A Quantitative Non-radial Oscillation Model for the Subpulses in PSR B0943+10

In this paper, we analyze time series measurements of PSR B0943+10 and fit them with a non-radial oscillation model. The model we apply was first developed for total intensity measurements in an earlier paper, and expanded to encompass linear polarization in a companion paper to this one. We use PSR B0943+10 for the initial tests of our model because it has a simple geometry, it has been exhaustively studied in the literature, and its behavior is well-documented. As prelude to quantitative fitting, we have reanalyzed previously published archival data of PSR B0943+10 and uncovered subtle but significant behavior that is difficult to explain in the framework of the drifting spark model. Our fits of a non-radial oscillation model are able to successfully reproduce the observed behavior in this pulsar.Comment: 45 pages, 16 figures, accepted Ap

Planar laser-induced fluorescence imaging of OH in the exhaust of a bi-propellant thruster

Planar laser-induced fluorescence imaging of the hydroxyl radical has been performed on the flow produced by the exhaust of a subscale H2/O2 fueled bi-propellant rocket engine. Measurements were made to test the feasibility of OH (0,0) and (3,0) excitation strategies by using injection seeded XeCl and KrF excimer lasers, respectively. The flow is produced with hydrogen and oxygen reacting at a combustor chamber pressure of 5 atm which then exhausts to the ambient. The hydroxyl concentration in the exhaust flow is approximately 8 percent. Fluorescence images obtained by pumping the Q1(3) transition in the (0,0) band exhibited very high signals but also showed the effect of laser beam absorption. To obtain images when pumping the P1(8) transition in the (3,0) band it was necessary to use exceptionally fast imaging optics and unacceptably high intensifier gains. The result was single-shot images which displayed a signal-to-noise ratio of order unity or less when measured on a per pixel basis

Effective Elastic Moduli in Solids with High Crack Density

We investigate the weakening of elastic materials through randomly distributed circles and cracks numerically and compare the results to predictions from homogenization theories. We find a good agreement for the case of randomly oriented cracks of equal length in an isotropic plane-strain medium for lower crack densities; for higher densities the material is weaker than predicted due to precursors of percolation. For a parallel alignment of cracks, where percolation does not occur, we analytically predict a power law decay of the effective elastic constants for high crack densities, and confirm this result numerically.Comment: 8 page

The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers

A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons

Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset.

Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal glomerulus. To identify additional candidate genes involved in glomerular function in humans we generated a human renal glomerulus-enriched gene expression dataset (REGGED) by comparing gene expression profiles from human glomeruli and tubulointerstitium obtained from six transplant living donors using Affymetrix HG-U133A arrays. This analysis resulted in 677 genes with prominent overrepresentation in the glomerulus. Genes with 'a priori' known prominent glomerular expression served for validation and were all found in the novel dataset (e.g. CDKN1, DAG1, DDN, EHD3, MYH9, NES, NPHS1, NPHS2, PDPN, PLA2R1, PLCE1, PODXL, PTPRO, SYNPO, TCF21, TJP1, WT1). The mRNA expression of several novel glomerulus-enriched genes in REGGED was validated by qRT-PCR. Gene ontology and pathway analysis identified biological processes previously not reported to be of relevance in glomeruli of healthy human adult kidneys including among others axon guidance. This finding was further validated by assessing the expression of the axon guidance molecules neuritin (NRN1) and roundabout receptor ROBO1 and -2. In diabetic nephropathy, a prevalent glomerulopathy, differential regulation of glomerular ROBO2 mRNA was found.In summary, novel transcripts with predominant expression in the human glomerulus could be identified using a comparative strategy on microdissected nephrons. A systematic analysis of this glomerulus-specific gene expression dataset allows the detection of target molecules and biological processes involved in glomerular biology and renal disease

