La gestión de la calidad en las organizaciones de educación superior. Aportación del enfoque de la Organización Internacional de Normalización (ISO)

La universidad española se encuentra ante el desafío de la convergencia europea en materia de educación superior. La Declaración de Bolonia (1999), en la que se establecen las bases del EEES, plantea a los países comprometidos una serie de objetivos estratégicos en materia de calidad, con claras intenciones normalizadoras para facilitar la comparabilidad. En este artículo, se expone el concepto moderno de calidad, su paulatina incorporación a la cultura de las organizaciones de educación superior y se describe el enfoque normativo de la Organización Internacional de Normalización (ISO) para la gestión de un Sistema de la Calidad, según la norma internacional ISO 9001:2000, que garantice la calidad de un producto formativo que satisfaga los requisitos de los estudiantes universitarios y demás partes interesadas, con un valor añadido superior al del simple cumplimiento de los requisitos de la acreditación

Reconstrucción de dos premolares con postes intramandibulares e incrustaciones E-Max

Depto. de Odontología Conservadora y PrótesisFac. de OdontologíaTRUEsubmitte

Microservicios para Big Data Genómico en la Nube

El crecimiento de la Genómica hace prever que pronto se convertirá en la disciplina con mayor demanda de almacenamiento de datos. El procesamiento de estos datos en la Medicina de Precisión plantea a la Genómica nuevos retos computacionales, dando ha dado lugar al Big Data Genómico y a la necesidad de almacenar y procesar estos datos en la Nube. De la evolución de las arquitecturas SOA y el auge de la tecnología de contenedores surgen las arquitecturas basadas en microservicios como un patrón de diseño de aplicaciones de potencial aplicabilidad en el Big Data genómico. El objetivo de este TFM es recopilar los requisitos necesarios para dar soporte al ciclo de vida de una aplicación basada en microservicios genómicos en la nube y, tras realizar una revisión de las tecnologías existentes, proponer la solución más adecuada para el despliegue y gestión de microservicios que abarque desde el proceso de desarrollo, la integración y entrega continua y la gestión del ciclo de vida de los mismos.Genomics is soon expected to become the discipline with the greatest demand for data storage. The processing of these data in the Precision Medicine field outline new computational challenges to Genomics, giving rise to the Genomic Big Data and the need to store and process these data in the Cloud. From the evolution of SOA architectures and the rise of containers technology, Microservices architecture emerge as design pattern for applications with potential applicability in the genomic Big Data. The objective of this TFM is to gather the requirements needed to support the life cycle of an application based on genomic microservices in the cloud and, after conducting a review of existing technologies, propose the most appropriate solution for the deployment and management of microservices covering from the process of development, the integration and continuous delivery and the management of the cycle of life of Genomic Microservices in the Cloud.Cidad Vila, A. (2018). Microservicios para Big Data Genómico en la Nube. http://hdl.handle.net/10251/109390TFG

Retinoblastoma unilateral. Estudio epidemiológico, clínico y genético en la población española entre 1996 y 2013

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 11-02-2016Esta tesis tiene embargado el acceso al texto completo hasta el 11-08-201

Does the Central Bank’s perception regarding the state of the economy affect industrial entrepreneurs’ expectations? Are such expectations important for investment? Evidence from Brazil

AbstractStudies on central bank communication in emerging countries are still scarce. There are no studies regarding the influence of central bank communication on entrepreneurs’ expectations. This paper contributes to the literature in the following aspects: (a) based on the minutes of the Monetary Policy Committee (Copom) meetings, we develop an indicator that reveals the Central Bank’s perception related to the state of the economy, and (b) we analyze the influence of the Central Bank’s communication on the expectations and confidence of entrepreneurs, and the influence of such expectations on the aggregate investment. The findings reveal that the information provided by the Central Bank of Brazil regarding the economic environment affects entrepreneurs’ expectations and that aggregate investment is influenced by these expectations. KeywordsCommunication; expectation; monetary policy TÍTULO EM PORTUGUÊSAs percepções do Banco Central em relação ao estado da economia afetam as expectativas dos empresários da indústria? Essas expectativas são importantes para o investimento? Evidências do BrasilResumoEstudos sobre comunicação dos bancos centrais em países emergentes ainda são escassos. Não existem pesquisas sobre a influência da comunicação dos bancos centrais sobre as expectativas dos empresários. Este trabalho contribui para a literatura nos seguintes aspectos: (a) com base nas atas das reuniões do Comitê de Política Monetária (Copom), desenvolve um indicador que revela a percepção do Banco Central relacionada ao estado da economia, e (b) analisa a influência da comunicação do Banco Central sobre as expectativas e a confiança dos empresários e a influência de tais expectativas sobre o investimento agregado. Os resultados revelam que as informações fornecidas pelo Banco Central do Brasil em relação ao ambiente econômico afetam as expectativas dos empresários e que o investimento agregado é influenciado por essas expectativas. Palavras-chaveComunicação; expectativa; política monetáriaClassificação JEL: E22, E52, E58Artigo recebido em jul. 2014 e aceito para publicação em jan. 2016

Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension

Producción CientíficaIncreased vascular tone in essential hypertension involves a sustained rise in total peripheral resistance. A model has been proposed in which the combination of membrane depolarization and higher L‐type Ca2+ channel activity generates augmented Ca2+ influx into vascular smooth muscle cells (VSMCs), contraction and vasoconstriction. The search for culprit ion channels responsible for membrane depolarization has provided several candidates, including members of the canonical transient receptor potential (TRPC) family. TRPC3 and TRPC6 are diacylglycerol‐activated, non‐selective cationic channels contributing to stretch‐ or agonist‐induced depolarization. Conflicting information exists regarding changes in TRPC3/TRPC6 functional expression in hypertension. However, although TRPC3‐TRPC6 channels can heteromultimerize, the possibility that differences in their association pattern may change their functional contribution to vascular tone is largely unexplored. We probe this hypothesis using a model of essential hypertension (BPH mice; blood pressure high) and its normotensive control (BPN mice; blood pressure normal). First, non‐selective cationic currents through homo‐ and heterotetramers recorded from transfected Chinese hamster ovary cells indicated that TRPC currents were sensitive to the selective antagonist Pyr10 only when TRPC6 was present, whereas intracellular anti‐TRPC3 antibody selectively blocked TRPC3‐mediated currents. In mesenteric VSMCs, basal and agonist‐induced currents were more sensitive to Pyr3 and Pyr10 in BPN cells. Consistently, myography studies showed a larger Pyr3/10‐induced vasodilatation in BPN mesenteric arteries. mRNA and protein expression data supported changes in TRPC3 and TRPC6 proportions and assembly, with a higher TRPC3 channel contribution in BPH VSMCs that could favour cell depolarization. These differences in functional and pharmacological properties of TRPC3 and TRPC6 channels, depending on their assembly, could represent novel therapeutical opportunities.Instituto de Salud Carlos III (project RD12/0042/0006)Programa Estatal de Investigación (project BFU2013-45867-R

High blood pressure associates with the remodelling of inward rectifier K+ channels in mice mesenteric vascular smooth muscle cells

Producción CientíficaThe increased vascular tone that defines essential hypertension is associated with depolarization of vascular smooth muscle cells (VSMCs) and involves a change in the expression profile of ion channels promoting arterial contraction. As a major regulator of VSMC resting membrane potential (VM), K+channel activity is an important determinant of vascular tone and vessel diameter. However, hypertension-associated changes in the expression and/or modulation of K+channels are poorly defined, due to their large molecular diversity and their bed-specific pattern of expression. Moreover, the impact of these changes on the integrated vessel functionand their contribution to the development of altered vascular tone under physiological conditions need to be confirmed. Hypertensive (BPH) and normotensive (BPN) mice strains obtained by phenotypic selection were used to explore whether changes in the functional expression of VSMC inward rectifier K+channels contribute to the more depolarized resting VM and the increased vascular reactivity of hypertensive arteries. We determined the expression levels of inward rectifierK+channel mRNA in several vascular beds from BPN and BPH animals, and their functional contribution to VSMC excitability and vascular tone in mesenteric arteries. We found a decrease in the expression of Kir2.1, Kir4.1, Kir6.x and SUR2 mRNA in BPH VSMCs, and a decreased functional contribution of both KIRand KATP channels in isolated BPH VSMCs. However, only the effect of KATP channel modulators was impaired when exploring vascular tone, suggesting that decreased functional expression of KATP channels may be an important element in the remodelling of VSMCs in essential hypertension.Ministerio de Sanidad, Consumo y Bienestar Social - Instituto de Salud Carlos III (grant R006/009)Ministerio de Ciencia, Innovación y Universidades (grant BFU2010-15898)Junta de Castilla y León (grant VA094A11-2

Characterization of Ion Channels Involved in the Proliferative Response of Femoral Artery Smooth Muscle Cells

31 páginas, 6 figuras, adicionales 6 figuras y 3 tablas.[Objective]: Vascular smooth muscle cells (VSMCs) contribute significantly to occlusive vascular diseases by virtue of their ability to switch to a noncontractile, migratory, and proliferating phenotype. Although the participation of ion channels in this phenotypic modulation (PM) has been described previously, changes in their expression are poorly defined because of their large molecular diversity. We obtained a global portrait of ion channel expression in contractile versus proliferating mouse femoral artery VSMCs, and explored the functional contribution to the PM of the most relevant changes that we observed. [Methods and Results]: High-throughput real-time polymerase chain reaction of 87 ion channel genes was performed in 2 experimental paradigms: an in vivo model of endoluminal lesion and an in vitro model of cultured VSMCs obtained from explants. mRNA expression changes showed a good correlation between the 2 proliferative models, with only 2 genes, Kv1.3 and Kvβ2, increasing their expression on proliferation. The functional characterization demonstrates that Kv1.3 currents increased in proliferating VSMC and that their selective blockade inhibits migration and proliferation. [Conclusion]: These findings establish the involvement of Kv1.3 channels in the PM of VSMCs, providing a new therapeutical target for the treatment of intimal hyperplasia.This work was supported by Ministerio de Sanidad, Instituto de Salud Carlos III grants R006/009 (Red Heracles), FS041139-0 (M.R.), and PI041044 (J.R.L.-L.); Ministerio de Educacio´n y Ciencia grants BFU2004-05551 (M.T.P.-G.) and BFU2007-61524 (J.R.L.-L.); and Junta de Castilla y Leon grant GR242. Dr Moreno-Domínguez is a fellow of the Spanish Ministerio de Educacion y Ciencia.Peer reviewe