The polemist Eugene Ionescu in "NO" and his longing for the center

Our analytic research proposes an exegesis of young Eugene lonescu's polemic pages in his tome of critique published in Romanian in 1934. Our analytic perspective will consider the meaning of aesthetic values in literature and critique in order to impose a minoritary culture on a universal level. The critical nihilism in NO comes as a result of the pressure of the author's longing for the recognition of true cultural values; a pressure which cannot accept any compromise. Eugene Ionescu is a Robespierre of inter-war Romanian critique, who wanted, through a combative critique, to open a way for the Romanian culture towards the center of European culture. Abstract. Lair Samuel, Octave Mirbeau et le

The Uruz's literary case from the perspective of aesthetics of grotesque

We are trying in the following phenomenological approach to go on with our description concerning the grotesque in Romanian literature. In the first part of our work, we will make a short and diachronic review of the most important writings belonging to Romanian authors from the XIX-th century till the first decade of the XX-th century. It is then when a mysterious and shy Romanian writer, called URMUZ, gave birth to a few but influential literary pages of the absurd and the grotesque. In the second part of our work we will analyze the distinguishing traits of his ten works of prose through the mirror of the grotesque. This ignored Romanian writer was baptized “a new Alfred Jarry”, although he never had heard about this French author and never read about Ubu. The hidden influence of Urmuz unknowingly modernized the concept of literarity.41259715Studia Romanica Posnaniensi

Dicționar grotesc

A little writing not enough researched and reaching a few pages belonging to Vasile Alecsandri proves the keen interest of a comedies and vaudeville author for language issues, especially for the building of a beautiful and fluent literary language. From our point of view, of a today's researcher, it is the only work published towards the end of the 19th century (approx. 1876), which includes in the title the term of grotesque with certain connotations, unusual for the Romanian cultural space. Through an analysis sourcing in the New Criticism, we will show the links, avant la lettre, with the aesthetics of the grotesque in the Romanian space and the intuitions of a writer, considered “easy”, although a classic of Romanian literature.A little writing not enough researched and reaching a few pages belonging to Vasile Alecsandri proves the keen interest of a comedies and vaudeville author for language issues, especially for the building of a beautiful and fluent literary language. From our point of view, of a today's researcher, it is the only work published towards the end of the 19th century (approx. 1876), which includes in the title the term of grotesque with certain connotations, unusual for the Romanian cultural space. Through an analysis sourcing in the New Criticism, we will show the links, avant la lettre, with the aesthetics of the grotesque in the Romanian space and the intuitions of a writer, considered “easy”, although a classic of Romanian literature

Toleranţa in "Peccavistanul" lui Salman Rushdie între ruşine şi neruşinare

After a little theoretical and philosophical introduction to what tolerance means for our contemporary society, we are trying to analyse two ways of the tolerance of the contemporary novelist, Salman Rushdie, in his novel "The Shame". The first of them concerns the discursive tolerance, as a narrative organisation or structure, and the second is about the internal tolerance of the epic ideas. Drawing the conclusions, we can assert the following: for both ways of our examination: the faint and the marginal fight to occupy a central positon belonging to the strong. However, this never wins or if he wins, it is only temporarily. So, even the tolerance has to exist, in fact, it does not exist

Use of Anti-Cytokine Therapy in Kidney Transplant Recipients with COVID-19

In the context of the coronavirus disease 2019 (COVID-19) pandemic, we aimed to evaluate the impact of anti-cytokine therapies (AT) in kidney transplant recipients requiring hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This is an observational retrospective study, which included patients from March to May 2020. An inverse probability of treatment weighting from a propensity score to receive AT was used in all statistical analyses, and we applied a bootstrap procedure in order to calculate an estimation of the 2.5th and 97.5th percentiles of odds ratio (OR). outcomes were measured using an ordinal scale determination (OSD). A total of 33 kidney recipients required hospitalization and 54% of them received at least one AT, mainly tocilizumab (42%), followed by anakinra (12%). There was no statistical effect in terms of intensive care unit (ICU) admission, respiratory secondary infections (35% vs. 7%) or mortality (16% vs. 13%) comparing patients that received AT with those who did not. Nevertheless, patients who received AT presented better outcomes during hospitalization in terms of OSD ≥5 ((OR 0.31; 2.5th, 97.5th percentiles (0.10; 0.72)). These analyses indicate, as a plausible hypothesis, that the use of AT in kidney transplant recipients presenting with COVID-19 could be beneficial, even though multicenter randomized control trials using these therapies in transplanted patients are needed

Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing

Antiviral resistance; Solid organ transplant; Next-generation sequencingResistencia a los antivirales; Trasplante de órganos sólidos; Secuenciación de próxima generaciónResistència als antivirals; Trasplantament d'òrgans sòlids; Seqüenciació de pròxima generacióOBJETIVES: The aim of this study was to identify CMV drug resistance mutations (DRM) in solid organ transplant (SOT) recipients with suspected resistance comparing next-generation sequencing (NGS) with Sanger sequencing and assessing risk factors and the clinical impact of resistance. METHODS: Using Sanger sequencing as the reference method, we prospectively assessed the ability of NGS to detect CMV DRM in the UL97 and UL54 genes in a nationwide observational study from September 2013 to August 2016. RESULTS: Among 44 patients recruited, 14 DRM were detected by Sanger in 12 patients (27%) and 20 DRM were detected by NGS, in 16 (36%). NGS confirmed all the DRM detected by Sanger. The additional six mutations detected by NGS were present in <20% of the sequenced population, being located in the UL97 gene and conferring high-level resistance to ganciclovir. The presence of DRM by NGS was associated with lung transplantation (p = 0.050), the administration of prophylaxis (p = 0.039), a higher mean time between transplantation and suspicion of resistance (p = 0.038) and longer antiviral treatment duration before suspicion (p = 0.024). However, the latter was the only factor independently associated with the presence of DRM by NGS in the multivariate analysis (OR 2.24, 95% CI 1.03 to 4.87). CONCLUSIONS: NGS showed a higher yield than Sanger sequencing for detecting CMV resistance mutations in SOT recipients. The presence of DRM detected by NGS was independently associated with longer antiviral treatment.The present study was funded by Agency for Health Technology Assessment and Research and Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (PS12/02131 and PI17/02150) and by the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR, FI-DGR 2017, Grant No. 00794), which is supported by the Secretaria d'Universitats i Recerca (Economy and Knowledge Department, Generalitat de Catalunya), and co-funded by the European Social Fund and by Fundacio Marato TV3 project (201824). The study sponsor had no role in the collection, analysis, or interpretation of the data

Primary herpes simplex virus type 1 infection with acute liver failure in solid organ transplantation: Report of three cases and review

Herpes virus infections is not uncommon in solid organ transplantation patients. We report 3 cases with primary Herpes simplex virus type-1 (HSV1) infection with acute liver failure (ALF). This is a rare and potentially fatal entity that could be a donor-derived infection. Although the initial clinical presentation is non-specific, it should be considered as a differential diagnosis in HSV-negative serology patients with liver failure and empirical treatment must be started in combination with a drastic reduction of immunosuppression. A strategy of HSV prophylaxis for pre-transplant HSV seronegative patients must be stablished in order to reduce the risk of clinical disease.© 2022 Published by Elsevier Ltd

Carpal Tunnel Syndrome and Peripheral Polyneuropathy in Patients with End Stage Kidney Disease

This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis (HD) and 48 on peritoneal dialysis (PD), were enrolled. The duration of ESKD and dialysis, the site of the arteriovenous (A-V) fistula for HD, laboratory data such as blood urea nitrogen, creatinine, and beta-2-microglobulin were determined. Clinical evaluation of CTS and electrophysiological studies for the diagnosis of CTS and peripheral neuropathy were performed. The electrophysiological studies showed that the frequency of CTS was not different in the HD and PD groups (P = 0.823) and the frequency of CTS was not different in the limb with the A-V fistula compared to the contralateral limb (P = 0.816). The frequency of HD and PD were not related to beta-2-microglobulin levels, an indicator of amyloidosis. The frequency of CTS did not increase as the severity of the peripheral neuropathy and the duration of ESKD and dialysis increased (P = 0.307). The results of this study do not support that microglobulin induced amyloidosis or placement of an A-V fistula are associated with an increase in CTS

Tratamiento sustitutivo renal y toma de decisiones compartidas

Enfermedad renal crónica; Tratamiento sustitutivo renal; Toma de decisiones compartidasMalaltia renal crònica; Tractament substitutiu renal; Presa de decisions compartidesChronic renal disease; Renal replacement treatment; Shared decision makingEl proyecto Decisiones Compartidas en Cataluña es una iniciativa de la Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS) y del Consell Consultiu de pacients del Departament de Salut de la Generalitat de Catalunya. El objetivo de la misma es facilitar a las personas sanas o enfermas herramientas de información para decidir, conjuntamente con el profesional sanitario, qué intervenciones médicas, en base a la evidencia científica, son mejores según sus preferencias y valores

Correlates of the Severity of Coronary Atherosclerosis in Long-term Kidney Transplant Patients

Coronary artery disease remains the leading cause of early death and graft loss in renal transplant patients. The aim of this study was to identify clinical and echocardiographic parameters independently associated with the angiographically-determined severity of coronary atherosclerosis in long-term kidney transplant patients. Fifty-two kidney transplant recipients who underwent elective coronary angiography were reviewed retrospectively. Angiographic severity was evaluated using the modified Gensini index (MGI). The mean age at coronary angiography was 52.5±7.9 yr with a mean prior transplant duration of 118.1±58.8 months. Pearson correlation analysis demonstrated a positive correlation of MGI with transplant duration before coronary angiography and chronic allograft nephropathy, whereas an inverse correlation was demonstrated with ejection fraction and statin use. On subsequent multivariate linear regression analysis, transplant duration before coronary angiography, statin use, and ejection fraction were independently associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. In summary, our study demonstrates that statin use, ejection fraction, and transplant duration before coronary angiography are independent parameters associated with the severity of coronary atherosclerosis in long-term kidney transplant patients. Further investigation is required to reduce the atherosclerotic burden in kidney transplant patients