The late Ordovician Soom Shale Lagerstȁtte: an extraordinary post-glacial fossil and sedimentary record

Fossils of the Late Ordovician Soom Shale Lagerstätte are characterized by exceptional preservation of their soft tissues in clay minerals. The low-diversity community lived in an unusual cold-water setting, dominated by anoxic bottom waters, in the immediate aftermath of the Hirnantian glaciation. Giant conodonts represented by complete tooth sets, and one with trunk musculature and liver preserved, unarmoured jawless fish, lobopods and enigmatic taxa are some of the more important fossils. Furthermore, this Lagerstätte also preserves biomineralized Ordovician taxa such as brachiopods, orthoconic nautiloids and trilobites. It is important in capturing the only known examples of many taxa, extending temporal ranges of others and providing a unique glimpse of a post-glacial refugium, at a time when other Lagerstätten are unknown

Comparison and contrast in perceptual categorization

People categorized pairs of perceptual stimuli that varied in both category membership and pairwise similarity. Experiments 1 and 2 showed categorization of 1 color of a pair to be reliably contrasted from that of the other. This similarity-based contrast effect occurred only when the context stimulus was relevant for the categorization of the target (Experiment 3). The effect was not simply owing to perceptual color contrast (Experiment 4), and it extended to pictures from common semantic categories (Experiment 5). Results were consistent with a sign-and-magnitude version of N. Stewart and G. D. A. Brown's (2005) similarity-dissimilarity generalized context model, in which categorization is affected by both similarity to and difference from target categories. The data are also modeled with criterion setting theory (M. Treisman & T. C. Williams, 1984), in which the decision criterion is systematically shifted toward the mean of the current stimuli

Anti-tumour therapeutic efficacy of OX40L in murine tumour model

OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c.) established colon (CT26) and breast (4T1) carcinomas. Vaccination with OX40L was significantly enhanced by combination treatment with intra-tumour injection of a disabled infectious single cycle-herpes simplex virus (DISC-HSV) vector encoding murine granulocyte macrophage-colony stimulating factor (mGM-CSF). Tumour rejection in response to OX40L therapy required functional CD4+ and CD8+ T cells and correlated with splenocyte cytotoxic T lymphocytes (CTLs) activity against the AH-1 gp70 peptide of the tumour associated antigen expressed by CT26 cells. These results demonstrate the potential role of the OX40L in cancer immunotherapy

Predominant Influence of Environmental Determinants on the Persistence and Avidity Maturation of Antibody Responses to Vaccines in Infants

BackgroundImmune responses are complex traits influenced by genetic and environmental factors. We previously reported that genetic factors control early antibody responses to vaccines in Gambian infants. For the present study, we evaluated the determinants of the memory phase of immunoglobulin G (IgG) responses MethodsAntibody responses to tetanus toxoid (TT), measles vaccines, and environmental antigens (total IgG levels) were measured in 210 Gambian twin pairs recruited at birth. Intrapair correlations for monozygous and dizygous pairs were compared to estimate the environmental and genetic components of variations in response ResultsIn contrast to antibody responses measured in infants at age 5 months, 1 month after immunization, no significant contribution of genetic factors to anti-TT antibody and total IgG levels was detected at age 12 months. Genetic factors controlled measles antibody responses in 12-month-old infants, which indicates that the increasing influence of environmental determinants on anti-TT responses was not related to the older age of the children but, rather, to the time elapsed since immunization. Environmental factors also predominantly controlled affinity maturation and the production of high-avidity antibodies to TT ConclusionsGenetic determinants control the early phase of the vaccine antibody response in Gambian infants, whereas environmental determinants predominantly influence antibody persistence and avidity maturatio

RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly

A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia. Conversely, a greater understanding of essential mechanisms involved in tail formation may offer contraceptive opportunities, or more broadly, therapeutic strategies for global cilia defects. Here we have identified Rab-like 2 (RABL2) as an essential requirement for sperm tail assembly and function. RABL2 is a member of a poorly characterized clade of the RAS GTPase superfamily. RABL2 is highly enriched within developing male germ cells, where it localizes to the mid-piece of the sperm tail. Lesser amounts of Rabl2 mRNA were observed in other tissues containing motile cilia. Using a co-immunoprecipitation approach and RABL2 affinity columns followed by immunochemistry, we demonstrated that within developing haploid germ cells RABL2 interacts with intra-flagella transport (IFT) proteins and delivers a specific set of effector (cargo) proteins, including key members of the glycolytic pathway, to the sperm tail. RABL2 binding to effector proteins is regulated by GTP. Perturbed RABL2 function, as exemplified by the Mot mouse line that contains a mutation in a critical protein-protein interaction domain, results in male sterility characterized by reduced sperm output, and sperm with aberrant motility and short tails. Our data demonstrate a novel function for the RABL protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum.This work was supported by grants from the NHMRC to MKO (#606445) and CJO, the Australian Research Council (MKO, RJA, and CJO), the New South Wales Cancer Council (CJO), Cancer Institute New South Wales (CJO), Banque Nationale de Paris-Paribas Australia and New Zealand (CJO), RT Hall Trust (CJO), and the National Breast Cancer Foundation (CJO). JCYL is the recipient of a NHMRC PhD scholarship. MKO and CJO are the recipients of NHMRC Senior Research Fellowships (#545805 and #481310). CCG is the recipient an NHMRC Australia Fellowship. JCW is the recipient of an Australian Research Council Federation Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Synthesis and characterisation of Ca1-xCexZrTi2-2xCr2xO7: Analogue zirconolite wasteform for the immobilisation of stockpiled UK plutonium

