Intelligent Ground Vehicle Competition

The Intelligent Ground Vehicle Competition (IGVC) draws teams from various universities to compete in the annual autonomous vehicle challenge at the Oakland University campus. To compete, a vehicle must be fully autonomous and can navigate a course designated by various obstacles and painted white lines. Some design challenges are motor control, navigation, environment sensing and safety. A complex navigation system will utilize several tools including a high-precision differential GPS. The vehicle’s surroundings will be mapped using a combination of Light Detection and Ranging (LiDAR) and computer-vision enabled imaging. To comply with IGVC rules, the vehicle must also follow several safety requirements such as physical and wireless emergency stop, safety lighting, and the ability to assume manual control. By fulfilling these design challenges, the design team is seeking to compete in the 2017 Intelligent Ground Vehicle Competition

The multispace adaptable building concept and its extension into mass customisation

UK government Policy Planning Guidance promotes optimum use of the existing building stock through mixed use in urban centres and encourages conversion of redundant office and retail space into leisure, service or residential uses. Whilst social pressures are evident in the push to more effectively utilise existing building stock, new building stock also has to meet the commercial requirements of the client, which often translates into maximum occupancy of the building. This is encouraging greater innovation in the design of new buildings to allow change of use throughout the structure’s lifetime. This paper describes the concepts surrounding an adaptable design for new buildings, along with a review of factors influencing the mode of use. The major physical parameters of storey height, building proximity, plan depth, structural design, services, fire safety, cladding and noise abatement are evaluated in the context of adaptable building use. In addition to improved building utilisation, the UK government has identified a weakness in the productivity of the construction industry. The report ‘Rethinking Construction’ (Egan, 1998) suggested that up to 80% of inputs into buildings are repeated and that parallels should be drawn with the designing and planning of new cars in the automotive sector. This suggests that improvements in quality, cost and delivery time of new structures could be achieved through mass-customisation incorporating a significant element of pre-design

Humber Bridge: suppressing main cable corrosion by means of dehumidification

The Humber Bridge officially opened in 1981 and carries 4 lanes of traffic across the Humber Estuary between Barton and Hessle to the west of Kingston-upon-Hull in East Yorkshire, England. When opened, it was the longest span suspension bridge in the world with a main span of 1410m but it currently ranks as the fifth longest span in the world. Humber Bridge Board (HBB) commissioned an internal inspection of the main cables following the discovery of extensive corrosion and broken wires in the main cables of two older suspension bridges in the UK. The main cable inspections revealed widespread, if generally light corrosion with localised pitting and a very small number of broken wires. Dehumidification of suspension bridge main cables is becoming standard practice not only in the UK but worldwide. This paper examines the installation of the Humber Bridge system, discusses the mechanics of atmospheric steel corrosion and explains how the cable dehumidification system will suppress future corrosion

How and When Socially Entrepreneurial Nonprofit Organizations Benefit From Adopting Social Alliance Management Routines to Manage Social Alliances?

Social alliance is defined as the collaboration between for-profit and nonprofit organizations. Building on the insights derived from the resource-based theory, we develop a conceptual framework to explain how socially entrepreneurial nonprofit organizations (SENPOs) can improve their social alliance performance by adopting strategic alliance management routines. We test our framework using the data collected from 203 UK-based SENPOs in the context of cause-related marketing campaign-derived social alliances. Our results confirm a positive relationship between social alliance management routines and social alliance performance. We also find that relational mechanisms, such as mutual trust, relational embeddedness, and relational commitment, mediate the relationship between social alliance management routines and social alliance performance. Moreover, our findings suggest that different types of social alliance motivation can influence the impact of social alliance management routines on different types of the relational mechanisms. In general, we demonstrate that SENPOs can benefit from adopting social alliance management routines and, in addition, highlight how and when the social alliance management routines–social alliance performance relationship might be shaped. Our study offers important academic and managerial implications, and points out future research directions