Active Brownian Motion Tunable by Light

Active Brownian particles are capable of taking up energy from their environment and converting it into directed motion; examples range from chemotactic cells and bacteria to artificial micro-swimmers. We have recently demonstrated that Janus particles, i.e. gold-capped colloidal spheres, suspended in a critical binary liquid mixture perform active Brownian motion when illuminated by light. In this article, we investigate in some more details their swimming mechanism leading to active Brownian motion. We show that the illumination-borne heating induces a local asymmetric demixing of the binary mixture generating a spatial chemical concentration gradient, which is responsible for the particle's self-diffusiophoretic motion. We study this effect as a function of the functionalization of the gold cap, the particle size and the illumination intensity: the functionalization determines what component of the binary mixture is preferentially adsorbed at the cap and the swimming direction (towards or away from the cap); the particle size determines the rotational diffusion and, therefore, the random reorientation of the particle; and the intensity tunes the strength of the heating and, therefore, of the motion. Finally, we harness this dependence of the swimming strength on the illumination intensity to investigate the behaviour of a micro-swimmer in a spatial light gradient, where its swimming properties are space-dependent

Evidence from K2 for rapid rotation in the descendant of an intermediate-mass star

Using patterns in the oscillation frequencies of a white dwarf observed by K2, we have measured the fastest rotation rate, 1.13(02) hr, of any isolated pulsating white dwarf known to date. Balmer-line fits to follow-up spectroscopy from the SOAR telescope show that the star (SDSSJ0837+1856, EPIC 211914185) is a 13,590(340) K, 0.87(03) solar-mass white dwarf. This is the highest mass measured for any pulsating white dwarf with known rotation, suggesting a possible link between high mass and fast rotation. If it is the product of single-star evolution, its progenitor was a roughly 4.0 solar-mass main-sequence B star; we know very little about the angular momentum evolution of such intermediate-mass stars. We explore the possibility that this rapidly rotating white dwarf is the byproduct of a binary merger, which we conclude is unlikely given the pulsation periods observed.Comment: 5 pages, 4 figure, 1 table; accepted for publication in The Astrophysical Journal Letter

White Dwarf Rotation as a Function of Mass and a Dichotomy of Mode Linewidths: Kepler Observations of 27 Pulsating DA White Dwarfs Through K2 Campaign 8

We present photometry and spectroscopy for 27 pulsating hydrogen-atmosphere white dwarfs (DAVs, a.k.a. ZZ Ceti stars) observed by the Kepler space telescope up to K2 Campaign 8, an extensive compilation of observations with unprecedented duration (>75 days) and duty cycle (>90%). The space-based photometry reveals pulsation properties previously inaccessible to ground-based observations. We observe a sharp dichotomy in oscillation mode linewidths at roughly 800 s, such that white dwarf pulsations with periods exceeding 800 s have substantially broader mode linewidths, more reminiscent of a damped harmonic oscillator than a heat-driven pulsator. Extended Kepler coverage also permits extensive mode identification: We identify the spherical degree of 61 out of 154 unique radial orders, providing direct constraints of the rotation period for 20 of these 27 DAVs, more than doubling the number of white dwarfs with rotation periods determined via asteroseismology. We also obtain spectroscopy from 4m-class telescopes for all DAVs with Kepler photometry. Using these homogeneously analyzed spectra we estimate the overall mass of all 27 DAVs, which allows us to measure white dwarf rotation as a function of mass, constraining the endpoints of angular momentum in low- and intermediate-mass stars. We find that 0.51-to-0.73-solar-mass white dwarfs, which evolved from 1.7-to-3.0-solar-mass ZAMS progenitors, have a mean rotation period of 35 hr with a standard deviation of 28 hr, with notable exceptions for higher-mass white dwarfs. Finally, we announce an online repository for our Kepler data and follow-up spectroscopy, which we collect at http://www.k2wd.org.Comment: 33 pages, 31 figures, 5 tables; accepted for publication in ApJS. All raw and reduced data are collected at http://www.k2wd.or