturbative analysis of the classical system reveals the condition for the stability of the classical system in terms of the existence of an anti-gravity phase.Comment: Latex file, 10 pages, 3 figure

Saturation properties of nuclear matter in a relativistic mean field model constrained by the quark dynamics

We have built an effective Walecka-type hadronic Lagrangian in which the hadron masses and the density dependence of the coupling constants are deduced from the quark dynamics using a Nambu-Jona-Lasinio model. In order to stabilize nuclear matter an eight-quark term has been included. The parameters of this Nambu-Jona-Lasinio model have been determined using the meson properties in the vacuum but also in the medium through the omega meson mass in nuclei measured by the TAPS collaboration. Realistic properties of nuclear matter have been obtained.Comment: 14 pages, 2 figures, submitted to Nuclear Physics

A Gravitational Aharonov-Bohm Effect, and its Connection to Parametric Oscillators and Gravitational Radiation

A thought experiment is proposed to demonstrate the existence of a gravitational, vector Aharonov-Bohm effect. A connection is made between the gravitational, vector Aharonov-Bohm effect and the principle of local gauge invariance for nonrelativistic quantum matter interacting with weak gravitational fields. The compensating vector fields that are necessitated by this local gauge principle are shown to be incorporated by the DeWitt minimal coupling rule. The nonrelativistic Hamiltonian for weak, time-independent fields interacting with quantum matter is then extended to time-dependent fields, and applied to problem of the interaction of radiation with macroscopically coherent quantum systems, including the problem of gravitational radiation interacting with superconductors. But first we examine the interaction of EM radiation with superconductors in a parametric oscillator consisting of a superconducting wire placed at the center of a high Q superconducting cavity driven by pump microwaves. We find that the threshold for parametric oscillation for EM microwave generation is much lower for the separated configuration than the unseparated one, which then leads to an observable dynamical Casimir effect. We speculate that a separated parametric oscillator for generating coherent GR microwaves could also be built.Comment: 25 pages, 5 figures, YA80 conference (Chapman University, 2012

Model Independent Higgs Boson Mass Limits at LEP

We derive model-independent constraints on Higgs mass and couplings from associated signals for higher masses, accessible at LEP2. This work is motivated by the fact that, in many extensions of the standard model, the Higgs boson can have substantial "invisible" decay modes, for example, into light or massless weakly interacting Goldstone bosons associated to the spontaneous violation of lepton number below the weak scale.Comment: FTUV/93-19, 13 pag + 2 figures(not included but available upon request), Late

Multimodal Highlighting of Structural Abnormalities in Diabetic Rat and Human Corneas.

PURPOSE: This study aimed to highlight structural corneal changes in a model of type 2 diabetes, using in vivo corneal confocal microscopy (CCM). The abnormalities were also characterized by transmission electron microscopy (TEM) and second harmonic generation (SHG) microscopy in rat and human corneas. METHODS: Goto-Kakizaki (GK) rats were observed at age 12 weeks (n = 3) and 1 year (n = 6), and compared to age-matched controls. After in vivo CCM examination, TEM and SHG microscopy were used to characterize the ultrastructure and the three-dimensional organization of the abnormalities. Human corneas from diabetic (n = 3) and nondiabetic (n = 3) patients were also included in the study. RESULTS: In the basal epithelium of GK rats, CCM revealed focal hyper-reflective areas, and histology showed proliferative cells with irregular basement membrane. In the anterior stroma, extracellular matrix modifications were detected by CCM and confirmed in histology. In the Descemet's membrane periphery of all the diabetic corneas, hyper-reflective deposits were highlighted using CCM and characterized as long-spacing collagen fibrils by TEM. SHG microscopy revealed these deposits with high contrast, allowing specific detection in diabetic human and rat corneas without preparation and characterization of their three-dimensional organization. CONCLUSION: Pathologic findings were observed early in the development of diabetes in GK rats. Similar abnormalities have been found in corneas from diabetic patients. TRANSLATIONAL RELEVANCE: This multidisciplinary study highlights diabetes-induced corneal abnormalities in an animal model, but also in diabetic donors. This could constitute a potential early marker for diagnosis of hyperglycemia-induced tissue changes