Emotions and language in cognitive development

The present study is dedicated to the question of the role of emotional activity of a human being in the making of cultural forms of behavior, consciousness and language. The study is carried out within the framework of cognitive practices directed at the making of consciousness and thinking. The author proceeds from the assumption that the basis for recording sense regulators in the human psyche was the emotional activity that was developing in the communities of higher animals. The appearance of words is connected with the increasing differentiation of senses. At this stage there appear binary oppositions, and rational rules of operating senses are formed. In the language synthesis of emotional and rational a cognitive means of mastering and transmitting senses is created

Fraktalna analiza seizmoakustičnih signala u sedimentnim stijenama blizu površine na Kamčatki

We studied, by the mono- and multifractal detrended fluctuation analysis (DFA), time fluctuations in the dynamics of seismoacoustic data, recorded in Karymshina site, which is located in a seismic area of Kamchatka. We took a series of seismoacoustic responses to the regional seismic events with the mag-nitudes M > 4 for the period 2017–2018. The series was divided into three groups (high, medium and low) based on the amplitude of recorded seismoacoustic re-sponse. Background noise segments of the signals demonstrated monofractal behavior similar to white noise by almost constant values of generalized Hurst exponent Hq≈0.5 and very small width of the multifractal spectrum Δa ≈ 0.1. Analysis of the high amplitude seismoacoustic signals with clear P-, S- and coda waves showed that P- and S-waves demonstrate wider multifractal spectrum (ΔaP = 0.37, ΔaS = 0.35) and range of generalized Hurst exponents Hq in com-parison with coda wave, characterized by almost constant Hq and minimal width of multifractal spectrum (ΔaCODA = 0.13). We showed that the properties of the multifractal spectrum could be used in detection of seismic wave arrival, estima-tion its duration and separation of P-, S- and coda waves. Application of the monofractal DFA in a sliding window showed that the acoustic signal transits from monofractal and uncorrelated background noise (Hurst exponent equals to 0.5) into the long-range dependent state during seismic waves arrival, that is helpful in analysis of the signals, particularly in case of low amplitude acous-tic responses, usually demonstrating an unclear waveform. Difference in mul-tifractal spectrum width between the original low amplitude signal and its sur-rogates, obtained by random shuffling showed that the multifractality in the signal is dominantly due to long-range correlations.U ovom smo radu mono- i multifraktalnom detrendiranom fluktuacijskom analizom (DFA) proučavali vremenske fluktuacije u dinamici seizmoakustičnih podataka zabilježe-nih na postaji Karymshina, koja je smještena u seizmički aktivnom području Kamčatke. U analizi smo koristili niz seizmoakustičnih odziva prilagođenih na regionalne potrese s magnitudama M > 4 za razdoblje 2017.–2018. Niz smo podijelili u tri grupe (visoka, sred-nja i niska) na temelju amplitude zabilježenog seizmoakustičnog odziva. Dio mikroseiz-mičkog nemira prisutnog unutar signala iskazuje monofraktalnu strukturu sličnu bijelom šumu s gotovo konstantnim vrijednostima generaliziranog Hurstovog eksponenta Hq ≈ 0,5 i vrlo malom širinom multifraktalnog spektra Δa ≈ 0,1. Analiza seizmoakustičnog signa-la visoke amplitude s jasnim P-, S- i koda valovima pokazala je da P- i S-valovi pokazuju širi multifraktalni spektar (ΔaP = 0,37, ΔaS = 0,35) i raspon generaliziranih Hurstovih eksponenata Hq u usporedbi s koda valovima, koje karakterizira gotovo konstantan Hq i minimalna širina multifraktalnog spektra (ΔaCODA = 0,13). Pokazali smo da se svojstva multifraktalnog spektra mogu upotrijebiti za otkrivanje nailaska seizmičkih valova, pro-cjenu nihovog trajanja i razdvajanje P-, S- i koda valova. Primjena monofraktalne DFA metode na zapise u kliznom prozoru pokazala je da akustički signal prelazi iz monofrak-talnog i nekoreliranog mikroseizmičkog nemira (Hurstov eksponent jednak 0,5) u stanje dugog dometa tijekom dolaska seizmičkih valova, što je korisno u analizi signala, poseb-no u slučaju akustičnih odziva niske amplitude s nejasnim valnim oblikom. Razlika u širini multifraktalnog spektra između izvornog signala niske amplitude i njegovih zam-jenskih oblika, dobivenih nasumičnim odabirom, ukazuje da multifraktalnost u signalu dominantno ovisi o dalekosežnim korelacijama

Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides

a-Glucosyl ceramides 4 and 5 have been synthesised and evaluated for their ability to stimulate the activation and expansion of human iNKT cells. The key challenge in the synthesis of both target molecules was the stereoselective synthesis of the a-glycosidic linkage. Of the methods examined, glycosylation using per-TMS-protected glucosyl iodide 16 was completely a-selective and provided gram quantities of amine 11, from which a-glucosyl ceramides 4 and 5 were obtained by N-acylation. a-GlcCer 4, containing a C24 saturated acyl chain, stimulated a marked proliferation and expansion of human circulating iNKT cells in short-term cultures. a-GlcCer 5, which contains a C20 11,14-cis-diene acyl chain (C20:2),induced extremely similar levels of iNKT cell activation and expansion

Patterning GaSe by High-Powered Laser Beams

We report the high-powered laser modification of the chemical, physical, and structural properties of the two-dimensional (2D) van der Waals material GaSe. Our results show that contrary to expectations and previous reports, GaSe at the periphery of a high-power laser beam does not entirely decompose into Se and Ga2O3. In contrast, we find unexpectedly that the Raman signal from GaSe gets amplified around regions where it was not expected to exist. Atomic force microscopy (AFM), dielectric force microscopy (DFM), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) results show that laser irradiation induces the formation of nanoparticles. Our analyses demonstrate that, except for a fraction of Ga2Se3, these nanoparticles still belong to the GaSe phase but possess different electrical and optical properties. These changes are evidenced in the increased Raman intensity attributed to the near-resonance conditions with the Raman excitation laser. The elemental analysis of nanoparticles shows that the relative selenium content increased to as much as 70% from a 50:50 value in stoichiometric GaSe. This elemental change is related to the formation of the Ga2Se3 phase identified by Raman spectroscopy at some locations near the edge. Further, we exploit the localized high-power laser processing of GaSe to induce the formation of Ag–GaSe nanostructures by exposure to a solution of AgNO3. The selective reaction of AgNO3 with laser-irradiated GaSe gives rise to composite nanostructures that display photocatalytic activity originally absent in the pristine 2D material. The photocatalytic activity was investigated by the transformation of 4-nitrobenzenethiol to its amino and dimer forms detected in situ by Raman spectroscopy. This work improves the understanding of light–matter interaction in layered systems, offering an approach to the formation of laser-induced composites with added functionality

Pharmaceutical And Biomedical Applications Of Affinity Chromatography: Recent Trends And Developments

Affinity chromatography is a separation technique that has become increasingly important in work with biological samples and pharmaceutical agents. This method is based on the use of a biologically-related agent as a stationary phase to selectively retain analytes or to study biological interactions. This review discusses the basic principles behind affinity chromatography and examines recent developments that have occurred in the use of this method for biomedical and pharmaceutical analysis. Techniques based on traditional affinity supports are discussed, but an emphasis is placed on methods in which affinity columns are used as part of HPLC systems or in combination with other analytical methods. General formats for affinity chromatography that are considered include step elution schemes, weak affinity chromatography, affinity extraction and affinity depletion. Specific separation techniques that are examined include lectin affinity chromatography, boronate affinity chromatography, immunoaffinity chromatography, and immobilized metal ion affinity chromatography. Approaches for the study of biological interactions by affinity chromatography are also presented, such as the measurement of equilibrium constants, rate constants, or competition and displacement effects. In addition, related developments in the use of immobilized enzyme reactors, molecularly imprinted polymers, dye ligands and aptamers are briefly considered

Socio-economic problems of intensified utilization of land resources in agriculture of regional agro-industrial complex (e.g. steppe regions of Northern Caucasus and Lower Volga region)

Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Emotions and language in cognitive development

The present study is dedicated to the question of the role of emotional activity of a human being in the making of cultural forms of behavior, consciousness and language. The study is carried out within the framework of cognitive practices directed at the making of consciousness and thinking. The author proceeds from the assumption that the basis for recording sense regulators in the human psyche was the emotional activity that was developing in the communities of higher animals. The appearance of words is connected with the increasing differentiation of senses. At this stage there appear binary oppositions, and rational rules of operating senses are formed. In the language synthesis of emotional and rational a cognitive means of mastering and transmitting senses is created

Interfering with the sugar code : design and synthesis of oligosaccharide mimics

Oligosaccharide determinants of cellular glycoconjugates interact with protein receptors triggering a variety of cellular responses within a wide range of physiological and pathological processes and with exquisitely tuned selectivity. This has led to the formulation of the hypothesis that a sugar code exists and that sugar-binding proteins (lectins) act to decipher it and translate it into biological responses. Interference with these recognition events by functional mimics of carbohydrates could thus be used to modulate or alter signal transmission, or to prevent the onset of diseases. Attempts to design and prepare glycomimetic inhibitors of well-known target lectins (cholera toxin, DC-SIGN) are reviewed in this concept paper