Temperatures and cooling rates recorded by the New Caledonia ophiolite: implications for cooling mechanisms in young forearc sequences.

To unveil how forearc lithosphere cools and re-equilibrates, we carried out a comprehensive geothermometric investigation of the New Caledonia ophiolite, which represents a rare example of proto-arc section generated during subduction infancy. A large dataset, including more than eighty samples (peridotites and mafic-ultramafic intrusives), was considered. Closure temperatures calculated for the lherzolites using slow (TREE-Y) and fast diffusing (TCa-in-Opx, TBKN, TCa-in-Ol, TOl-Sp) geothermometers provide some of the highest values ever documented for ophiolitic peridotites, akin to modern sub-oceanic mantle. Cooling rates deduced from TREE-Y and TBKN yield values of ≈ 10-3 °C/y, similar to those obtained with TCa-in-Ol. These features are consistent with a post-melting history of emplacement, possibly along a transform fault, and thermal re-equilibration via conduction. Cpx-free harzburgites register a high-T evolution, followed by quenching and obduction. The relatively high TCa-in-Ol, TOl-Sp and cooling rates computed from TCa-in-Ol (≈ 10-3 °C/y) are atypical for this geodynamic setting, mirroring the development of an ephemeral subduction system, uplift and emplacement of the Peridotite Nappe. Temperature profiles across the crust-mantle transect point to high closure temperatures, with limited variations with depth. These results are indicative of injection and crystallization of non-cogenetic magma batches in the forearc lithosphere, followed by thermal re-equilibration at rates of ≈ 10-4-10-3 °C/y. Our study shows that the thermal conditions recorded by forearc sequences are intimately related to specific areal processes and previous lithospheric evolution. Thus, detailed sampling and exhaustive knowledge of the geological background are critical to unravel the cooling mechanisms in this geodynamic setting

Mechanism-Independent Method for Predicting Response to Multidrug Combinations in Bacteria

Drugs are commonly used in combinations larger than two for treating bacterial infection. However, it is generally impossible to infer directly from the effects of individual drugs the net effect of a multidrug combination. Here we develop a mechanism-independent method for predicting the microbial growth response to combinations of more than two drugs. Performing experiments in both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria, we demonstrate that for a wide range of drugs, the bacterial responses to drug pairs are sufficient to infer the effects of larger drug combinations. To experimentally establish the broad applicability of the method, we use drug combinations comprising protein synthesis inhibitors (macrolides, aminoglycosides, tetracyclines, lincosamides, and chloramphenicol), DNA synthesis inhibitors (fluoroquinolones and quinolones), folic acid synthesis inhibitors (sulfonamides and diaminopyrimidines), cell wall synthesis inhibitors, polypeptide antibiotics, preservatives, and analgesics. Moreover, we show that the microbial responses to these drug combinations can be predicted using a simple formula that should be widely applicable in pharmacology. These findings offer a powerful, readily accessible method for the rational design of candidate therapies using combinations of more than two drugs. In addition, the accurate predictions of this framework raise the question of whether the multidrug response in bacteria obeys statistical, rather than chemical, laws for combinations larger than two.Molecular and Cellular Biolog

Torsional Directed Walks, Entropic Elasticity, and DNA Twist Stiffness

DNA and other biopolymers differ from classical polymers due to their torsional stiffness. This property changes the statistical character of their conformations under tension from a classical random walk to a problem we call the `torsional directed walk'. Motivated by a recent experiment on single lambda-DNA molecules [Strick et al., Science 271 (1996) 1835], we formulate the torsional directed walk problem and solve it analytically in the appropriate force regime. Our technique affords a direct physical determination of the microscopic twist stiffness C and twist-stretch coupling D relevant for DNA functionality. The theory quantitatively fits existing experimental data for relative extension as a function of overtwist over a wide range of applied force; fitting to the experimental data yields the numerical values C=120nm and D=50nm. Future experiments will refine these values. We also predict that the phenomenon of reduction of effective twist stiffness by bend fluctuations should be testable in future single-molecule experiments, and we give its analytic form.Comment: Plain TeX, harvmac, epsf; postscript available at http://dept.physics.upenn.edu/~nelson/index.shtm

Evidence for the Universal Scaling Behaviour of a Freely Relaxing DNA Molecule

Relaxation measurements on a fluorescently labelled free DNA molecule after stretching by a Poiseuille flow in a capillary vessel reveal universal scaling features: at intermediate times the scaling exponent of the decay law for the molecule length as a function of time is found to be 0.51 +/- 0.05. This law is in agreement with the prediction of the Brochard-Wyart "stem and flower" model for the relaxation of a stretched polymer chain.Molecular and Cellular BiologyPhysic

Perturbation Theory in k-Inflation Coupled to Matter

We consider k-inflation models where the action is a non-linear function of both the inflaton and the inflaton kinetic term. We focus on a scalar-tensor extension of k-inflation coupled to matter for which we derive a modified Mukhanov-Sasaki equation for the curvature perturbation. Significant corrections to the power spectrum appear when the coupling function changes abruptly along the inflationary trajectory. This gives rise to a modification of Starobinsky's model of perturbation features. We analyse the way the power spectrum is altered in the infrared when such features are present.Comment: 20 pages, 1 figur

Syntectonic mobility of supergene nickel ores of New Caledonia (Southwest Pacific). Evidence from faulted regolith and garnierite veins.

International audienceSupergene nickel deposits of New Caledonia that have been formed in the Neogene by weathering of obducted ultramafic rocks are tightly controlled by fracture development. The relationship of tropical weathering and tectonic structures, faults and tension gashes, have been investigated in order to determine whether fractures have play a passive role only, as previously thought; or alternatively, if brittle tectonics was acting together with alteration. From the observation of time-relationship, textures, and mineralogy of various fracture fills and fault gouges, it may be unambiguously established that active faulting has play a prominent role not only in facilitating drainage and providing room for synkinematic crystallisation of supergene nickel silicate, but also in mobilising already formed sparse nickel ore, giving birth to the very high grade ore nicknamed "green gold"