A series of Ca1-xCexZrTi2-2xCr2xO7 zirconolite ceramics (0 ≤ x ≤ 0.35) were reactively sintered in air at 1350 °C for 20 h. Single phase zirconolite-2M was formed for x ≤ 0.15, with Cr2O3 and an undesirable Ce-bearing perovskite phase present above x = 0.20. Electron diffraction analysis confirmed that the zirconolite-2M polytype was maintained over the solid solution. X-ray absorption near edge structure (XANES) data determined that between 10–20% Ce was speciated as Ce3+, and Cr was present uniformly as Cr3+ with near edge features consistent with occupation of octahedral sites within the zirconolite-2M structure. A sample corresponding to x = 0.20 was processed by reactive spark plasma sintering (RSPS), with a rapid processing time of less than 1 h. XANES data confirmed complete reduction to Ce3+ during RSPS, promoting the formation of a Ce-bearing perovskite, comprising 19.3 ± 0.4 wt. % of the phase assemblage

Home-body/Kitchen Table Solo Show (2020 – 23) exhibited in 'Rupture, Rapture: Womxn in Collage'

Home-body/Kitchen Table Solo Show, is a composite installation of a series of works made during the pandemic - from within sixty weeks of shielding: In this context, one type of interior is the shell - a networked container maintained by labour and producing waste, reaching for community and receiving shopping. Another interior is the body within, navigating complex dependencies and desires. These works were all made on the edges of a kitchen table and draw on Mendelson's, often positive, experiences of the home-as-skin. A new, painted platform was produced for this exhibition, allowing the 'kitchen table' itself to fold into the work. ‘Rupture, Rapture: Womxn in Collage’ is a publication, residency and survey exhibition. 25 August - 23 September 2023 Patricia Fleming Gallery, Glasgow 'Rupture, Rapture: Womxn in Collage' brings together new and existing works, alongside special commissions to showcase collage in an expanded field, incorporating multimedia, sculpture, sound and performance art. Displaying over twenty collage works by 14 womxn artists, this exhibition challenges the notion of collage as a fixed category or form—instead revealing collage as a feminist praxis of transformation, rupture, and collision. Commissioned works will be presented by 16NSt resident artists’ Edie Baker, Gabrielle Lockwood Estrin, and Hannan Jones, developed in-situ at Patricia Fleming Gallery, along with a collage installation and performance from Jen DeNike (16th Sep), exhibiting the artist’s work in Scotland for the first time. New and historic work will be shown by Sam Ainsley, Claire Barclay, Barbara F. Kendrick, Janie Nicoll, Kate V. Robertson, and Catherine Street. Significant existing works will be displayed by Louise Hopkins, Zoë Mendelson, Victoria Morton, and Alberta Whittle. Curated by Aga Paulina Młyńczak and Nell Cardozo with support from Kelly Rappleye (16NSt Curatorial Collective), Sam Ainsley (artist and former Head of Glasgow School of Art’s MFA) and artist Janie Nicoll, this survey exhibition hosted by Patricia Fleming Gallery displays a diverse repertoire of over twenty collage works, several of which have never been shown before. By putting multimedia sculptural installations together with paper works, Młyńczak and Cardozo aim to expand the notion of what contemporary collage can do. Displaying work from womxn artists at various stages in their careers who use expanded collage processes, this exhibition aims to create an inter-generational feminist dialogue. 16NSt’s Rupture, Rapture: Womxn in Collage project comprises an emerging artists’ residency and publication alongside this exhibition to trace an alternative, feminist lineage of collage in everyday practices by womxn and queer communities, which have traditionally been refused art historical recognition, from scrapbooking to collage poetry. These homegrown acts of cultural transformation inform the ethos of cross-media experimentation and re-assemblage of everyday material that is shared across the works in this exhibition. PUBLICATION Accompanying the exhibition will launch a limited-release publication ‘RUPTURE, RAPTURE’, featuring rarely-seen collage works by Maud Sulter alongside a critical survey of contemporary womxn’s collage in Scotlan

Global Ends, Local Means: cross-national homogeneity in professional service firms

An expanding institutionalist literature on professional service firms (PSFs) emphasizes that these are ridden by contradictions, paradoxes and conflicting logics. More specifically, literature looking at PSFs in a global context has highlighted how these contradictions prevent firms from becoming truly global in nature. What it takes to make partner in the Big 4 is at the core of such interrogations because partners belong to global firms yet are promoted at the national level. We undertake a cross-country comparison of partner promotion processes in Big 4 PSFs in Canada, France, Spain and the UK. Synthesizing existing institutionalist work with Bourdieusian theory, our results suggest that PSFs in different countries resemble each other very closely in terms of the requirements demanded of their partners. Although heterogeneity can be observed in the way in which different forms of capital are converted into each other, we show there is an overall homogeneity in that economic capital hurdles are the most significant, if not the sole, set of criteria upon which considerations of partnership admissions are based