A search for Galactic transients disguised as gamma-ray bursts

A significant fraction of cosmological gamma-ray bursts (GRBs) are characterised by a fast rise and exponential decay (FRED) temporal structure. This is not a distinctive feature of this class, since it is observed in many Galactic transients and is likely descriptive of a sudden release of energy followed by a diffusion process. Possible evidence has recently been reported by Tello et al. (2012) for a Galactic contamination in the sample of FRED GRBs discovered with Swift. We searched for possible Galactic intruders disguised as FRED GRBs in the Swift catalogue up to September 2014. We selected 181 FRED GRBs (2/3 with unknown redshift) and considered different subsamples. We tested the degree of isotropy through the dipole and the quadrupole moment distributions, both with reference to the Galaxy and in a coordinate-system-independent way, as well as with the two-point angular autocovariance function. In addition, we searched for possible indicators of a Galactic origin among the spectral and temporal properties of individual GRBs. We found marginal (~3 sigma) evidence for an excess of FREDs with unknown redshift towards the Galactic plane compared with what is expected for an isotropic distribution corrected for the non-uniform sky exposure. However, when we account for the observational bias against optical follow-up observations of low-Galactic latitude GRBs, the evidence for anisotropy decreases to ~2 sigma. In addition, we found no statistical evidence for different spectral or temporal properties from the bulk of cosmological GRBs. We found marginal evidence for the presence of a disguised Galactic population among Swift GRBs with unknown redshift. The estimated fraction is f=(19 +- 11)%, with an upper limit of 34% (90% confidence).Comment: 6 pages, 4 figures, accepted by A&

Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1-dioxides

Sixteen new isothiazoloisoxazole 1,1-dioxides, one new isothiazolotriazole and one new isothiazolopyrazole have been synthesised by using 1,3-dipolar cycloadditions to isothiazole 1,1-dioxides. One sub-set of these isothiazoloisoxazoles showed low μM activity against a human breast carcinoma cell line, whilst a second sub-set plus the isothiazolotriazole demonstrated an interesting restricted rotation of sterically hindered bridgehead substituents. A thiazete 1,1-dioxide produced from one of the isothiazole 1,1-dioxides underwent conversion into an unknown 1,2,3-oxathiazolin-2-oxide upon treatment with Lewis acids, but was inert towards 1,3-dipoles and cyclopropenones. Six supporting crystal structures are included

Responsabilidad Social de la Empresa: análisis de las memorias en Argentina.

El presente trabajo refiere a un estudio desarrollado en el marco de una beca de ayudantía de investigación en la Universidad Nacional de Río Cuarto (UNRC), sobre Responsabilidad Social Empresarial (RSE). El objetivo central del estudio es analizar el grado de adopción de las pautas del Global Reporting Initiative (GRI) en la presentación de la información de Sostenibilidad por parte de las entidades radicadas en Argentina. Para ello se recurre al análisis documental de las Memorias de Sostenibilidad de las empresas de Telecomunicaciones, Mineras-Petroleras, Eléctricas y Bancarias presentadas en el año 2008 correspondientes al periodo 2007. This work was developed within the framework of a research scholarship at National University of Río Cuarto (UNRC). It’s about corporate social responsibility (SCR) Social Company Responsibility. The central objective of the study is to analyze the degree of adoption of guidelines on the submission of information of sustainability by entities in Argentina based in Global Reporting Initiative (GRI). For this we refer to sustainability annual reports documental analysis from different enterprises such as telecommunication, mining, petrol electricity and banking presented in 2008 (from year 2007).Responsabilidad Social Empresaria. Memorias de Sostenibilidad. Comunicación a los grupos de interés, indicadores de desempeño, Guía G3. Social company responsibility. Memories of sustainability. Communication interest groups indicators of performance, guide G3.

