An Exploratory Study on the Distribution for The Results of IT-Enabled Value Co-Creation

This paper proposes to discover the phenomenon from an existing online user-generated platform to understand the issue on distributing the final value from the Information Technology (IT)-enabled value collaboration. The main purpose of this paper is to fill up the gap that there is no method to make sure the distribution fairly to find an impartial way on distributing the result of the value collaboration works. It is expected that this paper will help people know the importance of distribution on final value from co-creation and help the virtual platforms of value co-creation improve their performance of collaboration by identifying the participants’ true needs or benefits in order to design a better environment for the next cooperation works

Thromboembolic Risks of Recombinant Factor VIIa Use in Warfarin-Associated Intracranial Hemorrhage: A Case–Control Study

Background: Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and may carry significant thromboembolic risks. We compared incidence of baseline thromboembolic risk factors and thromboembolism rates in wICH patients treated with additional rFVIIa to those treated with standard therapy of fresh frozen plasma (FFP) and vitamin K alone. Methods: We identified 45 consecutive wICH patients treated with additional rFVIIa over 5-year period, and 34 consecutive wICH patients treated with standard therapy alone as comparison group. We compared the incidence of post-hemorrhage cardiac and extra-cardiac thromboembolic complications between two treatment groups, and used logistic regression to adjust for significant confounders such as baseline thromboembolic risk factors. We performed secondary analysis comparing the quantity of FFP transfused between two treatment cohorts. Results: Both rFVIIa-treated and standard therapy-treated wICH patients had a high prevalence of pre-existing thromboembolic diseases including atrial fibrillation (73% vs 68%), deep venous thrombosis (DVT) or pulmonary embolism (PE) (22% vs 18%), coronary artery disease (CAD) (38% vs 32%), and abnormal electrocardiogram (EKG) (78% vs 85%). Troponin elevation following wICH was prevalent in both groups (47% vs 41%). Clinically significant myocardial infarction (MI), defined as troponin > 1.0 ng/dL, occurred in 13% of rFVIIa-treated and 6% of standard therapy-treated patients (p=0.52). Past history of CAD (p=0.0061) and baseline abnormal EKG (p=0.02) were independently associated with clinically significant MI following wICH while rFVIIa use was not. The incidences of DVT/PE (2% vs 9%; p=0.18) and ischemic stroke (2% vs 0%; p=0.38) were similar between two treatment groups. Recombinant FVIIa-treated patients had lower mean INR at 3 (p=0.0001) and 6 hours (p<0.0001) and received fewer units of FFP transfusion (3 vs 5; p=0.003). Conclusions: Pre-existing thromboembolic risk factors as well as post-hemorrhage troponin elevation are prevalent in wICH patients. Clinically significant MI occurs in up to 13% of wICH patients. rFVIIa use was not associated with increased incidence of clinically significant MI or other venous or arterial thromboembolic events in this wICH cohort

Magnetic ordering in electronically phase-separated La2-xSrxCuO4+y: Neutron diffraction experiments

We present results of magnetic neutron diffraction experiments on the codoped superoxygenated La2-xSrxCuO4+y (LSCO+O) system with x=0.09. We find that the magnetic phase is long-range ordered incommensurate antiferromagnetic with a Neacuteel temperature T-N coinciding with the superconducting ordering temperature T-c=40 K. The incommensurability value is consistent with a hole doping of n(h)approximate to 1>8 but in contrast to nonsuperoxygenated La2-xSrxCuO4 with hole doping close to n(h)approximate to 18 the magnetic-order parameter is not field dependent. We attribute this to the magnetic order being fully developed in LSCO+O as in the spin and charge ordered "stripe" compounds La1.48Nd0.40Sr0.12CuO4 and La7/8Ba1/8CuO4

Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors

10.1371/journal.pone.0116933PLoS ONE101e011693

Measurement of unique magnetic and superconducting phases in oxygen-doped high-temperature superconductors La_2-xSr_xCuO_4+y

We present a combined magnetic neutron scattering and muon spin rotation study of the nature of the magnetic and superconducting phases in electronically phase separated La(2-x)Sr(x)CuO(4+y), x = 0.04, 065, 0.09. For all samples, we find long-range modulated magnetic order below T_N ~ T_c = 39 K. In sharp contrast wit oxygen-stoichiometric La(2-x)Sr(x)CuO(4), we find that the magnetic propagation vector as well as the ordered magnetic moment is independent of Sr content and consistent with that of the 'striped' cuprates. Our study provides direct proof that superoxygenation in La(2-x)Sr(x)CuO(4+y) allows the spin stripe ordered phase to emerge and phase separate from superconducting regions with the hallmarks of optimally doped oxygen-stoichiometric La(2-x)Sr(x)CuO(4)

Comparative regioselective and sttereosellective metabolism of 7-dhiloroIbe]niz[fl]aini(tIhiiraceiiie amd 7-bromobeinizMaMilIhiiraceinie by momise amid rat liver mcrosomes