Designing a complex intervention for dementia case management in primary care

Background: Community-based support will become increasingly important for people with dementia, but currently services are fragmented and the quality of care is variable. Case management is a popular approach to care co-ordination, but evidence to date on its effectiveness in dementia has been equivocal. Case management interventions need to be designed to overcome obstacles to care co-ordination and maximise benefit. A successful case management methodology was adapted from the United States (US) version for use in English primary care, with a view to a definitive trial. Medical Research Council guidance on the development of complex interventions was implemented in the adaptation process, to capture the skill sets, person characteristics and learning needs of primary care based case managers. Methods: Co-design of the case manager role in a single NHS provider organisation, with external peer review by professionals and carers, in an iterative technology development process. Results: The generic skills and personal attributes were described for practice nurses taking up the case manager role in their workplaces, and for social workers seconded to general practice teams, together with a method of assessing their learning needs. A manual of information material for people with dementia and their family carers was also created using the US intervention as its source. Conclusions: Co-design produces rich products that have face validity and map onto the complexities of dementia and of health and care services. The feasibility of the case manager role, as described and defined by this process, needs evaluation in ‘real life’ settings

Conceptualising sustainability in UK urban Regeneration: a discursive Formation

Despite the wide usage and popular appeal of the concept of sustainability in UK policy, it does not appear to have challenged the status quo in urban regeneration because policy is not leading in its conceptualisation and therefore implementation. This paper investigates how sustainability has been conceptualised in a case-based research study of the regeneration of Eastside in Birmingham, UK, through policy and other documents, and finds that conceptualisations of sustainability are fundamentally limited. The conceptualisation of sustainability operating within urban regeneration schemes should powerfully shape how they make manifest (or do not) the principles of sustainable development. Documents guide, but people implement regeneration—and the disparate conceptualisations of stakeholders demonstrate even less coherence than policy. The actions towards achieving sustainability have become a policy ‘fix’ in Eastside: a necessary feature of urban policy discourse that is limited to solutions within market-based constraints

Hydrogen Epoch of Reionization Array (HERA)

The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to measure 21 cm emission from the primordial intergalactic medium (IGM) throughout cosmic reionization ($z=6-12$), and to explore earlier epochs of our Cosmic Dawn ($z\sim30$). During these epochs, early stars and black holes heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is designed to characterize the evolution of the 21 cm power spectrum to constrain the timing and morphology of reionization, the properties of the first galaxies, the evolution of large-scale structure, and the early sources of heating. The full HERA instrument will be a 350-element interferometer in South Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz. Currently, 19 dishes have been deployed on site and the next 18 are under construction. HERA has been designated as an SKA Precursor instrument. In this paper, we summarize HERA's scientific context and provide forecasts for its key science results. After reviewing the current state of the art in foreground mitigation, we use the delay-spectrum technique to motivate high-level performance requirements for the HERA instrument. Next, we present the HERA instrument design, along with the subsystem specifications that ensure that HERA meets its performance requirements. Finally, we summarize the schedule and status of the project. We conclude by suggesting that, given the realities of foreground contamination, current-generation 21 cm instruments are approaching their sensitivity limits. HERA is designed to bring both the sensitivity and the precision to deliver its primary science on the basis of proven foreground filtering techniques, while developing new subtraction techniques to unlock new capabilities. The result will be a major step toward realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table

Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction

Myocardial infarction (MI) accelerates immune ageing characterised by lymphopenia, expansion of terminally differentiated CD8+ T-lymphocytes (CD8+ TEMRA) and inflammation. Pre-clinical data showed that TA-65, an oral telomerase activator, reduced immune ageing and inflammation after MI. We conducted a double blinded randomised controlled pilot trial evaluating the use of TA-65 to reduce immune cell ageing in patients following MI. Ninety MI patients aged over 65 years were randomised to either TA-65 (16 mg daily) or placebo for 12 months. Peripheral blood leucocytes were analysed by flow cytometry. The pre-defined primary endpoint was the proportion of CD8+ T-lymphocytes which were CD8+ TEMRA after 12 months. Secondary outcomes included high-sensitivity C-reactive protein (hsCRP) levels. Median age of participants was 71 years. Proportions of CD8+ TEMRA did not differ after 12 months between treatment groups. There was a significant increase in mean total lymphocyte count in the TA-65 group after 12 months (estimated treatment effect: + 285 cells/μl (95% CI: 117–452 cells/ μ l, p < 0.004), driven by significant increases from baseline in CD3+, CD4+, and CD8+ T-lymphocytes, B-lymphocytes and natural killer cells. No increase in lymphocyte populations was seen in the placebo group. At 12 months, hsCRP was 62% lower in the TA-65 group compared to placebo (1.1 vs. 2.9 mg/L). Patients in the TA-65 arm experienced significantly fewer adverse events (130 vs. 185, p = 0.002). TA-65 did not alter CD8+ TEMRA but increased all major lymphocyte subsets and reduced hsCRP in elderly patients with MI after 12 months