Experimental characterization of lithium-ion cell strain using laser sensors

The characterization of thickness change during operation of LFP/Graphite prismatic batteries is presented in this work. In this regard, current rate dependence, hysteresis behaviour between charge and discharge and correlation with phase changes are deepened. Experimental tests are carried out with a battery testing equipment correlated with optical laser sensors to evaluate swelling. Furthermore, thickness change is computed analytically with a mathematical model based on lattice parameters of the crystal structures of active materials. The results of the model are validated with experimental data. Thickness change is able to capture variations of the internal structure of the battery, referred to as phase change, characteristic of a certain state of charge. Furthermore, phase change shift is a characteristic of battery ageing. Being able to capture these properties with sensors mounted on the external surface the cell is a key feature for improving state of charge and state of health estimation in battery management system

Phase-Insensitive Scattering of Terahertz Radiation

The nonlinear interaction between Near-Infrared (NIR) and Terahertz pulses is principally investigated as a means for the detection of radiation in the hardly accessible THz spectral region. Most studies have targeted second-order nonlinear processes, given their higher efficiencies, and only a limited number have addressed third-order nonlinear interactions, mainly investigating four-wave mixing in air for broadband THz detection. We have studied the nonlinear interaction between THz and NIR pulses in solid-state media (specifically diamond), and we show how the former can be frequency-shifted up to UV frequencies by the scattering from the nonlinear polarisation induced by the latter. Such UV emission differs from the well-known electric-field-induced second harmonic (EFISH) one, as it is generated via a phase-insensitive scattering, rather than a sum- or difference-frequency four-wave-mixing process

Identification of the first enantiopure Rac1–Tiam1 protein–protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

A phospine free hydroarylation reaction applied to norbornene derivatives is described for the first time and was exploited for the regioselective gram scale synthesis of AR-148, a known Rac1\u2013Tiam1 PPI inhibitor. Umpolung conversion of the nitro group into free amine allowed the regiocontrol of the key arylation step via a long range effect. The effect of AR-148 in comparison with its enantiomers on Rac1 activation of has been evaluated and ( 12)AR-148 has been identified as the first enantiomerically pure inhibitor of Rac1\u2013Tiam1 PPI

Laser-assisted guiding of electric discharges around objects

Electric breakdown in air occurs for electric fields exceeding 34 kV/cm and results in a large current surge that propagates along unpredictable trajectories. Guiding such currents across specific paths in a controllable manner could allow protection against lightning strikes and high-voltage capacitor discharges. Such capabilities can be used for delivering charge to specific targets, for electronic jamming, or for applications associated with electric welding and machining. We show that judiciously shaped laser radiation can be effectively used to manipulate the discharge along a complex path and to produce electric discharges that unfold along a predefined trajectory. Remarkably, such laser-induced arcing can even circumvent an object that completely occludes the line of sight

Predictive Values of Transcutaneous Oxygen Tension for Above-the-ankle Amputation in Diabetic Patients with Critical Limb Ischemia

ObjectiveTo assess the values of transcutaneous oxygen tension (TcPO2) capable of predicting above-the-ankle amputation in diabetic patients diagnosed for critical limb ischemia (CLI) according to the criteria of the TransAtlantic Inter-Society Consensus.DesignRetrospective study.MethodsFrom January 1999 to December 2003, 564 diabetic patients were consecutively hospitalized for CLI in one limb. Revascularization with angioplasty or bypass graft was performed when possible and, if not possible, prostanoid therapy was used. In patients in whom therapies did not relieve the rest pain or the gangrene was extended above the Chopart joint, an above-the-ankle-amputation was performed. After treatment TcPO2 values were evaluated in all patients at the dorsum of the foot.ResultsFifty-five (9.8%) patients underwent an above-the-ankle amputation: 22 of 420 patients who underwent angioplasty, 17 of 117 patients who underwent bypass (14.5%) and 16 of 27 patients in whom revascularization was not possible. Post-treatment TcPO2, measured by a receiver operating characteristic (ROC) curve, showed a value 34mmHg as the best threshold for determining the need for revascularization, with an area under the curve of 0.89 (95%CI 0.85–0.94).Using logistic regression analysis the probability of above-the-ankle amputation for this threshold is 9.7% and reduces to 3% for TcPO2>40mmHg.ConclusionTcPO2 levels<34mmHg indicate the need for revascularization, while for values ≥ 34<40mmHg this need appears less pressing, although there remains a considerable probability of amputation. TcPO2 levels greater than 40mmHg suggest that revascularization is dependent on the severity of tissue loss and possible morbidity caused by the procedure