Quantitative metabolism of 7-chlorobenz[a]anthracene (7-C1-BA) and 7-bromobenz[a]anthracene (7-Br-BA) by liver microsomes of uninduced mice and rats was studied. Both enzymatic systems metabolize 7-C1-BA preferentially at the C-8 and C-9 aromatic double bond region, -42 and -56% respectively, of the total metabolites. 7-C1-BA and 7-Br-BA were metabolized considerably at C-3 and C-4, C-5 and C-6, C-8 and C-9, and C-10 and C-ll. While 7-C1-BA &lt;rans-3,4-dihydrodiol was formed in a 7-8% yield of the total metabolites in both enzymatic systems, 7-Br-BA trans-3,4-dihdyrodiol was formed 16.0 and 9.9% respectively, from the mouse and rat liver microsomal metabolism. In mutagenicity assays with the Salmonella typhimurium tester strain TA100 in the presence of S9 activation enzymes, both of these fra/w-3,4-dihydrodiols exhibited higher mutagenicity than 7-C1-BA and 7-Br-BA, while the other ftwis-dihydrodiol metabolites were either essentially inactive or weaker than the parent compounds. These results suggest that 7-C1-BA *ra/is-3,4-dihydrodiol and 7-Br-BA *ra/is-3,4-dihydrodiol are the proximate metabolites of 7-CI-BA and 7-Br-BA. Metabolism of 7-CI-BA and 7-Br-BA by mouse liver mkrosomes was also in a stereoselective manner, preferentially giving /nz/u-dihydrodiol metabolites an R, R stereochemistry

Application of pharmacogenomics and bioinformatics to exemplify the utility of human <i>ex vivo</i> organoculture models in the field of precision medicine

Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines. Diseased tissue ethically acquired from patients suffering from chronic obstructive pulmonary disease (COPD), was used to investigate inter-patient variability in drug efficacy using ex vivo organocultures of fresh lung tissue as the test system. The reduction in inflammatory cytokines in the presence of various test drugs was used as the measure of drug efficacy and the individual patient responses were then matched against genotype and microRNA profiles in an attempt to identify unique predictors of drug responsiveness. Our findings suggest that genetic variation in CYP2E1 and SMAD3 genes may partly explain the observed variation in drug response

Integration of Women Veterans into VA Quality Improvement Research Efforts: What Researchers Need to Know

The Department of Veterans Affairs (VA) and other federal agencies require funded researchers to include women in their studies. Historically, many researchers have indicated they will include women in proportion to their VA representation or pointed to their numerical minority as justification for exclusion. However, women’s participation in the military—currently 14% of active military—is rapidly changing veteran demographics, with women among the fastest growing segments of new VA users. These changes will require researchers to meet the challenge of finding ways to adequately represent women veterans for meaningful analysis. We describe women veterans’ health and health-care use, note how VA care is organized to meet their needs, report gender differences in quality, highlight national plans for women veterans’ quality improvement, and discuss VA women’s health research. We then discuss challenges and potential solutions for increasing representation of women veterans in VA research, including steps for implementation research

Fuzzy segmentation of postmodern tourists.

In postmodern tourism, the experiences of each tourist could not be summarized only through a unique perspective but multiple and disjointed perspectives are necessary. The aim of this paper is to create a nexus between postmodern tourist and fuzzy clustering, and to propose a suitable clustering procedure to segment postmodern tourists. From a methodological perspective, the main contribution of this paper is related to the use of the fuzzy theory from the beginning to the end of the clustering process. Furthermore, the suggested procedure is capable of analysing the uncertainty and vagueness that characterise the experiences and perceptions of postmodern consumers. From a managerial perspective, fuzzy clustering methods offer to practitioners a more realistic multidimensional description of the market not forcing consumers to belong to one cluster. Moreover, the results are easy and comprehensible to read since they are similar to those obtained with more traditional clustering techniques

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

The caspase recruitment domain (CARD) is present in death-domain superfamily proteins involved in inflammation and apoptosis. BinCARD is named for its ability to interact with Bcl10 and inhibit downstream signalling. Human BinCARD is expressed as two isoforms that encode the same N-terminal CARD region but which differ considerably in their C-termini. Both isoforms are expressed in immune cells, although BinCARD-2 is much more highly expressed. Crystals of the CARD fold common to both had low symmetry (space group P1). Molecular replacement was unsuccessful in this low-symmetry space group and, as the construct contains no methionines, first one and then two residues were engineered to methionine for MAD phasing. The double-methionine variant was produced as a selenomethionine derivative, which was crystallized and the structure was solved using data measured at two wavelengths. The crystal structures of the native and selenomethionine double mutant were refined to high resolution (1.58 and 1.40 Å resolution, respectively), revealing the presence of a cis-peptide bond between Tyr39 and Pro40. Unexpectedly, the native crystal structure revealed that all three cysteines were oxidized. The mitochondrial localization of BinCARD-2 and the susceptibility of its CARD region to redox modification points to the intriguing possibility of a redox-regulatory role