Differential Transverse Flow in Central C-Ne and C-Cu Collisions at 3.7 GeV/nucleon

Differential transverse flow of protons and pions in central C-Ne and C-Cu collisions at a beam energy of 3.7 GeV/nucleon was measured as a function of transverse momentum at the SKM-200-GIBS setup of JINR. In agreement with predictions of a transversely moving thermal model, the strength of proton differential transverse flow is found to first increase gradually and then saturate with the increasing transverse momentum in both systems. While pions are preferentially emitted in the same direction of the proton transverse flow in the reaction of C-Ne, they exhibit an anti-flow to the opposote direction of the proton transverse flow in the reaction of C-Cu due to stronger shadowing effects of the heavier target in thr whole range of transverse momentum.Comment: 15 pages, 5 figure

Coherent particle production in collisions of relativistic nuclei

Here we give the results of our study of features of dense groups, or spikes, of particles produced in Mg-Mg and C-Cu collisions at, respectively, 4.3 and 4.5 GeV/c/nucleon aimed to search for a coherent, Cerenkov-like, mechanism of hadroproduction. We investigate the distributions of spike centers and, for Mg-Mg interactions, the energy spectra of negatively charged particles in spikes. The spike-center distributions are obtained to exhibit the structure expected from coherent gluon-jet emission dynamics. This structure is similar in both cases considered, namely for all charged and negatively charged particles, and is also similar to that observed recently for all-charged-particle spikes in hadronic interactions. The energy distribution within spikes is found to have a significant peak over the inclusive background, while the inclusive spectrum shows exponential decrease with two characteristic values of average kinetic energy. The value of the peak energy and its width are in a good agreement with those expected for pions produced in a nuclear medium in the framework of the Cerenkov quantum approach. The peak energy obtained is consistent with the value of the cross-section maximum observed in coincidence nucleon-nucleus interaction experiments.Comment: 8 pages, 5 figures. Invited talk presented by E.S. at the 9th International Workshop on Multiparticle Production: New Frontiers in Soft Physics and Correlations on the Threshold of the Third Millenium, Turin, Italy, June 12 - 17, 200

Anisotropic flow in 4.2A GeV/c C+Ta collisions

Anisotropic flow of protons and negative pions in 4.2A GeV/c C+Ta collisions is studied using the Fourier analysis of azimuthal distributions. The protons exhibit pronounced directed flow. Directed flow of pions is positive in the entire rapidity interval and indicates that the pions are preferentially emitted in the reaction plane from the target to the projectile. The elliptic flow of protons and negative pions is close to zero. Comparison with the quark-gluon-string model (QGSM) and relativistic transport model (ART 1.0) show that they both yield a flow signature similar to the experimental data.Comment: 4 pages, 3 figures, Accepted for publication in Phys. Rev.

Flow analysis from multiparticle azimuthal correlations

We present a new method for analyzing directed and elliptic flow in heavy ion collisions. Unlike standard methods, it separates the contribution of flow to azimuthal correlations from contributions due to other effects. The separation relies on a cumulant expansion of multiparticle azimuthal correlations, and includes corrections for detector inefficiencies. This new method allows the measurement of the flow of identified particles in narrow phase-space regions, and can be used in every regime, from intermediate to ultrarelativistic energies.Comment: 31 pages, revtex. Published version (references added

The co-evolution of the genome and epigenome in colorectal cancer.

Colorectal malignancies are a leading cause of cancer-related death1 and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4-7. Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at single-clone resolution using spatial multi-omic profiling of individual glands. We collected 1,370 samples from 30 primary cancers and 8 concomitant adenomas and generated 1,207 chromatin accessibility profiles, 527 whole genomes and 297 whole transcriptomes. We found positive selection for DNA mutations in chromatin modifier genes and recurrent somatic chromatin accessibility alterations, including in regulatory regions of cancer driver genes that were otherwise devoid of genetic mutations. Genome-wide alterations in accessibility for transcription factor binding involved CTCF, downregulation of interferon and increased accessibility for SOX and HOX transcription factor families, suggesting the involvement of developmental genes during tumourigenesis. Somatic chromatin accessibility alterations were heritable and distinguished adenomas from cancers. Mutational signature analysis showed that the epigenome in turn influences the accumulation of DNA mutations. This study provides a map of genetic and epigenetic tumour heterogeneity, with fundamental implications for understanding colorectal cancer biology

Evolutionary dynamics of residual disease in human glioblastoma.

