21 research outputs found
Studies of the Formation of All-carbon Quaternary Centres, en route to Lyngbyatoxin A. A Comparison of Phenyl and 7-Substituted Indole Systems
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Toward the enantioselective total synthesis of lyngbyatoxin A: on the stereocontrolled introduction of the quaternary stereogenic centre
No full textStereoselective Quaternary Center Construction via Atom-Transfer Radical Cyclization Using Silicon Tethers on Acyclic Precursors
No full textAffinity purification and characterization of a G-protein coupled receptor, Saccharomyces cerevisiae Ste2p
No full textSynthesis and reactivity of metal carbene complexes with heterobiaryl spacer substituents
No full textThe synthesis of Azadirachtin: a potent insect antifeedant
No full textWe describe in full the first synthesis of the potent insect antifeedant azadirachtin through a highly convergent approach. An O-alkylation reaction is used to unite decalin ketone and propargylic mesylate fragments, after which a Claisen rearrangement constructs the central C8[BOND]C14 bond in a stereoselective fashion. The allene which results from this sequence then enables a second critical carbon[BOND]carbon bond forming event whereby the [3.2.1] bicyclic system, present in the natural product, is generated via a 5-exo-radical cyclisation process. Finally, using knowledge gained through our early studies into the reactivity of the natural product, a series of carefully designed steps completes the synthesis of this challenging molecule
Konjugierte Umpolung von β,β-disubstituierten Enalen durch duale Katalyse mit N-heterocyclischen Carbenen und Brønsted-Säuren: einfacher Aufbau benachbarter, quartärer Stereozentren
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