Mécanismes de la transmission synaptique GABAergique des cellules pyramidales et interneurones de l'hippocampe chez le rat

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders

Opérationnaliser, aux plans théorique et pratique, l'intégration de l'éthique dans le processus d'ETMIS : Exposé de la revue systématique

International audienc

Opérationnaliser, aux plans théorique et pratique, l'intégration de l'éthique dans le processus d'ETMIS : Exposé de la revue systématique

International audienc

Value of statistical life year in extreme poverty: a randomized experiment of measurement methods in rural Burkina Faso

Background: Value of a Statistical Life Year (VSLY) provides an important economic measure of an individual’s trade-off between health risks and other consumption, and is a widely used policy parameter. Measuring VSLY is complex though, especially in low-income and low-literacy communities. Methods: Using a large randomized experiment (N = 3027), we study methodological aspects of stated-preference elicitation with payment cards (price lists) in an extreme poverty context. In a 2 × 2 design, we systematically vary whether buying or selling prices are measured, crossed with the range of the payment card. Results: We find substantial effects of both the pricing method and the list range on elicited VSLY. Estimates of the gross domestic product per capita multiplier for VSLY range from 3.5 to 33.5 depending on the study design. Importantly, all estimates are economically and statistically significantly larger than the current World Health Organization threshold of 3.0 for cost-effectiveness analyses. Conclusions: Our results inform design choice in VSLY measurements, and provide insight into the potential variability of these measurements and possibly robustness checks

Méthodologie et orientations du projet : Opérationnaliser, aux plans théorique et pratique, l'intégration de l'éthique dans le processus d’évaluation des technologies et des modes d'intervention en santé (ETMIS)

National audienc

Bologna resilient city: from the adaptation plan to local actions | Bologna città resiliente: dal piano di adattamento alle azioni locali

The possible effects of climate change in urbanized areas – evidenced by several studies – led the City of Bologna to adopt a Climate Change Adaptation Plan to assess potential risks and vulnerabilities as a basis for adaptation actions prioritizing interventions through a coordinated local strategy. This paper summarizes some measures implemented at local level in collaboration with the Department of Architecture of the University of Bologna and, in particular, the pilot actions for urban greening developed within the European project H2020 - ROCK and the proposals for intervention included made during the “Design for Adaptation” project. Resilient Urban Communities” PhD Climate KIC summer school

Value of statistical life year in extreme poverty: A randomized experiment of measurement methods in rural Burkina Faso

Background Value of a Statistical Life Year (VSLY) provides an important economic measure of an individual's trade-off between health risks and other consumption, and is a widely used policy parameter. Measuring VSLY is complex though, especially in low-income and low-literacy communities. Methods Using a large randomized experiment (N = 3027), we study methodological aspects of stated-preference elicitation with payment cards (price lists) in an extreme poverty context. In a 2 x 2 design, we systematically vary whether buying or selling prices are measured, crossed with the range of the payment card. Results We find substantial effects of both the pricing method and the list range on elicited VSLY. Estimates of the gross domestic product per capita multiplier for VSLY range from 3.5 to 33.5 depending on the study design. Importantly, all estimates are economically and statistically significantly larger than the current World Health Organization threshold of 3.0 for cost-effectiveness analyses. Conclusions Our results inform design choice in VSLY measurements, and provide insight into the potential variability of these measurements and possibly robustness checks