Background Glioblastoma is the most common and aggressive adult brain malignancy against which conventional surgery and chemoradiation provide limited benefit. Even when a good treatment response is obtained, recurrence inevitably occurs either locally (∼80%) or distally (∼20%), driven by cancer clones that are often genomically distinct from those in the primary tumour. Glioblastoma cells display a characteristic infiltrative phenotype, invading the surrounding tissue and often spreading across the whole brain. Cancer cells responsible for relapse can reside in two compartments of residual disease that are left behind after treatment: the infiltrated normal brain parenchyma and the sub-ventricular zone. However, these two sources of residual disease in glioblastoma are understudied because of the difficulty in sampling these regions during surgery.Patient and methods Here, we present the results of whole-exome sequencing of 69 multi-region samples collected using fluorescence-guided resection from 11 patients, including the infiltrating tumour margin and the sub-ventricular zone for each patient, as well as matched blood. We used a phylogenomic approach to dissect the spatio-temporal evolution of each tumour and unveil the relation between residual disease and the main tumour mass. We also analysed two patients with paired primary-recurrence samples with matched residual disease.Results Our results suggest that infiltrative subclones can arise early during tumour growth in a subset of patients. After treatment, the infiltrative subclones may seed the growth of a recurrent tumour, thus representing the 'missing link' between the primary tumour and recurrent disease.Conclusions These results are consistent with recognised clinical phenotypic behaviour and suggest that more specific therapeutic targeting of cells in the infiltrated brain parenchyma may improve patient's outcome

Theory of Sound Propagation in Superfluid Solutions Filled Porous Media

A theory of the propagation of acoustic waves in a porous medium filled with superfluid solution is developed. The elastic coefficients in the system of equations are expressed in terms of physically measurable quantities. The equations obtained describe all volume modes that can propagate in a porous medium saturated with superfluid solution. Finally, derived equations are applied to the most important particular case when the normal fluid component is locked inside a highly porous media (aerogel) by viscous forces and the velocities of two longitudinal sound modes are calculated.Comment: 13 pages, 0 figure

Vilnius Declaration on chronic respiratory diseases : multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases

Correction: Volume: 10 Issue: 1 Article Number: 49 DOI: 10.1186/s13601-020-00357-4 Published: DEC 17 2020Background: Over 1 billion people suffer from chronic respiratory diseases such as asthma, COPD, rhinitis and rhinosinusitis. They cause an enormous burden and are considered as major non-communicable diseases. Many patients are still uncontrolled and the cost of inaction is unacceptable. A meeting was held in Vilnius, Lithuania (March 23, 2018) under the patronage of the Ministry of Health and several scientific societies to propose multisectoral care pathways embedding guided self-management, mHealth and air pollution in selected chronic respiratory diseases (rhinitis, chronic rhinosinusitis, asthma and COPD). The meeting resulted in the Vilnius Declaration that was developed by the participants of the EU Summit on chronic respiratory diseases under the leadership of Euforea. Conclusion: The Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge.Peer reviewe

Lambda hyperons produced in central nucleus-nucleus interactions at 4.5 GeV/c momentum per incident nucleon

Transverse momenta and rapidities of Lambda 's produced in central nucleus-nucleus collisions at 4.5 GeV/c·u (C-C,...,O-Pb) were studied and compared with those from inelastic He-Li interactions at the same incident momentum. Polarization of the Lambda hyperons was found to be consistent with zero ( alpha P=-0.06=0.11 for Lambda 's from central collisions). An upper limit of the Lambda -bar / Lambda production ratio was estimated to be less than 4.5 x 10-3. The experiment was performed in a triggered streamer chamber